Accuracy and efficiency define Bxb1 integrase as the best of fifteen candidate serine recombinases for the integration of DNA into the human genome

BMC Biotechnology

Volumn 13, Issue , 2013, Pages

  Xu, Zhengyao ^a   Thomas, Louise ^b   Davies, Ben ^c   Chalmers, Ronald ^a   Smith, Maggie ^b,d   Brown, William ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^b UNIVERSITY OF ABERDEEN   (United Kingdom)

^c UNIVERSITY OF OXFORD   (United Kingdom)

^d UNIVERSITY OF YORK   (United Kingdom)

Author keywords

DNA damage; Genome manipulation; Serine recombinases

Indexed keywords

DNA DAMAGES; DNA MANIPULATION; GENOME ENGINEERING; HUMAN FIBROBLAST; MOUSE EMBRYONIC STEM CELLS; RECOMBINASES; SITE-SPECIFIC RECOMBINATION; VERTEBRATE CELLS;

AMINO ACIDS; CELL CULTURE; CELL ENGINEERING; ESCHERICHIA COLI; GENES;

DNA;

A118 INTEGRASE; BL3 INTEGRASE; BXB1 INTEGRASE; DNA; FC1 INTEGRASE; INTEGRASE; K38 INTEGRASE; MR11 INTEGRASE; PHI 370 INTEGRASE; PHI BT1 INTEGRASE; PHI C31 INTEGRASE; PHI R4 INTEGRASE; PHI RV INTEGRASE; REAGENT; TG1 INTEGRASE; TP901 1 INTEGRASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DNA DAMAGE; DNA INTEGRATION; EMBRYO; EMBRYONIC STEM CELL; ESCHERICHIA COLI; FIBROBLAST; GENETIC ENGINEERING; GENETIC RECOMBINATION; HUMAN; HUMAN CELL; HUMAN GENOME; MAMMAL CELL; MOUSE; NONHUMAN; REPORTER GENE;

MAMMALIA; VERTEBRATA;

AMINO ACID SEQUENCE; ANIMALS; ATTACHMENT SITES, MICROBIOLOGICAL; BACTERIOPHAGES; CELL LINE, TUMOR; CLONING, MOLECULAR; DNA; DNA NUCLEOTIDYLTRANSFERASES; EMBRYONIC STEM CELLS; ESCHERICHIA COLI; FIBROSARCOMA; GENE DELETION; GENOME, HUMAN; HUMANS; INTEGRASES; MICE; MOLECULAR SEQUENCE DATA; PLASMIDS; RECOMBINASES; RECOMBINATION, GENETIC; SERINE;

EID: 84885506325     PISSN: None     EISSN: 14726750     Source Type: Journal    
DOI: 10.1186/1472-6750-13-87     Document Type: Article

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