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Volumn 126, Issue 19, 2013, Pages 4469-4478

Trafficking of the EGFR ligand spitz regulates its signaling activity in polarized tissues

Author keywords

Egfr; Imaginal disc; Palmitoylation; Rhomboid; Spitz

Indexed keywords

CHIMERIC PROTEIN; EPIDERMAL GROWTH FACTOR RECEPTOR; MEMBRANE PROTEIN; PALMITIC ACID; SONIC HEDGEHOG PROTEIN;

EID: 84885466563     PISSN: 00219533     EISSN: 14779137     Source Type: Journal    
DOI: 10.1242/jcs.131169     Document Type: Article
Times cited : (20)

References (65)
  • 1
    • 1642321955 scopus 로고    scopus 로고
    • Knockouts of Kekkon1 define sequence elements essential for Drosophila epidermal growth factor receptor inhibition
    • Alvarado, D., Rice, A. H. and Duffy, J. B. (2004). Knockouts of Kekkon1 define sequence elements essential for Drosophila epidermal growth factor receptor inhibition. Genetics 166, 201-211.
    • (2004) Genetics , vol.166 , pp. 201-211
    • Alvarado, D.1    Rice, A.H.2    Duffy, J.B.3
  • 2
    • 0025372020 scopus 로고
    • Cell-cell adhesion mediated by binding of membrane-anchored transforming growth factor alpha to epidermal growth factor receptors promotes cell proliferation
    • Anklesaria, P., Teixidó , J., Laiho, M., Pierce, J. H., Greenberger, J. S., and Massagué, J. (1990). Cell-cell adhesion mediated by binding of membrane-anchored transforming growth factor alpha to epidermal growth factor receptors promotes cell proliferation. Proc. Natl. Acad. Sci. USA 87, 3289-3293.
    • (1990) Proc. Natl. Acad. Sci. USA , vol.87 , pp. 3289-3293
    • Anklesaria, P.1    Teixidó, J.2    Laiho, M.3    Pierce, J.H.4    Greenberger, J.S.5    Massagué, J.6
  • 3
    • 0029055716 scopus 로고
    • Gliotactin, a novel transmembrane protein on peripheral glia, is required to form the blood-nerve barrier in Drosophila
    • Auld, V. J., Fetter, R. D., Broadie, K., and Goodman, C. S. (1995). Gliotactin, a novel transmembrane protein on peripheral glia, is required to form the blood-nerve barrier in Drosophila. Cell 81, 757-767.
    • (1995) Cell , vol.81 , pp. 757-767
    • Auld, V.J.1    Fetter, R.D.2    Broadie, K.3    Goodman, C.S.4
  • 5
    • 34249989074 scopus 로고    scopus 로고
    • The EGFR ligands Spitz, and Keren act cooperatively in the Drosophila eye
    • Brown, K. E., Kerr, M., and Freeman, M. (2007). The EGFR ligands Spitz, and Keren act cooperatively in the Drosophila eye. Dev. Biol. 307, 105-113.
    • (2007) Dev. Biol. , vol.307 , pp. 105-113
    • Brown, K.E.1    Kerr, M.2    Freeman, M.3
  • 7
    • 0025187057 scopus 로고
    • Characterization, and gene cloning of neurotactin, a Drosophila transmembrane protein related to cholinesterases
    • de la Escalera, S., Bockamp, E. O., Moya, F., Piovant, M., and Jiménez, F. (1990). Characterization, and gene cloning of neurotactin, a Drosophila transmembrane protein related to cholinesterases. EMBO J. 9, 3593-3601.
    • (1990) EMBO J. , vol.9 , pp. 3593-3601
    • de la Escalera, S.1    Bockamp, E.O.2    Moya, F.3    Piovant, M.4    Jiménez, F.5
  • 8
    • 0037403645 scopus 로고    scopus 로고
    • Basolateral sorting of transforming growth factor-alpha precursor in polarized epithelial cells: characterization of cytoplasmic domain determinants
    • Dempsey, P. J., Meise, K. S., and Coffey, R. J. (2003). Basolateral sorting of transforming growth factor-alpha precursor in polarized epithelial cells: characterization of cytoplasmic domain determinants. Exp. Cell Res. 285, 159-174.
    • (2003) Exp. Cell Res. , vol.285 , pp. 159-174
    • Dempsey, P.J.1    Meise, K.S.2    Coffey, R.J.3
  • 9
    • 0032991651 scopus 로고    scopus 로고
    • Metalloprotease-mediated ligand release regulates autocrine signaling through the epidermal growth factor receptor
    • Dong, J., Opresko, L. K., Dempsey, P. J., Lauffenburger, D. A., Coffey, R. J., and Wiley, H. S. (1999). Metalloprotease-mediated ligand release regulates autocrine signaling through the epidermal growth factor receptor. Proc. Natl. Acad. Sci. USA 96, 6235-6240.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 6235-6240
    • Dong, J.1    Opresko, L.K.2    Dempsey, P.J.3    Lauffenburger, D.A.4    Coffey, R.J.5    Wiley, H.S.6
  • 10
    • 19644373566 scopus 로고    scopus 로고
    • The membrane-anchoring domain of epidermal growth factor receptor ligands dictates their ability to operate in juxtacrine mode
    • Dong, J., Opresko, L. K., Chrisler, W., Orr, G., Quesenberry, R. D., Lauffenburger, D. A., and Wiley, H. S. (2005). The membrane-anchoring domain of epidermal growth factor receptor ligands dictates their ability to operate in juxtacrine mode. Mol. Biol. Cell 16, 2984-2998.
    • (2005) Mol. Biol. Cell , vol.16 , pp. 2984-2998
    • Dong, J.1    Opresko, L.K.2    Chrisler, W.3    Orr, G.4    Quesenberry, R.D.5    Lauffenburger, D.A.6    Wiley, H.S.7
  • 11
    • 0030584086 scopus 로고    scopus 로고
    • Reiterative use of the EGF receptor triggers differentiation of all cell types in the Drosophila eye
    • Freeman, M. (1996). Reiterative use of the EGF receptor triggers differentiation of all cell types in the Drosophila eye. Cell 87, 651-660.
    • (1996) Cell , vol.87 , pp. 651-660
    • Freeman, M.1
  • 12
    • 0026631093 scopus 로고
    • The argos gene encodes a diffusible factor that regulates cell fate decisions in the Drosophila eye
    • Freeman, M., Klãmbt, C., Goodman, C. S., and Rubin, G. M. (1992). The argos gene encodes a diffusible factor that regulates cell fate decisions in the Drosophila eye. Cell 69, 963-975.
    • (1992) Cell , vol.69 , pp. 963-975
    • Freeman, M.1    Klãmbt, C.2    Goodman, C.S.3    Rubin, G.M.4
  • 13
    • 0033582934 scopus 로고    scopus 로고
    • The transmembrane molecule kekkon 1 acts in a feedback loop to negatively regulate the activity of the Drosophila EGF receptor during oogenesis
    • Ghiglione, C., Carraway, K. L., III, Amundadottir, L. T., Boswell, R. E., Perrimon, N., and Duffy, J. B. (1999). The transmembrane molecule kekkon 1 acts in a feedback loop to negatively regulate the activity of the Drosophila EGF receptor during oogenesis. Cell 96, 847-856.
    • (1999) Cell , vol.96 , pp. 847-856
    • Ghiglione, C.1    Carraway, K.L.2    Amundadottir, L.T.3    Boswell, R.E.4    Perrimon, N.5    Duffy, J.B.6
  • 14
    • 0029855245 scopus 로고    scopus 로고
    • The Drosophila embryonic midline is the site of Spitz processing,, and induces activation of the EGF receptor in the ventral ectoderm
    • Golembo, M., Raz, E., and Shilo, B. Z. (1996a). The Drosophila embryonic midline is the site of Spitz processing,, and induces activation of the EGF receptor in the ventral ectoderm. Development 122, 3363-3370.
    • (1996) Development , vol.122 , pp. 3363-3370
    • Golembo, M.1    Raz, E.2    Shilo, B.Z.3
  • 15
    • 0029671192 scopus 로고    scopus 로고
    • Argos transcription is induced by the Drosophila EGF receptor pathway to form an inhibitory feedback loop
    • Golembo, M., Schweitzer, R., Freeman, M., and Shilo, B. Z. (1996b). Argos transcription is induced by the Drosophila EGF receptor pathway to form an inhibitory feedback loop. Development 122, 223-230.
    • (1996) Development , vol.122 , pp. 223-230
    • Golembo, M.1    Schweitzer, R.2    Freeman, M.3    Shilo, B.Z.4
  • 17
    • 0025606148 scopus 로고
    • Drosophila neurotactin, a surface glycoprotein with homology to serine esterases, is dynamically expressed during embryogenesis
    • Hortsch, M., Patel, N. H., Bieber, A. J., Traquina, Z. R., and Goodman, C. S. (1990). Drosophila neurotactin, a surface glycoprotein with homology to serine esterases, is dynamically expressed during embryogenesis. Development 110, 1327-1340.
    • (1990) Development , vol.110 , pp. 1327-1340
    • Hortsch, M.1    Patel, N.H.2    Bieber, A.J.3    Traquina, Z.R.4    Goodman, C.S.5
  • 18
    • 18344390418 scopus 로고    scopus 로고
    • ERBB receptors, and cancer: the complexity of targeted inhibitors
    • Hynes, N. E., and Lane, H. A. (2005). ERBB receptors, and cancer: the complexity of targeted inhibitors. Nat. Rev. Cancer 5, 341-354.
    • (2005) Nat. Rev. Cancer , vol.5 , pp. 341-354
    • Hynes, N.E.1    Lane, H.A.2
  • 19
    • 0033520312 scopus 로고    scopus 로고
    • Contact-dependent growth inhibition, and apoptosis of epidermal growth factor (EGF) receptor-expressing cells by themembrane-anchored form of heparin-binding EGF-like growth factor
    • Iwamoto, R., Handa, K., and Mekada, E. (1999). Contact-dependent growth inhibition, and apoptosis of epidermal growth factor (EGF) receptor-expressing cells by themembrane-anchored form of heparin-binding EGF-like growth factor. J. Biol. Chem. 274, 25906-25912.
    • (1999) J. Biol. Chem. , vol.274 , pp. 25906-25912
    • Iwamoto, R.1    Handa, K.2    Mekada, E.3
  • 20
    • 64549110803 scopus 로고    scopus 로고
    • EGFR signaling regulates the proliferation of Drosophila adult midgut progenitors
    • Jiang, H., and Edgar, B. A. (2009). EGFR signaling regulates the proliferation of Drosophila adult midgut progenitors. Development 136, 483-493.
    • (2009) Development , vol.136 , pp. 483-493
    • Jiang, H.1    Edgar, B.A.2
  • 22
    • 0032544565 scopus 로고    scopus 로고
    • The LIN-2/LIN-7/LIN-10 complex mediates basolateral membrane localization of the Celegans EGF receptor LET-23 in vulval epithelial cells.
    • Kaech, S. M., Whitfield, C. W., and Kim, S. K. (1998). The LIN-2/LIN-7/LIN-10 complex mediates basolateral membrane localization of the C. elegans EGF receptor LET-23 in vulval epithelial cells. Cell 94, 761-771.
    • (1998) Cell , vol.94 , pp. 761-771
    • Kaech, S.M.1    Whitfield, C.W.2    Kim, S.K.3
  • 23
    • 0035942989 scopus 로고    scopus 로고
    • Sightless has homology to transmembrane acyltransferases, and is required to generate active Hedgehog protein
    • Lee, J. D., and Treisman, J. E. (2001). Sightless has homology to transmembrane acyltransferases, and is required to generate active Hedgehog protein. Curr. Biol. 11, 1147-1152.
    • (2001) Curr. Biol. , vol.11 , pp. 1147-1152
    • Lee, J.D.1    Treisman, J.E.2
  • 24
    • 0035913906 scopus 로고    scopus 로고
    • Regulated intracellular ligand transport, and proteolysis control EGF signal activation in Drosophila
    • Lee, J. R., Urban, S., Garvey, C. F., and Freeman, M. (2001). Regulated intracellular ligand transport, and proteolysis control EGF signal activation in Drosophila. Cell 107, 161-171.
    • (2001) Cell , vol.107 , pp. 161-171
    • Lee, J.R.1    Urban, S.2    Garvey, C.F.3    Freeman, M.4
  • 25
    • 0032894310 scopus 로고    scopus 로고
    • Several levels of EGF receptor signaling during photoreceptor specification in wild-type, Ellipse,, and null mutant Drosophila
    • Lesokhin, A. M., Yu, S. Y., Katz, J., and Baker, N. E. (1999). Several levels of EGF receptor signaling during photoreceptor specification in wild-type, Ellipse,, and null mutant Drosophila. Dev. Biol. 205, 129-144.
    • (1999) Dev. Biol. , vol.205 , pp. 129-144
    • Lesokhin, A.M.1    Yu, S.Y.2    Katz, J.3    Baker, N.E.4
  • 26
    • 30644480899 scopus 로고    scopus 로고
    • The endocytic pathway, and formation of the Wingless morphogen gradient
    • Marois, E., Mahmoud, A., and Eaton, S. (2006). The endocytic pathway, and formation of the Wingless morphogen gradient. Development 133, 307-317.
    • (2006) Development , vol.133 , pp. 307-317
    • Marois, E.1    Mahmoud, A.2    Eaton, S.3
  • 28
    • 31744439979 scopus 로고    scopus 로고
    • Palmitoylation of the EGFR ligand Spitz by Rasp increases Spitz activity by restricting its diffusion
    • Miura, G. I., Buglino, J., Alvarado, D., Lemmon, M. A., Resh, M. D., and Treisman, J. E. (2006). Palmitoylation of the EGFR ligand Spitz by Rasp increases Spitz activity by restricting its diffusion. Dev. Cell 10, 167-176.
    • (2006) Dev. Cell , vol.10 , pp. 167-176
    • Miura, G.I.1    Buglino, J.2    Alvarado, D.3    Lemmon, M.A.4    Resh, M.D.5    Treisman, J.E.6
  • 29
    • 0027368350 scopus 로고
    • The Drosophila dorsoventral patterning gene gurken produces a dorsally localized RNA, and encodes a TGF alphalike protein
    • Neuman-Silberberg, F. S., and Schũpbach, T. (1993). The Drosophila dorsoventral patterning gene gurken produces a dorsally localized RNA, and encodes a TGF alphalike protein. Cell 75, 165-174.
    • (1993) Cell , vol.75 , pp. 165-174
    • Neuman-Silberberg, F.S.1    Schũpbach, T.2
  • 30
    • 0034604339 scopus 로고    scopus 로고
    • Senseless, a Zn finger transcription factor, is necessary, and sufficient for sensory organ development in Drosophila
    • Nolo, R., Abbott, L. A., and Bellen, H. J. (2000). Senseless, a Zn finger transcription factor, is necessary, and sufficient for sensory organ development in Drosophila. Cell 102, 349-362.
    • (2000) Cell , vol.102 , pp. 349-362
    • Nolo, R.1    Abbott, L.A.2    Bellen, H.J.3
  • 31
    • 0036055034 scopus 로고    scopus 로고
    • The soluble, and membrane-anchored forms of heparin-binding epidermal growth factor-like growth factor appear to play opposing roles in the survival, and apoptosis of human luteinized granulosa cells
    • Pan, B., Sengoku, K., Goishi, K., Takuma, N., Yamashita, T., Wada, K., and Ishikawa, M. (2002). The soluble, and membrane-anchored forms of heparin-binding epidermal growth factor-like growth factor appear to play opposing roles in the survival, and apoptosis of human luteinized granulosa cells. Mol. Hum. Reprod. 8, 734-741.
    • (2002) Mol. Hum. Reprod. , vol.8 , pp. 734-741
    • Pan, B.1    Sengoku, K.2    Goishi, K.3    Takuma, N.4    Yamashita, T.5    Wada, K.6    Ishikawa, M.7
  • 32
    • 84866031904 scopus 로고    scopus 로고
    • Planar polarized protrusions break the symmetry of EGFR signaling during Drosophila bract cell fate induction
    • Peng, Y., Han, C., and Axelrod, J. D. (2012). Planar polarized protrusions break the symmetry of EGFR signaling during Drosophila bract cell fate induction. Dev. Cell 23, 507-518.
    • (2012) Dev. Cell , vol.23 , pp. 507-518
    • Peng, Y.1    Han, C.2    Axelrod, J.D.3
  • 34
    • 0033555978 scopus 로고    scopus 로고
    • The role of star in the production of an activated ligand for the EGF receptor signaling pathway
    • Pickup, A. T., and Banerjee, U. (1999). The role of star in the production of an activated ligand for the EGF receptor signaling pathway. Dev. Biol. 205, 254-259.
    • (1999) Dev. Biol. , vol.205 , pp. 254-259
    • Pickup, A.T.1    Banerjee, U.2
  • 35
    • 77954362381 scopus 로고    scopus 로고
    • The heparin-binding domain of HB-EGF mediates localization to sites of cell-cell contact, and prevents HB-EGF proteolytic release
    • Prince, R. N., Schreiter, E. R., Zou, P., Wiley, H. S., Ting, A. Y., Lee, R. T., and Lauffenburger, D. A. (2010). The heparin-binding domain of HB-EGF mediates localization to sites of cell-cell contact, and prevents HB-EGF proteolytic release. J. Cell Sci. 123, 2308-2318.
    • (2010) J. Cell Sci. , vol.123 , pp. 2308-2318
    • Prince, R.N.1    Schreiter, E.R.2    Zou, P.3    Wiley, H.S.4    Ting, A.Y.5    Lee, R.T.6    Lauffenburger, D.A.7
  • 36
    • 0037102252 scopus 로고    scopus 로고
    • Keren, a new ligand of the Drosophila epidermal growth factor receptor, undergoes two modes of cleavage
    • Reich, A., and Shilo, B. Z. (2002). Keren, a new ligand of the Drosophila epidermal growth factor receptor, undergoes two modes of cleavage. EMBO J. 21, 4287-4296.
    • (2002) EMBO J. , vol.21 , pp. 4287-4296
    • Reich, A.1    Shilo, B.Z.2
  • 37
    • 0033803415 scopus 로고    scopus 로고
    • Postsynaptic filopodia in muscle cells interact with innervating motoneuron axons
    • Ritzenthaler, S., Suzuki, E., and Chiba, A. (2000). Postsynaptic filopodia in muscle cells interact with innervating motoneuron axons. Nat. Neurosci. 3, 1012-1017.
    • (2000) Nat. Neurosci. , vol.3 , pp. 1012-1017
    • Ritzenthaler, S.1    Suzuki, E.2    Chiba, A.3
  • 38
    • 28044437141 scopus 로고    scopus 로고
    • Genetic, and biochemical analysis of the role of Egfr in the morphogenetic furrow of the developing Drosophila eye
    • Rodrigues, A. B., Werner, E., and Moses, K. (2005). Genetic, and biochemical analysis of the role of Egfr in the morphogenetic furrow of the developing Drosophila eye. Development 132, 4697-4707.
    • (2005) Development , vol.132 , pp. 4697-4707
    • Rodrigues, A.B.1    Werner, E.2    Moses, K.3
  • 39
    • 0026687788 scopus 로고
    • The Drosophila spitz gene encodes a putative EGF-like growth factor involved in dorsalventral axis formation, and neurogenesis
    • Rutledge, B. J., Zhang, K., Bier, E., Jan, Y. N., and Perrimon, N. (1992). The Drosophila spitz gene encodes a putative EGF-like growth factor involved in dorsalventral axis formation, and neurogenesis. Genes Dev. 6, 1503-1517.
    • (1992) Genes Dev. , vol.6 , pp. 1503-1517
    • Rutledge, B.J.1    Zhang, K.2    Bier, E.3    Jan, Y.N.4    Perrimon, N.5
  • 40
    • 33750614996 scopus 로고    scopus 로고
    • Control of ErbB signaling through metalloprotease mediated ectodomain shedding of EGF-like factors
    • Sanderson, M. P., Dempsey, P. J., and Dunbar, A. J. (2006). Control of ErbB signaling through metalloprotease mediated ectodomain shedding of EGF-like factors. Growth Factors 24, 121-136.
    • (2006) Growth Factors , vol.24 , pp. 121-136
    • Sanderson, M.P.1    Dempsey, P.J.2    Dunbar, A.J.3
  • 41
    • 58149376976 scopus 로고    scopus 로고
    • The epidermal growth factor receptor ligands at a glance
    • Schneider, M. R., and Wolf, E. (2009). The epidermal growth factor receptor ligands at a glance. J. Cell. Physiol. 218, 460-466.
    • (2009) J. Cell. Physiol. , vol.218 , pp. 460-466
    • Schneider, M.R.1    Wolf, E.2
  • 42
    • 0029744895 scopus 로고    scopus 로고
    • Vein is a novel component in the Drosophila epidermal growth factor receptor pathway with similarity to the neuregulins
    • Schnepp, B., Grumbling, G., Donaldson, T., and Simcox, A. (1996). Vein is a novel component in the Drosophila epidermal growth factor receptor pathway with similarity to the neuregulins. Genes Dev. 10, 2302-2313.
    • (1996) Genes Dev. , vol.10 , pp. 2302-2313
    • Schnepp, B.1    Grumbling, G.2    Donaldson, T.3    Simcox, A.4
  • 43
    • 0038118551 scopus 로고    scopus 로고
    • Gliotactin, a novel marker of tricellular junctions, is necessary for septate junction development in Drosophila
    • Schulte, J., Tepass, U., and Auld, V. J. (2003). Gliotactin, a novel marker of tricellular junctions, is necessary for septate junction development in Drosophila. J. Cell Biol. 161, 991-1000.
    • (2003) J. Cell Biol. , vol.161 , pp. 991-1000
    • Schulte, J.1    Tepass, U.2    Auld, V.J.3
  • 44
    • 0029015431 scopus 로고
    • Secreted Spitz triggers the DER signaling pathway, and is a limiting component in embryonic ventral ectoderm determination
    • Schweitzer, R., Shaharabany, M., Seger, R., and Shilo, B. Z. (1995). Secreted Spitz triggers the DER signaling pathway, and is a limiting component in embryonic ventral ectoderm determination. Genes Dev. 9, 1518-1529.
    • (1995) Genes Dev. , vol.9 , pp. 1518-1529
    • Schweitzer, R.1    Shaharabany, M.2    Seger, R.3    Shilo, B.Z.4
  • 45
    • 0034614938 scopus 로고    scopus 로고
    • The tetraspanin CD9 associates with transmembrane TGF-alpha, and regulates TGF-alpha-induced EGF receptor activation, and cell proliferation
    • Shi, W., Fan, H., Shum, L., and Derynck, R. (2000). The tetraspanin CD9 associates with transmembrane TGF-alpha, and regulates TGF-alpha-induced EGF receptor activation, and cell proliferation. J. Cell Biol. 148, 591-602.
    • (2000) J. Cell Biol. , vol.148 , pp. 591-602
    • Shi, W.1    Fan, H.2    Shum, L.3    Derynck, R.4
  • 46
    • 26444536535 scopus 로고    scopus 로고
    • Regulating the dynamics of EGF receptor signaling in space, and time
    • Shilo, B. Z. (2005). Regulating the dynamics of EGF receptor signaling in space, and time. Development 132, 4017-4027.
    • (2005) Development , vol.132 , pp. 4017-4027
    • Shilo, B.Z.1
  • 47
    • 0028981084 scopus 로고
    • Distinguishable functions for engrailed, and invected in anterior-posterior patterning in the Drosophila wing
    • Simmonds, A. J., Brook, W. J., Cohen, S. M., and Bell, J. B. (1995). Distinguishable functions for engrailed, and invected in anterior-posterior patterning in the Drosophila wing. Nature 376, 424-427.
    • (1995) Nature , vol.376 , pp. 424-427
    • Simmonds, A.J.1    Brook, W.J.2    Cohen, S.M.3    Bell, J.B.4
  • 48
    • 22144431886 scopus 로고    scopus 로고
    • Autocrine, paracrine, and juxtacrine signaling by EGFR ligands
    • Singh, A. B., and Harris, R. C. (2005). Autocrine, paracrine, and juxtacrine signaling by EGFR ligands. Cell. Signal. 17, 1183-1193.
    • (2005) Cell. Signal. , vol.17 , pp. 1183-1193
    • Singh, A.B.1    Harris, R.C.2
  • 49
    • 2342446235 scopus 로고    scopus 로고
    • Membrane-associated HB-EGF modulates HGF-induced cellular responses in MDCK cells
    • Singh, A. B., Tsukada, T., Zent, R., and Harris, R. C. (2004). Membrane-associated HB-EGF modulates HGF-induced cellular responses in MDCK cells. J. Cell Sci. 117, 1365-1379.
    • (2004) J. Cell Sci. , vol.117 , pp. 1365-1379
    • Singh, A.B.1    Tsukada, T.2    Zent, R.3    Harris, R.C.4
  • 50
    • 36049034205 scopus 로고    scopus 로고
    • Juxtacrine activation of EGFR regulates claudin expression, and increases transepithelial resistance
    • Singh, A. B., Sugimoto, K., Dhawan, P., and Harris, R. C. (2007). Juxtacrine activation of EGFR regulates claudin expression, and increases transepithelial resistance. Am. J. Physiol. 293, C1660-C1668.
    • (2007) Am. J. Physiol. , vol.293
    • Singh, A.B.1    Sugimoto, K.2    Dhawan, P.3    Harris, R.C.4
  • 51
    • 33745758496 scopus 로고    scopus 로고
    • Cell fate-specific regulation of EGF receptor trafficking during Caenorhabditis elegans vulval development
    • Stetak, A., Hoier, E. F., Croce, A., Cassata, G., Di Fiore, P. P., and Hajnal, A. (2006). Cell fate-specific regulation of EGF receptor trafficking during Caenorhabditis elegans vulval development. EMBO J. 25, 2347-2357.
    • (2006) EMBO J. , vol.25 , pp. 2347-2357
    • Stetak, A.1    Hoier, E.F.2    Croce, A.3    Cassata, G.4    Di Fiore, P.P.5    Hajnal, A.6
  • 52
    • 0034704824 scopus 로고    scopus 로고
    • Wingless gradient formation in the Drosophila wing
    • Strigini, M., and Cohen, S. M. (2000). Wingless gradient formation in the Drosophila wing. Curr. Biol. 10, 293-300.
    • (2000) Curr. Biol. , vol.10 , pp. 293-300
    • Strigini, M.1    Cohen, S.M.2
  • 53
    • 72149124813 scopus 로고    scopus 로고
    • Sequence-specific intramembrane proteolysis: identification of a recognition motif in rhomboid substrates
    • Strisovsky, K., Sharpe, H. J., and Freeman, M. (2009). Sequence-specific intramembrane proteolysis: identification of a recognition motif in rhomboid substrates. Mol. Cell 36, 1048-1059.
    • (2009) Mol. Cell , vol.36 , pp. 1048-1059
    • Strisovsky, K.1    Sharpe, H.J.2    Freeman, M.3
  • 54
    • 0030712331 scopus 로고    scopus 로고
    • The membrane-bound form of heparin-binding epidermal growth factor-like growth factor promotes survival of cultured renal epithelial cells
    • Takemura, T., Kondo, S., Homma, T., Sakai, M., and Harris, R. C. (1997). The membrane-bound form of heparin-binding epidermal growth factor-like growth factor promotes survival of cultured renal epithelial cells. J. Biol. Chem. 272, 31036-31042.
    • (1997) J. Biol. Chem. , vol.272 , pp. 31036-31042
    • Takemura, T.1    Kondo, S.2    Homma, T.3    Sakai, M.4    Harris, R.C.5
  • 55
    • 0037080869 scopus 로고    scopus 로고
    • Intracellular trafficking by Star regulates cleavage of the Drosophila EGF receptor ligand Spitz
    • Tsruya, R., Schlesinger, A., Reich, A., Gabay, L., Sapir, A., and Shilo, B. Z. (2002). Intracellular trafficking by Star regulates cleavage of the Drosophila EGF receptor ligand Spitz. Genes Dev. 16, 222-234.
    • (2002) Genes Dev. , vol.16 , pp. 222-234
    • Tsruya, R.1    Schlesinger, A.2    Reich, A.3    Gabay, L.4    Sapir, A.5    Shilo, B.Z.6
  • 57
    • 0035913908 scopus 로고    scopus 로고
    • Drosophila rhomboid-1 defines a family of putative intramembrane serine proteases
    • Urban, S., Lee, J. R., and Freeman, M. (2001). Drosophila rhomboid-1 defines a family of putative intramembrane serine proteases. Cell 107, 173-182.
    • (2001) Cell , vol.107 , pp. 173-182
    • Urban, S.1    Lee, J.R.2    Freeman, M.3
  • 58
    • 0037456842 scopus 로고    scopus 로고
    • Segregation of receptor, and ligand regulates activation of epithelial growth factor receptor
    • Vermeer, P. D., Einwalter, L. A., Moninger, T. O., Rokhlina, T., Kern, J. A., Zabner, J., and Welsh, M. J. (2003). Segregation of receptor, and ligand regulates activation of epithelial growth factor receptor. Nature 422, 322-326.
    • (2003) Nature , vol.422 , pp. 322-326
    • Vermeer, P.D.1    Einwalter, L.A.2    Moninger, T.O.3    Rokhlina, T.4    Kern, J.A.5    Zabner, J.6    Welsh, M.J.7
  • 60
    • 0034234250 scopus 로고    scopus 로고
    • A family of rhomboid-like genes: Drosophila rhomboid-1, and roughoid/rhomboid-3 cooperate to activate EGF receptor signaling
    • Wasserman, J. D., Urban, S., and Freeman, M. (2000). A family of rhomboid-like genes: Drosophila rhomboid-1, and roughoid/rhomboid-3 cooperate to activate EGF receptor signaling. Genes Dev. 14, 1651-1663.
    • (2000) Genes Dev. , vol.14 , pp. 1651-1663
    • Wasserman, J.D.1    Urban, S.2    Freeman, M.3
  • 61
    • 0024504360 scopus 로고
    • The TGF-alpha precursor expressed on the cell surface binds to the EGF receptor on adjacent cells, leading to signal transduction
    • Wong, S. T., Winchell, L. F., McCune, B. K., Earp, H. S., Teixidó, J., Massagué, J., Herman, B., and Lee, D. C. (1989). The TGF-alpha precursor expressed on the cell surface binds to the EGF receptor on adjacent cells, leading to signal transduction. Cell 56, 495-506.
    • (1989) Cell , vol.56 , pp. 495-506
    • Wong, S.T.1    Winchell, L.F.2    McCune, B.K.3    Earp, H.S.4    Teixidó, J.5    Massagué, J.6    Herman, B.7    Lee, D.C.8
  • 62
    • 79955521176 scopus 로고    scopus 로고
    • EGFR, Wingless, and JAK/STAT signaling cooperatively maintain Drosophila intestinal stem cells
    • Xu, N., Wang, S. Q., Tan, D., Gao, Y., Lin, G., and Xi, R. (2011). EGFR, Wingless, and JAK/STAT signaling cooperatively maintain Drosophila intestinal stem cells. Dev. Biol. 354, 31-43.
    • (2011) Dev. Biol. , vol.354 , pp. 31-43
    • Xu, N.1    Wang, S.Q.2    Tan, D.3    Gao, Y.4    Lin, G.5    Xi, R.6
  • 63
    • 0034611607 scopus 로고    scopus 로고
    • Defective cleavage of membrane bound TGFalpha leads to enhanced activation of the EGF receptor in malignant cells
    • Yang, H., Jiang, D., Li, W., Liang, J., Gentry, L. E., and Brattain, M. G. (2000). Defective cleavage of membrane bound TGFalpha leads to enhanced activation of the EGF receptor in malignant cells. Oncogene 19, 1901-1914.
    • (2000) Oncogene , vol.19 , pp. 1901-1914
    • Yang, H.1    Jiang, D.2    Li, W.3    Liang, J.4    Gentry, L.E.5    Brattain, M.G.6
  • 64
    • 78149374724 scopus 로고    scopus 로고
    • Polarized secretion of Drosophila EGFR ligand from photoreceptor neurons is controlled by ER localization of the ligand-processing machinery
    • Yogev, S., Schejter, E. D., and Shilo, B. Z. (2010). Polarized secretion of Drosophila EGFR ligand from photoreceptor neurons is controlled by ER localization of the ligand-processing machinery. PLoS Biol. 8, e1000505.
    • (2010) PLoS Biol. , vol.8
    • Yogev, S.1    Schejter, E.D.2    Shilo, B.Z.3
  • 65
    • 0026543975 scopus 로고
    • Localization of DER, and the pattern of cell divisions in wild-type, and Ellipse eye imaginal discs
    • Zak, N. B., and Shilo, B. Z. (1992). Localization of DER, and the pattern of cell divisions in wild-type, and Ellipse eye imaginal discs. Dev. Biol. 149, 448-456.
    • (1992) Dev. Biol. , vol.149 , pp. 448-456
    • Zak, N.B.1    Shilo, B.Z.2


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