The association of Pro12ala polymorphism in the peroxisome proliferator-activated receptor-gamma2 gene with the metabolic characteristics in chinese women with polycystic ovary syndrome

International Journal of Clinical and Experimental Pathology

Volumn 6, Issue 9, 2013, Pages 1894-1902

  Yang, Jiejin ^a   Gong, Hao ^a   Liu, Wei ^a   Tao, Tao ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Central obesity; Hypertriglyceridemia; Peroxisome proliferator activated receptor gamma2; Polycystic ovary syndrome; Polymorphism

Indexed keywords

BIOLOGICAL MARKER; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; TRIACYLGLYCEROL;

ABDOMINAL OBESITY; ADOLESCENT; ADULT; ARTICLE; ASIAN; BLOOD; CASE CONTROL STUDY; CENTRAL OBESITY; CHINA; ETHNOLOGY; FEMALE; GENE FREQUENCY; GENETIC POLYMORPHISM; GENETIC PREDISPOSITION; GENETICS; HUMAN; HYPERTRIGLYCERIDEMIA; OBESITY; OVARY POLYCYSTIC DISEASE; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR-GAMMA2; PHENOTYPE; POLYMORPHISM; RISK FACTOR; WAIST HIP RATIO; YOUNG ADULT;

CENTRAL OBESITY; HYPERTRIGLYCERIDEMIA; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR-GAMMA2; POLYCYSTIC OVARY SYNDROME; POLYMORPHISM;

ADIPOSITY; ADOLESCENT; ADULT; ASIAN CONTINENTAL ANCESTRY GROUP; BIOLOGICAL MARKERS; CASE-CONTROL STUDIES; CHINA; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; HUMANS; OBESITY, ABDOMINAL; PHENOTYPE; POLYCYSTIC OVARY SYNDROME; POLYMORPHISM, GENETIC; PPAR GAMMA; RISK FACTORS; TRIGLYCERIDES; WAIST-HIP RATIO; YOUNG ADULT;

EID: 84885464504     PISSN: None     EISSN: 19362625     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. Diamanti-Kandarakis E, Kouli CR, Bergiele AT, Filandra FA, Tsianateli TC, Spina GG, Zapanti ED and Bartzis MI. A survey of the polycysticovary syndrome in the Greek island of Lesbos:hormonal and metabolic profile. J Clin Endocrinol Metab 1999; 84: 4006-4011.
2. Carmina E and Lobo RA. Polycystic ovary syndrome (PCOS): arguably the most common endocrinopathy is associated with significant morbidity in women. J Clin Endocrinol Metab 1999; 84: 1897-1899.
3. Venkatesan AM, Dunaif A and Corbould A. Insulin resistance in polycystic ovary syndrome: progress and paradoxes. Recent Prog Horm Res 2001; 56: 295-308.
4. Auwerx J. PPARgamma, the ultimate thrifty gene. Diabetologia 1999; 42: 1033-1049.
5. Yen CJ, Beamer BA, Negri C, Silver K, Brown KA, Yarnall DP, Burns DK, Roth J and Shuldiner AR. Molecular scanning of the human peroxisome proliferator activated receptor gamma (hPPARgamma) gene in diabetic Caucasians: identification of a Pro12AlaPPAR gamma 2 missense mutation. Biochem Biophys Res Commun 1997; 241: 270-274.
6. Deeb SS, Fajas L, Nemoto M, Pihlajamäki J, Mykkänen L, Kuusisto J, Laakso M, Fujimoto W and Auwerx J. A Pro12Ala substitution in PPARgamma2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity. Nat Genet 1998; 20: 284-287.
7. Florez JC, Hirschhorn J and Altshuler D. The inherited basis of diabetes mellitus: implications for the genetic analysis of complex traits. Annu Rev Genomics Hum Genet 2003; 4: 257-291.
8. Scott LJ, Mohlke KL, Bonnycastle LL, Willer CJ, Li Y, Duren WL, Erdos MR, Stringham HM, Chines PS, Jackson AU, Prokunina-Olsson L, Ding CJ, Swift AJ, Narisu N, Hu T, Pruim R, Xiao R, Li XY, Conneely KN, Riebow NL, Sprau AG, Tong M, White PP, Hetrick KN, Barnhart MW, Bark CW, Goldstein JL, Watkins L, Xiang F, Saramies J, Buchanan TA, Watanabe RM, Valle TT, Kinnunen L, Abecasis GR, Pugh EW, Doheny KF, Bergman RN, Tuomilehto J, Collins FS and Boehnke M. A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. Science 2007; 316: 1341-1345.
9. Spiegelman BM. PPAR-gamma: adipogenic regulator and thiazolidinedione receptor. Diabetes 1998; 47: 507-514.
10. Tok EC, Aktas A, Ertunc D, Erdal EM and Dilek S. Evaluation of glucose metabolism and reproductive hormones in polycystic ovary syndrome on the basis of peroxisome proliferator-activated receptor (PPAR)-gamma2 Pro12Ala genotype. Hum Reprod 2005; 20: 1590-1595.
11. Hahn S, Fingerhut A, Khomtsiv U, Khomtsiv L, Tan S, Quadbeck B, Herrmann BL, Knebel B, Müller-Wieland D, Mann K and Janssen OE. The peroxisome proliferator activated receptor gamma Pro12Ala polymorphism is associated with a lower hirsutism score and increased insulin sensitivity in women with polycystic ovary syndrome. Clin Endocrinol (Oxf) 2005; 62: 573-579.
12. Hara M, Alcoser SY, Qaadir A, Beiswenger KK, Cox NJ and Ehrmann DA. Insulin resistance is attenuated in women with polycystic ovary syndrome with the Pro(12)Ala polymorphism in the PPARgamma gene. J Clin Endocrinol Metab 2002; 87: 772-775.
13. Orio F Jr, Palomba S, Cascella T, Di Biase S, Labella D, Russo T, Savastano S, Zullo F, Colao A, Vettor R and Lombardi G. Lack of an association between peroxisome proliferator-activated receptor-gamma gene Pro12Ala polymorphism and adiponectin levels in the polycystic ovary syndrome. J Clin Endocrinol Metab 2004; 89: 5110-5115.
14. Xita N, Lazaros L, Georgiou I and Tsatsoulis A. The Pro12Ala polymorphism of the PPAR-gamma gene is not associated with the polycystic ovary syndrome. Hormones (Athens) 2009; 8: 267-272.
15. Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Fertil Steril 2004; 81: 19-25.
16. Lane DE. Polycystic ovary syndrome and its differential diagnosis. Obstet Gynecol Surv 2006; 61: 125-135.
17. Adams J, Franks S, Polson DW, Mason HD, Abdulwahid N, Tucker M, Morris DV, Price J and Jacobs HS. Multifollicular ovaries: clinical and endocrine features and response to pusatile gonadotropin releasing hormone. Lancet 1985; 2: 1375-1379.
18. World Health Organisation, International Association for the Study of Obesity, International Obesity TaskForce. The Asia-Pacific Perspective: Redefining obesity and its treatment. Sydney: Health Communications, 2000.
19. Haffner SM, Kennedy E, Gonzalez C, Stern MP and Miettinen H. A prospective analysis of the HOMA model. The Mexico City Diabetes Study. Diabetes Care 1996; 19: 1138-1141.
20. Alberti KG, Zimmet P and Shaw J. Metabolic syndrome--a new world-wide definition. A Consensus Statement from the International Diabetes Federation. Diabet Med 2006; 23: 469-480.
21. Hamada T, Kotani K, Tsuzaki K, Sano Y, Murata T, Tabata M, Sato S and Sakane N. Association of Pro12Ala polymorphism in the peroxisome proliferator-activated receptor γ2 gene with small dense low-density lipoprotein in the general population. Metabolism 2007; 56: 1345-1349.
22. Cardona F, Morcillo S, Gonzalo-Marín M, Garrido-Sanchez L, Macias-Gonzalez M and Tinahones FJ. Pro12Ala Sequence Variant of the PPARG Gene Is Associated with Postprandial hypertriglyceridemia in Non-E3/E3 Patients with the Metabolic Syndrome. Clin Chem 2006; 52: 1920-1925.
23. Kim KS, Choi SM, Shin SU, Yang HS and Yoon Y. Effects of peroxisome proliferator-activated receptor-γ2 Pro12Ala polymorphism on body fat distribution in female Korean subjects. Metabolism 2004; 53: 1538-1543.
24. Chae SJ, Kim JJ, Choi YM, Kim JM, Cho YM and Moon SY. Peroxisome proliferator-activated receptor-gamma and its coactivator-1alpha gene polymorphisms in Korean women with polycystic ovary syndrome. Gynecol Obstet Invest 2010; 70: 1-7.
25. Srámková D, Kunesová M, Hainer V, Hill M, Vcelák J and Bendlová B. Is a Pro12Ala polymorphism of the PPARγ2 gene related to obesity and type 2 diabetes mellitus in the Czech population? Ann N Y Acad Sci 2002; 967: 265-273.
26. Lemieux I, Pascot A, Couillard C, Lamarche B, Tchernof A, Alméras N, Bergeron J, Gaudet D, Tremblay G, Prud'homme D, Nadeau A and Després JP. Hypertriglyceridemic waist: A marker of the atherogenic metabolic triad (hyperinsulinemia; hyperapolipoprotein B; small, dense LDL) in men? Circulation 2000; 102: 179-184.
27. Kekki M. Lipoprotein-lipase action determining plasma high density lipoprotein cholesterol level in adult normolipaemics. Atherosclerosis 1980; 37: 143-150.
28. Li LL, Ma XL, Ran JX, Sun XF, Xu LM, Ren J and Mao XM. Genetic polymorphism of peroxisome proliferator-activated receptor-gamma 2 Pro12Ala on ethnic susceptibility to diabetes in Uygur, Kazak and Han subjects. Clin Exp Pharmacol Physiol 2008; 35: 187-191.
29. Wang Y, Wu X, Cao Y, Yi L, Fan H and Chen J. Polymorphisms of the peroxisome proliferator-activated receptor-gamma and its coactivator-1alpha genes in Chinese women with polycystic ovary syndrome. Fertil Steril 2006; 85: 1536-1540.
30. Carmienke S, Freitag MH, Pischon T, Schlattmann P, Fankhaenel T, Goebel H and Gensichen J. General and abdominal obesity parameters and their combination in relation to mortality: a systematic review and meta-regression analysis. Eur J Clin Nutr 2013; 67: 573-585.