Potent vinblastine C20′ ureas displaying additionally improved activity against a vinblastine-resistant cancer cell line

ACS Medicinal Chemistry Letters

Volumn 4, Issue 10, 2013, Pages 985-988

  Barker, Timothy J ^a   Duncan, Katharine K ^a   Otrubova, Katerina ^a   Boger, Dale L ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

C20 urea derivatives; chemotherapy; Vinblastine; vincristine

Indexed keywords

ALKENE; C20 UREA; FERRIC ION; MULTIDRUG RESISTANCE PROTEIN; NAVELBINE; SODIUM BOROHYDRIDE; UNCLASSIFIED DRUG; UREA DERIVATIVE; VINBLASTINE; VINCRISTINE;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BEAR; CANCER CELL CULTURE; CANCER GROWTH; CANCER INHIBITION; CANCER RESISTANCE; CELL STRAIN HCT116; CELL STRAIN LNCAP; DRUG STRUCTURE; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; IC 50; LEUKEMIA L 1210; NONHUMAN; PRIORITY JOURNAL; TUMOR CELL LINE;

EID: 84885457038     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/ml400281w     Document Type: Article

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