A remarkable series of vinblastine analogues displaying enhanced activity and an unprecedented tubulin binding steric tolerance: C20′ urea derivatives

Journal of Medicinal Chemistry

Volumn 56, Issue 3, 2013, Pages 628-639

  Leggans, Erick K ^a   Duncan, Katharine K ^a   Barker, Timothy J ^a   Schleicher, Kristin D ^a   Boger, Dale L ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TUBULIN; UREA DERIVATIVE; VINBLASTINE DERIVATIVE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BINDING SITE; CELL STRAIN HCT116; DRUG POTENCY; DRUG PROTEIN BINDING; HUMAN; HUMAN CELL; IC 50; X RAY CRYSTALLOGRAPHY;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CELL DIVISION; DRUG SCREENING ASSAYS, ANTITUMOR; LEUKEMIA, EXPERIMENTAL; MICE; MODELS, MOLECULAR; PROTEIN BINDING; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SPECTROPHOTOMETRY, INFRARED; TUBULIN; UREA; VINBLASTINE;

EID: 84872772908     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm3015684     Document Type: Article

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