Respiratory virus-induced EGFR activation suppresses IRF1-dependent interferon λ and antiviral defense in airway epithelium

Journal of Experimental Medicine

Volumn 210, Issue 10, 2013, Pages 1929-1936

  Ueki, Iris F ^a,b   Min Oo, Gundula ^a,b   Kalinowski, April ^c   Ballon Landa, Eric ^d   Lanier, Lewis L ^a,b   Nadel, Jay A ^a,b   Koff, Jonathan L ^c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c YALE UNIVERSITY   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; GEFITINIB; INTERFERON; INTERFERON LAMBDA; INTERFERON REGULATORY FACTOR 1; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ANIMAL MODEL; ANTIVIRAL ACTIVITY; ARTICLE; DOSE RESPONSE; ENZYME LINKED IMMUNOSORBENT ASSAY; IMMUNE RESPONSE; IN VITRO STUDY; IN VIVO STUDY; INFLUENZA VIRUS A; INNATE IMMUNITY; INTERFERON PRODUCTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROPHYLAXIS; PROTEIN FUNCTION; RESPIRATORY EPITHELIUM; RESPIRATORY VIRUS; RHINOVIRUS; SIGNAL TRANSDUCTION; VIRUS INFECTION;

HUMANS; INTERFERON REGULATORY FACTOR-1; INTERFERON-GAMMA; PROTEIN KINASE INHIBITORS; RECEPTOR, EPIDERMAL GROWTH FACTOR; RESPIRATORY MUCOSA; VIRUS DISEASES; VIRUS INTERNALIZATION;

EID: 84885456710     PISSN: 00221007     EISSN: 15409538     Source Type: Journal    
DOI: 10.1084/jem.20121401     Document Type: Article

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