Epidithiodiketopiperazine biosynthesis: A four-enzyme cascade converts glutathione conjugates into transannular disulfide bridges

Angewandte Chemie - International Edition

Volumn 52, Issue 42, 2013, Pages 11092-11095

  Scharf, Daniel H ^a   Chankhamjon, Pranatchareeya ^a   Scherlach, Kirstin ^a   Heinekamp, Thorsten ^a   Willing, Karsten ^a   Brakhage, Axel A ^a,b   Hertweck, Christian ^a,b  

^a HANS KNÖLL INSTITUTE   (Germany)

^b FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

Author keywords

Aspergillus fumigatus; biosynthesis; dipeptidase; gliotoxin; mycotoxins

Indexed keywords

ASPERGILLUS FUMIGATUS; DIPEPTIDASE; DISULFIDE BRIDGE; GLIOTOXIN; GLUTATHIONES; METABOLIC PATHWAYS; MYCOTOXINS; NATURAL PRODUCTS;

ASPERGILLUS; BIOCHEMISTRY; COVALENT BONDS; ENZYMES;

BIOSYNTHESIS;

DIPEPTIDASE; DISULFIDE; EPIDITHIODIKETOPIPERAZINE; GLIOTOXIN; GLUTATHIONE; MYCOTOXIN; PIPERAZINE DERIVATIVE;

ARTICLE; ASPERGILLUS FUMIGATUS; BIOSYNTHESIS; CHEMICAL STRUCTURE; CHEMISTRY; ENZYMOLOGY; METABOLISM; SYNTHESIS;

ASPERGILLUS FUMIGATUS; BIOSYNTHESIS; DIPEPTIDASE; GLIOTOXIN; MYCOTOXINS;

ASPERGILLUS FUMIGATUS; DIPEPTIDASES; DISULFIDES; GLIOTOXIN; GLUTATHIONE; MODELS, MOLECULAR; PIPERAZINES;

EID: 84885440457     PISSN: 14337851     EISSN: 15213773     Source Type: Journal    
DOI: 10.1002/anie.201305059     Document Type: Article

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