Transient reduction in myocardial free oxygen radical levels is involved in the improved cardiac function and structure after long-term allopurinol treatment initiated in established chronic heart failure

European Heart Journal

Volumn 26, Issue 15, 2005, Pages 1544-1550

  Mellin, Virginie ^a   Isabelle, Marc ^a   Oudot, Alexandra ^b   Vergely Vandriesse, Catherine ^b   Monteil, Christelle ^a   Di Meglio, Benoit ^a   Henry, Jean Paul ^a   Dautreaux, Brigitte ^a   Rochette, Luc ^b   Thuillez, Christian ^a   Mulder, Paul ^a  

^a INSERM   (France)

^b Laboratoire de Physiopathologie et Pharmacologie Cardiovasculaires Experimentales   (France)

Author keywords

Allopurinol; Heart failure; Reactive oxygen species

Indexed keywords

ALLOPURINOL; COLLAGEN; FREE RADICAL; GELATINASE A; REACTIVE OXYGEN METABOLITE; THIOBARBITURIC ACID REACTIVE SUBSTANCE; URIC ACID; XANTHINE OXIDASE; XANTHINE OXIDASE INHIBITOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERIAL PRESSURE; ARTICLE; CONTROLLED STUDY; CORONARY ARTERY LIGATION; DRUG EFFECT; ELECTRON SPIN RESONANCE; ENZYME INHIBITION; HEART FAILURE; HEART LEFT VENTRICLE ENDDIASTOLIC PRESSURE; HEART MUSCLE RELAXATION; HEART OUTPUT; HEART VENTRICLE FUNCTION; HEART VENTRICLE SIZE; HEART WEIGHT; HEMODYNAMIC MONITORING; LIPID PEROXIDATION; LONG TERM CARE; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; URIC ACID BLOOD LEVEL;

ALLOPURINOL; ANIMALS; BLOOD PRESSURE; CORONARY VESSELS; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; FREE RADICAL SCAVENGERS; FREE RADICALS; HEART FAILURE, CONGESTIVE; LIGATION; LIPID PEROXIDATION; MALE; MYOCARDIAL INFARCTION; OXYGEN; RATS; RATS, WISTAR; REACTIVE OXYGEN SPECIES; XANTHINE OXIDASE;

EID: 23644454293     PISSN: 0195668X     EISSN: None     Source Type: Journal    
DOI: 10.1093/eurheartj/ehi305     Document Type: Article

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