-
1
-
-
13044304179
-
Distinctive gene expression patterns in human mammary epithelial cells and breast cancers
-
Perou CM, Jeffrey SS, van de Rijn M, et al. Distinctive gene expression patterns in human mammary epithelial cells and breast cancers. Proc Natl Acad Sci USA 1999; 96:9212-9217.
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 9212-9217
-
-
Perou, C.M.1
Jeffrey, S.S.2
Van De Rijn, M.3
-
2
-
-
0034680102
-
Molecular portraits of human breast tumours
-
Perou CM, Sorlie T, Eisen MB, et al. Molecular portraits of human breast tumours. Nature 2000; 406:747-752.
-
(2000)
Nature
, vol.406
, pp. 747-752
-
-
Perou, C.M.1
Sorlie, T.2
Eisen, M.B.3
-
3
-
-
0035845511
-
Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications
-
Sorlie T, Perou CM, Tibshirani R, et al. Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc Natl Acad Sci USA 2001; 98:10869-10874.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 10869-10874
-
-
Sorlie, T.1
Perou, C.M.2
Tibshirani, R.3
-
4
-
-
80053539103
-
Adjuvant trastuzumab in HER2-positive breast cancer
-
Slamon D, Eiermann W, Robert N, et al. Adjuvant trastuzumab in HER2-positive breast cancer. N Engl J Med 2011; 365:1273-1283.
-
(2011)
N Engl J Med
, vol.365
, pp. 1273-1283
-
-
Slamon, D.1
Eiermann, W.2
Robert, N.3
-
5
-
-
84862914692
-
Pertuzumab plus trastuzumab plus docetaxel for metastatic breast cancer
-
Baselga J, Cortes J, Kim SB, et al. Pertuzumab plus trastuzumab plus docetaxel for metastatic breast cancer. N Engl J Med 2012; 366:109-119.
-
(2012)
N Engl J Med
, vol.366
, pp. 109-119
-
-
Baselga, J.1
Cortes, J.2
Kim, S.B.3
-
6
-
-
84868520609
-
Trastuzumab emtansine for HER2-positive advanced breast cancer
-
Verma S, Miles D, Gianni L, et al. Trastuzumab emtansine for HER2-positive advanced breast cancer. N Engl J Med 2012; 367:1783-1791.
-
(2012)
N Engl J Med
, vol.367
, pp. 1783-1791
-
-
Verma, S.1
Miles, D.2
Gianni, L.3
-
7
-
-
58149186582
-
Do molecularly targeted agents in oncology have reduced attrition rates?
-
Walker I, Newell H. Do molecularly targeted agents in oncology have reduced attrition rates? Nat Rev Drug Discov 2009; 8:15-16.
-
(2009)
Nat Rev Drug Discov
, vol.8
, pp. 15-16
-
-
Walker, I.1
Newell, H.2
-
8
-
-
0029075872
-
Comparison of the effects of a pure steroidal antiestrogen with those of tamoxifen in a model of human breast cancer
-
Osborne CK, Coronado-Heinsohn EB, Hilsenbeck SG, et al. Comparison of the effects of a pure steroidal antiestrogen with those of tamoxifen in a model of human breast cancer. J Natl Cancer Inst 1995; 87:746-750.
-
(1995)
J Natl Cancer Inst
, vol.87
, pp. 746-750
-
-
Osborne, C.K.1
Coronado-Heinsohn, E.B.2
Hilsenbeck, S.G.3
-
9
-
-
38849091433
-
Tamoxifen resistance in breast tumors is driven by growth factor receptor signaling with repression of classic estrogen receptor genomic function
-
Massarweh S, Osborne CK, Creighton CJ, et al. Tamoxifen resistance in breast tumors is driven by growth factor receptor signaling with repression of classic estrogen receptor genomic function. Cancer Res 2008; 68:826-833.
-
(2008)
Cancer Res
, vol.68
, pp. 826-833
-
-
Massarweh, S.1
Osborne, C.K.2
Creighton, C.J.3
-
10
-
-
9144256614
-
Cross-talk between estrogen receptor and growth factor pathways as a molecular target for overcoming endocrine resistance
-
Schiff R, Massarweh SA, Shou J, et al. Cross-talk between estrogen receptor and growth factor pathways as a molecular target for overcoming endocrine resistance. Clin Cancer Res 2004; 10:331S-336S.
-
(2004)
Clin Cancer Res
, vol.10
-
-
Schiff, R.1
Massarweh, S.A.2
Shou, J.3
-
11
-
-
79952259688
-
Gefitinib or placebo in combination with tamoxifen in patients with hormone receptor-positive metastatic breast cancer: A randomized phase II study
-
Osborne CK, Neven P, Dirix LY, et al. Gefitinib or placebo in combination with tamoxifen in patients with hormone receptor-positive metastatic breast cancer: a randomized phase II study. Clin Cancer Res 2011; 17:1147-1159.
-
(2011)
Clin Cancer Res
, vol.17
, pp. 1147-1159
-
-
Osborne, C.K.1
Neven, P.2
Dirix, L.Y.3
-
12
-
-
77949754385
-
Phase II, randomized trial to compare anastrozole combined with gefitinib or placebo in postmenopausal women with hormone receptor-positive metastatic breast cancer
-
Cristofanilli M, Valero V, Mangalik A, et al. Phase II, randomized trial to compare anastrozole combined with gefitinib or placebo in postmenopausal women with hormone receptor-positive metastatic breast cancer. Clin Cancer Res 2010; 16:1904-1914.
-
(2010)
Clin Cancer Res
, vol.16
, pp. 1904-1914
-
-
Cristofanilli, M.1
Valero, V.2
Mangalik, A.3
-
13
-
-
34548537574
-
A phase II placebo-controlled trial of neoadjuvant anastrozole alone or with gefitinib in early breast cancer
-
Smith IE, Walsh G, Skene A, et al. A phase II placebo-controlled trial of neoadjuvant anastrozole alone or with gefitinib in early breast cancer. J Clin Oncol 2007; 25:3816-3822.
-
(2007)
J Clin Oncol
, vol.25
, pp. 3816-3822
-
-
Smith, I.E.1
Walsh, G.2
Skene, A.3
-
14
-
-
23944464495
-
Phase II and tumor pharmacodynamic study of gefitinib in patients with advanced breast cancer
-
Baselga J, Albanell J, Ruiz A, et al. Phase II and tumor pharmacodynamic study of gefitinib in patients with advanced breast cancer. J Clin Oncol 2005; 23:5323-5333.
-
(2005)
J Clin Oncol
, vol.23
, pp. 5323-5333
-
-
Baselga, J.1
Albanell, J.2
Ruiz, A.3
-
15
-
-
80155131176
-
A kinome-wide screen identifies the insulin/IGF-I receptor pathway asamechanism of escape from hormone dependence in breast cancer
-
Fox EM, Miller TW, Balko JM, et al. A kinome-wide screen identifies the insulin/IGF-I receptor pathway asamechanism of escape from hormone dependence in breast cancer. Cancer Res 2011; 71:6773-6784.
-
(2011)
Cancer Res
, vol.71
, pp. 6773-6784
-
-
Fox, E.M.1
Miller, T.W.2
Balko, J.M.3
-
16
-
-
84871568254
-
Enhanced expression of the PDGFR/Abl signaling pathway in aromatase inhibitor-resistant breast cancer
-
Weigel MT, Banerjee S, Arnedos M, et al. Enhanced expression of the PDGFR/Abl signaling pathway in aromatase inhibitor-resistant breast cancer. Ann Oncol 2013; 24:126-133.
-
(2013)
Ann Oncol
, vol.24
, pp. 126-133
-
-
Weigel, M.T.1
Banerjee, S.2
Arnedos, M.3
-
17
-
-
33846811714
-
Chronic exposure to fulvestrant promotes overexpression of the c-Met receptor in breast cancer cells: Implications for tumour-stroma interactions
-
Hiscox S, Jordan NJ, Jiang W, et al. Chronic exposure to fulvestrant promotes overexpression of the c-Met receptor in breast cancer cells: implications for tumour-stroma interactions. Endocr Relat Cancer 2006; 13:1085-1099.
-
(2006)
Endocr Relat Cancer
, vol.13
, pp. 1085-1099
-
-
Hiscox, S.1
Jordan, N.J.2
Jiang, W.3
-
18
-
-
84879108302
-
GDNF-RET signaling in ER-positive breast cancers is a key determinant of response and resistance to aromatase inhibitors
-
Morandi A, Martin LA, Gao Q, et al. GDNF-RET signaling in ER-positive breast cancers is a key determinant of response and resistance to aromatase inhibitors. Cancer Res 2013; 73:3783-3795.
-
(2013)
Cancer Res
, vol.73
, pp. 3783-3795
-
-
Morandi, A.1
Martin, L.A.2
Gao, Q.3
-
19
-
-
84877593565
-
De-repression of PDGFRbeta transcription promotes acquired resistance to EGFR tyrosine kinase inhibitors in glioblastoma patients
-
Akhavan D, Pourzia AL, Nourian AA, et al. De-repression of PDGFRbeta transcription promotes acquired resistance to EGFR tyrosine kinase inhibitors in glioblastoma patients. Cancer Discov 2013; 3:534-547.
-
(2013)
Cancer Discov
, vol.3
, pp. 534-547
-
-
Akhavan, D.1
Pourzia, A.L.2
Nourian, A.A.3
-
20
-
-
84885229945
-
Parallel RNA interference screens identify EGFR activation as an escape mechanism in FGFR3 mutant cancer
-
Herrera-Abreu MT, Pearson A, Campbell J, et al. Parallel RNA interference screens identify EGFR activation as an escape mechanism in FGFR3 mutant cancer. Cancer Discov 2013; 3:1058-1071.
-
(2013)
Cancer Discov
, vol.3
, pp. 1058-1071
-
-
Herrera-Abreu, M.T.1
Pearson, A.2
Campbell, J.3
-
21
-
-
79959916680
-
MET-independent lung cancer cells evading EGFR kinase inhibitors are therapeutically susceptible to BH3 mimetic agents
-
Fan W, Tang Z, Yin L, et al. MET-independent lung cancer cells evading EGFR kinase inhibitors are therapeutically susceptible to BH3 mimetic agents. Cancer Res 2011; 71:4494-4505.
-
(2011)
Cancer Res
, vol.71
, pp. 4494-4505
-
-
Fan, W.1
Tang, Z.2
Yin, L.3
-
22
-
-
82055187255
-
ERalpha-dependent E2F transcription can mediate resistance to estrogen deprivation in human breast cancer
-
Miller TW, Balko JM, Fox EM, et al. ERalpha-dependent E2F transcription can mediate resistance to estrogen deprivation in human breast cancer. Cancer Discov 2011; 1:338-351.
-
(2011)
Cancer Discov
, vol.1
, pp. 338-351
-
-
Miller, T.W.1
Balko, J.M.2
Fox, E.M.3
-
23
-
-
77954974573
-
Hyperactivation of phosphatidylinositol-3 kinase promotes escape from hormone dependence in estrogen receptor-positive human breast cancer
-
Miller TW, Hennessy BT, Gonzalez-Angulo AM, et al. Hyperactivation of phosphatidylinositol-3 kinase promotes escape from hormone dependence in estrogen receptor-positive human breast cancer. J Clin Invest 2010; 120:2406-2413.
-
(2010)
J Clin Invest
, vol.120
, pp. 2406-2413
-
-
Miller, T.W.1
Hennessy, B.T.2
Gonzalez-Angulo, A.M.3
-
24
-
-
84867441207
-
Effectiveness and molecular interactions of the clinically active mTORC1 inhibitor everolimus in combination with tamoxifen or letrozole in vitro and in vivo
-
Martin LA, Pancholi S, Farmer I, et al. Effectiveness and molecular interactions of the clinically active mTORC1 inhibitor everolimus in combination with tamoxifen or letrozole in vitro and in vivo. Breast Cancer Res 2012; 14:R132.
-
(2012)
Breast Cancer Res
, vol.14
-
-
Martin, L.A.1
Pancholi, S.2
Farmer, I.3
-
25
-
-
35248889408
-
EGFR associated expression profiles vary with breast tumor subtype
-
Hoadley KA, Weigman VJ, Fan C, et al. EGFR associated expression profiles vary with breast tumor subtype. BMC Genomics 2007; 8:258.
-
(2007)
BMC Genomics
, vol.8
, pp. 258
-
-
Hoadley, K.A.1
Weigman, V.J.2
Fan, C.3
-
26
-
-
84860697370
-
Cetuximab + cisplatin in estrogen receptor-negative, progesterone receptor-negative, HER2-negative (triple-negative) metastatic breast cancer: Results of the randomized phase II BALI-1 trial
-
Baselga J, Stemmer S, Pego A, et al. Cetuximab + cisplatin in estrogen receptor-negative, progesterone receptor-negative, HER2-negative (triple-negative) metastatic breast cancer: results of the randomized phase II BALI-1 trial. Cancer Res 2010; 70:95s.
-
(2010)
Cancer Res
, vol.70
-
-
Baselga, J.1
Stemmer, S.2
Pego, A.3
-
27
-
-
84864101306
-
TBCRC 001: Randomized phase II study of cetuximab in combination with carboplatin in stage IV triple-negative breast cancer
-
Carey LA, Rugo HS, Marcom PK, et al. TBCRC 001: randomized phase II study of cetuximab in combination with carboplatin in stage IV triple-negative breast cancer. J Clin Oncol 2012; 30:2615-2623.
-
(2012)
J Clin Oncol
, vol.30
, pp. 2615-2623
-
-
Carey, L.A.1
Rugo, H.S.2
Marcom, P.K.3
-
28
-
-
84862526929
-
The clonal and mutational evolution spectrum of primary triple-negative breast cancers
-
Shah SP, Roth A, Goya R, et al. The clonal and mutational evolution spectrum of primary triple-negative breast cancers. Nature 2012; 486:395-399.
-
(2012)
Nature
, vol.486
, pp. 395-399
-
-
Shah, S.P.1
Roth, A.2
Goya, R.3
-
29
-
-
84873918443
-
Activating HER2 mutations in HER2 gene amplification negative breast cancer
-
Bose R, Kavuri SM, Searleman AC, et al. Activating HER2 mutations in HER2 gene amplification negative breast cancer. Cancer Discov 2013; 3:224-237.
-
(2013)
Cancer Discov
, vol.3
, pp. 224-237
-
-
Bose, R.1
Kavuri, S.M.2
Searleman, A.C.3
-
30
-
-
84880661427
-
Lung cancer that harbors an HER2 mutation: Epidemiologic characteristics and therapeutic perspectives
-
Mazieres J, Peters S, Lepage B, et al. Lung cancer that harbors an HER2 mutation: epidemiologic characteristics and therapeutic perspectives. J Clin Oncol 2013; 31:1997-2003.
-
(2013)
J Clin Oncol
, vol.31
, pp. 1997-2003
-
-
Mazieres, J.1
Peters, S.2
Lepage, B.3
-
31
-
-
33746905531
-
Phosphotyrosine interactome of the ErbB-receptor kinase family
-
Schulze WX, Deng L, Mann M. Phosphotyrosine interactome of the ErbB-receptor kinase family. Mol Syst Biol 2005; 1:; 2005.0008.
-
(2005)
Mol Syst Biol
, vol.1
, Issue.2005
, pp. 0008
-
-
Schulze, W.X.1
Deng, L.2
Mann, M.3
-
32
-
-
33846552656
-
Escape from HER-family tyrosine kinase inhibitor therapy by the kinase-inactive HER3
-
Sergina NV, Rausch M, Wang D, et al. Escape from HER-family tyrosine kinase inhibitor therapy by the kinase-inactive HER3. Nature 2007; 445:437-441.
-
(2007)
Nature
, vol.445
, pp. 437-441
-
-
Sergina, N.V.1
Rausch, M.2
Wang, D.3
-
34
-
-
84857417355
-
Feedback upregulation of HER3 (ErbB3) expression and activity attenuates antitumor effect of PI3K inhibitors
-
Chakrabarty A, Sanchez V, Kuba MG, et al. Feedback upregulation of HER3 (ErbB3) expression and activity attenuates antitumor effect of PI3K inhibitors. Proc Natl Acad Sci USA 2012; 109:2718-2723.
-
(2012)
Proc Natl Acad Sci USA
, vol.109
, pp. 2718-2723
-
-
Chakrabarty, A.1
Sanchez, V.2
Kuba, M.G.3
-
35
-
-
75149170979
-
Fibroblast growth factor signalling: From development to cancer
-
Turner N, Grose R. Fibroblast growth factor signalling: from development to cancer. Nat Rev Cancer 2010; 10:116-129.
-
(2010)
Nat Rev Cancer
, vol.10
, pp. 116-129
-
-
Turner, N.1
Grose, R.2
-
36
-
-
34447325266
-
FGFR1 amplification in breast carcinomas: A chromogenic in situ hybridisation analysis
-
Elbauomy Elsheikh S, Green AR, Lambros MB, et al. FGFR1 amplification in breast carcinomas: a chromogenic in situ hybridisation analysis. Breast Cancer Res 2007; 9:R23.
-
(2007)
Breast Cancer Res
, vol.9
-
-
Elbauomy Elsheikh, S.1
Green, A.R.2
Lambros, M.B.3
-
37
-
-
77950278598
-
FGFR1 amplification drives endocrine therapy resistance and is a therapeutic target in breast cancer
-
Turner N, Pearson A, Sharpe R, et al. FGFR1 amplification drives endocrine therapy resistance and is a therapeutic target in breast cancer. Cancer Res 2010; 70:2085-2094.
-
(2010)
Cancer Res
, vol.70
, pp. 2085-2094
-
-
Turner, N.1
Pearson, A.2
Sharpe, R.3
-
38
-
-
33845331706
-
FGFR1 emerges as a potential therapeutic target for lobular breast carcinomas
-
Reis-Filho JS, Simpson PT, Turner NC, et al. FGFR1 emerges as a potential therapeutic target for lobular breast carcinomas. Clin Cancer Res 2006; 12:6652-6662.
-
(2006)
Clin Cancer Res
, vol.12
, pp. 6652-6662
-
-
Reis-Filho, J.S.1
Simpson, P.T.2
Turner, N.C.3
-
39
-
-
0032818363
-
Upregulation of basic fibroblast growth factor in breast carcinoma and its relationship to vascular density, oestrogen receptor, epidermal growth factor receptor and survival
-
Smith K, Fox SB, Whitehouse R, et al. Upregulation of basic fibroblast growth factor in breast carcinoma and its relationship to vascular density, oestrogen receptor, epidermal growth factor receptor and survival. Ann Oncol 1999; 10:707-713.
-
(1999)
Ann Oncol
, vol.10
, pp. 707-713
-
-
Smith, K.1
Fox, S.B.2
Whitehouse, R.3
-
40
-
-
77950866696
-
Integrative molecular profiling of triple negative breast cancers identifies amplicon drivers and potential therapeutic targets
-
Turner N, Lambros MB, Horlings HM, et al. Integrative molecular profiling of triple negative breast cancers identifies amplicon drivers and potential therapeutic targets. Oncogene 2010; 29:2013-2023.
-
(2010)
Oncogene
, vol.29
, pp. 2013-2023
-
-
Turner, N.1
Lambros, M.B.2
Horlings, H.M.3
-
41
-
-
84878781242
-
Identification of targetable FGFR gene fusions in diverse cancers
-
Wu YM, Su F, Kalyana-Sundaram S, et al. Identification of targetable FGFR gene fusions in diverse cancers. Cancer Discov 2013; 3:636-647.
-
(2013)
Cancer Discov
, vol.3
, pp. 636-647
-
-
Wu, Y.M.1
Su, F.2
Kalyana-Sundaram, S.3
-
42
-
-
84879859652
-
Targeting FGFR with dovitinib (TKI258): Preclinical and clinical data in breast cancer
-
Andre F, Bachelot T, Campone M, et al. Targeting FGFR with dovitinib (TKI258): preclinical and clinical data in breast cancer. Clin Cancer Res 2013; 19:3693-3702.
-
(2013)
Clin Cancer Res
, vol.19
, pp. 3693-3702
-
-
Andre, F.1
Bachelot, T.2
Campone, M.3
-
43
-
-
84877028141
-
Comprehensive molecular portraits of human breast tumours
-
The Cancer Genome Atlas Network T.
-
The Cancer Genome Atlas Network T. Comprehensive molecular portraits of human breast tumours. Nature 2012; 490:61-70.
-
(2012)
Nature
, vol.490
, pp. 61-70
-
-
-
44
-
-
84861527388
-
The genomic and transcriptomic architecture of 2, 000 breast tumours reveals novel subgroups
-
Curtis C, Shah SP, Chin SF, et al. The genomic and transcriptomic architecture of 2, 000 breast tumours reveals novel subgroups. Nature 2012.
-
(2012)
Nature
-
-
Curtis, C.1
Shah, S.P.2
Chin, S.F.3
-
45
-
-
0345447402
-
Hormone responsive human breast cancer in long-term tissue culture: Effect of insulin
-
Osborne CK, Bolan G, Monaco ME, Lippman ME. Hormone responsive human breast cancer in long-term tissue culture: effect of insulin. Proc Natl Acad Sci USA 1976; 73:4536-4540.
-
(1976)
Proc Natl Acad Sci USA
, vol.73
, pp. 4536-4540
-
-
Osborne, C.K.1
Bolan, G.2
Monaco, M.E.3
Lippman, M.E.4
-
46
-
-
0027366338
-
Simian virus 40 large tumor antigen is unable to transform mouse embryonic fibroblasts lacking type 1 insulin-like growth factor receptor
-
Sell C, Rubini M, Rubin R, et al. Simian virus 40 large tumor antigen is unable to transform mouse embryonic fibroblasts lacking type 1 insulin-like growth factor receptor. Proc Natl Acad Sci USA 1993; 90:11217-11221.
-
(1993)
Proc Natl Acad Sci USA
, vol.90
, pp. 11217-11221
-
-
Sell, C.1
Rubini, M.2
Rubin, R.3
-
47
-
-
0030962307
-
Gene expression profiles in normal and cancer cells
-
Zhang L, Zhou W, Velculescu VE, et al. Gene expression profiles in normal and cancer cells. Science 1997; 276:1268-1272.
-
(1997)
Science
, vol.276
, pp. 1268-1272
-
-
Zhang, L.1
Zhou, W.2
Velculescu, V.E.3
-
48
-
-
84875257995
-
Ganitumab with either exemestane or fulvestrant for postmenopausal women with advanced, hormone-receptor-positive breast cancer: A randomised, controlled, doubleblind, phase 2 trial
-
Robertson JF, Ferrero JM, Bourgeois H, et al. Ganitumab with either exemestane or fulvestrant for postmenopausal women with advanced, hormone-receptor-positive breast cancer: a randomised, controlled, doubleblind, phase 2 trial. Lancet Oncol 2013; 14:228-235.
-
(2013)
Lancet Oncol
, vol.14
, pp. 228-235
-
-
Robertson, J.F.1
Ferrero, J.M.2
Bourgeois, H.3
-
49
-
-
79958696336
-
Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling
-
Yu Y, Yoon SO, Poulogiannis G, et al. Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling. Science 2011; 332:1322-1326.
-
(2011)
Science
, vol.332
, pp. 1322-1326
-
-
Yu, Y.1
Yoon, S.O.2
Poulogiannis, G.3
-
50
-
-
84863078767
-
Everolimus in postmenopausal hormone-receptor-positive advanced breast cancer
-
Baselga J, Campone M, Piccart M, et al. Everolimus in postmenopausal hormone-receptor-positive advanced breast cancer. N Engl J Med 2012; 366:520-529.
-
(2012)
N Engl J Med
, vol.366
, pp. 520-529
-
-
Baselga, J.1
Campone, M.2
Piccart, M.3
-
51
-
-
84867281628
-
HER3 signalling is regulated through a multitude of redundant mechanisms in HER2-driven tumour cells
-
Amin DN, Sergina N, Lim L, et al. HER3 signalling is regulated through a multitude of redundant mechanisms in HER2-driven tumour cells. Biochem J 2012; 447:417-425.
-
(2012)
Biochem J
, vol.447
, pp. 417-425
-
-
Amin, D.N.1
Sergina, N.2
Lim, L.3
-
52
-
-
80655126355
-
MTOR kinase inhibition causes feedback-dependent biphasic regulation of Akt signaling
-
Rodrik-Outmezguine VS, Chandarlapaty S, Pagano NC, et al. mTOR kinase inhibition causes feedback-dependent biphasic regulation of Akt signaling. Cancer Discov 2011; 1:248-259.
-
(2011)
Cancer Discov
, vol.1
, pp. 248-259
-
-
Rodrik-Outmezguine, V.S.1
Chandarlapaty, S.2
Pagano, N.C.3
-
54
-
-
73649102105
-
Preexistence and clonal selection of MET amplification in EGFR mutant NSCLC
-
Turke AB, Zejnullahu K, Wu YL, et al. Preexistence and clonal selection of MET amplification in EGFR mutant NSCLC. Cancer Cell 2010; 17:77-88.
-
(2010)
Cancer Cell
, vol.17
, pp. 77-88
-
-
Turke, A.B.1
Zejnullahu, K.2
Wu, Y.L.3
-
55
-
-
69149108735
-
Met induces mammary tumors with diverse histologies and is associated with poor outcome and human basal breast cancer
-
Ponzo MG, Lesurf R, Petkiewicz S, et al. Met induces mammary tumors with diverse histologies and is associated with poor outcome and human basal breast cancer. Proc Natl Acad Sci USA 2009; 106: 12903-12908.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 12903-12908
-
-
Ponzo, M.G.1
Lesurf, R.2
Petkiewicz, S.3
-
56
-
-
84875215810
-
Met signaling regulates growth, repopulating potential and basal cell-fate commitment of mammary luminal progenitors: Implications for basal-like breast cancer
-
Gastaldi S, Sassi F, Accornero P, et al. Met signaling regulates growth, repopulating potential and basal cell-fate commitment of mammary luminal progenitors: implications for basal-like breast cancer. Oncogene 2013; 32:1428-1440.
-
(2013)
Oncogene
, vol.32
, pp. 1428-1440
-
-
Gastaldi, S.1
Sassi, F.2
Accornero, P.3
-
57
-
-
84865208757
-
Cabozantinib (XL184) in patients with metastatic breast cancer: Results from a phase 2 randomized discontinuation trial
-
Tolaney S, Nechushtan H, Berger R, et al. Cabozantinib (XL184) in patients with metastatic breast cancer: results from a phase 2 randomized discontinuation trial. Cancer Res 2011; 71:P1-P17.
-
(2011)
Cancer Res
, vol.71
-
-
Tolaney, S.1
Nechushtan, H.2
Berger, R.3
-
58
-
-
79952292499
-
Activation of multiple proto-oncogenic tyrosine kinases in breast cancer via loss of the PTPN12 phosphatase
-
Sun T, Aceto N, Meerbrey KL, et al. Activation of multiple proto-oncogenic tyrosine kinases in breast cancer via loss of the PTPN12 phosphatase. Cell 2011; 144:703-718.
-
(2011)
Cell
, vol.144
, pp. 703-718
-
-
Sun, T.1
Aceto, N.2
Meerbrey, K.L.3
-
59
-
-
79959508436
-
Targeting the phosphoinositide-3 (PI3) kinase pathway in breast cancer
-
Baselga J. Targeting the phosphoinositide-3 (PI3) kinase pathway in breast cancer. Oncologist 2011; 16 (Suppl. 1):12-19.
-
(2011)
Oncologist
, vol.16
, Issue.SUPPL. 1
, pp. 12-19
-
-
Baselga, J.1
-
60
-
-
65249190250
-
S6 kinase 1 regulates estrogen receptor alpha in control of breast cancer cell proliferation
-
Yamnik RL, Digilova A, Davis DC, et al. S6 kinase 1 regulates estrogen receptor alpha in control of breast cancer cell proliferation. J Biol Chem 2009; 284:6361-6369.
-
(2009)
J Biol Chem
, vol.284
, pp. 6361-6369
-
-
Yamnik, R.L.1
Digilova, A.2
Davis, D.C.3
-
61
-
-
84859423453
-
Defining the expressed breast cancer kinome
-
Midland AA, Whittle MC, Duncan JS, et al. Defining the expressed breast cancer kinome. Cell Res 2012; 22:620-623.
-
(2012)
Cell Res
, vol.22
, pp. 620-623
-
-
Midland, A.A.1
Whittle, M.C.2
Duncan, J.S.3
-
62
-
-
84859765844
-
Dynamic reprogramming of the kinome in response to targeted MEK inhibition in triple-negative breast cancer
-
Duncan JS, Whittle MC, Nakamura K, et al. Dynamic reprogramming of the kinome in response to targeted MEK inhibition in triple-negative breast cancer. Cell 2012; 149:307-321.
-
(2012)
Cell
, vol.149
, pp. 307-321
-
-
Duncan, J.S.1
Whittle, M.C.2
Nakamura, K.3
-
63
-
-
84863230465
-
Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR
-
Prahallad A, Sun C, Huang S, et al. Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR. Nature 2012; 483:100-103.
-
(2012)
Nature
, vol.483
, pp. 100-103
-
-
Prahallad, A.1
Sun, C.2
Huang, S.3
|