Tissue microarray analysis reveals the expression and prognostic significance of phosphorylated AktThr308 in oral squamous cell carcinoma

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

Volumn 116, Issue 5, 2013, Pages 591-597

  Li, Yanzhong ^a   Wang, Jing ^b   Wang, Fang ^b   Wang, Hui ^b   Wang, Jiayi ^b   Zeng, Xin ^b   Liao, Ga ^b   Dan, Hongxia ^b   Chen, Qianming ^b  

^a SICHUAN UNIVERSITY   (China)

^b SICHUAN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN KINASE B; TUMOR MARKER;

ARTICLE; CANCER STAGING; FEMALE; HUMAN; IMMUNOHISTOCHEMISTRY; LYMPH NODE METASTASIS; MALE; METABOLISM; MIDDLE AGED; MOUTH TUMOR; PATHOLOGY; PHOSPHORYLATION; PROGNOSIS; SQUAMOUS CELL CARCINOMA; SURVIVAL RATE; TISSUE MICROARRAY; TUMOR RECURRENCE;

CARCINOMA, SQUAMOUS CELL; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; MOUTH NEOPLASMS; NEOPLASM RECURRENCE, LOCAL; NEOPLASM STAGING; PHOSPHORYLATION; PROGNOSIS; PROTO-ONCOGENE PROTEINS C-AKT; SURVIVAL RATE; TISSUE ARRAY ANALYSIS; TUMOR MARKERS, BIOLOGICAL;

EID: 84885428868     PISSN: 22124403     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.oooo.2013.06.031     Document Type: Article

References (28)

1. S. Warnakulasuriya Global epidemiology of oral and oropharyngeal cancer Oral Oncol 45 2009 309 316
2. J.P. Shah, and Z. Gil Current concepts in management of oral cancer - surgery Oral Oncol 45 2009 394 401
3. K. Gogilashvili, N. Shonia, and G. Burkadze The role of human papillomavirus in oral squamous cell carcinoma Georgian Med News 213 2012 32 36
4. J. Chen, Q.Y. He, A.P. Yuen, and J.F. Chiu Proteomics of buccal squamous cell carcinoma: the involvement of multiple pathways in tumorigenesis Proteomics 4 2004 2465 2475
5. M.P. Scheid, and J.R. Woodgett Unravelling the activation mechanisms of protein kinase B/Akt FEBS Lett 546 2003 108 112
6. P.J. Coffer, J. Jin, and J.R. Woodgett Protein kinase B(c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation Biochem J 335 1998 1 13
7. L.C. Cantley, and B.G. Neel New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway Proc Natl Acad Sci U S A 96 1999 4240 4245
8. J. Downward PI 3-kinase, Akt and cell survival Semin Cell Dev Biol 15 2004 177 182
9. A.L. Edinger, and C.B. Thompson Akt maintains cell size and survival by increasing mTOR-dependent nutrient uptake Mol Biol Cell 13 2002 2276 2288
10. K. Inoki, Y. Li, T. Zhu, J. Wu, and K.L. Guan TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling Nat Cell Biol 4 2002 648 657
11. I. Vivanco, and C.L. Sawyers The phosphatidylinositol 3-kinase AKT pathway in human cancer Nat Rev Cancer 2 2002 489 501
12. Z. Yu, P.M. Weinberger, and C. Sasaki Phosphorylation of Akt (Ser473) predicts poor clinical outcome in oropharyngeal squamous cell cancer Cancer Epidemiol Biomark Prev 16 2007 553 558
13. J. Lim, J.H. Kim, and J.Y. Paeng Prognostic value of activated Akt expression in oral squamous cell carcinoma J Clin Pathol 58 2005 1199 1205
14. S. Tanno, Y. Mitsuuchi, D.A. Altomare, G.H. Xiao, and J.R. Testa AKT activation up-regulates insulin-like growth factor I receptor expression and promotes invasiveness of human pancreatic cancer cells Cancer Res 61 2001 589 593
15. A. Iamaroon, and S. Krisanaprakornkit Overexpression and activation of Akt2 protein in oral squamous cell carcinoma Oral Oncol 45 2009 e175 e179
16. A. Bellacosa, D. de Feo, and A.K. Godwin Molecular alterations of the AKT2 oncogene in ovarian and breast carcinomas Int J Cancer 64 1995 280 285
17. J.I. Kreisberg, S.N. Malik, and T.J. Prihoda Phosphorylation of Akt (Ser473) is an excellent predictor of poor clinical outcome in prostate cancer Cancer Res 64 2004 5232 5236
18. M.G. Schlieman, B.N. Fahy, R. Ramsamooj, L. Beckett, and R.J. Bold Incidence, mechanism and prognostic value of activated AKT in pancreas cancer Br J Cancer 89 2003 2110 2115
19. J.A. Swets Measuring the accuracy of diagnostic systems Science 240 1988 1285 1293
20. K. Kozaki, I. Imoto, and A. Pimkhaokham PIK3CA mutation is an oncogenic aberration at advanced stages of oral squamous cell carcinoma Cancer Sci 97 2006 1351 1358
21. C. Clark, S. Shah, and L. Herman-Ferdinandez Teasing out the best molecular marker in the AKT/mTOR pathway in head and neck squamous cell cancer patients Laryngoscope 120 2010 1159 1165
22. L. Fang, H. Wang, L. Zhou, and D. Yu Akt-FOXO3a signaling axis dysregulation in human oral squamous cell carcinoma and potent efficacy of FOXO3a-targeted gene therapy Oral Oncol 47 2011 16 21
23. D.R. Alessi, M. Andjelkovic, and B. Caudwell Mechanism of activation of protein kinase B by insulin and IGF-1 EMBO J 15 1996 6541 6551
24. E. Jacinto, V. Facchinetti, and D. Liu SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity Cell 127 2006 125 137
25. H.A. Pontes, F.C. de Aquino Xavier, and T.S. da Silva Metallothionein and p-Akt proteins in oral dysplasia and in oral squamous cell carcinoma: an immunohistochemical study J Oral Pathol Med 38 2009 644 650
26. N. Gallay, C. Dos Santos, and L. Cuzin The level of AKT phosphorylation on threonine 308 but not on serine 473 is associated with high-risk cytogenetics and predicts poor overall survival in acute myeloid leukaemia Leukemia 23 2009 1029 1038
27. J.P. Shah, and W. Lydiatt Treatment of cancer of the head and neck Cancer J Clin 45 1995 352 368
28. K.R. Jones, D. Lodge-Rigal, R.L. Reddick, G.E. Tudor, and W.W. Shockley Prognostic factors in the recurrence of stage I and II squamous cell cancer of the oral cavity Arch Otolaryngol Head Neck Surg 118 1992 483 485