Potent activity of nobiletin-rich Citrus reticulata peel extract to facilitate cAMP/PKA/ERK/CREB signaling associated with learning and memory in cultured hippocampal neurons: Identification of the substances responsible for the pharmacological action

Journal of Neural Transmission

Volumn 120, Issue 10, 2013, Pages 1397-1409

  Kawahata, Ichiro ^a   Yoshida, Masaaki ^b   Sun, Wen ^a   Nakajima, Akira ^a,e   Lai, Yanxin ^a   Osaka, Naoya ^a   Matsuzaki, Kentaro ^c   Yokosuka, Akihito ^d   Mimaki, Yoshihiro ^d   Naganuma, Akira ^a   Tomioka, Yoshihisa ^a   Yamakuni, Tohru ^a  

^a TOHOKU UNIVERSITY   (Japan)

^b Kotaro Pharmaceutical Co Ltd   (Japan)

^c SHIMANE UNIVERSITY   (Japan)

^d TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCES   (Japan)

^e NAGOYA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

CRE mediated transcription; Hippocampal neurons; Learning and memory; Nobiletin rich Citrus reticulata peel; PKA ERK CREB signaling

Indexed keywords

6 DEMETHOXYNOBILETIN; CITRUS RETICULATA EXTRACT; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; FLAVONOID; HESPERIDIN; MITOGEN ACTIVATED PROTEIN KINASE; NARIRUTIN; NOBILETIN; PLANT EXTRACT; SINENSETIN; TANGERETIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BREATHING MECHANICS; CHROMATOGRAPHY; CONTROLLED STUDY; DEMENTIA; DRY WEIGHT; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIPPOCAMPAL NEURONAL CULTURE; IMMUNOREACTIVITY; INTRACELLULAR SIGNALING; LEARNING; LEARNING DISORDER; MALE; MANDARIN; MEMORY; MEMORY DISORDER; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION;

ANIMALS; BLOTTING, WESTERN; CELLS, CULTURED; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CITRUS; CYCLIC AMP; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DRUGS, CHINESE HERBAL; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FLAVONES; FRUIT; HIPPOCAMPUS; LEARNING; MEDICINE, KAMPO; MEMORY; MICE; NEURONS; PLANT EXTRACTS; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; TRANSFECTION;

EID: 84885423206     PISSN: 03009564     EISSN: 14351463     Source Type: Journal    
DOI: 10.1007/s00702-013-1025-x     Document Type: Article

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