A study of selective neuronal vulnerability in the human central nervous system;Estudio de la vulnerabilidad neuronal selectiva en el sistema nervioso central humano

Revista Espanola de Geriatria y Gerontologia

Volumn 48, Issue 5, 2013, Pages 216-223

  Naudí, Alba ^a   Jové, Mariona ^a   Ayala, Victoria ^a   Cabré, Rosanna ^a   Portero Otin, Manuel ^a   Ferrer, Isidre ^b   Pamplona, Reinald ^a  

^a UNIVERSITY OF LLEIDA   (Spain)

^b HOSPITAL UNIVERSITARI DE BELLVITGE   (Spain)

Author keywords

Arachidonic acid; Desaturase; Docosahexaenoic acid; Lipid peroxidation; Oxidative stress

Indexed keywords

MONOUNSATURATED FATTY ACID; POLYUNSATURATED FATTY ACID;

ADAPTATION; ARTICLE; CENTRAL NERVOUS SYSTEM; CHROMATOGRAPHY; ENZYME ACTIVITY; HUMAN; NERVE CELL; NERVE CELL MEMBRANE; NORMAL HUMAN; OXIDATIVE STRESS; PEROXIDATION; REGULATORY MECHANISM;

ARACHIDONIC ACID; ÁCIDO ARAQUIDÓNICO; ÁCIDO DOCOSAHEXAENOICO; DESATURASAS; DESATURASE; DOCOSAHEXAENOIC ACID; ESTRÉS OXIDATIVO; LIPID PEROXIDATION; OXIDATIVE STRESS; PEROXIDACIÓN LIPÍDICA;

CENTRAL NERVOUS SYSTEM; FATTY ACIDS; HUMANS; NEURONS;

EID: 84885422875     PISSN: 0211139X     EISSN: 15781747     Source Type: Journal    
DOI: 10.1016/j.regg.2013.04.005     Document Type: Article

References (29)

1. Mattson M.P., Magnus T. Ageing and neuronal vulnerability. Nat Rev Neurosci 2006, 7:278-294.
2. Wang X., Michaelis E.K. Selective neuronal vulnerability to oxidative stress in the brain. Front Aging Neurosci 2010, 2:12.
3. Martínez A., Portero-Otin M., Pamplona R., Ferrer I. Protein targets of oxidative damage in human neurodegenerative diseases with abnormal protein aggregates. Brain Pathol 2010, 20:281-297.
4. Yin F., Boveris A., Cadenas E. Mitochondrial energy metabolism and redox signaling in brain aging and neurodegeneration. Antioxid Redox Signal 2012 Sep 5, 10.1089/ars.2012.4774.
5. Calabrese V., Cornelius C., Mancuso C., Lentile R., Stella A.M., Butterfield D.A. Redox homeostasis and cellular stress response in aging and neurodegeneration. Methods Mol Biol 2010, 610:285-308.
6. Vereb G., Szollosi J., Matko J., Nagy P., Farkas T., Vigh L., et al. Dynamic, yet structured: The cell membrane three decades after the Singer-Nicolson model. Proc Natl Acad Sci U S A 2003, 100:8053-8058.
7. Pamplona R. Membrane phospholipids, lipoxidative damage and molecular integrity: A causal role in aging and longevity. Biochim Biophys Acta 2008, 1777:1249-1262.
8. Hulbert A.J., Pamplona R., Buffenstein R., Buttemer W.A. Life and death: Metabolic rate, membrane composition, and life span of animals. Physiol Rev 2007, 87:1175-1213.
9. Holman R.T. Autoxidation of fats and related substances. Progress in chemistry of fats and other lipids 1954, 51-98. Pergamon Press, London. R.T. Holman, W.O. Lundberg, T. Malkin (Eds.).
10. Guillou H., Zadravec D., Martin P.G., Jacobsson A. The key roles of elongases and desaturases in mammalian fatty acid metabolism: Insights from transgenic mice. Prog Lipid Res 2010, 49:186-199.
11. Esterbauer H., Schaur R.J., Zollner H. Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes. Free Radic Biol Med 1991, 11:81-128.
12. Pamplona R. Advanced lipoxidation end-products. Chem Biol Interact 2011, 192:14-20.
13. Naudí A., Jové M., Ayala V., Cabré R., Portero-Otín M., Pamplona R. Non-enzymatic modification of aminophospholipids by carbonyl-amine reactions. Int J Mol Sci 2013, 14:3285-3313.
14. Marnett L.J. Oxy radicals, lipid peroxidation and DNA damage. Toxicology 2002, 18:1-182. 219-22.
15. Igarashi M., DeMar J.C., Ma K., Chang L., Bell J.M., Rapoport S.I. Docosahexaenoic acid synthesis from alpha-linolenic acid by rat brain is unaffected by dietary n-3 PUFA deprivation. J Lipid Res 2007, 48:1150-1158.
16. Lauritzen L., Hansen H.S., Jorgensen M.H., Michaelsen K.F. The essentiality of long chain n-3 fatty acids in relation to development and function of the brain and retina. Prog Lipid Res 2001, 40:1-94.
17. Crawford M.A., Broadhurst C.L., Guest M., Nagar A., Wang Y., Ghebremeskel K., et al. A quantum theory for the irreplaceable role of docosahexaenoic acid in neural cell signaling throughout evolution. Prostaglandins Leukot Essent Fatty Acids 2013, 88:5-13.
18. Pamplona R., Dalfo E., Ayala V., Bellmunt M.J., Prat J., Ferrer I., et al. Proteins in human brain cortex are modified by oxidation, glycoxidation, and lipoxidation. Effects of Alzheimer disease and identification of lipoxidation targets. J Biol Chem 2005, 280:21522-21530.
19. Pamplona R., Barja G. Highly resistant macromolecular components and low rate of generation of endogenous damage: Two key traits of longevity. Ageing Res Rev 2007, 6:189-210.
20. Pamplona R., Barja G. An evolutionary comparative scan for longevity-related oxidative stress resistance mechanisms in homeotherms. Biogerontology 2011, 12:409-435.
21. Sanz A., Pamplona R., Barja G. Is the mitochondrial free radical theory of aging intact?. Antioxid Redox Signal 2006, 8:582-599.
22. Ferrer I. Altered mitochondria, energy metabolism, voltage-dependent anion channel, and lipid rafts converge to exhaust neurons in Alzheimer's disease. J Bioenerg Biomembr 2009, 41:425-431.
23. Dalfó E., Portero-Otín M., Ayala V., Martínez A., Pamplona R., Ferrer I. Evidence of oxidative stress in the neocortex in incidental Lewy body disease. J Neuropathol Exp Neurol 2005, 64:816-830.
24. Muntané G., Dalfó E., Martínez A., Rey M.J., Avila J., Pérez M., et al. Glial fibrillary acidic protein is a major target of glycoxidative and lipoxidative damage in Pick's disease. J Neurochem 2006, 99:177-185.
25. Ilieva E.V., Ayala V., Jové M., Dalfó E., Cacabelos D., Povedano M., et al. Oxidative and endoplasmic reticulum stress interplay in sporadic amyotrophic lateral sclerosis. Brain 2007, 130:3111-3123.
26. Fourcade S., López-Erauskin J., Galino J., Duval C., Naudi A., Jove M., et al. Early oxidative damage underlying neurodegeneration in X-adrenoleukodystrophy. Hum Mol Genet 2008, 17:1762-1773.
27. Pamplona R., Naudí A., Gavín R., Pastrana M.A., Sajnani G., Ilieva E.V., et al. Increased oxidation, glycoxidation, and lipoxidation of brain proteins in prion disease. Free Radic Biol Med 2008, 45:1159-1166.
28. Martínez A., Carmona M., Portero-Otín M., Naudí A., Pamplona R., Ferrer I. Type-dependent oxidative damage in frontotemporal lobar degeneration: cortical astrocytes are targets of oxidative damage. J Neuropathol Exp Neurol 2008, 67:1122-1136.
29. Ilieva E.V., Kichev A., Naudí A., Ferrer I., Pamplona R., Portero-Otín M. Mitochondrial dysfunction and oxidative and endoplasmic reticulum stress in argyrophilic grain disease. J Neuropathol Exp Neurol 2011, 70:253-263.