메뉴 건너뛰기




Volumn 39, Issue 11, 2013, Pages 1896-1908

Safety of off-label erythropoiesis stimulating agents in critically ill patients: A meta-analysis

Author keywords

Critical illness; Drug safety; Epoetin alfa; Erythropoiesis stimulating agents; Meta analysis; Off label use

Indexed keywords

ANTIANEMIC AGENT; NOVEL ERYTHROPOIESIS STIMULATING PROTEIN; RECOMBINANT ERYTHROPOIETIN;

EID: 84885422340     PISSN: 03424642     EISSN: 14321238     Source Type: Journal    
DOI: 10.1007/s00134-013-3030-9     Document Type: Review
Times cited : (25)

References (92)
  • 1
    • 0035092672 scopus 로고    scopus 로고
    • Nutritional deficiencies and blunted erythropoietin response as causes of the anemia of critical illness
    • 11230723 10.1053/jcrc.2001.21795 1:CAS:528:DC%2BD3MXit1Citbk%3D
    • Rodriguez RM, Corwin HL, Gettinger A, Corwin MJ, Gubler D, Pearl RG (2001) Nutritional deficiencies and blunted erythropoietin response as causes of the anemia of critical illness. J Crit Care 16:36-41
    • (2001) J Crit Care , vol.16 , pp. 36-41
    • Rodriguez, R.M.1    Corwin, H.L.2    Gettinger, A.3    Corwin, M.J.4    Gubler, D.5    Pearl, R.G.6
  • 2
    • 29144460986 scopus 로고    scopus 로고
    • The role of erythropoietin therapy in the critically ill
    • 16373185 10.1016/j.tmrv.2005.08.002
    • Corwin HL (2006) The role of erythropoietin therapy in the critically ill. Transfus Med Rev 20:27-33
    • (2006) Transfus Med Rev , vol.20 , pp. 27-33
    • Corwin, H.L.1
  • 3
    • 53049093520 scopus 로고    scopus 로고
    • Efficacy of red blood cell transfusion in the critically ill: A systematic review of the literature
    • 18679112 10.1097/CCM.0b013e3181844677
    • Marik PE, Corwin HL (2008) Efficacy of red blood cell transfusion in the critically ill: A systematic review of the literature. Crit Care Med 36:2667-2674
    • (2008) Crit Care Med , vol.36 , pp. 2667-2674
    • Marik, P.E.1    Corwin, H.L.2
  • 4
    • 34748925835 scopus 로고    scopus 로고
    • Erythropoietin-receptor agonists in critically ill patients: A meta-analysis of randomized controlled trials
    • 17823140
    • Zarychanski R, Turgeon AF, McIntyre L, Fergusson DA (2007) Erythropoietin-receptor agonists in critically ill patients: A meta-analysis of randomized controlled trials. CMAJ 177:725-734
    • (2007) CMAJ , vol.177 , pp. 725-734
    • Zarychanski, R.1    Turgeon, A.F.2    McIntyre, L.3    Fergusson, D.A.4
  • 5
    • 11244333356 scopus 로고    scopus 로고
    • New avenues of exploration for erythropoietin
    • 15632341 10.1001/jama.293.1.90 1:CAS:528:DC%2BD2MXht1Gmtw%3D%3D
    • Maiese K, Li F, Chong ZZ (2005) New avenues of exploration for erythropoietin. JAMA 293:90-95
    • (2005) JAMA , vol.293 , pp. 90-95
    • Maiese, K.1    Li, F.2    Chong, Z.Z.3
  • 6
    • 77954062316 scopus 로고    scopus 로고
    • The role of erythropoiesis-stimulating agents in the treatment of anemia
    • Fishbane S (2010) The role of erythropoiesis-stimulating agents in the treatment of anemia. Am J Manag Care 16 (Suppl Issues): S67-S73
    • (2010) Am J Manag Care , vol.16 , Issue.SUPPL.
    • Fishbane, S.1
  • 7
    • 58249134621 scopus 로고    scopus 로고
    • A US multicenter, retrospective, observational study of erythropoiesis-stimulating agent utilization in anemic, critically ill patients admitted to the intensive care unit
    • 19167591 10.1016/j.clinthera.2008.12.024 1:CAS:528:DC%2BD1MXisFSgt7Y%3D
    • Brophy GM, Sheehan V, Shapiro MJ, Lottenberg L, Scarlata D, Audhya P (2008) A US multicenter, retrospective, observational study of erythropoiesis-stimulating agent utilization in anemic, critically ill patients admitted to the intensive care unit. Clin Ther 30:2324-2334
    • (2008) Clin Ther , vol.30 , pp. 2324-2334
    • Brophy, G.M.1    Sheehan, V.2    Shapiro, M.J.3    Lottenberg, L.4    Scarlata, D.5    Audhya, P.6
  • 8
    • 84885420297 scopus 로고    scopus 로고
    • Dosing and transfusion patterns of erythropoietic stimulating therapies in critically ill patients
    • 10.1097/00003246-200612002-00440
    • Vekeman F, Lefebvre P, Mody SH, Raut M, McKenzie RS, Watson S et al (2006) Dosing and transfusion patterns of erythropoietic stimulating therapies in critically ill patients. Crit Care Med 34:A128
    • (2006) Crit Care Med , vol.34 , pp. 128
    • Vekeman, F.1    Lefebvre, P.2    Mody, S.H.3    Raut, M.4    McKenzie, R.S.5    Watson, S.6
  • 10
    • 65449117261 scopus 로고    scopus 로고
    • Recombinant human erythropoiesis-stimulating agents and mortality in patients with cancer: A meta-analysis of randomised trials
    • 19410717 10.1016/S0140-6736(09)60502-X 1:CAS:528:DC%2BD1MXltlaqurg%3D
    • Bohlius J, Schmidlin K, Brillant C, Schwarzer G, Trelle S, Seidenfeld J et al (2009) Recombinant human erythropoiesis-stimulating agents and mortality in patients with cancer: A meta-analysis of randomised trials. Lancet 373:1532-1542
    • (2009) Lancet , vol.373 , pp. 1532-1542
    • Bohlius, J.1    Schmidlin, K.2    Brillant, C.3    Schwarzer, G.4    Trelle, S.5    Seidenfeld, J.6
  • 12
    • 33846669860 scopus 로고    scopus 로고
    • Mortality and target haemoglobin concentrations in anaemic patients with chronic kidney disease treated with erythropoietin: A meta-analysis
    • 17276778 10.1016/S0140-6736(07)60194-9 1:CAS:528:DC%2BD2sXht1OrsLY%3D
    • Phrommintikul A, Haas SJ, Elsik M, Krum H (2007) Mortality and target haemoglobin concentrations in anaemic patients with chronic kidney disease treated with erythropoietin: A meta-analysis. Lancet 369:381-388
    • (2007) Lancet , vol.369 , pp. 381-388
    • Phrommintikul, A.1    Haas, S.J.2    Elsik, M.3    Krum, H.4
  • 13
    • 67049114157 scopus 로고    scopus 로고
    • Benefits and harms of erythropoiesis-stimulating agents for anemia related to cancer: A meta-analysis
    • 19407261
    • Tonelli M, Hemmelgarn B, Reiman T, Manns B, Reaume MN, Lloyd A et al (2009) Benefits and harms of erythropoiesis-stimulating agents for anemia related to cancer: A meta-analysis. CMAJ 180:E62-E71
    • (2009) CMAJ , vol.180
    • Tonelli, M.1    Hemmelgarn, B.2    Reiman, T.3    Manns, B.4    Reaume, M.N.5    Lloyd, A.6
  • 14
    • 77955722809 scopus 로고    scopus 로고
    • Meta-analysis: Erythropoiesis-stimulating agents in patients with chronic kidney disease
    • 20439566 10.7326/0003-4819-153-1-201007060-00252
    • Palmer SC, Navaneethan SD, Craig JC, Johnson DW, Tonelli M, Garg AX et al (2010) Meta-analysis: Erythropoiesis-stimulating agents in patients with chronic kidney disease. Ann Intern Med 153:23-33
    • (2010) Ann Intern Med , vol.153 , pp. 23-33
    • Palmer, S.C.1    Navaneethan, S.D.2    Craig, J.C.3    Johnson, D.W.4    Tonelli, M.5    Garg, A.X.6
  • 16
    • 84885434288 scopus 로고    scopus 로고
    • Safety of off-label erythropoiesis stimulating agents (ESAs) in critically ill patients: A systematic review and meta-analysis
    • Mesgarpour B, Heidinger B, Schwameis M, Kienbacher K, Müller M, Herkner H (2012) Safety of off-label erythropoiesis stimulating agents (ESAs) in critically ill patients: A systematic review and meta-analysis. Pharmacoepidemiol Drug Saf 21(Supplement s3):113
    • (2012) Pharmacoepidemiol Drug Saf , vol.21 , Issue.SUPPL. S3 , pp. 113
    • Mesgarpour, B.1    Heidinger, B.2    Schwameis, M.3    Kienbacher, K.4    Müller, M.5    Herkner, H.6
  • 22
    • 39549095784 scopus 로고    scopus 로고
    • Arcsine test for publication bias in meta-analyses with binary outcomes
    • 17592831 10.1002/sim.2971
    • Rucker G, Schwarzer G, Carpenter J (2008) Arcsine test for publication bias in meta-analyses with binary outcomes. Stat Med 27:746-763
    • (2008) Stat Med , vol.27 , pp. 746-763
    • Rucker, G.1    Schwarzer, G.2    Carpenter, J.3
  • 23
    • 0030922816 scopus 로고    scopus 로고
    • Bias in meta-analysis detected by a simple, graphical test
    • 9310563 10.1136/bmj.315.7109.629 1:STN:280:DyaK2svls1KjtA%3D%3D
    • Egger M, Davey Smith G, Schneider M, Minder C (1997) Bias in meta-analysis detected by a simple, graphical test. BMJ 315:629-634
    • (1997) BMJ , vol.315 , pp. 629-634
    • Egger, M.1    Davey Smith, G.2    Schneider, M.3    Minder, C.4
  • 24
    • 0034736553 scopus 로고    scopus 로고
    • Hierarchical models in generalized synthesis of evidence: An example based on studies of breast cancer screening
    • 11122501 10.1002/1097-0258(20001230)19:24<3359: AID-SIM710>3.0. CO;2-N 1:STN:280:DC%2BD3MzgsVWmug%3D%3D
    • Prevost TC, Abrams KR, Jones DR (2000) Hierarchical models in generalized synthesis of evidence: an example based on studies of breast cancer screening. Stat Med 19:3359-3376
    • (2000) Stat Med , vol.19 , pp. 3359-3376
    • Prevost, T.C.1    Abrams, K.R.2    Jones, D.R.3
  • 25
    • 84880045342 scopus 로고    scopus 로고
    • Incorporating data from various trial designs into a mixed treatment comparison model
    • 23440610 10.1002/sim.5764
    • Schmitz S, Adams R, Walsh C (2013) Incorporating data from various trial designs into a mixed treatment comparison model. Stat Med 32:2935-2949
    • (2013) Stat Med , vol.32 , pp. 2935-2949
    • Schmitz, S.1    Adams, R.2    Walsh, C.3
  • 26
    • 39549093107 scopus 로고    scopus 로고
    • Recent developments in meta-analysis
    • 17590884 10.1002/sim.2934
    • Sutton AJ, Higgins JP (2008) Recent developments in meta-analysis. Stat Med 27:625-650
    • (2008) Stat Med , vol.27 , pp. 625-650
    • Sutton, A.J.1    Higgins, J.P.2
  • 27
    • 84874184027 scopus 로고    scopus 로고
    • Convincing evidence from controlled and uncontrolled studies on the lipid-lowering effect of a statin [editorial]
    • Accessed January 15, 2013
    • Higgins J (2012) Convincing evidence from controlled and uncontrolled studies on the lipid-lowering effect of a statin [editorial]. Cochrane Database Syst Rev 12: ED000049. http://www.thecochranelibrary.com/details/editorial/ 3992221/Convincing-evidence-from-controlled-and-uncontrolled-studies-on-the- lipid-loweri.html. Accessed January 15, 2013
    • (2012) Cochrane Database Syst Rev , vol.12
    • Higgins, J.1
  • 28
    • 70350523713 scopus 로고    scopus 로고
    • Update on phase II studies of erythropoietin in acute myocardial infarction. Rationale and design of exogenous erythropoietin in acute myocardial infarction: New outlook and dose association study (EPAMINONDAS)
    • 19533304 10.1007/s11239-009-0363-x 1:CAS:528:DC%2BD1MXhtlSlsL%2FI
    • Andreotti F, Agati L, Conti E, Santucci E, Rio T, Tarantino F et al (2009) Update on phase II studies of erythropoietin in acute myocardial infarction. Rationale and design of exogenous erythropoietin in acute myocardial infarction: New outlook and dose association study (EPAMINONDAS). J Thromb Thrombolysis 28:489-495
    • (2009) J Thromb Thrombolysis , vol.28 , pp. 489-495
    • Andreotti, F.1    Agati, L.2    Conti, E.3    Santucci, E.4    Rio, T.5    Tarantino, F.6
  • 29
    • 70349492321 scopus 로고    scopus 로고
    • Erythropoietin to augment myocardial salvage induced by coronary thrombolysis in patients with ST segment elevation acute myocardial infarction
    • 19801020 10.1016/j.amjcard.2009.05.050 1:CAS:528:DC%2BD1MXht1WntbjE
    • Binbrek AS, Rao NS, Al Khaja N, Assaqqaf J, Sobel BE (2009) Erythropoietin to augment myocardial salvage induced by coronary thrombolysis in patients with ST segment elevation acute myocardial infarction. Am J Cardiol 104:1035-1040
    • (2009) Am J Cardiol , vol.104 , pp. 1035-1040
    • Binbrek, A.S.1    Rao, N.S.2    Al Khaja, N.3    Assaqqaf, J.4    Sobel, B.E.5
  • 30
    • 44349156987 scopus 로고    scopus 로고
    • Clinical efficacy of recombinant human erythropoietin on sepsis with anemia
    • Chen B, Xiao ZJ (2008) Clinical efficacy of recombinant human erythropoietin on sepsis with anemia. Chin J Emerg Med 17:510-512
    • (2008) Chin J Emerg Med , vol.17 , pp. 510-512
    • Chen, B.1    Xiao, Z.J.2
  • 31
    • 79951722690 scopus 로고    scopus 로고
    • High-dose erythropoietin in patients with acute myocardial infarction: A pilot, randomised, placebo-controlled study
    • 19906454 10.1016/j.ijcard.2009.10.028
    • Ferrario M, Arbustini E, Massa M, Rosti V, Marziliano N, Raineri C et al (2011) High-dose erythropoietin in patients with acute myocardial infarction: A pilot, randomised, placebo-controlled study. Int J Cardiol 147:124-131
    • (2011) Int J Cardiol , vol.147 , pp. 124-131
    • Ferrario, M.1    Arbustini, E.2    Massa, M.3    Rosti, V.4    Marziliano, N.5    Raineri, C.6
  • 32
    • 77953605982 scopus 로고    scopus 로고
    • Importance of erythropoietin in brain protection after cardiac surgery: A pilot study
    • 20534421 10.1532/HSF98.20091150
    • Lakic N, Surlan K, Jerin A, Meglic B, Curk N, Bunc M (2010) Importance of erythropoietin in brain protection after cardiac surgery: A pilot study. Heart Surg Forum 13:E185-E189
    • (2010) Heart Surg Forum , vol.13
    • Lakic, N.1    Surlan, K.2    Jerin, A.3    Meglic, B.4    Curk, N.5    Bunc, M.6
  • 33
    • 57549083429 scopus 로고    scopus 로고
    • Effect of EPO administration on myocardial infarct size in patients with non-STE acute coronary syndromes; Results from a pilot study
    • 17931721 10.1016/j.ijcard.2007.07.076
    • Liem A, van de Woestijne AP, Bruijns E, Roeters van Lennep HW, de Boo JA, van Halteren HK et al (2009) Effect of EPO administration on myocardial infarct size in patients with non-STE acute coronary syndromes; results from a pilot study. Int J Cardiol 131:285-287
    • (2009) Int J Cardiol , vol.131 , pp. 285-287
    • Liem, A.1    Van De Woestijne, A.P.2    Bruijns, E.3    Roeters Van Lennep, H.W.4    De Boo, J.A.5    Van Halteren, H.K.6
  • 34
    • 33745025709 scopus 로고    scopus 로고
    • A single bolus of a long-acting erythropoietin analogue darbepoetin alfa in patients with acute myocardial infarction: A randomized feasibility and safety study
    • 16761193 10.1007/s10557-006-7680-5 1:CAS:528:DC%2BD28XlsVCiu74%3D
    • Lipsic E, van der Meer P, Voors AA, Westenbrink BD, van den Heuvel AF, de Boer HC et al (2006) A single bolus of a long-acting erythropoietin analogue darbepoetin alfa in patients with acute myocardial infarction: A randomized feasibility and safety study. Cardiovasc Drugs Ther 20:135-141
    • (2006) Cardiovasc Drugs Ther , vol.20 , pp. 135-141
    • Lipsic, E.1    Van Der Meer, P.2    Voors, A.A.3    Westenbrink, B.D.4    Van Den Heuvel, A.F.5    De Boer, H.C.6
  • 35
    • 60349105457 scopus 로고    scopus 로고
    • Endogenous erythropoietin and a single bolus of 40,000 IU of epoetin alpha do not protect the heart from ischaemia-reperfusion injury during extracorporeal circulation for cardiac surgery
    • 19029270 10.1177/0267659108097627 1:STN:280:DC%2BD1cjmtFGhtg%3D%3D
    • Mocini D, Muso P, Guendouz E, De Marco L, Mele L, Cini R et al (2008) Endogenous erythropoietin and a single bolus of 40,000 IU of epoetin alpha do not protect the heart from ischaemia-reperfusion injury during extracorporeal circulation for cardiac surgery. Perfusion 23:187-192
    • (2008) Perfusion , vol.23 , pp. 187-192
    • Mocini, D.1    Muso, P.2    Guendouz, E.3    De Marco, L.4    Mele, L.5    Cini, R.6
  • 36
    • 36248977612 scopus 로고    scopus 로고
    • Erythropoietin in patients with aneurysmal subarachnoid haemorrhage: A double blind randomised clinical trial
    • 17876497 10.1007/s00701-007-1284-z 1:STN:280:DC%2BD2snmvFemuw%3D%3D
    • Springborg JB, Moller C, Gideon P, Jorgensen OS, Juhler M, Olsen NV (2007) Erythropoietin in patients with aneurysmal subarachnoid haemorrhage: A double blind randomised clinical trial. Acta Neurochir 149:1089-1101
    • (2007) Acta Neurochir , vol.149 , pp. 1089-1101
    • Springborg, J.B.1    Moller, C.2    Gideon, P.3    Jorgensen, O.S.4    Juhler, M.5    Olsen, N.V.6
  • 37
    • 84859368408 scopus 로고    scopus 로고
    • Erythropoietin-induced progenitor cell mobilisation in patients with acute ST-segment-elevation myocardial infarction and restenosis
    • 22318706 10.1160/TH11-08-0552 1:CAS:528:DC%2BC38XmslWmu7s%3D
    • Stein A, Mohr F, Laux M, Thieme S, Lorenz B, Cetindis M et al (2012) Erythropoietin-induced progenitor cell mobilisation in patients with acute ST-segment-elevation myocardial infarction and restenosis. Thromb Haemost 107:769-774
    • (2012) Thromb Haemost , vol.107 , pp. 769-774
    • Stein, A.1    Mohr, F.2    Laux, M.3    Thieme, S.4    Lorenz, B.5    Cetindis, M.6
  • 38
    • 67650851481 scopus 로고    scopus 로고
    • Acute systemic erythropoietin therapy to reduce delayed ischemic deficits following aneurysmal subarachnoid hemorrhage: A Phase II randomized, double-blind, placebo-controlled trial. Clinical article
    • 19344224 10.3171/2009.3.JNS081332 1:CAS:528:DC%2BD1MXovVCrsLs%3D
    • Tseng MY, Hutchinson PJ, Richards HK, Czosnyka M, Pickard JD, Erber WN et al (2009) Acute systemic erythropoietin therapy to reduce delayed ischemic deficits following aneurysmal subarachnoid hemorrhage: A Phase II randomized, double-blind, placebo-controlled trial. Clinical article. J Neurosurg 111:171-180
    • (2009) J Neurosurg , vol.111 , pp. 171-180
    • Tseng, M.Y.1    Hutchinson, P.J.2    Richards, H.K.3    Czosnyka, M.4    Pickard, J.D.5    Erber, W.N.6
  • 39
    • 79251585247 scopus 로고    scopus 로고
    • Effect of erythropoietin on level of circulating endothelial progenitor cells and outcome in patients after acute ischemic stroke
    • 21269484 10.1186/cc10002
    • Yip HK, Tsai TH, Lin HS, Chen SF, Sun CK, Leu S et al (2011) Effect of erythropoietin on level of circulating endothelial progenitor cells and outcome in patients after acute ischemic stroke. Crit Care 15:R40
    • (2011) Crit Care , vol.15 , pp. 40
    • Yip, H.K.1    Tsai, T.H.2    Lin, H.S.3    Chen, S.F.4    Sun, C.K.5    Leu, S.6
  • 40
    • 84862561588 scopus 로고    scopus 로고
    • Co-treatment with darbepoetin and granulocyte-colony stimulating factor is efficient to recruit pro-angiogenic cell populations in patients with acute myocardial infarction
    • 22449332 10.3727/096368911X627499
    • Kang HJ, Yoon EJ, Lee EJ, Kim MK, Seo JW, Park KW et al (2012) Co-treatment with darbepoetin and granulocyte-colony stimulating factor is efficient to recruit pro-angiogenic cell populations in patients with acute myocardial infarction. Cell Transplant 21:1055-1061
    • (2012) Cell Transplant , vol.21 , pp. 1055-1061
    • Kang, H.J.1    Yoon, E.J.2    Lee, E.J.3    Kim, M.K.4    Seo, J.W.5    Park, K.W.6
  • 41
    • 80052666905 scopus 로고    scopus 로고
    • Effect of erythropoietin as an adjunct to primary percutaneous coronary intervention: A randomised controlled clinical trial
    • 21900585 10.1136/hrt.2011.223867 1:CAS:528:DC%2BC3MXhtlKjtb3M
    • Ludman AJ, Yellon DM, Hasleton J, Ariti C, Babu GG, Boston-Griffiths E et al (2011) Effect of erythropoietin as an adjunct to primary percutaneous coronary intervention: A randomised controlled clinical trial. Heart 97:1560-1565
    • (2011) Heart , vol.97 , pp. 1560-1565
    • Ludman, A.J.1    Yellon, D.M.2    Hasleton, J.3    Ariti, C.4    Babu, G.G.5    Boston-Griffiths, E.6
  • 42
    • 84885418327 scopus 로고    scopus 로고
    • Effect of blood transfusion versus erythropoietin injection on peripheral erythropoietin response in burnt patients
    • Ahmed YA, El Beih EAS, El Moneim AA, El Oteify MA, Ashmawe MM, Thabet N et al (2001) Effect of blood transfusion versus erythropoietin injection on peripheral erythropoietin response in burnt patients. Assiut Med J 25:97-110
    • (2001) Assiut Med J , vol.25 , pp. 97-110
    • Ahmed, Y.A.1    El Beih, E.A.S.2    El Moneim, A.A.3    El Oteify, M.A.4    Ashmawe, M.M.5    Thabet, N.6
  • 44
    • 84885420314 scopus 로고    scopus 로고
    • Effect of blood transfusion versus erythropoietin injection on peripheral erythropoietic response in burnt patients
    • Ahmed YA, Eloteify MA, Ashmawe MM, El Beih EA, Elmonem AA, Thabet N et al (2000) Effect of blood transfusion versus erythropoietin injection on peripheral erythropoietic response in burnt patients. Vox Sang 79:P164
    • (2000) Vox Sang , vol.79 , pp. 164
    • Ahmed, Y.A.1    Eloteify, M.A.2    Ashmawe, M.M.3    El Beih, E.A.4    Elmonem, A.A.5    Thabet, N.6
  • 45
    • 84885424165 scopus 로고    scopus 로고
    • Efficacy of recombinant human erythropoietin in critically ill anaemic septic patients
    • Effat HS (2010) Efficacy of recombinant human erythropoietin in critically ill anaemic septic patients. Intensive Care Med 36:S406
    • (2010) Intensive Care Med , vol.36 , pp. 406
    • Effat, H.S.1
  • 46
    • 84885425444 scopus 로고    scopus 로고
    • Erythropoietin plus methylprednisolone or methylprednisolone in the treatment of acute spinal cord injury: A preliminary report [Abstract]
    • 10.1097/CCM.0b013e3181b4a972
    • Alibai E, Zand F, Rahimi A (2010) Erythropoietin plus methylprednisolone or methylprednisolone in the treatment of acute spinal cord injury: A preliminary report [Abstract]. Crit Care Med 38:A209
    • (2010) Crit Care Med , vol.38 , pp. 209
    • Alibai, E.1    Zand, F.2    Rahimi, A.3
  • 47
    • 84885425567 scopus 로고    scopus 로고
    • Critically ill patients with multiple comorbidities are more likely to receive an erythropoiesis stimulating agent in clinical practice [Abstract]
    • 10.1097/01.CCM.9998295471.83762.7F
    • Brophy GM, Harpe S, Pyles M (2007) Critically ill patients with multiple comorbidities are more likely to receive an erythropoiesis stimulating agent in clinical practice [Abstract]. Crit Care Med 35:A119
    • (2007) Crit Care Med , vol.35 , pp. 119
    • Brophy, G.M.1    Harpe, S.2    Pyles, M.3
  • 51
    • 0031892778 scopus 로고    scopus 로고
    • High-dose recombinant human erythropoietin stimulates reticulocyte production in patients with multiple organ dysfunction syndrome
    • 9498512 10.1097/00005373-199802000-00023 1:CAS:528:DyaK1cXitFyksLg%3D
    • Gabriel A, Kozek S, Chiari A, Fitzgerald R, Grabner C, Geissler K et al (1998) High-dose recombinant human erythropoietin stimulates reticulocyte production in patients with multiple organ dysfunction syndrome. J Trauma 44:361-367
    • (1998) J Trauma , vol.44 , pp. 361-367
    • Gabriel, A.1    Kozek, S.2    Chiari, A.3    Fitzgerald, R.4    Grabner, C.5    Geissler, K.6
  • 52
    • 33646348607 scopus 로고    scopus 로고
    • Recombinant human erythropoietin therapy in critically ill patients: A dose-response study [ISRCTN48523317]
    • 16277712 10.1186/cc3786
    • Georgopoulos D, Matamis D, Routsi C, Michalopoulos A, Maggina N, Dimopoulos G et al (2005) Recombinant human erythropoietin therapy in critically ill patients: A dose-response study [ISRCTN48523317]. Crit Care 9:R508-R515
    • (2005) Crit Care , vol.9
    • Georgopoulos, D.1    Matamis, D.2    Routsi, C.3    Michalopoulos, A.4    Maggina, N.5    Dimopoulos, G.6
  • 53
    • 77953285048 scopus 로고    scopus 로고
    • Epoetin alfa reduces blood transfusion requirements in patients with intertrochanteric fracture
    • 19592206 10.1016/j.jcrc.2009.04.008
    • Kateros K, Sakellariou VI, Sofianos IP, Papagelopoulos PJ (2010) Epoetin alfa reduces blood transfusion requirements in patients with intertrochanteric fracture. J Crit Care 25:348-353
    • (2010) J Crit Care , vol.25 , pp. 348-353
    • Kateros, K.1    Sakellariou, V.I.2    Sofianos, I.P.3    Papagelopoulos, P.J.4
  • 54
    • 84856547427 scopus 로고    scopus 로고
    • Single high-dose erythropoietin administration immediately after reperfusion in patients with ST-segment elevation myocardial infarction: Results of the erythropoietin in myocardial infarction trial
    • 22305837 10.1016/j.ahj.2011.11.005 1:CAS:528:DC%2BC38XhvVWrur8%3D
    • Prunier F, Biere L, Gilard M, Boschat J, Mouquet F, Bauchart JJ et al (2012) Single high-dose erythropoietin administration immediately after reperfusion in patients with ST-segment elevation myocardial infarction: Results of the erythropoietin in myocardial infarction trial. Am Heart J 163:200-207
    • (2012) Am Heart J , vol.163 , pp. 200-207
    • Prunier, F.1    Biere, L.2    Gilard, M.3    Boschat, J.4    Mouquet, F.5    Bauchart, J.J.6
  • 55
    • 79957445321 scopus 로고    scopus 로고
    • The effect of intravenous administration of erythropoietin on the infarct size in primary percutaneous coronary intervention
    • 20199815 10.1016/j.ijcard.2010.02.002
    • Suh JW, Chung WY, Kim YS, Kim KI, Jeon EJ, Cho YS et al (2011) The effect of intravenous administration of erythropoietin on the infarct size in primary percutaneous coronary intervention. Int J Cardiol 149:216-220
    • (2011) Int J Cardiol , vol.149 , pp. 216-220
    • Suh, J.W.1    Chung, W.Y.2    Kim, Y.S.3    Kim, K.I.4    Jeon, E.J.5    Cho, Y.S.6
  • 56
    • 78349233886 scopus 로고    scopus 로고
    • Erythropoietin prevention trial of coronary restenosis and cardiac remodeling after ST-elevated acute myocardial infarction (EPOC-AMI): A pilot, randomized, placebo-controlled study
    • 20834185 10.1253/circj.CJ-10-0267
    • Taniguchi N, Nakamura T, Sawada T, Matsubara K, Furukawa K, Hadase M et al (2010) Erythropoietin prevention trial of coronary restenosis and cardiac remodeling after ST-elevated acute myocardial infarction (EPOC-AMI): A pilot, randomized, placebo-controlled study. Circ J 74:2365-2371
    • (2010) Circ J , vol.74 , pp. 2365-2371
    • Taniguchi, N.1    Nakamura, T.2    Sawada, T.3    Matsubara, K.4    Furukawa, K.5    Hadase, M.6
  • 57
    • 0033838942 scopus 로고    scopus 로고
    • Response of erythropoiesis and iron metabolism to recombinant human erythropoietin in intensive care unit patients
    • 10966249 10.1097/00003246-200008000-00015
    • van Iperen CE, Gaillard CA, Kraaijenhagen RJ, Braam BG, Marx JJ, van de Wiel A (2000) Response of erythropoiesis and iron metabolism to recombinant human erythropoietin in intensive care unit patients. Crit Care Med 28:2773-2778
    • (2000) Crit Care Med , vol.28 , pp. 2773-2778
    • Van Iperen, C.E.1    Gaillard, C.A.2    Kraaijenhagen, R.J.3    Braam, B.G.4    Marx, J.J.5    Van De Wiel, A.6
  • 58
    • 77958518157 scopus 로고    scopus 로고
    • A single dose of erythropoietin in ST-elevation myocardial infarction
    • 20802250 10.1093/eurheartj/ehq304 1:CAS:528:DC%2BC3cXhsVSlt7jI
    • Voors AA, Belonje AM, Zijlstra F, Hillege HL, Anker SD, Slart RH et al (2010) A single dose of erythropoietin in ST-elevation myocardial infarction. Eur Heart J 31:2593-2600
    • (2010) Eur Heart J , vol.31 , pp. 2593-2600
    • Voors, A.A.1    Belonje, A.M.2    Zijlstra, F.3    Hillege, H.L.4    Anker, S.D.5    Slart, R.H.6
  • 59
    • 84885424552 scopus 로고    scopus 로고
    • Randomized, double-blind, placebo-controlled trial of recombinant human erythropoietin administration to reduce red blood cell transfusions in anemic pediatric intensive care patients
    • Chicella MF, Jansen P, Falkos S, Krueger KP (2003) Randomized, double-blind, placebo-controlled trial of recombinant human erythropoietin administration to reduce red blood cell transfusions in anemic pediatric intensive care patients. Pharmacotherapy 23:407-408
    • (2003) Pharmacotherapy , vol.23 , pp. 407-408
    • Chicella, M.F.1    Jansen, P.2    Falkos, S.3    Krueger, K.P.4
  • 60
    • 34548418912 scopus 로고    scopus 로고
    • Efficacy and safety of epoetin alfa in critically ill patients
    • 17804841 10.1056/NEJMoa071533 1:CAS:528:DC%2BD2sXhtVensrbE
    • Corwin HL, Gettinger A, Fabian TC, May A, Pearl RG, Heard S et al (2007) Efficacy and safety of epoetin alfa in critically ill patients. N Engl J Med 357:965-976
    • (2007) N Engl J Med , vol.357 , pp. 965-976
    • Corwin, H.L.1    Gettinger, A.2    Fabian, T.C.3    May, A.4    Pearl, R.G.5    Heard, S.6
  • 61
    • 0037065340 scopus 로고    scopus 로고
    • Efficacy of recombinant human erythropoietin in critically ill patients: A randomized controlled trial
    • 12472324 10.1001/jama.288.22.2827 1:CAS:528:DC%2BD38XpsVWqtLs%3D
    • Corwin HL, Gettinger A, Pearl RG, Fink MP, Levy MM, Shapiro MJ et al (2002) Efficacy of recombinant human erythropoietin in critically ill patients: A randomized controlled trial. JAMA 288:2827-2835
    • (2002) JAMA , vol.288 , pp. 2827-2835
    • Corwin, H.L.1    Gettinger, A.2    Pearl, R.G.3    Fink, M.P.4    Levy, M.M.5    Shapiro, M.J.6
  • 62
    • 0032760409 scopus 로고    scopus 로고
    • Efficacy of recombinant human erythropoietin in the critically ill patient: A randomized, double-blind, placebo-controlled trial
    • 10579246 10.1097/00003246-199911000-00004 1:STN:280: DC%2BD3c%2FktlyntQ%3D%3D
    • Corwin HL, Gettinger A, Rodriguez RM, Pearl RG, Gubler KD, Enny C et al (1999) Efficacy of recombinant human erythropoietin in the critically ill patient: A randomized, double-blind, placebo-controlled trial. Crit Care Med 27:2346-2350
    • (1999) Crit Care Med , vol.27 , pp. 2346-2350
    • Corwin, H.L.1    Gettinger, A.2    Rodriguez, R.M.3    Pearl, R.G.4    Gubler, K.D.5    Enny, C.6
  • 63
    • 77955915903 scopus 로고    scopus 로고
    • Early intervention with erythropoietin does not affect the outcome of acute kidney injury (the EARLYARF trial)
    • 20164823 10.1038/ki.2010.25 1:CAS:528:DC%2BC3cXmtVSgtb8%3D
    • Endre ZH, Walker RJ, Pickering JW, Shaw GM, Frampton CM, Henderson SJ et al (2010) Early intervention with erythropoietin does not affect the outcome of acute kidney injury (the EARLYARF trial). Kidney Int 77:1020-1030
    • (2010) Kidney Int , vol.77 , pp. 1020-1030
    • Endre, Z.H.1    Walker, R.J.2    Pickering, J.W.3    Shaw, G.M.4    Frampton, C.M.5    Henderson, S.J.6
  • 64
    • 33747475739 scopus 로고    scopus 로고
    • Efficacy of recombinant human erythropoietin in critically ill patients admitted to a long-term acute care facility: A randomized, double-blind, placebo-controlled trial
    • 16878035 10.1097/01.CCM.0000233873.17954.42 1:CAS:528: DC%2BD28Xot1eruro%3D
    • Silver M, Corwin MJ, Bazan A, Gettinger A, Enny C, Corwin HL (2006) Efficacy of recombinant human erythropoietin in critically ill patients admitted to a long-term acute care facility: A randomized, double-blind, placebo-controlled trial. Crit Care Med 34:2310-2316
    • (2006) Crit Care Med , vol.34 , pp. 2310-2316
    • Silver, M.1    Corwin, M.J.2    Bazan, A.3    Gettinger, A.4    Enny, C.5    Corwin, H.L.6
  • 65
    • 33744546570 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of once-weekly subcutaneous epoetin alfa in critically ill patients: Results of a randomized, double-blind, placebo-controlled trial
    • 16607233 10.1097/01.CCM.0000217919.22155.85 1:CAS:528: DC%2BD28XkvVWlsrg%3D
    • Vincent JL, Spapen HD, Creteur J, Piagnerelli M, Hubloue I, Diltoer M et al (2006) Pharmacokinetics and pharmacodynamics of once-weekly subcutaneous epoetin alfa in critically ill patients: Results of a randomized, double-blind, placebo-controlled trial. Crit Care Med 34:1661-1667
    • (2006) Crit Care Med , vol.34 , pp. 1661-1667
    • Vincent, J.L.1    Spapen, H.D.2    Creteur, J.3    Piagnerelli, M.4    Hubloue, I.5    Diltoer, M.6
  • 66
    • 79955877895 scopus 로고    scopus 로고
    • Intravenous erythropoietin in patients with ST-segment elevation myocardial infarction: REVEAL: A randomized controlled trial
    • 21558517 10.1001/jama.2011.592 1:CAS:528:DC%2BC3MXlvFGmt70%3D
    • Najjar SS, Rao SV, Melloni C, Raman SV, Povsic TJ, Melton L et al (2011) Intravenous erythropoietin in patients with ST-segment elevation myocardial infarction: REVEAL: A randomized controlled trial. JAMA 305:1863-1872
    • (2011) JAMA , vol.305 , pp. 1863-1872
    • Najjar, S.S.1    Rao, S.V.2    Melloni, C.3    Raman, S.V.4    Povsic, T.J.5    Melton, L.6
  • 67
    • 78349287458 scopus 로고    scopus 로고
    • Erythropoietin in patients with acute ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention: A randomized, double-blind trial
    • 20736448 10.1161/CIRCINTERVENTIONS.109.904425 1:CAS:528: DC%2BC3cXhsFaiur%2FJ
    • Ott I, Schulz S, Mehilli J, Fichtner S, Hadamitzky M, Hoppe K et al (2010) Erythropoietin in patients with acute ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention: A randomized, double-blind trial. Circ Cardiovasc Interv 3:408-413
    • (2010) Circ Cardiovasc Interv , vol.3 , pp. 408-413
    • Ott, I.1    Schulz, S.2    Mehilli, J.3    Fichtner, S.4    Hadamitzky, M.5    Hoppe, K.6
  • 68
    • 70949095435 scopus 로고    scopus 로고
    • Recombinant human erythropoietin in the treatment of acute ischemic stroke
    • 19834012 10.1161/STROKEAHA.109.564872 1:CAS:528:DC%2BD1MXhsValtbrK
    • Ehrenreich H, Weissenborn K, Prange H, Schneider D, Weimar C, Wartenberg K et al (2009) Recombinant human erythropoietin in the treatment of acute ischemic stroke. Stroke 40:e647-e656
    • (2009) Stroke , vol.40
    • Ehrenreich, H.1    Weissenborn, K.2    Prange, H.3    Schneider, D.4    Weimar, C.5    Wartenberg, K.6
  • 69
    • 84859107597 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled study to assess the effect of recombinant human erythropoietin on functional outcomes in anemic, critically ill, trauma subjects: The long term trauma outcomes study
    • 22177550 10.1016/j.amjsurg.2011.08.006 1:CAS:528:DC%2BC38XksFensb8%3D
    • Luchette FA, Pasquale MD, Fabian TC, Langholff WK, Wolfson M (2012) A randomized, double-blind, placebo-controlled study to assess the effect of recombinant human erythropoietin on functional outcomes in anemic, critically ill, trauma subjects: The long term trauma outcomes study. Am J Surg 203:508-516
    • (2012) Am J Surg , vol.203 , pp. 508-516
    • Luchette, F.A.1    Pasquale, M.D.2    Fabian, T.C.3    Langholff, W.K.4    Wolfson, M.5
  • 71
    • 0028898045 scopus 로고
    • A double-blinded prospective evaluation of recombinant human erythropoietin in acutely burned patients
    • 7869442 10.1097/00005373-199502000-00015
    • Still JM Jr, Belcher K, Law EJ, Thompson W, Jordan M, Lewis M et al (1995) A double-blinded prospective evaluation of recombinant human erythropoietin in acutely burned patients. J Trauma 38:233-236
    • (1995) J Trauma , vol.38 , pp. 233-236
    • Still, Jr.J.M.1    Belcher, K.2    Law, E.J.3    Thompson, W.4    Jordan, M.5    Lewis, M.6
  • 72
    • 84885422675 scopus 로고    scopus 로고
    • Erythropoiesis-stimulating agent exposure and incidence of venous thromboembolism in high-risk trauma patients receiving enoxaparin [Abstract]
    • Bush SE, Hampp C, Lottenberg L, LeClaire A (2008) Erythropoiesis- stimulating agent exposure and incidence of venous thromboembolism in high-risk trauma patients receiving enoxaparin [Abstract]. Crit Care Med 36:A51
    • (2008) Crit Care Med , vol.36 , pp. 51
    • Bush, S.E.1    Hampp, C.2    Lottenberg, L.3    Leclaire, A.4
  • 74
    • 84885428213 scopus 로고    scopus 로고
    • Effectiveness of epoetin alfa in reducing the number of blood transfusions in critically ill SICU patients [Abstract]
    • 10.1016/S1098-3015(10)62706-4
    • Luh VW, Barlev A, Kern J (2005) Effectiveness of epoetin alfa in reducing the number of blood transfusions in critically ill SICU patients [Abstract]. Value Health 8:281
    • (2005) Value Health , vol.8 , pp. 281
    • Luh, V.W.1    Barlev, A.2    Kern, J.3
  • 75
    • 84885433986 scopus 로고    scopus 로고
    • Efficacy of darbepoetin alfa in reducing red blood cell transfusions in critically ill patients: A retrospective analysis [Abstract]
    • Shuman C, Jefferson C, Ruppelt S, Erowele G (2009) Efficacy of darbepoetin alfa in reducing red blood cell transfusions in critically ill patients: A retrospective analysis [Abstract]. Crit Care Med 37:A409
    • (2009) Crit Care Med , vol.37 , pp. 409
    • Shuman, C.1    Jefferson, C.2    Ruppelt, S.3    Erowele, G.4
  • 76
    • 84885422425 scopus 로고    scopus 로고
    • Comparison of selected utilization variables in critically ill patients with anemia who received weekly recombinant human crythropoietin (rHuEPO) or no rHuEPO [Abstract]
    • 10.1592/phco.2005.25.5-Part-2.3S
    • Wittbrodt E, Rodriguez F, Medendorp J III, Sherman M (2005) Comparison of selected utilization variables in critically ill patients with anemia who received weekly recombinant human crythropoietin (rHuEPO) or no rHuEPO [Abstract]. Pharmacotherapy 25:1441
    • (2005) Pharmacotherapy , vol.25 , pp. 1441
    • Wittbrodt, E.1    Rodriguez, F.2    Medendorp III, J.3    Sherman, M.4
  • 77
    • 84885422100 scopus 로고    scopus 로고
    • Does epoetin alfa decrease mortality in the critically ill trauma population? [Abstract]
    • 10.1097/01.CCM.0000296271.08591.D2
    • Ginger M, Toevs C, Carol G, Capella J, Philp A, Putnam AT et al (2008) Does epoetin alfa decrease mortality in the critically ill trauma population? [Abstract]. Crit Care Med 36:A52
    • (2008) Crit Care Med , vol.36 , pp. 52
    • Ginger, M.1    Toevs, C.2    Carol, G.3    Capella, J.4    Philp, A.5    Putnam, A.T.6
  • 78
    • 84885434086 scopus 로고    scopus 로고
    • Risk of venous thromboembolisms in trauma patients receiving erythropoiesis stimulating agents [Abstract]
    • 10.1097/01.CCM.0000249851.94101.4F
    • Hecht KA, Fan J, Lee TB, Decerbo MC, Kuhls DA (2007) Risk of venous thromboembolisms in trauma patients receiving erythropoiesis stimulating agents [Abstract]. Crit Care Med 35:A64
    • (2007) Crit Care Med , vol.35 , pp. 64
    • Hecht, K.A.1    Fan, J.2    Lee, T.B.3    Decerbo, M.C.4    Kuhls, D.A.5
  • 79
    • 74049110427 scopus 로고    scopus 로고
    • Erythropoiesis stimulating agent administration improves survival after severe traumatic brain injury: A matched case control study
    • 19779323 10.1097/SLA.0b013e3181b844fa
    • Talving P, Lustenberger T, Kobayashi L, Inaba K, Barmparas G, Schnuriger B et al (2010) Erythropoiesis stimulating agent administration improves survival after severe traumatic brain injury: A matched case control study. Ann Surg 251:1-4
    • (2010) Ann Surg , vol.251 , pp. 1-4
    • Talving, P.1    Lustenberger, T.2    Kobayashi, L.3    Inaba, K.4    Barmparas, G.5    Schnuriger, B.6
  • 80
    • 38849150980 scopus 로고    scopus 로고
    • Early high-dose erythropoietin therapy and hypothermia after out-of-hospital cardiac arrest: A matched control study [Abstract]
    • 18037223 10.1016/j.resuscitation.2007.10.003 1:CAS:528: DC%2BD1cXhslartrw%3D
    • Cariou A, Claessens YE, Pene F, Marx JS, Spaulding C, Hababou C et al (2008) Early high-dose erythropoietin therapy and hypothermia after out-of-hospital cardiac arrest: A matched control study [Abstract]. Resuscitation 76:397-404
    • (2008) Resuscitation , vol.76 , pp. 397-404
    • Cariou, A.1    Claessens, Y.E.2    Pene, F.3    Marx, J.S.4    Spaulding, C.5    Hababou, C.6
  • 81
    • 67349285113 scopus 로고    scopus 로고
    • Erythropoietin facilitates the return of spontaneous circulation and survival in victims of out-of-hospital cardiac arrest
    • 19371997 10.1016/j.resuscitation.2009.03.010 1:CAS:528: DC%2BD1MXmtlOqsbk%3D
    • Grmec S, Strnad M, Kupnik D, Sinkovic A, Gazmuri RJ (2009) Erythropoietin facilitates the return of spontaneous circulation and survival in victims of out-of-hospital cardiac arrest. Resuscitation 80:631-637
    • (2009) Resuscitation , vol.80 , pp. 631-637
    • Grmec, S.1    Strnad, M.2    Kupnik, D.3    Sinkovic, A.4    Gazmuri, R.J.5
  • 82
    • 77957333506 scopus 로고    scopus 로고
    • Outcomes with the use of recombinant human erythropoietin in critically ill burn patients
    • 20836341
    • Lundy JB, Hetz K, Chung KK, Renz EM, White CE, King BT et al (2010) Outcomes with the use of recombinant human erythropoietin in critically ill burn patients. Am Surg 76:951-956
    • (2010) Am Surg , vol.76 , pp. 951-956
    • Lundy, J.B.1    Hetz, K.2    Chung, K.K.3    Renz, E.M.4    White, C.E.5    King, B.T.6
  • 83
    • 0037098198 scopus 로고    scopus 로고
    • Bayesian random effects meta-analysis of trials with binary outcomes: Methods for the absolute risk difference and relative risk scales
    • 12111922 10.1002/sim.1189 1:STN:280:DC%2BD38zmtlSntw%3D%3D
    • Warn DE, Thompson SG, Spiegelhalter DJ (2002) Bayesian random effects meta-analysis of trials with binary outcomes: Methods for the absolute risk difference and relative risk scales. Stat Med 21:1601-1623
    • (2002) Stat Med , vol.21 , pp. 1601-1623
    • Warn, D.E.1    Thompson, S.G.2    Spiegelhalter, D.J.3
  • 84
    • 67649236523 scopus 로고    scopus 로고
    • Improved survival of critically ill trauma patients treated with recombinant human erythropoietin
    • 18695463 10.1097/TA.0b013e31817f2c6e 1:CAS:528:DC%2BD1cXpvFynt7w%3D (discussion 297-289)
    • Napolitano LM, Fabian TC, Kelly KM, Bailey JA, Block EF, Langholff W et al (2008) Improved survival of critically ill trauma patients treated with recombinant human erythropoietin. J Trauma 65:285-297 (discussion 297-289)
    • (2008) J Trauma , vol.65 , pp. 285-297
    • Napolitano, L.M.1    Fabian, T.C.2    Kelly, K.M.3    Bailey, J.A.4    Block, E.F.5    Langholff, W.6
  • 87
    • 84865964648 scopus 로고    scopus 로고
    • Angiogenic effects of erythropoietin
    • 22959304 10.1016/B978-0-12-394310-1.00005-9 1:CAS:528:DC%2BC38XhslWktbfL
    • Ribatti D (2012) Angiogenic effects of erythropoietin. Int Rev Cell Mol Biol 299:199-234
    • (2012) Int Rev Cell Mol Biol , vol.299 , pp. 199-234
    • Ribatti, D.1
  • 89
    • 84859620720 scopus 로고    scopus 로고
    • Biosimilar recombinant human erythropoietins (epoetins) and future erythropoiesis-stimulating treatments
    • 22471247 10.1517/14712598.2012.672968 1:CAS:528:DC%2BC38XlsFSrsLs%3D
    • Jelkmann W (2012) Biosimilar recombinant human erythropoietins (epoetins) and future erythropoiesis-stimulating treatments. Expert Opin Biol Ther 12:581-592
    • (2012) Expert Opin Biol Ther , vol.12 , pp. 581-592
    • Jelkmann, W.1
  • 90
    • 77949469515 scopus 로고    scopus 로고
    • Are biosimilars really generics?
    • 20146636 10.1517/14712591003662615 1:CAS:528:DC%2BC3cXjtVyntr4%3D
    • Misra A (2010) Are biosimilars really generics? Expert Opin Biol Ther 10:489-494
    • (2010) Expert Opin Biol Ther , vol.10 , pp. 489-494
    • Misra, A.1
  • 91
    • 56549110284 scopus 로고    scopus 로고
    • Is there evidence for biased reporting of published adverse effects data in pharmaceutical industry-funded studies?
    • 18754841 10.1111/j.1365-2125.2008.03272.x
    • Golder S, Loke YK (2008) Is there evidence for biased reporting of published adverse effects data in pharmaceutical industry-funded studies? Br J Clin Pharmacol 66:767-773
    • (2008) Br J Clin Pharmacol , vol.66 , pp. 767-773
    • Golder, S.1    Loke, Y.K.2
  • 92
    • 84865543747 scopus 로고    scopus 로고
    • Conflict of interest reporting by authors involved in promotion of off-label drug use: An analysis of journal disclosures
    • 22899894 10.1371/journal.pmed.1001280
    • Kesselheim AS, Wang B, Studdert DM, Avorn J (2012) Conflict of interest reporting by authors involved in promotion of off-label drug use: an analysis of journal disclosures. PLoS Med 9:e1001280
    • (2012) PLoS Med , vol.9 , pp. 1001280
    • Kesselheim, A.S.1    Wang, B.2    Studdert, D.M.3    Avorn, J.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.