The effect of intravenous administration of erythropoietin on the infarct size in primary percutaneous coronary intervention

International Journal of Cardiology

Volumn 149, Issue 2, 2011, Pages 216-220

  Suh, Jung Won ^a   Chung, Woo Young ^a   Kim, Yong Seok ^b   Kim, Kwang Il ^a   Jeon, Eun Ju ^a   Cho, Young Seok ^a   Youn, Tae Jin ^a   Chae, In Ho ^a   Kim, Cheol Ho ^a   Choi, Dong Ju ^a  

^a Seoul National University Bundang Hospital   (South Korea)

^b Dongguk University Ilsan Hospital   (South Korea)

Author keywords

Acute myocardial infarction; Erythropoietin; Reperfusion injury

Indexed keywords

CREATINE KINASE; CREATINE KINASE MB; RECOMBINANT ERYTHROPOIETIN;

ACUTE HEART INFARCTION; ADULT; ANGIOCARDIOGRAPHY; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG SAFETY; ENZYME BLOOD LEVEL; FEMALE; HEART INFARCTION SIZE; HEMATOCRIT; HUMAN; LEFT ANTERIOR DESCENDING CORONARY ARTERY; MAJOR CLINICAL STUDY; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; OUTCOME ASSESSMENT; PERCUTANEOUS CORONARY INTERVENTION; PILOT STUDY; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; ST SEGMENT ELEVATION MYOCARDIAL INFARCTION; THROMBOCYTE COUNT; TREATMENT RESPONSE;

ANGIOPLASTY, BALLOON, CORONARY; ERYTHROPOIETIN; FEMALE; FOLLOW-UP STUDIES; HUMANS; INJECTIONS, INTRAVENOUS; MALE; MIDDLE AGED; MYOCARDIAL INFARCTION; PILOT PROJECTS; PROSPECTIVE STUDIES; RECOMBINANT PROTEINS; TREATMENT OUTCOME;

EID: 79957445321     PISSN: 01675273     EISSN: 18741754     Source Type: Journal    
DOI: 10.1016/j.ijcard.2010.02.002     Document Type: Article

References (30)

1. D.M. Yellon, and D.J. Hausenloy Myocardial reperfusion injury N Eng J Med 357 2007 1121 1135
2. E.C. Keely, J.A. Boura, and C.L. Grines Primary angioplasty versus intravenous thrombolytic therapy for acute myocardial infarction: a quantitative review of 23 randomised trials Lancet 361 2003 13 20 (Pubitemid 36050955)
3. N.P. Riksen, D.J. Hausenloy, and D.M. Yellon Erythropoietin: ready for prime-time cardioprotection Trends Pharmacol Sci 29 2008 258 267
4. J. Kajstura, W. Cheng, and K. Reiss Apoptotic and necrotic myocyte cell deaths are independent contributing variables of infarct size in rats Lab Invest 74 1996 86 107 (Pubitemid 26041012)
5. M.T. Crow, K. Mani, and Y.J. Nam The mitochondrial death pathway and cardiac myocyte apoptosis Circ Res 95 2004 957 970 (Pubitemid 39532326)
6. Z.Q. Zhao, D.A. Velez, and N.P. Wang Progressively developed myocardial apoptotic cell death during late phase of reperfusion Apoptosis 6 2001 279 290 (Pubitemid 32708522)
7. N.G. Frangogiannis, C.W. Smith, and M.L. Entman The inflammatory response in myocardial infarction Cardiovasc Res 53 2002 31 47 (Pubitemid 34020764)
8. T. Rui, Q. Feng, and M. Lei Erythropoietin prevents the acute myocardial inflammatory response induced by ischemia/reperfusion via induction of AP-1 Cardiovasc Res 65 2005 719 727 (Pubitemid 40138993)
9. K. Kourea, J.T. Parissis, and D. Farmakis Effects of darbepoetin-alpha on plasma pro-inflammatory cytokines, anti-inflammatory cytokine interleukin-10 and soluble Fas/Fas ligand system in anemic patient with chronic heart failure Atherosclerosis 199 2008 215 221 (Pubitemid 351842695)
10. A.A. Kocher, M.D. Schuster, and M.J. Szabolcs Neovascularization of ischemic myocardiumby human bone-marrow-derived angioblasts prevents cardiomyocyte apoptosis, reduces remodeling and improves cardiac function Nat Med 7 2001 460 466
11. D. Ribatti, M. Presta, and A. Vacca Human erythropoietin induces a pro-angiogenic phenotype in cultured endothelial cells and stimulates neovascularization in vivo Blood 93 1999 2627 2636 (Pubitemid 29181195)
12. C. Heeschen, A. Aicher, and R. Lehmann Erythropoietin is a potent physiologic stimulus for endothelial progenitor cell mobilization Blood 102 2003 1340 1346 (Pubitemid 36988041)
13. E. Lipsic, P. van der Meer, and A.A. Voors A single bolus of a long-acting erythropoietin analogue darbopoetin alfa in patients with acute myocardial infarction: a randomized feasibility and safety study Cardiovasc Drugs Ther 20 2006 135 141 (Pubitemid 43876097)
14. J.E. Baker, D. Kizik, and A.K. Hsu Darbepoetin alfa protects the rat heart against infarction: dose-response, phase of action, and mechanisms J Cardiovasc Pharmacol 49 2007 337 345 (Pubitemid 47000307)
15. E. Lipsic, P. van der Meer, and R.H. Henning Timing of erythropoietin treatment for cardioprotection in ischemia/reperfusion J Cardiovasc Pharmacol 44 2004 473 479 (Pubitemid 39305089)
16. X. Liu, W. Xie, and P. Liu Mechanism of the cardioprotection of rhEPO pretreatment on suppressing the inflammatory response in ischemia-reperfusion Life Sci 78 2006 2255 2264
17. M. Nishihara, T. Miura, and T. Miki Erythropoietin affords additional cardioprotection to preconditioned hearts by enhanced phosphorylation of glycogen synthase kinase-3 beta Am J Physiol Heart Circ Physiol 291 2006 H748 H755
18. C. Klopsch, D. Furlani, and R. Gäbel Intracardiac injection of erythropoietin induces stem cell recruitment and improves cardiac functions in a rat myocardial infarction model J Cell Mol Med 13 2009 664 679
19. C.J. Parsa, J. Kim, and R.U. Riel Cardioprotective effects of erythropoietin in the reperfused ischemic heart: a potential role for cardiac fibroblasts J Biol Chem 279 2004 20655 20662 (Pubitemid 38656460)
20. D. Burger, M. Lei, and N. Geonggan-Morphet Erythropoietin protects cardiomyocytes from apoptosis via up-regulation of endothelial nitric oxide synthase Cardiovasc Res 72 2006 51 59 (Pubitemid 44310637)
21. A. Hirata, T. Minamino, and H. Asanuma Erythropoietin just before reperfusion reduces both lethal arrhythmias and infarct size via the phosphatidylinositol-3 kinase-dependent pathway in canine hearts Cardiovasc Drugs Ther 19 2005 33 40 (Pubitemid 40767770)
22. J. Kristensen, M. Maeng, and M. Rehling Lack of acute cardioprotective effect from preischaemic erythropoietin administration in a porcine coronary occlusion model Clin Physiol Funct Imaging 25 2005 305 310 (Pubitemid 41223535)
23. F.D. Olea, G. Vera Janavel, and A. De Lorenzi High-dose erythropoietin has no long-term protective effects in sheep with reperfused myocardial infarction J Cardiovasc Pharmacol 47 2006 736 741 (Pubitemid 44305246)
24. C. Toma, D.P. Letts, and M. Tanabe Positive effect of darbepoetin on peri-infarction remodeling in a porcine model of myocardial ischemia-reperfusion J Mol Cell Cardiol 43 2007 130 136 (Pubitemid 47069386)
25. M. Ferrario, E. Arbustini, and M. Massa High-dose erythropoietin in patients with acute myocardial infarction: a pilot, randomised, placebo-controlled study Int J Cardiol 147 2009 124 131
26. H. Ehrenreich, M. Hasselblatt, and C. Dembowski Erythropoietin therapy for acute stroke is both safe and beneficial Mol Med 8 2002 495 505 (Pubitemid 36337492)
27. F. Burzotta, C. Trani, and E. Romagnoli Manual thrombus-aspiration improves myocardial reperfusion. The randomized evaluation of the effect of mechanical reduction of distal embolization by thrombus-aspiration in primary and rescue angioplasty (REMEDIA) trial J Am Coll Cardiol 46 2005 371 376 (Pubitemid 40966871)
28. T. Svilaas, P.J. Vlaar, and I.C. van der Horst Thrombus aspiration during primary percutaneous coronary intervention N Eng J Med 358 2008 557 567 (Pubitemid 351214283)
29. F. Andreotti, C. Autore, and E. Conti Update on phase II studies of erythropoietin in acute myocardial infarction. Rationale and design of Exogenous erythroPoietin in Acute Myocardial Infarction: New Outlook aNd Dose Association Study (EPAMINONDAS) J Thromb Thrombolysis 28 2009 489 495
30. A.J. Coats Ethical authorship and publishing Int J Cardiol 131 2009 149 150