A US multicenter, retrospective, observational study of erythropoiesis-stimulating agent utilization in anemic, critically ill patients admitted to the intensive care unit

Clinical Therapeutics

Volumn 30, Issue 12, 2008, Pages 2324-2334

  Brophy, Gretchen M ^a   Sheehan, Valerie ^b   Shapiro, Marc J ^c   Lottenberg, Lawrence ^d   Scarlata, Debra ^e   Audhya, Paul ^e  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^b McKesson   (United States)

^c STONY BROOK UNIVERSITY   (United States)

^d UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^e AMGEN INC   (United States)

Author keywords

anemia; critical care; darbepoietin alfa; epoetin alfa; hemoglobin; transfusion

Indexed keywords

HEMOGLOBIN; IRON; NOVEL ERYTHROPOIESIS STIMULATING PROTEIN; RECOMBINANT ERYTHROPOIETIN;

ADULT; ANEMIA; ARTICLE; BLOOD TRANSFUSION; CRITICALLY ILL PATIENT; DRUG DOSE REGIMEN; FEMALE; HEMOGLOBIN DETERMINATION; HUMAN; INTENSIVE CARE UNIT; MAJOR CLINICAL STUDY; MALE; OBSERVATIONAL STUDY; SINGLE DRUG DOSE;

ADULT; AGED; AGED, 80 AND OVER; ANEMIA; COHORT STUDIES; CRITICAL ILLNESS; DRUG UTILIZATION REVIEW; EPOETIN ALFA; ERYTHROCYTE TRANSFUSION; ERYTHROPOIESIS; ERYTHROPOIETIN; FEMALE; HEMATINICS; HEMOGLOBINS; HUMANS; INTENSIVE CARE UNITS; LENGTH OF STAY; MALE; MIDDLE AGED; PATIENT ADMISSION; RETROSPECTIVE STUDIES; TIME FACTORS; UNITED STATES;

EID: 58249134621     PISSN: 01492918     EISSN: 1879114X     Source Type: Journal    
DOI: 10.1016/j.clinthera.2008.12.024     Document Type: Article

References (18)

1. Corwin H.L., Gettinger A., Pearl R.G., et al. The CRIT Study: Anemia and blood transfusion in the critically ill-current clinical practice in the United States. Crit Care Med. 32 (2004) 39-52
2. Vincent J.L., Baron J.F., Reinhart K., et al., for the ABC (Anemia and Blood Transfusion in Critical Care) Investigators. Anemia and blood transfusion in critically ill patients. JAMA 288 (2002) 1499-1507
3. Corwin H.L., Parsonnet K.C., and Gettinger A. RBC transfusion in the ICU. Is there a reason?. Chest 108 (1995) 767-771
4. Rodriguez R.M., Corwin H.L., Gettinger A., et al. Nutritional deficiencies and blunted erythropoietin response as causes of the anemia of critical illness. J Crit Care. 16 (2001) 36-41
5. Rogiers P., Zhang H., Leeman M., et al. Erythropoietin response is blunted in critically ill patients. Intensive Care Med. 23 (1997) 159-162
6. van Iperen C.E., Gaillard C.A., Kraaijenhagen R.J., et al. Response of erythropoiesis and iron metabolism to recombinant human erythropoietin in intensive care unit patients. Crit Care Med. 28 (2000) 2773-2778
7. Hébert P.C., Wells G., Blajchman M.A., et al., for the Transfusion Requirements in Critical Care Investigators, Canadian Critical Care Trials Group. A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care [published correction appears in N Engl J Med. 1999;340:1056]. N Engl J Med. 340 (1999) 409-417
8. Corwin H.L., Gettinger A., Rodriguez R.M., et al. Efficacy of recombinant human erythropoietin in the critically ill patient: A randomized, double-blind, placebo-controlled trial. Crit Care Med. 27 (1999) 2346-2350
9. Corwin H.L., Gettinger A., Pearl R.G., et al., for the EPO Critical Care Trials Group. Efficacy of recombinant human erythropoietin in critically ill patients: A randomized controlled trial. JAMA 288 (2002) 2827-2835
10. Corwin H.L., Gettinger A., Fabian T.C., et al., for the EPO Critical Care Trials Group. Efficacy and safety of epoetin alfa in critically ill patients. N Engl J Med. 357 (2007) 965-976
11. Voils S.A., Harpe S.H., and Brophy G.M. Comparison of darbepoietin alfa and epoetin alfa in the management of anemia of critical illness. Pharmacotherapy. 27 (2007) 535-541
12. Aranesp (darbepoietin alfa) [package insert] (March 2007), Amgen Inc, Thousand Oaks, Calif. http://www.aranesp.com Accessed September 15, 2008
13. Procrit (epoetin alfa) [package insert] (March 2007), Ortho Biotech Products, LP, Raritan, NJ. http://www.procrit.com Accessed September 15, 2008
14. World Health Organization (WHO). International Statistical Classification of Diseases and Related Health Problems (1994), WHO, Geneva, Switzerland 9th rev
15. World Health Organization. Nutritional anemia: Report of a WHO Scientific Group. Technical Report Series. No 405 (1968), WHO, Geneva, Switzerland
16. von Ahsen N., Müller C., Serke S., et al. Important role of nondiagnostic blood loss and blunted erythropoietic response in the anemia of medical intensive care patients. Crit Care Med. 27 (1999) 2630-2639
17. Walsh T.S., Lee R.J., Maciver C.R., et al. Anemia during and at discharge from intensive care: The impact of restrictive blood transfusion practice. Intensive Care Med. 32 (2006) 100-109
18. Nguyen B.V., Bota D.P., Mélot C., and Vincent J.L. Time course of hemoglobin concentrations in nonbleeding intensive care unit patients. Crit Care Med. 31 (2003) 406-410