Successful gene therapy in older Rpe65-deficient dogs following subretinal injection of an adeno-associated vector expressing RPE65

Human Gene Therapy

Volumn 24, Issue 10, 2013, Pages 883-893

  Annear, Matthew J ^a   Mowat, Freya M ^a,b   Bartoe, Joshua T ^a   Querubin, Janice ^a   Azam, Selina A ^b   Basche, Mark ^b   Curran, Paul G ^a   Smith, Alexander J ^b   Bainbridge, James W B ^b   Ali, Robin R ^b   Petersen Jones, Simon M ^a  

^a MICHIGAN STATE UNIVERSITY   (United States)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; COMPLEMENTARY DNA; RPE65 PROTEIN; UNCLASSIFIED DRUG; VISUAL PIGMENT;

ADENO ASSOCIATED VIRUS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AQUEOUS HUMOR; ARTICLE; BIOMICROSCOPY; CONTROLLED STUDY; DOG; ELECTRORETINOGRAPHY; GENE EXPRESSION; GENE MUTATION; GENE THERAPY; HISTOLOGY; ILLUMINATION; IMMUNOHISTOCHEMISTRY; LEBER CONGENITAL AMAUROSIS; NONHUMAN; OPHTHALMOSCOPY; PHOTORECEPTOR; PIGMENT EPITHELIUM; PROMOTER REGION; SLIT LAMP; TREATMENT OUTCOME; VIRAL GENE DELIVERY SYSTEM; VISION; VISION TEST; VITRECTOMY;

AGE FACTORS; ANIMALS; CIS-TRANS-ISOMERASES; DEPENDOVIRUS; DISEASE MODELS, ANIMAL; DOGS; ELECTRORETINOGRAPHY; FLUORESCEIN ANGIOGRAPHY; GENE EXPRESSION; GENETIC THERAPY; GENETIC VECTORS; HUMANS; LEBER CONGENITAL AMAUROSIS; RETINA; TREATMENT OUTCOME; VISION TESTS;

EID: 84885416747     PISSN: 10430342     EISSN: 15577422     Source Type: Journal    
DOI: 10.1089/hum.2013.146     Document Type: Article

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