Digitoflavone Inhibits IκBα Kinase and Enhances Apoptosis Induced by TNFα through Downregulation of Expression of Nuclear Factor κB-Regulated Gene Products in Human Pancreatic Cancer Cells

PLoS ONE

Volumn 8, Issue 10, 2013, Pages

  Cai, Xueting ^a,b   Lu, Wuguang ^a,b   Yang, Yang ^a,b   Yang, Jie ^a,b   Ye, Juan ^a,b   Gu, Zhenhua ^a,b   Hu, Chunping ^a,b   Wang, Xiaoning ^a,b   Cao, Peng ^a,b  

^a INSTITUTE OF CHINESE MATERIA MEDICA   (China)

^b Jiangsu Province Academy of Traditional Chinese Medicine   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN D1; CYCLOOXYGENASE 2; FLICE INHIBITORY PROTEIN; GELATINASE B; I KAPPA B KINASE ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LUTEOLIN; MYC PROTEIN; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN MCL 1; STRESS ACTIVATED PROTEIN KINASE; SURVIVIN; TUMOR NECROSIS FACTOR ALPHA; VASCULOTROPIN;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BCL 2 GENE; BCL XL GENE; C IAP1 GENE; C IAP2 GENE; CANCER CELL; CELL NUCLEUS; CELL PROLIFERATION; CELL SURVIVAL; CHEMOSENSITIZATION; CONTROLLED STUDY; COX 2 GENE; CYCLIN D1 GENE; DOWN REGULATION; DRUG EFFECT; ENZYME ACTIVATION; ENZYME DEGRADATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; FLIP GENE; GENE; GENE EXPRESSION REGULATION; GENE PRODUCT; HUMAN; HUMAN CELL; INTRACELLULAR TRANSPORT; MCL 1 GENE; MMP 9 GENE; MOLECULAR BIOLOGY; ONCOGENE C MYC; PANCREAS CANCER; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; SURVIVIN GENE; TRANSCRIPTION REGULATION; TUMOR VASCULARIZATION; VEGF GENE;

APOPTOSIS; CELL LINE, TUMOR; ENZYME ACTIVATION; FLAVONES; GENE EXPRESSION; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, REPORTER; HUMANS; I-KAPPA B KINASE; JNK MITOGEN-ACTIVATED PROTEIN KINASES; NF-KAPPA B; PANCREATIC NEOPLASMS; PHOSPHORYLATION; PROTEOLYSIS; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR-ALPHA; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84885415996     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0077126     Document Type: Article

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