The protective effect of trefoil factor 3 on the intestinal tight junction barrier is mediated by toll-like receptor 2 via a PI3K/Akt dependent mechanism

Biochemical and Biophysical Research Communications

Volumn 440, Issue 1, 2013, Pages 143-149

  Lin, Nan ^a   Xu, Ling fen ^a   Sun, Mei ^a  

^a CHINA MEDICAL UNIVERSITY   (China)

Author keywords

Intestinal permeability; Intestinal tight junction; Toll like receptor 2; Trefoil factor 3

Indexed keywords

CLAUDIN 1; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; INTESTINAL TREFOIL FACTOR; MESSENGER RNA; OCCLUDIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN ZO1; TOLL LIKE RECEPTOR 2; TREFOIL FACTOR 3; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ARTICLE; CELL STRAIN CACO 2; DOWN REGULATION; ENZYME ACTIVATION; GENE OVEREXPRESSION; INTESTINE MUCOSA PERMEABILITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TIGHT JUNCTION; UPREGULATION;

INTESTINAL PERMEABILITY; INTESTINAL TIGHT JUNCTION; TOLL-LIKE RECEPTOR 2; TREFOIL FACTOR 3;

CACO-2 CELLS; CYTOKINES; GENE EXPRESSION REGULATION; HUMANS; INFLAMMATION MEDIATORS; INTERLEUKIN-1BETA; INTESTINAL MUCOSA; PEPTIDES; PERMEABILITY; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; TIGHT JUNCTIONS; TOLL-LIKE RECEPTOR 2;

LOTUS;

EID: 84885386132     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2013.09.049     Document Type: Article

References (33)

1. Chen J., Rao J.N., Zou T., Liu L., Marasa B.S., Xiao L., Zeng X., Turner D.J., Wang J.Y. Polyamines are required for expression of Toll-like receptor 2 modulating intestinal epithelial barrier integrity. Am. J. Physiol. Gastrointest. Liver Physiol. 2007, 293:G568-576.
2. Hollander D. Intestinal permeability, leaky gut, and intestinal disorders. Curr. Gastroenterol. Rep. 1999, 1:410-416.
3. Matter K., Aijaz S., Tsapara A., Balda M.S. Mammalian tight junctions in the regulation of epithelial differentiation and proliferation. Curr. Opin. Cell. Biol. 2005, 17:453-458.
4. Balda M.S., Garrett M.D., Matter K. The ZO-1-associated Y-box factor ZONAB regulates epithelial cell proliferation and cell density. J. Cell Biol. 2003, 160:423-432.
5. Balda M.S., Matter K. Epithelial cell adhesion and the regulation of gene expression. Trends Cell Biol. 2003, 13:310-318.
6. Buda A., Jepson M.A., Pignatelli M. Regulatory function of trefoil peptides (TFF) on intestinal cell junctional complexes. Cell Commun. Adhes. 2012, 19:63-68.
7. Hoffmann W. Trefoil factor family (TFF) peptides: regulators of mucosal regeneration and repair, and more. Peptides 2004, 25:727-730.
8. Wright N.A., Poulsom R., Stamp G., Van Norden S., Sarraf C., Elia G., Ahnen D., Jeffery R., Longcroft J., Pike C., et al. Trefoil peptide gene expression in gastrointestinal epithelial cells in inflammatory bowel disease. Scand. J. Gastroenterol. 1992, 193(Suppl.):76-82.
9. Xu L.F., Teng X., Guo J., Sun M. Protective effect of intestinal trefoil factor on injury of intestinal epithelial tight junction induced by platelet activating factor. Inflammation 2012, 35:308-315.
10. Cario E., Gerken G., Podolsky D.K. Toll-like receptor 2 controls mucosal inflammation by regulating epithelial barrier function. Gastroenterology 2007, 132:1359-1374.
11. Takeda K., Kaisho T., Akira S. Toll-like receptors. Annu Rev Immunol 2003, 21:335-376.
12. Ey B., Eyking A., Gerken G., Podolsky D.K., Cario E. TLR2 mediates gap junctional intercellular communication through connexin-43 in intestinal epithelial barrier injury. J. Biol. Chem. 2009, 284:22332-22343.
13. Podolsky D.K., Gerken G., Eyking A., Cario E. Colitis-associated variant of TLR2 causes impaired mucosal repair because of TFF3 deficiency. Gastroenterology 2009, 137:209-220.
14. Wahlang B., Pawar Y.B., Bansal A.K. Identification of permeability-related hurdles in oral delivery of curcumin using the Caco-2 cell model. Eur. J. Pharm. Biopharm. 2011, 77:275-282.
15. Schneeberger E.E., Lynch R.D. The tight junction: a multifunctional complex. Am. J. Physiol. Cell Physiol. 2004, 286:C1213-1228.
16. Klingberg T.D., Pedersen M.H., Cencic A., Budde B.B. Application of measurements of transepithelial electrical resistance of intestinal epithelial cell monolayers to evaluate probiotic activity. Appl. Environ. Microbiol. 2005, 71:7528-7530.
17. Welcker K., Martin A., Kolle P., Siebeck M., Gross M. Increased intestinal permeability in patients with inflammatory bowel disease. Eur. J. Med. Res. 2004, 9:456-460.
18. Nakamura M., Saito H., Kasanuki J., Tamura Y., Yoshida S. Cytokine production in patients with inflammatory bowel disease. Gut 1992, 33:933-937.
19. Al-Sadi R., Ye D., Dokladny K., Ma T.Y. Mechanism of IL-1beta-induced increase in intestinal epithelial tight junction permeability. J. Immunol. 2008, 180:5653-5661.
20. Al-Sadi R., Ye D., Said H.M., Ma T.Y. IL-1beta-induced increase in intestinal epithelial tight junction permeability is mediated by MEKK-1 activation of canonical NF-kappaB pathway. Am. J. Pathol. 2010, 177:2310-2322.
21. Ma T.Y., Boivin M.A., Ye D., Pedram A., Said H.M. Mechanism of TNF-{alpha} modulation of Caco-2 intestinal epithelial tight junction barrier: role of myosin light-chain kinase protein expression. Am. J. Physiol. Gastrointest. Liver Physiol. 2005, 288:G422-430.
22. Cario E., Podolsky D.K. Differential alteration in intestinal epithelial cell expression of toll-like receptor 3 (TLR3) and TLR4 in inflammatory bowel disease. Infect. Immun. 2000, 68:7010-7017.
23. Otte J.M., Cario E., Podolsky D.K. Mechanisms of cross hyporesponsiveness to Toll-like receptor bacterial ligands in intestinal epithelial cells. Gastroenterology 2004, 126:1054-1070.
24. Cario E., Gerken G., Podolsky D.K. Toll-like receptor 2 enhances ZO-1-associated intestinal epithelial barrier integrity via protein kinase C. Gastroenterology 2004, 127:224-238.
25. Ey B., Eyking A., Klepak M., Salzman N.H., Gothert J.R., Runzi M., Schmid K.W., Gerken G., Podolsky D.K., Cario E. Loss of TLR2 worsens spontaneous colitis in MDR1A deficiency through commensally induced pyroptosis. J. Immunol. 2013, 190:5676-5688.
26. Ma T.Y., Iwamoto G.K., Hoa N.T., Akotia V., Pedram A., Boivin M.A., Said H.M. TNF-alpha-induced increase in intestinal epithelial tight junction permeability requires NF-kappa B activation. Am. J. Physiol. Gastrointest. Liver Physiol. 2004, 286:G367-376.
27. Prasad S., Mingrino R., Kaukinen K., Hayes K.L., Powell R.M., MacDonald T.T., Collins J.E. Inflammatory processes have differential effects on claudins 2, 3 and 4 in colonic epithelial cells. Lab. Invest. 2005, 85:1139-1162.
28. *-dependent and -independent changes in expression and localization of tight junction proteins in intestinal epithelial cells. Shock 2003, 19:229-237.
29. Oppong G.O., Rapsinski G.J., Newman T.N., Nishimori J.H., Biesecker S.G., Tukel C. Epithelial cells augment barrier function via activation of the Toll-like receptor 2/phosphatidylinositol 3-kinase pathway upon recognition of Salmonella enterica serovar Typhimurium curli fibrils in the gut. Infect. Immun. 2013, 81:478-486.
30. Rakoff-Nahoum S., Hao L., Medzhitov R. Role of toll-like receptors in spontaneous commensal-dependent colitis. Immunity 2006, 25:319-329.
31. Rakoff-Nahoum S., Paglino J., Eslami-Varzaneh F., Edberg S., Medzhitov R. Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis. Cell 2004, 118:229-241.
32. Clevers H. At the crossroads of inflammation and cancer. Cell 2004, 118:671-674.
33. Coussens L.M., Werb Z. Inflammation and cancer. Nature 2002, 420:860-867.