Isocitric acid production from rapeseed oil by Yarrowia lipolytica yeast

Applied Microbiology and Biotechnology

Volumn 97, Issue 20, 2013, Pages 9133-9144

  Kamzolova, Svetlana V ^a   Dedyukhina, Emiliya G ^a   Samoilenko, Vladimir A ^a   Lunina, Julia N ^a   Puntus, Irina F ^a   Allayarov, Ramil L ^a,b   Chiglintseva, Maria N ^a   Mironov, Alexey A ^a,b   Morgunov, Igor G ^a,b  

^a SKRYABIN INSTITUTE OF BIOCHEMISTRY AND PHYSIOLOGY OF MICROORGANISMS   (Russian Federation)

^b PUSHCHINO STATE UNIVERSITY   (Russian Federation)

Author keywords

Citric acid; Iron; Isocitric acid; Itaconic acid; Microbial production; Rapeseed oil; Yarrowia lipolytica

Indexed keywords

EFFECTS OF TEMPERATURE; ITACONIC ACID; MICROBIAL PRODUCTION; OPTIMAL CONDITIONS; RAPESEED OIL; SELECTED STRAINS; WILD-TYPE STRAIN; YARROWIA LIPOLYTICA;

CITRIC ACID; IRON; METAL IONS; YEAST;

VEGETABLE OILS;

ACONITATE HYDRATASE; CALCIUM CARBONATE; CITRIC ACID; DISSOLVED OXYGEN; IRON; ISOCITRATE LYASE; ISOCITRIC ACID; ITACONIC ACID; NITROGEN; RAPESEED OIL;

ACID; AERATION; CITRIC ACID; ESSENTIAL OIL; IRON; PH; TEMPERATURE EFFECT; YEAST;

AERATION; ARTICLE; BIOMASS; BIOSYNTHESIS; CANDIDA; CANDIDA CATENULATA; CANDIDA PALUDIGENA; CANDIDA RUGOSA; CANDIDA ZEYLANOIDES; CELL GROWTH; CONTROLLED STUDY; DEBARYOMYCES HANSENII; DISSOLUTION; FUNGAL BIOMASS; FUNGAL CELL CULTURE; FUNGAL STRAIN; FUNGUS GROWTH; FUNGUS MUTANT; LIPID COMPOSITION; NONHUMAN; PH; PICHIA; PICHIA ANOMALA; PICHIA BESSEYI; PICHIA GUILLIERMONDII; PICHIA INOSITOVORA; PICHIA MEDIA; SACCHAROMYCES CEREVISIAE; TEMPERATURE; WILD TYPE; YARROWIA LIPOLYTICA; YEAST CELL;

BRASSICA NAPUS; CANDIDA; PICHIA; SACCHAROMYCES; TORULOPSIS; YARROWIA; YARROWIA LIPOLYTICA;

CULTURE MEDIA; ISOCITRATES; PLANT OILS; YARROWIA; YEASTS;

EID: 84885384520     PISSN: 01757598     EISSN: 14320614     Source Type: Journal    
DOI: 10.1007/s00253-013-5182-5     Document Type: Article

References (50)

1. Akiyama S, Suzuki T, Sumino Y, Nakao Y, Fukuda H (1973) Induction and citric acid productivity of fluoroacetate-sensitive mutant strains of Candida lipolytica. Agr Biol Chem 37:879-888
2. Aurich A, Specht R, Müller RA, Stottmeister U, Yovkova V, Otto C, Holz M, Barth G, Heretsch P, Thomas FA, Sicker D, Giannis A (2012) Microbiologically produced carboxylic acids used as building blocks in organic synthesis. In: Wang X, Chen J, Quinn P (eds) Reprogramming microbial metabolic pathways. Springer, Dordrecht, pp 391-424
3. Barth G, Gaillardin C (1996) Yarrowia lipolytica. In: Wolf K (ed) Non conventional yeasts in biotechnology: A handbook. Springer, Berlin, pp 313-388
4. Barth G, Gaillardin C (1997) Physiology and genetics of the dimorphic fungus Yarrowia lipolytica. FEMS Microbiol Rev 19:219-237
5. Berg IA, Filatova LV, Ivanovsky RN (2002) Inhibition of acetate and propionate assimilation by itaconate via propionyl-CoA carboxylase in isocitrate lyase-negative purple bacterium Rhodospirillum rubrum. FEMS Microbiol Lett 216(1):49-54
6. Burkholder P, McVeigh J, Moyer D (1944) Studies on some growth factors of yeasts. J Bacteriol 48:385-391
7. Ermakova IT, Shishkanova NV, Melnikova OF, Finogenova TV (1986) Properties of Candida lipolytica mutants with the modified glyoxylate cycle and their ability to produce citric and isocitric acid. I. Physiological, biochemical and cytological characteristics of mutants grown on glucose or hexadecane. Appl Microbiol Biotechnol 23:372-377
8. Evans CT, Ratledge C (1985) The physiological significance of citric acid in the control of metabolism in lipid-accumulating yeasts. Biotechnol Genet Eng Rev 3:85-111
9. Fickers P, Benetti PH, Wache Y, Marty A, Mauersberger S, Smit MS, Nicaud JM (2005) Hydrophobic substrate utilisation by the yeast Yarrowia lipolytica, and its potential applications. FEMS Yeast Res 5:527-543
10. Finogenova TV, Shishkanova NV, Ermakova IT, Kataeva IA (1986) Properties of Candida lipolytica mutants with the modified glyoxylate cycle and their ability to produce citric and isocitric acid. II. Synthesis of citric and isocitric acid by Candida lipolytica mutants and peculiarities of their enzyme systems. Appl Microbiol Biotechnol 23:378-383
11. Finogenova TV, Shishkanova NV, Fausek EA, Eremina SS (1991) Biosynthesis of isocitric acid from ethanol by yeasts. Appl Microbiol Biotechnol 36:231-235
12. Finogenova TV, Morgunov IG, Kamzolova SV, Chernyavskaya OG (2005) Organic acid production by the yeast Yarrowia lipolytica: a review of prospects. Appl Biochem Microbiol 41:418-425
13. Förster A, Jacobs K, Juretzek T, Mauersberger S, Barth G (2007a) Overexpression of the ICL1 gene changes the product ratio of citric acid production by Yarrowia lipolytica. Appl Microbiol Biotechnol 77:861-869
14. Förster A, Aurich A, Mauersberger S, Barth G (2007b) Citric acid production from sucrose using a recombinant strain of the yeast Yarrowia lipolytica. Appl Microbiol Biotechnol 75:1409-1417
15. Good DW, Droniuk R, Lawford RG, Fein JE (1985) Isolation and characterization of a Saccharomycopsis lipolytica mutant showing increased production of citric acid from canola oil. Can J Microbiol 31:436-440
16. Groenewald M, Boekhout T, Neuvéglise C, Gaillardin C, van Dijck PW, Wyss M (2013) Yarrowia lipolytica: safety assessment of an oleaginous yeast with a great industrial potential. Crit Rev Microbiol. doi: 10.3109/1040841X. 2013.770386
17. Heretsch P, Thomas F, Aurich A, Krautscheid H, Sicker D, Giannis A (2008) Syntheses with a chiral building block from the citric acid cycle: (2R,3S)-isocitric acid by fermentation of sunflower oil. Angew Chem Int Ed Engl 47:1958-1960
18. Holdsworth JE, Veenhuis H, Ratledge C (1988) Enzyme activities in oleaginous yeasts accumulating and utilizing exogenous or endogenous lipids. J Gen Microbiol 134:2907-2915
19. Holz M, Förster A, Mauersberger S, Barth G (2009) Aconitase overexpression changes the product ratio of citric acid production by Yarrowia lipolytica. Appl Microbiol Biotechnol 81:1087-1096
20. JezËek, Suhaj (2001) Application of capillary isotachophoresis for fruit juice authentication. J Chromatogr A 916(1-2):185-189
21. Kamzolova SV, Shishkanova NV, Morgunov IG, Finogenova TV (2003) Oxygen requirements for growth and citric acid production of Yarrowia lipolytica. FEMS Yeast Res 3:217-222
22. Kamzolova SV, Morgunov IG, Aurich A, Perevoznikova OA, Shishkanova NV, Stottmeister U, Finogenova TV (2005) Lipase secretion and citric acid production in Yarrowia lipolytica yeast grown on animal and vegetable fat. Food Technol Biotechnol 43:113-122
23. Kamzolova SV, Finogenova TV, Lunina YN, Perevoznikova OA, Minachova LN, Morgunov IG (2007) Characteristics of the growth on rapeseed oil and synthesis of citric and isocitric acids Yarrowia lipolytica yeasts. Microbiology (Moscow) 76:20-24
24. Kamzolova SV, Finogenova TV, Morgunov IG (2008) Microbial production of citric and isocitric acids from sunflower oil. Food Technol Biotechnol 46:51-59
25. Kamzolova SV, Lunina JN, Morgunov IG (2011) Biochemistry of citric acid production from rapeseed oil by Yarrowia lipolytica yeast. JAOCS 88:1965-1976
26. Kamzolova SV, Chiglintseva MN, Lunina JN, Morgunov IG (2012) α-Ketoglutaric acid production by Yarrowia lipolytica and its regulation. Appl Microbiol Biotechnol 96:783-791
27. Kamzolova SV, Morgunov IG (2013) α-Ketoglutaric acid production from rapeseed oil by Yarrowia lipolytica yeast. Appl Microbiol Biotechnol 97(12):5517-5525
28. Karklin R, Peltzmane I, Raminya L, Korde G (1991) Overproduction of isocitric acid by wild strain of Candida lipolytica. In: Finogenova TV, Sharishev AA (eds) Metabolism of n-alkanes and oversynthesis of products by microorganisms. Pushchino scientific center of Russian Academy of Sciences, Pushchino, Russia, pp 143-146
29. Krátký M, Vinšová J (2012) Advances in mycobacterial isocitrate lyase targeting and inhibitors. Curr Med Chem 19(36):6126-6137
30. Lozinov AB, Glazunova LM, Ermakova IT (1976) Activity of enzymes of the citrate glyoxylate and pentose phosphate cycles during growth of yeasts on hexadecane and glucose. Microbiology (Moscow) 45:33-40
31. Mattey M (1992) The production of organic acids. Crit Rev Biotechnol 12:87-132
32. Mauersberger S, Kruse K, Barth G (2003) Induction of citric acid/isocitric acid and α-ketoglutaric acid production in the yeast Yarrowia lipolytica. In: Wolf KH, Breunig K, Barth G (eds) Nonconventional yeasts in genetics, biochemistry and biotechnology. Practical protocols. Springer, Berlin, pp 393-400
33. Munir E, Hattori T, Shimada M (2002) Purification and characterization of isocitrate lyase from the wood-destroying basidiomycete Fomitopsis palustris grown on glucose. Arch Biochem Biophys 399(2):225-231
34. Nakahara T, Kaimaktchiev AC, Oogaki-Chino M, Uchida Y, Tabuchi T (1987) Isocitric acid production from n-alkanes by Candida catenulata. Agric Biol Chem 51:2111-2116
35. Oogaki M, Inoue M, Kaimaktchiev AC, Nakahara T, Tabuchi T (1983) Production of isocitric acid from glucose by Candida ravautii. Agric Biol Chem 48:789-795
36. Otto C, Yovkova V, Aurich A, Mauersberger S, Barth G (2012) Variation of the by-product spectrum during α-ketoglutaric acid production from raw glycerol by overexpression of fumarase and pyruvate carboxylase genes in Yarrowia lipolytica. Appl Microbiol Biotechnol 95:905-917
37. Papanikolaou S, Aggelis G (2010) Yarrowia lipolytica: a model microorganism used for the production of tailor-made lipids. Eur J Lipid Sci Technol 112:639-654
38. Papanikolaou S, Aggelis G (2011) Lipids of oleaginous yeasts. Part II: technology and potential applications. Eur J Lipid Sci Technol 113:1052-1073
39. Ränby M, Gojceta T, Gustafsson K, Hansson KM, Lindahl TL (1999) Isocitrate as calcium ion activity buffer in coagulation assays. Clin Chem 45(8 Pt 1):1176-1180
40. Rane KD, Sims K (1994) Oxygen uptake and citric acid production by Candida lipolytica Y 1095. Biotechnol Bioeng 43:131-137
41. Ratledge C, Wynn J (2002) The biochemistry and molecular biology of lipid accumulation in oleaginous microorganisms. Adv Appl Microbiol 51:1-51
42. Rywińska A, Musial I, Rymowicz W, Åarowska B, Boruczkowski T (2012) Effect of agitation and aeration on the citric acid production by Yarrowia lipolytica grown on glycerol. Prep Biochem Biotechnol 42:279-291
43. Sakaguchi K, Abe S, Beppu T (1960) Method of producing allo-isocitric acid by fermentation. US Patent 2949404, 16 Aug 1960
44. Stahmann KP, Revuelta JL, Seulberger H (2000) Three biotechnical processes using Ashbya gossypii, Candida famata, or Bacillus subtilis compete with chemical riboflavin production. Appl Microbiol Biotechnol 53(5):509-516
45. Stottmeister U, Behrens U, Weissbrodt E, Barth G, Franke-Rinker D, Schulze E (1982) Utilization of paraffins and other noncarbohydrate carbon sources for microbial citric acid synthesis. Z Allg Mikrobiol 22:399-424
46. Sultanovich YA, Nechaev AP, Barsukova IA (1982) Method for the quantitative determination of the fatty acid composition of microbial lipids. USSR Inventor's Certificate No. 968072. Byull Izobret 39:136
47. Treton B, Le Dall MT, Heslot H (1978) Excretion of citric and isocitric acid by the yeast Saccharomycopsis lipolytica. Eur J Appl Microbiol Biotechnol 6:67-77
48. Venter T, Kock JL, Botes PJ, Smit MS, Hugo A, Joseph M (2004) Acetate enhances citric acid production by Yarrowia lipolytica when grown on sunflower oil. Syst Appl Microbiol 27(2):135-138
49. Vickery HB (1962) A suggested new nomenclature for the isomers of isocitric acid. J Biol Chem 237:1739-1741
50. Whitworth DA, Ratledge C (1975) An analysis of intermediary metabolism and its control in a fat-synthesizing yeast (Candida 107) growing on glucose or alkanes. J Gen Microbiol 88:275-288