In vivo efficacy and synergistic interaction of 16α-hydroxycleroda-3, 13 (14) Z-dien-15, 16-olide, a clerodane diterpene from Polyalthia longifolia against methicillin-resistant Staphylococcus aureus

Applied Microbiology and Biotechnology

Volumn 97, Issue 20, 2013, Pages 9121-9131

  Gupta, Vivek Kumar ^a,b   Verma, Surjeet ^a   Pal, Anirban ^a   Srivastava, Santosh Kumar ^a   Srivastava, Pramod Kumar ^b   Darokar, Mahendra P ^a  

^a CSIR CENTRAL INSTITUTE OF MEDICINAL AND AROMATIC PLANTS   (India)

^b BANARAS HINDU UNIVERSITY   (India)

Author keywords

Clerodane diterpene; Cytoplasmic leakage assays; Membrane damage; Methicillin resistant Staphylococcus aureus; Polyalthia longifolia

Indexed keywords

DITERPENES; FLOW-CYTOMETRIC ANALYSIS; MEMBRANE DAMAGE; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; MINIMUM INHIBITORY CONCENTRATION; POLYALTHIA LONGIFOLIA; STAPHYLOCOCCUS AUREUS; SYNERGISTIC INTERACTION;

BACTERIA; OLEFINS;

ENZYME INHIBITION;

16ALPHA HYDROXYCLERODA 3,13(14) DIEN 15,16 OLIDE; ANTIBIOTIC AGENT; CLERODANE DERIVATIVE; DAPTOMYCIN; LINEZOLID; OXACILLIN; PROPIDIUM IODIDE; SODIUM CHLORIDE; TETRACYCLINE; UNCLASSIFIED DRUG;

ANTIBIOTICS; BACTERIUM; IODIDE; MEMBRANE; PATHOGEN; SALINITY TOLERANCE; STRAIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBACTERIAL ACTIVITY; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL COUNT; BACTERIAL GROWTH; BACTERIAL LOAD; BACTERIAL MEMBRANE; BACTERIAL STRAIN; BACTERIOLYSIS; BACTERIUM ISOLATE; BLOOD; CONTROLLED STUDY; DRUG EFFICACY; DRUG POTENTIATION; DRUG UPTAKE; FEMALE; FLOW CYTOMETRY; IN VITRO STUDY; IN VIVO STUDY; KIDNEY; LIVER; LUNG; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS INFECTION; MINIMUM INHIBITORY CONCENTRATION; MOUSE; NONHUMAN; PLANT LEAF; POLYALTHIA LONGIFOLIA; SALT TOLERANCE; SPLEEN;

BACTERIA (MICROORGANISMS); METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MUS; POLYALTHIA LONGIFOLIA; STAPHYLOCOCCUS AUREUS;

ANIMALS; ANTI-BACTERIAL AGENTS; DITERPENES, CLERODANE; DRUG SYNERGISM; FEMALE; HUMANS; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; MICE; MICROBIAL SENSITIVITY TESTS; MICROBIAL VIABILITY; MOLECULAR SEQUENCE DATA; POLYALTHIA; STAPHYLOCOCCAL INFECTIONS;

EID: 84885382887     PISSN: 01757598     EISSN: 14320614     Source Type: Journal    
DOI: 10.1007/s00253-013-5154-9     Document Type: Article

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