New diarylamides and diarylureas possessing 8-amino(acetamido)quinoline scaffold: Synthesis, antiproliferative activities against melanoma cell lines, kinase inhibition, and in silico studies

European Journal of Medicinal Chemistry

Volumn 70, Issue , 2013, Pages 10-21

  Koh, Eun Jeong ^a,b   El Gamal, Mohammed I ^a,c,e   Oh, Chang Hyun ^a,c   Lee, So Ha ^a   Sim, Taebo ^a   Kim, Garam ^d   Choi, Hong Seok ^d   Hong, Jun Hee ^d   Lee, Sang Gi ^b   Yoo, Kyung Ho ^a  

^a Korea Institute of Science and Technology   (South Korea)

^b Ewha Womans University   (South Korea)

^c University of Science and Technology (UST)   (South Korea)

^d Chosun University   (South Korea)

^e University of Mansoura   (Egypt)

Author keywords

Antiproliferative activity; Diarylamide; Diarylurea; ERK kinase; Melanoma; Quinoline

Indexed keywords

1 [3 (8 AMINOQUINOLIN 4 YL)PHENYL] 3 [3,5 BIS(TRIFLUOROMETHYL)PHENYL)UREA; ANTINEOPLASTIC AGENT; AROMATIC AMIDE; MOLECULAR SCAFFOLD; N [3 (8 ACETAMIDOQUINOLIN 4 YL) 4 METHYLPHENYL] 2,3 DIHYDROBENZO[B][1,4]DIOXINE 6 CARBOXAMIDE; N [3 (8 ACETAMIDOQUINOLIN 4 YL)PHENYL) 3,4 DIMETHOXYBENZAMIDE; N [3 (8 ACETAMIDOQUINOLIN 4 YL)PHENYL] 2,3 DIHYDROBENZO [B][1,4]DIOXINE 6 CARBOXAMIDE; N [3 (8 AMINOQUINOLIN 4 YL) 4 METHYLPHENYL] 2,3 DIHYDROBENZO[B][1,4]DIOXINE 6 CARBOXAMIDE; N [3 (8 AMINOQUINOLIN 4 YL)PHENYL] 2,3 DIHYDROBENZO[B][1,4]DIOXINE 6 CARBOXAMID; SORAFENIB; UNCLASSIFIED DRUG; UREA DERIVATIVE; VEMURAFENIB;

ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CELL LINE; COMPUTER MODEL; CONTROLLED STUDY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; MELANOMA CELL;

ANTIPROLIFERATIVE ACTIVITY; DIARYLAMIDE; DIARYLUREA; ERK KINASE; MELANOMA; QUINOLINE;

ACETAMIDES; AMIDES; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; COMPUTER SIMULATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; MELANOMA; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MOLECULAR STRUCTURE; PROTEIN KINASE INHIBITORS; QUINOLINES; STRUCTURE-ACTIVITY RELATIONSHIP; UREA;

EID: 84885358486     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2013.06.060     Document Type: Article

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