The impact of susceptibility loci for coronary artery disease on other vascular domains and recurrence risk

European Heart Journal

Volumn 34, Issue 37, 2013, Pages 2896-2904

  Tragante, Vinicius ^a   Doevendans, Pieter A F M ^a   Nathoe, Hendrik M ^a   Van Der Graaf, Yolanda ^a   Spiering, Wilko ^a   Algra, Ale ^a,b   De Borst, Gert Jan ^a   De Bakker, Paul I W ^a,c,d   Asselbergs, Folkert W ^a,e  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

^d BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^e ROYAL NETHERLANDS ACADEMY OF ARTS AND SCIENCES   (Netherlands)

Author keywords

Abdominal aortic aneurysm; Coronary artery disease; Genetic risk score; Ischaemic stroke; Peripheral artery disease; Pleiotropy

Indexed keywords

LOW DENSITY LIPOPROTEIN CHOLESTEROL;

ABDOMINAL AORTA ANEURYSM; ADULT; AGED; ALLELE; ARTICLE; BODY MASS; BRAIN ISCHEMIA; CARDIOVASCULAR RISK; CONTROLLED STUDY; CORONARY ARTERY DISEASE; FEMALE; GENE FREQUENCY; GENE LOCUS; GENETIC ASSOCIATION; GENETIC RISK; GENETIC SUSCEPTIBILITY; HUMAN; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PERIPHERAL OCCLUSIVE ARTERY DISEASE; PLEIOTROPY; PRIORITY JOURNAL; RECURRENCE RISK; SINGLE NUCLEOTIDE POLYMORPHISM;

ABDOMINAL AORTIC ANEURYSM; CORONARY ARTERY DISEASE; GENETIC RISK SCORE; ISCHAEMIC STROKE; PERIPHERAL ARTERY DISEASE; PLEIOTROPY;

ADOLESCENT; ADULT; AGED; AORTIC ANEURYSM, ABDOMINAL; CORONARY ARTERY DISEASE; FEMALE; GENETIC LOCI; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HUMANS; MALE; MIDDLE AGED; MYOCARDIAL INFARCTION; PERIPHERAL ARTERIAL DISEASE; POLYMORPHISM, SINGLE NUCLEOTIDE; RECURRENCE; RISK FACTORS; STROKE; YOUNG ADULT;

EID: 84885350397     PISSN: 0195668X     EISSN: 15229645     Source Type: Journal    
DOI: 10.1093/eurheartj/eht222     Document Type: Article

References (39)

1. Bogaert J, Dymarkowski S, Taylor A. Coronary artery disease. Clin Card MRI 2005; 381-437.
2. Mayou R, Bryant B. Quality of life in cardiovascular disease. Br Heart J 1993;69:460.
3. Okrainec K, Banerjee DK, Eisenberg MJ. Coronary artery disease in the developing world. Am Heart J 2004;148:7-15.
4. Soto Torres M, Márquez Calderón S, Ramos Díaz I, Barba Chacón A, López Fernández F, Failde Martínez I. Health-related quality of life in coronary heart disease compared to norms in Spanish population. Qual Life Res 2004;13: 1401-1407.
5. Cruz LN, Camey SA, Fleck MP, Polanczyk CA.World Health Organization quality of life instrument-brief and short form-36 in patients with coronary artery disease: Do they measure similar quality of life concepts? Psychol Health Med 2009;14:619-628.
6. Kannel WB, Dawber TR, Kagan A, Revotskie N, Stokes J III. Factors of risk in the development of coronary heart disease-six year follow-up experience. The Framingham Study. Ann Intern Med 1961;55:33.
7. Erdmann J, Großhennig A, Braund PS, Kö nig IR, Hengstenberg C, Hall AS, Linsel-Nitschke P, Kathiresan S, Wright B, Trégouét DA. New susceptibility locus for coronary artery disease on chromosome 3q22. 3. Nat Genet 2009;41:280-282.
8. Aoki A, Ozaki K, Sato H, Takahashi A, Kubo M, Sakata Y, Onouchi Y, Kawaguchi T, Lin T-H, Takano H, Yasutake M, Hsu P-C, Ikegawa S, Kamatani N, Tsunoda T, Juo S-HH, Hori M, Komuro I, Mizuno K, Nakamura Y, Tanaka T. SNPs on chromosome 5p15.3 associated with myocardial infarction in Japanese population. J Hum Genet 2011;56:47-51.
9. Shiffman D, Louie JZ, Rowland CM, Malloy MJ, Kane JP, Devlin JJ. Single variants can explain the association between coronary heart disease and haplotypes in the apolipoprotein (a) locus. Atherosclerosis 2010;212:193-196.
10. Erdmann J, Willenborg C, Nahrstaedt J, Preuss M, Kö nig IR, Baumert J, Linsel-Nitschke P, Gieger C, Tennstedt S, Belcredi P. Genome-wide association study identifies a new locus for coronary artery disease on chromosome 10p11.23. Eur Heart J 2011;32:158-168.
11. Schunkert H, Kö nig IR, Kathiresan S, Reilly MP, Assimes TL, Holm H, Preuss M, Stewart AFR, Barbalic M, Gieger C. Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. Nat Genet 2011;43:333-338.
12. Coronary Artery Disease (C4D) Genetics Consortium.Agenome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease. Nat Genet 2011;43:339-344.
13. Wang F, Xu CQ, He Q, Cai JP, Li XC, Wang D, Xiong X, Liao YH, Zeng QT, Yang YZ. Genome-wide association identifies a susceptibility locus for coronary artery disease in the Chinese Han population. Nat Genet 2011;43:345-349.
14. Roberts R, Stewart AFR. The genetics of coronary artery disease. Curr Opin Cardiol 2012;27:221.
15. Zeller T, Blankenberg S, Diemert P. Genomewide association studies in cardiovascular disease-an update 2011. Clin Chem 2012;58:92-103.
16. Adams HP, del Zoppo G, Alberts MJ, Bhatt DL, Brass L, Furlan A, Grubb RL, Higashida RT, Jauch EC, Kidwell C, Lyden PD, Morgenstern LB, Qureshi AI, Rosenwasser RH, Scott PA, Wijdicks EFM. Guidelines for the early management of adults with ischemic stroke: A guideline from the American Heart Association/American Stroke Association Stroke Council, Clinical Cardiology Council, Cardiovascular Radiology and Intervention Council, and the Atherosclerotic Peripheral Vascular Disease and Quality of Care Outcomes in Research Interdisciplinary Working Groups: The American Academy of Neurology affirms the value of this guideline as an educational tool for neurologists. Circulation 2007;115:e478-e534.
17. Sakalihasan N, Limet R, Defawe O. Abdominal aortic aneurysm. The Lancet 2005; 365:1577-1589.
18. Griffin BP, Topol EJ. Manual of Cardiovascular Medicine. Philadelphia, PA: Lippincott Williams & Wilkins, 2008.
19. Hanefeld M, Fischer S, Julius U, Schulze J, Schwanebeck U, Schmechel H, Ziegelasch H, Lindner J. Risk factors for myocardial infarction and death in newly detected NIDDM: The Diabetes Intervention Study, 11-year follow-up. Diabetologia 1996;39:1577-1583.
20. Beckman J, Creager MA, Libby P. Diabetes and atherosclerosis: Epidemiology, pathophysiology, and management. JAMA 2002;287:2570-2581.
21. Simons PCG, Algra A, Van de Laak M, Grobbee D, Van der Graaf Y. Second manifestations of ARTerial disease (SMART) study: Rationale and design. Eur J Epidemiol 1999;15:773-781.
22. Achterberg S, Cramer MJ, Kappelle LJ, de Borst GJ, Visseren FL, van der Graaf Y, Algra A. Patients with coronary, cerebrovascular or peripheral arterial obstructive disease differ in risk for new vascular events and mortality: The SMART study. Eur J Cardiovasc Prev Rehabil 2010;17:424-430.
23. Purcell S, Neale B, Todd-BrownK, Thomas L, Ferreira MA, Bender D, Maller J, Sklar P, De Bakker PI, Daly MJ. PLINK: A tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet 2007;81:559-575.
24. Helgadottir A, Thorleifsson G, Magnusson KP, Grétarsdottir S, Steinthorsdottir V, Manolescu A, Jones GT, Rinkel GJ, Blankensteijn JD, Ronkainen A. The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysm. Nat Genet 2008;40:217-224.
25. Matarin M, Brown WM, Singleton A, Hardy JA, Meschia JF. Whole genome analyses suggest ischemic stroke and heart disease share an association with polymorphisms on chromosome 9p21. Stroke 2008;39:1586-1589.
26. Cluett C, McDermott MM, Guralnik J, Ferrucci L, Bandinelli S, Miljkovic I, Zmuda JM, Li R, Tranah G, Harris T, Rice N, Henley W, Frayling TM, Murray A, Melzer D. The 9p21 myocardial infarction risk allele increases risk of peripheral artery disease in older people. Circ Cardiovasc Genet 2009;2:347-353.
27. Murabito JM, White CC, Kavousi M, Sun YV, Feitosa MF, Nambi V, Lamina C, Schillert A, Coassin S, Bis JC. Association between chromosome 9p21 variants and the ankle-brachial index identified by a meta-analysis of 21 genome-wide association studies. Circ Cardiovasc Genet 2012;5:100-112.
28. Kathiresan S, Willer CJ, Peloso GM, Demissie S, Musunuru K, Schadt EE, Kaplan L, Bennett D, Li Y, Tanaka T. Common variants at 30 loci contribute to polygenic dyslipidemia. Nat Genet 2008;41:56-65.
29. Johansen CT, Wang J, Lanktree MB, Cao H, McIntyre AD, Ban MR, Martins RA, Kennedy BA, Hassell RG, Visser ME. Excess of rare variants in genes identified by genome-wide association study of hypertriglyceridemia. Nat Genet 2010;42: 684-687.
30. Waterworth DM, Ricketts SL, Song K, Chen L, Zhao JH, Ripatti S, Aulchenko YS, Zhang W, Yuan X, Lim N. Genetic variants influencing circulating lipid levels and risk of coronary artery disease. Arterioscler Thromb Vasc Biol 2010;30:2264-2276.
31. Lanktree MB, Dichgans M, Hegele RA. Advances in genomic analysis of stroke: What have we learned and where are we headed? Stroke 2010;41:825-832.
32. Cole JW, Meschia JF. Stroke genetics update: 2011. Curr Cardiovasc Risk Rep 2011;5: 533-541.
33. Goldstein LB, Bushnell CD, Adams RJ, Appel LJ, Braun LT, Chaturvedi S, Creager MA, Culebras A, Eckel RH, Hart RG. Guidelines for the primary prevention of stroke: A guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke 2011;42:517-584.
34. Ripatti S, Tikkanen E, Orho-Melander M, Havulinna AS, Silander K, Sharma A, Guiducci C, Perola M, Jula A, Sinisalo J, Lokki M-L, Nieminen MS, Melander O, Salomaa V, Peltonen L, Kathiresan S. A multilocus genetic risk score for coronary heart disease: Case-control and prospective cohort analyses. Lancet 2010;376: 1393-1400.
35. Patel RS, Sun YV, Hartiala J, Veledar E, Su S, Sher S, Liu YX, Rahman A, Patel R, Rab ST. Association of a genetic risk score with prevalent and incident myocardial infarction in subjects undergoing coronary angiography. Circ Cardiovasc Genet 2012;5:441-449.
36. van Setten J, Isgum I, Smolonska J, Ripke S, de Jong PA, Oudkerk M, de Koning H, Lammers J-W, Zanen P, Groen HJ, Marike Boezen H, Postma DS, Wijmenga C, Viergever MA, Mali WP, de Bakker PI. Genome-wide association study of coronary and aortic calcification implicates risk loci for coronary artery disease and myocardial infarction. Atherosclerosis 2013;228:400-405.
37. Paynter NP, Chasman DI, Paré G, Buring JE, Cook NR, Miletich JP, Ridker PM. Association between a literature-based genetic risk score and cardiovascular events in women. JAMA 2010;303:631-637.
38. Talmud PJ, Shah S, Whittall R, Futema M, Howard P, Cooper JA, Harrison SC, Li K, Drenos F, Karpe F, Neil HAW, Descamps OS, Langenberg C, Lench N, Kivimaki M, Whittaker J, Hingorani AD, Kumari M, Humphries SE. Use of low-density lipoprotein cholesterol gene score to distinguish patients with polygenic and monogenic familial hypercholesterolaemia: A case-control study. Lancet 2013;381:1293-1301.
39. Deloukas P, Kanoni S, Willenborg C, Farrall M, Assimes TL, Thompson JR, Ingelsson E, Saleheen D, Erdmann J, Goldstein BA, Stirrups K, Kö nig IR, Cazier JB, Johansson A, Hall AS, Lee JY, Willer CJ, Chambers JC, Esko T, Folkersen L, Goel A, Grundberg E, Havulinna AS, Ho WK, Hopewell JC, Eriksson N, Kleber ME, Kristiansson K, Lundmark P, Lyytikinen LP, Rafelt S, Shungin D, Strawbridge RJ, Thorleifsson G, Tikkanen E, Van Zuydam N, Voight BF, Waite LL, Zhang W, Ziegler A, Absher D, Altshuler D, Balmforth AJ, Samani NJ. Large-scale association analysis identifies new risk loci for coronary artery disease. Nat Genet 2013;45:25-33.