Perioperative supplemental oxygen to reduce surgical site infection after open fixation of high-risk fractures: A randomized controlled pilot trial

Journal of Trauma and Acute Care Surgery

Volumn 75, Issue 4, 2013, Pages 657-663

  Stall, Alec ^a   Paryavi, Ebrahim ^a   Gupta, Rishi ^a   Zadnik, Mary ^a   Hui, Emily ^a   O'Toole, Robert V ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

calcaneus fracture; pilon fracture; supplemental perioperative oxygen; Surgical site infection; tibial plateau fracture

Indexed keywords

CEFAZOLIN;

ADULT; ANTIBIOTIC PROPHYLAXIS; ARTICLE; CALCANEUS FRACTURE; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; FEMALE; FOLLOW UP; FRACTURE FIXATION; HEALTH CARE QUALITY; HIGH RISK POPULATION; HOSPITALIZATION; HUMAN; HYPEROXIA; HYPOTHESIS; INFECTION RATE; INFECTION RISK; LEG FRACTURE; LENGTH OF STAY; MAJOR CLINICAL STUDY; MALE; NON REBREATHING VALVE; OPEN FRACTURE; OPEN REDUCTION; OPERATION DURATION; OSTEOSYNTHESIS; OUTCOME ASSESSMENT; OXYGEN SATURATION; OXYGEN THERAPY; PARALLEL DESIGN; PERIOPERATIVE PERIOD; PRIORITY JOURNAL; PULSE OXIMETRY; RANDOMIZATION; RANDOMIZED CONTROLLED TRIAL; RISK FACTOR; SURGICAL INFECTION; TIBIA FRACTURE; WOUND ASSESSMENT;

ADULT; CALCANEUS; DOUBLE-BLIND METHOD; FEMALE; FRACTURE FIXATION, INTERNAL; FRACTURES, OPEN; HUMANS; MALE; OXYGEN INHALATION THERAPY; PERIOPERATIVE PERIOD; PILOT PROJECTS; RISK FACTORS; SURGICAL WOUND INFECTION; TIBIAL FRACTURES;

EID: 84885349308     PISSN: 21630755     EISSN: 21630763     Source Type: Journal    
DOI: 10.1097/TA.0b013e3182a1fe83     Document Type: Article

References (32)

1. Kirkland KB, Briggs JP, Trivette SL, Wilkinson WE, Sexton DJ. The impact of surgical-site infections in the 1990s: attributable mortality, excess length of hospitalization, and extra costs. Infect Control Hosp Epidemiol. 1999;20:725-730.
2. Bratzler DW, Houck PM, Richards C, Steele L, Dellinger EP, Fry DE, Wright C, Ma A, Carr K, Red L. Use of antimicrobial prophylaxis for major surgery: baseline results from the National Surgical Infection Prevention Project. Arch Surg. 2005;140:174-182.
3. Barei DP, Nork SE, Mills WJ, Henley MB, Benirschke SK. Complications associated with internal fixation of high-energy bicondylar tibial plateau fractures utilizing a two-incision technique. J Orthop Trauma. 2004; 18:649-657.
4. Bhattacharyya T, Crichlow R, Gobezie R, Kim E, Vrahas MS. Complications associated with the posterolateral approach for pilon fractures. J Orthop Trauma. 2006;20:104-107.
5. Kline AJ, Gruen GS, Pape HC, Tarkin IS, Irrgang JJ, Wukich DK. Early complications following the operative treatment of pilon fractures with and without diabetes. Foot Ankle Int. 2009;30:1042-1047.
6. Sirkin M, Sanders R, DiPasquale T, Herscovici D Jr. A staged protocol for soft tissue management in the treatment of complex pilon fractures. J Orthop Trauma. 2004;18(Suppl 8):S32-S38.
7. Whitehouse JD, Friedman ND, Kirkland KB, Richardson WJ, Sexton DJ. The impact of surgical-site infections following orthopedic surgery at a community hospital and a university hospital: adverse quality of life, excess length of stay, and extra cost. Infect Control Hosp Epidemiol. 2002;23:183-189.
8. Belda FJ, Aguilera L, Garcia de la Asuncio'n J, Alberti J, Vincente R, Ferrandiz L, Rodriguez R, Company R, Sessler DI, Aguilar G, et al., Spanish Recuddion de la Tasa de Infeccion Quirurgica Group. Supplemental perioperative oxygen and the risk of surgical wound infection: a randomized controlled trial. JAMA. 2005;294:2035-2042.
9. Greif R, Akcia O, Horn EP, Kurz A, Sessler DI, Outcomes Research Group. Supplemental perioperative oxygen to reduce the incidence of surgicalwound infection. N Engl J Med. 2000;342:161-167.
10. Meyhoff CS, Wetterslev J, Jorgensen LN, Henneberg SW, Hdall C, Lundvall L, Svendsen PE, Mollerup H, Lunn TH, Simonsen I, et al., PROXI Trial Group. Effect of high perioperative oxygen fraction on surgical site infection and pulmonary complications after abdominal surgery: the PROXI randomized clinical trial. JAMA. 2009;302:1543-1550.
11. Pryor KO, Fahey TJ III, Lien CA, Goldstein PA. Surgical site infection and the routine use of perioperative hyperoxia in a general surgical population: a randomized controlled trial. JAMA. 2004;291:79-87.
12. Mayzler O, Weksler N, Domchik S, Klein M, Mizrahi S, Gurman GM. Does supplemental perioperative oxygen administration reduce the incidence of wound infection in elective colorectal surgery? Minerva Anestesiol. 2005;71:21-25.
13. Bickel A, Gurevits M, Vamos R, Ivry S, Eitan A. Perioperative hyperoxygenation and wound site infection following surgery for acute appendicitis: a randomized, prospective, controlled trial. Arch Surg. 2011; 146:464-470.
14. Fakhry SM. Peri-operative oxygen and the risk of surgical infection. Surg Infect (Larchmt). 2012;13:228-233.
15. Kao LS, Millas SG, Pedroza C, Tyson JE, Lally KP. Should perioperative supplemental oxygen be routinely recommended for surgery patients? A Bayesian meta-analysis. Ann Surg. 2012;256:894-901.
16. Thibon P, Borgey F, Boutreux S, Hanouz JL, Le Coutour X, Parienti JJ. Effect of perioperative oxygen supplementation on 30-day surgical site infection rate in abdominal, gynecologic, and breast surgery: the ISO2 randomized controlled trial. Anesthesiology. 2012;117:504-511.
17. Anthony T, Murray BW, Sum-Ping JT, Lenkovsky F, Vornik VD, Parker BJ, McFarlin JE, Hartless K, Huerta S. Evaluating an evidence-based bundle for preventing surgical site infection: a randomized trial. Arch Surg. 2011; 146:263-269.
18. Al-Niaimi A, Safdar N. Supplemental perioperative oxygen for reducing surgical site infection: a meta-analysis. J Eval Clin Pract. 2009;15: 360-365.
19. Qadan M, Akca O, Mahid SS, Hornung CA, Polk HC Jr. Perioperative supplemental oxygen therapy and surgical site infection: a meta-analysis of randomized controlled trials. Arch Surg. 2009;144:359-366.
20. Togioka B, Galvagno S, Sumida S, Murphy J, Ouanes JP,Wu C. The role of perioperative high inspired oxygen therapy in reducing surgical site infection: a meta-analysis. Anesth Analg. 2012;114:334-342.
21. Miles AA, Miles EM, Burke J. The value and duration of defence reactions of the skin to the primary lodgement of bacteria. Br J Exp Pathol. 1957;38:79-96.
22. Babior BM. Oxygen-dependent microbial killing by phagocytes (first of two parts). N Engl J Med. 1978;298:659-668.
23. Babior BM. Oxygen-dependent microbial killing by phagocytes (second of two parts). N Engl J Med. 1978;298:721-725.
24. Hopf HW, Hunt TK, West JM, Blomquist P, Goodson WH III, Jensen JA, Jonsson K, Paty PB, Rabkin JM, Upton RA, et al. Wound tissue oxygen tension predicts the risk of wound infection in surgical patients. Arch Surg. 1997;132:997-1004.
25. Haley RW, Culver DH, Morgan WM, White JW, Emori TG, Hooton TM. Identifying patients at high risk of surgical wound infection: a simple multivariate index of patient susceptibility and wound contamination. Am J Epidemiol. 1985;121:206-215.
26. Hunt TK, Linsey M, Grislis H, Sonne M, Jawetz E. The effect of differing ambient oxygen tensions on wound infection. Ann Surg. 1975;181:35-39.
27. Paryavi E, Stall A, Gupta R, Scharfstein DO, Castillo RC, Zadnik M, Hui E, O'Toole RV. Predictive model for surgical-site infection risk after surgery for high-energy lower extremity fractures: development of the Risk of Infection in Orthopaedic Trauma Surgery score. J Trauma Acute Care Surg. 2013;74:1521-1527.
28. Gustilo RB, Anderson JT. Prevention of infection in the treatment of one thousand and twenty-five open fractures of long bones: retrospective and prospective analysis. J Bone Joint Surg Am. 1976;58:453-458.
29. Horan TC, Gaynes RP, Martone WJ, Jarvis WR, Emori TG. CDC definitions of nosocomial surgical site infections, 1992: a modification of CDC definitions of surgical wound infections. Infect Control Hosp Epidemiol. 1992;13:606-608.
30. Wilson AP, Treasure T, Sturridge MF, Gruneberg RN. A scoring method (ASEPSIS) for postoperative wound infections for use in clinical trials of antibiotic prophylaxis. Lancet. 1986;1:311-313.
31. Culver DH, Horan TC, Gaynes RP, Martone WJ, Jarvis WR, Emori TG, Banerjee SN, Edwards JR, Tolson JS, Henderson TS, et al. Surgicalwound infection rates by wound class, operative procedure, and patient risk index: National Nosocomial Infections Surveillance System. Am J Med. 1991; 91:152SY157S.
32. Allen DB, Maguire JJ, Mahdavian M,Wicke C, Marcocci L, Scheuenstuhl H, Chang M, Le AX, Hopf HW, Hunt TK. Wound hypoxia and acidosis limit neutrophil bacterial killing mechanisms. Arch Surg. 1997;132: 991-996.