New di(hetero)arylethers and di(hetero)arylamines in the thieno[3,2-b]pyridine series: Synthesis, growth inhibitory activity on human tumor cell lines and non-tumor cells, effects on cell cycle and on programmed cell death

European Journal of Medicinal Chemistry

Volumn 69, Issue , 2013, Pages 855-862

  Queiroz, Maria João R P ^a   Peixoto, Daniela ^a   Calhelha, Ricardo C ^a,b   Soares, Pedro ^a   Dos Santos, Tiago ^c   Lima, Raquel T ^c   Campos, Joana F ^a   Abreu, Rui M V ^b   Ferreira, Isabel C F R ^b   Vasconcelos, M Helena ^c  

^a UNIVERSITY OF MINHO   (Portugal)

^b INSTITUTO POLITÉCNICO DE BRAGANÇA   (Portugal)

^c UNIVERSITY OF PORTO   (Portugal)

Author keywords

Cell cycle analysis and cell death; Di(hetero)arylethers Di(hetero)arylamines; Metal catalyzed couplings; Thieno 3,2 b pyridines; Tumor and nontumor cells growth inhibition

Indexed keywords

7 (2 FLUROPHENOXY)THIENO[3,2 BETA]PYRIDINE; 7 (2 METHOXYPHENOXY)THIENO[3,2 BETA]PYRIDINE; 7 (3 FLUROPHENOXY)THIENO[3,2 BETA]PYRIDINE; 7 (3 METHOXYPHENOXY)THIENO[3,2 BETA]PYRIDINE; 7 (4 FLUROPHENOXY)THIENO[3,2 BETA]PYRIDINE; 7 (4 METHOXYPHENOXY)THIENO[3,2 BETA]PYRIDINE; ANTINEOPLASTIC AGENT; AROMATIC AMINE; COPPER; DI(HETERO)ARYLAMINE DERIVATIVE; DI(HETERO)ARYLETHER DERIVATIVE; N (2 FLUOROPHENYL)THIENO[3,2 BETA]PYRIDIN 7 AMINE; N (2 METHOXYPHENYL)THIENO[3,2 BETA]PYRIDIN 7 AMINE; N (3 FLUOROPHENYL)THIENO[3,2 BETA]PYRIDIN 7 AMINE; N (3 METHOXYPHENYL)THIENO[3,2 BETA]PYRIDIN 7 AMINE; N (4 FLUOROPHENYL)THIENO[3,2 BETA]PYRIDIN 7 AMINE; N (4 METHOXYPHENYL)THIENO[3,2 BETA]PYRIDIN 7 AMINE; PALLADIUM; THIENO[3,2 BETA]PYRIDINE DERIVATIVE; THIENOPYRIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST ADENOCARCINOMA; CANCER INHIBITION; CELL CYCLE; COLON CARCINOMA; FLUORINATION; HUMAN; HUMAN CELL; LIVER CELL CARCINOMA; LIVER TOXICITY; LUNG NON SMALL CELL CANCER; TUMOR CELL LINE; UTERINE CERVIX CARCINOMA;

CELL CYCLE ANALYSIS AND CELL DEATH; DI(HETERO)ARYLAMINES; DI(HETERO)ARYLETHERS; METAL-CATALYZED COUPLINGS; THIENO[3,2-B]PYRIDINES; TUMOR AND NONTUMOR CELLS GROWTH INHIBITION;

AMINES; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL CYCLE; CELL LINE; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; ETHERS; HELA CELLS; HEP G2 CELLS; HUMANS; MCF-7 CELLS; MOLECULAR STRUCTURE; NEOPLASMS; PYRIDINES; STRUCTURE-ACTIVITY RELATIONSHIP; THIOPHENES;

EID: 84885340733     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2013.09.023     Document Type: Article

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