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Volumn 46, Issue 1, 2011, Pages 236-240

Synthesis and evaluation of tumor cell growth inhibition of methyl 3-amino-6-[(hetero)arylethynyl]thieno[3,2-b]pyridine-2-carboxylates. Structure-activity relationships, effects on the cell cycle and apoptosis

(6) Queiroz, Maria João R P a Calhelha, Ricardo C a Vale Silva, Luís A b Pinto, Eugénia b Almeida, Gabriela M b Vasconcelos, M Helena b

a UNIVERSITY OF MINHO (Portugal)

b UNIVERSITY OF PORTO (Portugal)

Author keywords

Antitumoral activity; Apoptosis; Cell cycle; Sonogashira coupling; Thieno 3,2 b pyridines

Indexed keywords

ANTINEOPLASTIC AGENT; CARBOXYLIC ACID DERIVATIVE; DOXORUBICIN; METHYL 3 AMINO 6 (2 PHENYLETHYNYL)THIENO[3,2 B]PYRIDINE 2 CARBOXYLIC ACID; METHYL 3 AMINO 6 [2 (2 AMINOPHENYL)ETHYNYL]THIENO[3,2 B]PYRIDINE 2 CARBOXYLIC ACID; METHYL 3 AMINO 6 [2 (2 FLUOROPHENYL)ETHYNYL]THIENO[3,2 B]PYRIDINE 2 CARBOXYLIC ACID; METHYL 3 AMINO 6 [2 (2 METHOXYPHENYL)ETHYNYL]THIENO[3,2 B]PYRIDINE 2 CARBOXYLIC ACID; METHYL 3 AMINO 6 [2 (3 AMINOPHENYL)ETHYNYL]THIENO[3,2 B]PYRIDINE 2 CARBOXYLIC ACID; METHYL 3 AMINO 6 [2 (3 METHOXYPHENYL)ETHYNYL]THIENO[3,2 B]PYRIDINE 2 CARBOXYLIC ACID; METHYL 3 AMINO 6 [2 (4 AMINOPHENYL)ETHYNYL]THIENO[3,2 B]PYRIDINE 2 CARBOXYLIC ACID; METHYL 3 AMINO 6 [2 (4 FLUOROPHENYL)ETHYNYL]THIENO[3,2 B]PYRIDINE 2 CARBOXYLIC ACID; METHYL 3 AMINO 6 [2 (4 METHOXYPHENYL)ETHYNYL]THIENO[3,2 B]PYRIDINE 2 CARBOXYLIC ACID; METHYL 3 AMINO 6 [2 (PYRIDIN 2 YL)ETHYNYL]THIENO[3,2 B]PYRIDINE 2 CARBOXYLIC ACID; METHYL 3 AMINO 6 [2 (PYRIDIN 3 YL)ETHYNYL]THIENO[3,2 B]PYRIDINE 2 CARBOXYLIC ACID; METHYL 3 AMINO 6 [2 (THIEN 3 YL)ETHYNYL]THIENO[3,2 B]PYRIDINE 2 CARBOXYLIC ACID; METHYL 3 AMINO 6 [2 [4 (DIMETHYLAMINO)PHENYL]ETHYNYL][3,2 B]PYRIDINE 2 CARBOXYLIC ACID; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CELL CYCLE ARREST; CELL GROWTH; CONTROLLED STUDY; DRUG MECHANISM; DRUG SYNTHESIS; HUMAN; HUMAN CELL; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CARBOXYLIC ACIDS; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 78650510707 PISSN: 02235234 EISSN: 17683254 Source Type: Journal
DOI: 10.1016/j.ejmech.2010.11.009 Document Type: Article

Times cited : (31)

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