Pharmacogenetic activation of midbrain dopaminergic neurons induces hyperactivity

Neuroscience Bulletin

Volumn 29, Issue 5, 2013, Pages 517-524

  Wang, Shujie ^a,b   Tan, Yan ^a,c   Zhang, Ju En ^b,d   Luo, Minmin ^b,d  

^a JILIN UNIVERSITY   (China)

^b NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES   (China)

^c People's Hospital of Jilin Province   (China)

^d TSINGHUA UNIVERSITY   (China)

Author keywords

clozapine N oxide; electrophysiology; motor activity; pharmacogenetics

Indexed keywords

CLOZAPINE N OXIDE; DOPAMINE; MUSCARINIC M3 RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BEHAVIOR; CELL FUNCTION; CONTROLLED STUDY; DOPAMINERGIC NERVE CELL; HYPERACTIVITY; LOCOMOTION; MESENCEPHALON; MOTOR ACTIVITY; MOUSE; NERVE CELL STIMULATION; NONHUMAN; PHARMACOGENETICS; PROTEIN EXPRESSION;

ANIMALS; CLOZAPINE; DOPAMINERGIC NEURONS; HYPERKINESIS; IMMUNOHISTOCHEMISTRY; MESENCEPHALON; MICE; MICE, TRANSGENIC; MOTOR ACTIVITY;

EID: 84885320777     PISSN: 16737067     EISSN: 19958218     Source Type: Journal    
DOI: 10.1007/s12264-013-1327-x     Document Type: Article

References (19)

1. Seeman P, Van Tol HH. Dopamine receptor pharmacology. Trends Pharmacol Sci 1994, 15: 264-270.
2. Bjorklund A, Dunnett SB. Dopamine neuron systems in the brain: an update. Trends Neurosci 2007, 30: 194-202.
3. Schultz W. Behavioral dopamine signals. Trends Neurosci 2007, 30: 203-210.
4. Xu M, Hu XT, Cooper DC, Moratalla R, Graybiel AM, White FJ, et al. Elimination of cocaine-induced hyperactivity and dopamine-mediated neurophysiological effects in dopamine D1 receptor mutant mice. Cell 1994, 79: 945-955.
5. Giros B, Jaber M, Jones SR, Wightman RM, Caron MG. Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter. Nature 1996, 379: 606-612.
6. Gainetdinov RR, Wetsel WC, Jones SR, Levin ED, Jaber M, Caron MG. Role of serotonin in the paradoxical calming effect of psychostimulants on hyperactivity. Science 1999, 283: 397-401.
7. Emilien G, Maloteaux JM, Geurts M, Hoogenberg K, Cragg S. Dopamine receptors - physiological understanding to therapeutic intervention potential. Pharmacol Ther 1999, 84: 133-156.
8. Olanow CW, Tatton WG. Etiology and pathogenesis of Parkinson's disease. Annu Rev Neurosci 1999, 22: 123-144.
9. Armbruster BN, Li X, Pausch MH, Herlitze S, Roth BL. Evolving the lock to fit the key to create a family of G proteincoupled receptors potently activated by an inert ligand. Proc Natl Acad Sci U S A 2007, 104: 5163-5168.
10. Alexander GM, Rogan SC, Abbas AI, Armbruster BN, Pei Y, Allen JA, et al. Remote control of neuronal activity in transgenic mice expressing evolved G protein-coupled receptors. Neuron 2009, 63: 27-39.
11. Dong S, Rogan SC, Roth BL. Directed molecular evolution of DREADDs: a generic approach to creating next-generation RASSLs. Nat Protoc 2010, 5: 561-573.
12. Zhang F, Gradinaru V, Adamantidis AR, Durand R, Airan RD, de Lecea L, et al. Optogenetic interrogation of neural circuits: technology for probing mammalian brain structures. Nat Protoc 2010, 5: 439-456.
13. Duan D, Yue Y, Engelhardt JF. Expanding AAV packaging capacity with trans-splicing or overlapping vectors: a quantitative comparison. Mol Ther 2001, 4: 383-391.
14. Zhuang X, Oosting RS, Jones SR, Gainetdinov RR, Miller GW, Caron MG, et al. Hyperactivity and impaired response habituation in hyperdopaminergic mice. Proc Natl Acad Sci U S A 2001, 98: 1982-1987.
15. Gong R, Ding C, Hu J, Lu Y, Liu F, Mann E, et al. Role for the membrane receptor guanylyl cyclase-C in attention deficiency and hyperactive behavior. Science 2011, 333: 1642-1646.
16. Volkow ND, Wang GJ, Kollins SH, Wigal TL, Newcorn JH, Telang F, et al. Evaluating dopamine reward pathway in ADHD: clinical implications. JAMA 2009, 302: 1084-1091.
17. Russell VA. Neurobiology of animal models of attentiondeficit hyperactivity disorder. J Neurosci Methods 2007, 161: 185-198.
18. Sagvolden T, Russell VA, Aase H, Johansen EB, Farshbaf M. Rodent models of attention-deficit/hyperactivity disorder. Biol Psychiatry 2005, 57: 1239-1247.
19. Hess EJ, Collins KA, Wilson MC. Mouse model of hyperkinesis implicates SNAP-25 in behavioral regulation. J Neurosci 1996, 16: 3104-3111.