CEST and PARACEST MR contrast agents

Acta Radiologica

Volumn 51, Issue 8, 2010, Pages 910-923

  Hancu, Ileana ^a   Dixon, W Thomas ^a   Woods, Mark ^b   Vinogradov, Elena ^c   Sherry, A Dean ^b,d   Lenkinski, Robert E ^c  

^a GE GLOBAL RESEARCH   (United States)

^b UNIVERSITY OF TEXAS AT DALLAS   (United States)

^c BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^d UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Magnetization transfer; Model studies; Paramagnetic agents; Target image

Indexed keywords

CHEMICAL EXCHANGE SATURATION TRANSFER; CLINICAL APPLICATION; CONTRAST AGENT; IN-VITRO; IN-VIVO; MAGNETIZATION TRANSFER; MODEL STUDIES; MR CONTRAST AGENTS; MR IMAGING; ONLINE VERSIONS; PARACEST; PARAMAGNETIC AGENTS; TARGET IMAGE;

MAGNETIC RESONANCE IMAGING; MAGNETIZATION; PARAMAGNETIC MATERIALS;

MAGNETIC RESONANCE;

CONTRAST MEDIUM; LANTHANIDE;

CHEMISTRY; HUMAN; MAGNETISM; METHODOLOGY; NUCLEAR MAGNETIC RESONANCE IMAGING; REVIEW;

CONTRAST MEDIA; HUMANS; LANTHANOID SERIES ELEMENTS; MAGNETIC RESONANCE IMAGING; MAGNETICS;

EID: 77956516259     PISSN: 02841851     EISSN: 16000455     Source Type: Journal    
DOI: 10.3109/02841851.2010.502126     Document Type: Review

References (47)

1. DeMartini W, Lehman C, Partridge S. Breast MRI for cancer detection and characterization: a review of evidencebased clinical applications. Acad Radiol 2008;15:408-416
2. Smirniotopoulos JG, Murphy FM, Rushing EJ, Rees JH, Schroeder JW. Patterns of contrast enhancement in the brain and meninges. Radiographics 2007;27:525-551
3. Bakshi R. Magnetic resonance imaging advances in multiple sclerosis. J Neuroimaging 2005;15(4 Suppl):5S-9S. (Pubitemid 43010527)
4. Blumenkrantz G, Majumdar S. Quantitative magnetic resonance imaging of articular cartilage in osteoarthritis. Eur Cell Mater 2007;13:76-86.
5. Hartman KB, Laus S, Bolskar RD, Muthupillai R, Helm L, Toth E, et al. Gadonanotubes as ultrasensitive pHsmart probes for magnetic resonance imaging. Nano Lett 2008;8:415-419
6. Huinink HP, Sanders HM, Erich SJ, Nicolay K, Strijkers GJ, Merkx M, et al. High-resolution NMR imaging of paramagnetic liposomes targeted to a functionalized surface. Magn Reson Med 2008;59:1282-1286
7. Forsen S, Hoffman RA. Study of moderately rapid chemical exchange reactions by means of nuclear magnetic double resonance. J Chem Phys 1963;39:2892-2901
8. Ward KM, Aletras AH, Balaban RS. A new class of contrast agents for MRI based on proton chemical exchange dependent saturation transfer (CEST). J Magn Reson 2000;143:79-87.
9. Henkelman RM, Stanisz GJ, Graham SJ. Magnetization transfer in MRI: a review. NMR Biomed 2001;14:57-64.
10. Zhang S, Winter P, Wu K, Sherry AD. A novel Europium(III)- based MRI contrast agent. J Am Chem Soc 2001;123: 1517-1518
11. Ward KM, Balaban RS. Determination of pH using water protons and chemical exchange dependent saturation transfer (CEST). Magn Reson Med 2000;44:799-802.
12. Goffeney N, Bulte JW, Duyn J, Bryant LH Jr, van Zijl PC. Sensitive NMR detection of cationic-polymer-based gene delivery systems using saturation transfer via proton exchange. J Am Chem Soc 2001;123:8628-8629
13. Pikkemaat JA, Wegh RT, Lamerichs R, van de Molengraaf RA, Langereis S, Burdinski D, et al. Dendritic PARACEST contrast agents for magnetic resonance imaging. Contrast Media Mol Imaging 2007;2:229-239
14. Gilad AA, McMahon MT, Walczak P, Winnard PT Jr, Raman V, van Laarhoven HW, et al. Artificial reporter gene providing MRI contrast based on proton exchange. Nat Biotechnol 2007;25:217-219
15. Hinckley CC. Lanthanide shift reagents. Proc Rare Earth Res Conf, 10th. 1973;1(CONF-730402-P1):362-371
16. Hinckley CC. Applications of lanthanide shift reagents. Mod Methods Steroid Anal 1973:265-279
17. Peters JA, Huskens J, Raber DJ. Lanthanide induced shifts and relaxation rate enhancements. Progress in Nuclear Magnetic Resonance Spectroscopy 1996;28:283-350.
18. Lauffer RB. Paramagnetic metal complexes as water proton relaxation agents for NMR imaging: theory and design. Chem Rev 1987;87:901-927
19. Caravan P, Ellison JJ, McMurry TJ, Lauffer RB. Gadolinium(III) chelates as MRI contrast agents: structure, dynamics, and applications. Chem Rev 1999;99:2293-2352
20. Merbach AE, Toth E, editors. The chemistry of contrast agents in medical magnetic resonance imaging. New York: Wiley; 2001.
21. Zhang S, Merrit M, Woessner DE, Lenkinski RE, Sherry AD. PARACEST agents: modulating MRI contrast via water proton exchange. Acc Chem Res 2003;36:783-790
22. Bleaney B. Nuclear magnetic resonance shifts in solution due to lanthanide ions. J Magn Reson 1972;8:91-100.
23. Bleaney B, Dobson CM, Levine BA, Martin RB, Williams RJP, Xavier AV. Origin of lanthanide nuclear magnetic resonance shifts and their uses. J Chem Soc Chem Commun 1972:791-793
24. Powell DH, Ni Dhubhghaill OM, Pubanz D, Helm L, Lebedev YS, Schlaepfer W, et al. High-pressure NMR kinetics. Part 74. Structural and dynamic parameters obtained from 17O NMR, EPR, and NMRD studies of monomeric and dimeric Gd3+ complexes of interest in magnetic resonance imaging: an integrated and theoretically self-consistent approach. J Am Chem Soc 1996;118:9333-9346
25. Aime S, Barge A, Bruce JI, Botta M, Howard JAK, Moloney JM, et al. NMR, relaxometric, and structural studies of the hydration and exchange dynamics of cationic lanthanide complexes of macrocyclic tetraamide ligands. J Am Chem Soc 1999;121:5762-5771
26. Ratnakar SJ, Woods M, Kovacs Z, Sherry AD. Modulation of water exchange in Europium(III) DOTA-tetraamide complexes via electronic substituent effects. J Am Chem Soc 2007;130:6-7.
27. Ren J, Trokowski R, Zhang S, Malloy CR, Sherry AD. Imaging the tissue distribution of glucose in livers using A PARACEST sensor. Magn Reson Med 2008;60:1047-1055
28. Trokowski R, Ren JM, Kalman FK, Sherry AD. Selective sensing of zinc ions with a PARACEST contrast agent. Angew Chem Int Ed Engl 2005;44:6920-6923
29. Trokowski R, Zhang S, Sherry AD. Cyclen-based phenylboronate ligands and their Eu3+ complexes for sensing glucose by MRI. Bioconjug Chem 2004;15:1431-1440
30. Terreno E, Castelli DD, Cravotto G, Milone L, Aime S. Ln(III)-DOTAMGly complexes: a versatile series to assess the determinants of the efficacy of paramagnetic chemical exchange saturation transfer agents for magnetic resonance imaging applications. Invest Radiol 2004;39:235-243
31. Zhou J, Lal B, Wilson DA, Laterra J, van Zijl PCM. Amide proton transfer (APT) contrast for imaging of brain tumors. Magn Reson Med 2003;50:1120-1126
32. Aime S, Delli Castelli D, Terreno E. Supramolecular adducts between poly-L-arginine and [TmIIIdotp]: a route to sensitivity- enhanced magnetic resonance imaging-chemical exchange saturation transfer agents. Angew Chem Int Ed Engl 2003;42:4527-4529
33. Aime S, Delli Castelli D, Terreno E. Highly sensitive MRI chemical exchange saturation transfer agents using liposomes. Angew Chem Int Ed Engl 2005;44:5513-5515
34. Terreno E, Barge A, Beltrami L, Cravotto G, Castelli DD, Fedeli F, et al. Highly shifted LIPOCEST agents based on the encapsulation of neutral polynuclear paramagnetic shift reagents. Chem Commun (Camb) 2008;7:600-602
35. Zhao JM, Har-el YE, McMahon MT, Zhou J, Sherry AD, Sgouros G, et al. Size-induced enhancement of chemical exchange saturation transfer (CEST) contrast in liposomes. J Am Chem Soc 2008;130:5178-5184
36. Aime S, Delli Castelli D, Lawson D, Terreno E. Gd-loaded liposomes as T1, susceptibility, and CEST agents, all in one. J Am Chem Soc 2007;129:2430-2431
37. Terreno E, Cabella C, Carrera C, Delli Castelli D, Mazzon R, Rollet C, et al. From spherical to osmotically shrunken paramagnetic liposomes: an improved generation of LIPOCEST MRI agents with highly shifted water protons. Angew Chem Int Ed Engl 2007;46:966-968
38. Terreno E, Castelli DD, Milone L, Rollet S, Stancanello J, Violante E, et al. First ex-vivo MRI co-localization of two LIPOCEST agents. Contrast Media Mol Imaging 2008;3:38-43.
39. Zhou J, Payen JF, Wilson DA, Traystman RJ, van Zijl PC. Using the amide proton signals of intracellular proteins and peptides to detect pH effects in MRI. Nat Med 2003;9:1085-1090
40. Jones CK, Schlosser MJ, van Zijl PC, Pomper MG, Golay X, Zhou J. Amide proton transfer imaging of human brain tumors at 3T. Magn Reson Med 2006;56:585-592
41. van Zijl PC, Jones CK, Ren J, Malloy CR, Sherry AD. MRI detection of glycogen in vivo by using chemical exchange saturation transfer imaging (glycoCEST). Proc Natl Acad Sci U S A 2007;104:4359-4364
42. Ling W, Regatte RR, Navon G, Jerschow A. Assessment of glycosaminoglycan concentration in vivo by chemical exchange-dependent saturation transfer (gagCEST). Proc Natl Acad Sci U S A 2008;105:2266-2270
43. Ali MM, Pagel MD. Longer in vivo retention and accumulation improves detection of PARACEST MRI contrast agents. Proceedings of the International Society for Magnetic Resonance in Medicine, Toronto, 2008.
44. Vinogradov E, Zhang S, Lubag A, Balschi JA, Sherry AD, Lenkinski RE. On-resonance low B1 pulses for imaging of the effects of PARACEST agents. J Magn Reson 2005;176:54-63.
45. Shaka AJ, Keeler J, Freeman R. Evaluation of a new broadband decoupling sequence: WALTZ-16. J Magn Reson 1983;53:313-340
46. Shaka AJ, Keeler J, Frenkiel T, Freeman R. An improved sequence for broadband decoupling: WALTZ-16. J Magn Reson 1983;52:335-338
47. Vinogradov E, He H, Lubag A, Balschi JA, Sherry AD, Lenkinski RE. MRI detection of paramagnetic chemical exchange effects in mice kidneys in vivo . Magn Reson Med 2007;58:650-655