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Volumn 14, Issue 10, 2013, Pages 891-899

The phosphatidylinositol-transfer protein Nir2 binds phosphatidic acid and positively regulates phosphoinositide signalling

Author keywords

EGFR signalling; HAD; lipid second messengers; PA; phosphoinositide signalling

Indexed keywords

GROWTH FACTOR; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDIC ACID; PHOSPHATIDYLINOSITIDE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE; PHOSPHATIDYLINOSITOL TRANSFER PROTEIN NIR2; PHOSPHOLIPID TRANSFER PROTEIN; UNCLASSIFIED DRUG;

EID: 84885312590     PISSN: 1469221X     EISSN: 14693178     Source Type: Journal    
DOI: 10.1038/embor.2013.113     Document Type: Article
Times cited : (102)

References (29)
  • 1
    • 0028451037 scopus 로고
    • Growth factor receptors, phospholipases, phospholipid kinases and actin reorganization
    • Gips SJ, Kandzari DE, Goldschmidt-Clermont PJ (1994) Growth factor receptors, phospholipases, phospholipid kinases and actin reorganization. Semin Cell Biol 5: 201-208
    • (1994) Semin Cell Biol , vol.5 , pp. 201-208
    • Gips, S.J.1    De, K.2    Goldschmidt-Clermont, P.J.3
  • 2
    • 0036280038 scopus 로고    scopus 로고
    • Phosphoinositides and signal transduction
    • Toker A (2002) Phosphoinositides and signal transduction. Cell Mol Life Sci 59: 761-779
    • (2002) Cell Mol Life Sci , vol.59 , pp. 761-779
    • Toker, A.1
  • 3
    • 77951568703 scopus 로고    scopus 로고
    • Phosphoinositide signalling in cancer: Beyond PI3K and PTEN
    • Bunney TD, Katan M (2010) Phosphoinositide signalling in cancer: Beyond PI3K and PTEN. Nat Rev Cancer 10: 342-352
    • (2010) Nat Rev Cancer , vol.10 , pp. 342-352
    • Bunney, T.D.1    Katan, M.2
  • 4
    • 0033571069 scopus 로고    scopus 로고
    • Phosphatidic acid, a key intermediate in lipid metabolism
    • Athenstaedt K, Daum G (1999) Phosphatidic acid, a key intermediate in lipid metabolism. Eur J Biochem 266: 1-16
    • (1999) Eur J Biochem , vol.266 , pp. 1-16
    • Athenstaedt, K.1    Daum, G.2
  • 5
    • 0033534687 scopus 로고    scopus 로고
    • Phospholipase D and its product, phosphatidic acid, mediate agonist-Dependent raf-1 translocation to the plasma membrane and the activation of the mitogen-Activated protein kinase pathway
    • Rizzo MA, Shome K, Vasudevan C, Stolz DB, Sung TC, Frohman MA, Watkins SC, Romero G (1999) Phospholipase D and its product, phosphatidic acid, mediate agonist-Dependent raf-1 translocation to the plasma membrane and the activation of the mitogen-Activated protein kinase pathway. J Biol Chem 274: 1131-1139
    • (1999) J Biol Chem , vol.274 , pp. 1131-1139
    • Ma, R.1    Shome, K.2    Vasudevan, C.3    Stolz, D.B.4    Sung, T.C.5    Ma, F.6    Watkins, S.C.7    Romero, G.8
  • 6
    • 34447568476 scopus 로고    scopus 로고
    • Phospholipase D2-Generated phosphatidic acid couples EGFR stimulation to Ras activation by Sos
    • Zhao C, Du G, Skowronek K, Frohman MA, Bar-Sagi D (2007) Phospholipase D2-Generated phosphatidic acid couples EGFR stimulation to Ras activation by Sos. Nat Cell Biol 9: 706-712
    • (2007) Nat Cell Biol , vol.9 , pp. 706-712
    • Zhao, C.1    Du, G.2    Skowronek, K.3    Ma, F.4    Bar-Sagi, D.5
  • 7
    • 0035976615 scopus 로고    scopus 로고
    • Phosphatidic acid-Mediated mitogenic activation of mTOR signaling
    • Fang Y, Vilella-Bach M, Bachmann R, Flanigan A, Chen J (2001) Phosphatidic acid-Mediated mitogenic activation of mTOR signaling. Science 294: 1942-1945
    • (2001) Science , vol.294 , pp. 1942-1945
    • Fang, Y.1    Vilella-Bach, M.2    Bachmann, R.3    Flanigan, A.4    Chen, J.5
  • 8
    • 0028346383 scopus 로고
    • Type i phosphatidylinositol 4-Phosphate 5-Kinase isoforms are specifically stimulated by phosphatidic acid
    • Jenkins GH, Fisette PL, Anderson RA (1994) Type I phosphatidylinositol 4-Phosphate 5-Kinase isoforms are specifically stimulated by phosphatidic acid. J Biol Chem 269: 11547-11554
    • (1994) J Biol Chem , vol.269 , pp. 11547-11554
    • Jenkins, G.H.1    Fisette, P.L.2    Anderson, R.A.3
  • 9
    • 0030721527 scopus 로고    scopus 로고
    • A new pathway for synthesis of phosphatidylinositol-4,5-Bisphosphate
    • Rameh LE, Tolias KF, Duckworth BC, Cantley LC (1997) A new pathway for synthesis of phosphatidylinositol-4,5-Bisphosphate. Nature 390: 192-196
    • (1997) Nature , vol.390 , pp. 192-196
    • Rameh, L.E.1    Tolias, K.F.2    Duckworth, B.C.3    Cantley, L.C.4
  • 10
    • 0034676003 scopus 로고    scopus 로고
    • Interaction of the type Ialpha PIPkinase with phospholipase D: A role for the local generation of phosphatidylinositol 4,5-Bisphosphate in the regulation of PLD2 activity
    • Divecha N, Roefs M, Halstead JR, D?Andrea S, Fernandez-Borga M, Oomen L, Saqib KM, Wakelam MJ, D?Santos C (2000) Interaction of the type Ialpha PIPkinase with phospholipase D: A role for the local generation of phosphatidylinositol 4,5-Bisphosphate .in the regulation of PLD2 activity. EMBO J 19: 5440-5449
    • (2000) EMBO J , vol.19 , pp. 5440-5449
    • Divecha, N.1    Roefs, M.2    Halstead, J.R.3    Dandrea, S.4    Fernandez-Borga, M.5    Oomen, L.6    Saqib, K.M.7    Wakelam, M.J.8    Dsantos, C.9
  • 11
    • 68949091932 scopus 로고    scopus 로고
    • Phosphatidic acid regulation of phosphatidylinositol 4-Phosphate 5-Kinases
    • Cockcroft S (2009) Phosphatidic acid regulation of phosphatidylinositol 4-Phosphate 5-Kinases. Biochim Biophys Acta 1791: 905-912
    • (2009) Biochim Biophys Acta , vol.1791 , pp. 905-912
    • Cockcroft, S.1
  • 13
    • 59149106049 scopus 로고    scopus 로고
    • Phosphatidic acid phosphatase, a key enzyme in the regulation of lipid synthesis
    • Carman GM, Han GS (2009) Phosphatidic acid phosphatase, a key enzyme in the regulation of lipid synthesis. J Biol Chem 284: 2593-2597
    • (2009) J Biol Chem , vol.284 , pp. 2593-2597
    • Carman, G.M.1    Han, G.S.2
  • 14
    • 2342449334 scopus 로고    scopus 로고
    • Mitotic phosphorylation of the peripheral Golgi protein Nir2 by Cdk1 provides a docking mechanism for Plk1 and affects cytokinesis completion
    • Litvak V, Argov R, Dahan N, Ramachandran S, Amarilio R, Shainskaya A, Lev S (2004) Mitotic phosphorylation of the peripheral Golgi protein Nir2 by Cdk1 provides a docking mechanism for Plk1 and affects cytokinesis completion. Mol Cell 14: 319-330
    • (2004) Mol Cell , vol.14 , pp. 319-330
    • Litvak, V.1    Argov, R.2    Dahan, N.3    Ramachandran, S.4    Amarilio, R.5    Shainskaya, A.6    Lev, S.7
  • 15
    • 14744294236 scopus 로고    scopus 로고
    • Maintenance of the diacylglycerol level in the Golgi apparatus by the Nir2 protein is critical for Golgi secretory function
    • Litvak V, Dahan N, Ramachandran S, Sabanay H, Lev S (2005) Maintenance of the diacylglycerol level in the Golgi apparatus by the Nir2 protein is critical for Golgi secretory function. Nat Cell Biol 7: 225-234
    • (2005) Nat Cell Biol , vol.7 , pp. 225-234
    • Litvak, V.1    Dahan, N.2    Ramachandran, S.3    Sabanay, H.4    Lev, S.5
  • 16
    • 0037015277 scopus 로고    scopus 로고
    • Targeting of Nir2 to lipid droplets is regulated by a specific threonine residue within its PI-Transfer domain
    • Litvak V, Shaul YD, Shulewitz M, Amarilio R, Carmon S, Lev S (2002) Targeting of Nir2 to lipid droplets is regulated by a specific threonine residue within its PI-Transfer domain. Curr Biol 12: 1513-1518
    • (2002) Curr Biol , vol.12 , pp. 1513-1518
    • Litvak, V.1    Shaul, Y.D.2    Shulewitz, M.3    Amarilio, R.4    Carmon, S.5    Lev, S.6
  • 17
    • 0032981482 scopus 로고    scopus 로고
    • Identification of a novel family of targets of PYK2 related to Drosophila retinal degeneration B (rdgB) protein
    • Lev S, Hernandez J,Martinez R, Chen A, Plowman G, Schlessinger J (1999) Identification of a novel family of targets of PYK2 related to Drosophila retinal degeneration B (rdgB) protein. Mol Cell Biol 19: 2278-2288
    • (1999) Mol Cell Biol , vol.19 , pp. 2278-2288
    • Lev, S.1    Hernandez Jmartinez, R.2    Chen, A.3    Plowman, G.4    Schlessinger, J.5
  • 18
    • 33646920976 scopus 로고    scopus 로고
    • The Saccharomyces cerevisiae Lipin homolog is a Mg2?-Dependent phosphatidate phosphatase enzyme
    • Han GS, Wu WI, Carman GM (2006) The Saccharomyces cerevisiae Lipin homolog is a Mg2?-Dependent phosphatidate phosphatase enzyme. J Biol Chem 281: 9210-9218
    • (2006) J Biol Chem , vol.281 , pp. 9210-9218
    • Han, G.S.1    Wu, W.I.2    Carman, G.M.3
  • 19
    • 33947542353 scopus 로고    scopus 로고
    • Three mammalian lipins act as phosphatidate phosphatases with distinct tissue expression patterns
    • Donkor J, Sariahmetoglu M, Dewald J, Brindley DN, Reue K (2007) Three mammalian lipins act as phosphatidate phosphatases with distinct tissue expression patterns. J Biol Chem 282: 3450-3457
    • (2007) J Biol Chem , vol.282 , pp. 3450-3457
    • Donkor, J.1    Sariahmetoglu, M.2    Dewald, J.3    Brindley, D.N.4    Reue, K.5
  • 20
    • 4344585269 scopus 로고    scopus 로고
    • Phosphoryl group transfer: Evolution of a catalytic scaffold
    • Allen KN, Dunaway-Mariano D (2004) Phosphoryl group transfer: Evolution of a catalytic scaffold. Trends Biochem Sci 29: 495-503
    • (2004) Trends Biochem Sci , vol.29 , pp. 495-503
    • Allen, K.N.1    Dunaway-Mariano, D.2
  • 21
    • 0033607641 scopus 로고    scopus 로고
    • Mechanistic studies of phosphoserine phosphatase, an enzyme related to P-Type ATPases
    • Collet JF, Stroobant V, Van Schaftingen E (1999) Mechanistic studies of phosphoserine phosphatase, an enzyme related to P-Type ATPases. J Biol Chem 274: 33985-33990
    • (1999) J Biol Chem , vol.274 , pp. 33985-33990
    • Collet, J.F.1    Stroobant, V.2    Van Schaftingen, E.3
  • 22
    • 79951904580 scopus 로고    scopus 로고
    • Lipins from plants are phosphatidate phosphatases that restore lipid synthesis in a pah1Delta mutant strain of Saccharomyces cerevisiae
    • Mietkiewska E, Siloto RM, Dewald J, Shah S, Brindley DN, Weselake RJ (2010) Lipins from plants are phosphatidate phosphatases that restore lipid synthesis in a pah1Delta mutant strain of Saccharomyces cerevisiae. FEBS J 278: 764-775
    • (2010) FEBS J , vol.278 , pp. 764-775
    • Mietkiewska, E.1    Siloto, R.M.2    Dewald, J.3    Shah, S.4    Brindley, D.N.5    Weselake, R.J.6
  • 23
    • 0029173702 scopus 로고
    • G Protein Activation Stimulates Phospholipase D Signaling in Plants
    • Munnik T, Arisz SA, De Vrije T, Musgrave A (1995) G Protein Activation Stimulates Phospholipase D Signaling in Plants. Plant Cell 7: 2197-2210
    • (1995) Plant Cell , vol.7 , pp. 2197-2210
    • Munnik, T.1    Arisz, S.A.2    De Vrije, T.3    Musgrave, A.4
  • 24
    • 0033594403 scopus 로고    scopus 로고
    • Akt/PKB localisation and 3 phosphoinositide generation at sites of epithelial cell-Matrix and cell-Cell interaction
    • Watton SJ, Downward J (1999) Akt/PKB localisation and 3? phosphoinositide generation at sites of epithelial cell-Matrix and cell-Cell interaction. Curr Biol 9: 433-436
    • (1999) Curr Biol , vol.9 , pp. 433-436
    • Watton, S.J.1    Downward, J.2
  • 25
    • 80053257932 scopus 로고    scopus 로고
    • Tyrosine phosphorylation of the Galpha-Interacting protein GIV promotes activation of phosphoinositide 3-Kinase during cell migration
    • Lin C, Ear J, Pavlova Y, Mittal Y, Kufareva I, Ghassemian M, Abagyan R, Garcia-Marcos M, Ghosh P (2011) Tyrosine phosphorylation of the Galpha-Interacting protein GIV promotes activation of phosphoinositide 3-Kinase during cell migration. Sci Signal 4: Ra64
    • (2011) Sci Signal , vol.4 , pp. 64
    • Lin, C.1    Ear, J.2    Pavlova, Y.3    Mittal, Y.4    Kufareva, I.5    Ghassemian, M.6    Abagyan, R.7    Garcia-Marcos, M.8    Ghosh, P.9
  • 26
    • 0032510323 scopus 로고    scopus 로고
    • Receptor-Induced transient reduction in plasma membrane PtdIns (4,5)P2 concentration monitored in living cells
    • Stauffer TP, Ahn S, Meyer T (1998) Receptor-Induced transient reduction in plasma membrane PtdIns(4,5)P2 concentration monitored in living cells. Curr Biol 8: 343-346
    • (1998) Curr Biol , vol.8 , pp. 343-346
    • Stauffer, T.P.1    Ahn, S.2    Meyer, T.3
  • 27
    • 0017332739 scopus 로고
    • Hereditary retinal degeneration in Drosophila melanogaster. A mutant defect associated with the phototransduction process
    • Harris WA, Stark WS (1977) Hereditary retinal degeneration in Drosophila melanogaster. A mutant defect associated with the phototransduction process. J Gen Physiol 69: 261-291
    • (1977) J Gen Physiol , vol.69 , pp. 261-291
    • Harris, W.A.1    Stark, W.S.2
  • 28
    • 0028812325 scopus 로고
    • Regulation of PLC-Mediated signalling in vivo by CDP-Diacylglycerol synthase
    • Wu L, Niemeyer B, Colley N, Socolich M, Zuker CS (1995) Regulation of PLC-Mediated signalling in vivo by CDP-Diacylglycerol synthase. Nature 373: 216-222
    • (1995) Nature , vol.373 , pp. 216-222
    • Wu, L.1    Niemeyer, B.2    Colley, N.3    Socolich, M.4    Zuker, C.S.5
  • 29
    • 0037200122 scopus 로고    scopus 로고
    • The intermolecular interaction between the PH domain and the C-Terminal domain of Arabidopsis dynamin-Like 6 determines lipid binding specificity
    • Lee SH, Jin JB, Song J, Min MK, Park DS, Kim YW, Hwang I (2002) The intermolecular interaction between the PH domain and the C-Terminal domain of Arabidopsis dynamin-Like 6 determines lipid binding specificity. J Biol Chem 277: 31842-31849
    • (2002) J Biol Chem , vol.277 , pp. 31842-31849
    • Lee, S.H.1    Jin, J.B.2    Song, J.3    Min, M.K.4    Park, D.S.5    Kim, Y.W.6    Hwang, I.7


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