Targeting of Nir2 to lipid droplets is regulated by a specific threonine residue within its PI-transfer domain

Current Biology

Volumn 12, Issue 17, 2002, Pages 1513-1518

  Litvak, Vladimir ^a   Shaul, Yoav D ^a   Shulewitz, Mark ^a   Amarilio, Roy ^a   Carmon, Shari ^a   Lev, Sima ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM BINDING PROTEIN; EYE PROTEIN; MEMBRANE PROTEIN; OLEIC ACID; PHOSPHOTHREONINE; PITPNM1 PROTEIN, HUMAN; PROTEIN SERINE THREONINE KINASE; THREONINE; TUMOR PROTEIN;

AMINO ACID SUBSTITUTION; ARTICLE; CELL FRACTIONATION; CELL MEMBRANE; CHEMISTRY; CYTOSOL; DENSITY GRADIENT CENTRIFUGATION; DOMINANT GENE; DRUG EFFECT; ENDOPLASMIC RETICULUM; GENETICS; GOLGI COMPLEX; HELA CELL; HUMAN; LIPID METABOLISM; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; PROTEIN PROCESSING; PROTEIN TERTIARY STRUCTURE; PROTEIN TRANSPORT; RETINA DEGENERATION;

AMINO ACID SUBSTITUTION; CALCIUM-BINDING PROTEINS; CELL FRACTIONATION; CELL MEMBRANE; CENTRIFUGATION, DENSITY GRADIENT; CYTOSOL; ENDOPLASMIC RETICULUM; EYE PROTEINS; GENES, DOMINANT; GOLGI APPARATUS; HELA CELLS; HUMANS; LIPID METABOLISM; MEMBRANE PROTEINS; NEOPLASM PROTEINS; OLEIC ACID; PHOSPHORYLATION; PHOSPHOTHREONINE; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN STRUCTURE, TERTIARY; PROTEIN TRANSPORT; PROTEIN-SERINE-THREONINE KINASES; RETINAL DEGENERATION; THREONINE;

EID: 0037015277     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-9822(02)01107-7     Document Type: Article

References (26)

1. Identification of a novel family of targets of PYK2 related to Drosophila retinal degeneration B (rdgB) protein
2. The phosphatidylinositol transfer protein domain of Drosophila retinal degeneration B protein is essential for photoreceptor cell survival and recovery from light stimulation
3. Light-induced retinal degeneration in rdgB (retinal degeneration B) mutant of Drosophila: Electrophysiological and morphological manifestations of degeneration
4. Hereditary retinal degeneration in Drosophila melanogaster. A mutant defect associated with the phototransduction process
5. Nir2, a novel regulator of cell morphogenesis
6. Ultrastructure of the retina of Drosophila melanogaster: The mutant ora (outer rhabdomeres absent) and its inhibition of degeneration in rdgB (retinal degeneration-B)
7. Immunolocalization of a Drosophila phosphatidylinositol transfer protein (rdgB) in normal and rdgA mutant photoreceptor cells with special reference to the subrhabdomeric cisternae
8. Isolation and characterization of the Drosophila retinal degeneration B (rdgB) gene
9. A neuronal-specific mammalian homolog of the Drosophila retinal degeneration B gene with expression restricted to the retina and dentate gyrus
10. Involvement of PITPnm, a mammalian homologue of Drosophila rdgB, in phosphoinositide synthesis on Golgi membranes
11. Molecular cloning and characterization of mammalian homologues of the Drosophila retinal degeneration B gene
12. Mammalian homolog of Drosophila retinal degeneration B rescues the mutant fly phenotype
13. Location and mechanism of alpha 2, 6-sialyltransferase dimer formation. Role of cysteine residues in enzyme dimerization, localization, activity, and processing
14. Role of microtubules in the organization of the Golgi complex
15. Brefeldin A causes disassembly of the Golgi complex and accumulation of secretory proteins in the endoplasmic reticulum
16. A caveolin dominant negative mutant associates with lipid bodies and induces intracellular cholesterol imbalance
17. Nile red staining of lysosomal phospholipid inclusions
18. Lipid nutrition and metabolism of cultured mammalian cells
19. TIP47 associates with lipid droplets
20. Intracellular lipid particles of eukaryotic cells
21. Lipid droplets: Proteins floating on a pool of fat
22. Phosphatidylinositol transfer proteins couple lipid transport to phosphoinositide synthesis
23. Localization of Drosophila retinal degeneration B, a membrane-associated phosphatidylinositol transfer protein
24. Structure of a multifunctional protein. Mammalian phosphatidylinositol transfer protein complexed with phosphatidylcholine
25. Phosphatidylinositol transfer proteins: The long and winding road to physiological function
26. The biogenesis and functions of lipid bodies in animals, plants and microorganisms