Significantly high level of late-night free cortisol to creatinine ratio in urine specimen in patients with subclinical Cushing's syndrome

Clinical Endocrinology

Volumn 79, Issue 5, 2013, Pages 617-622

  Shiwa, Tsuguka ^a   Oki, Kenji ^a   Yamane, Kiminori ^b   Yoneda, Masayasu ^a   Awaya, Tomokazu ^a   Nakanishi, Shuhei ^a   Kohno, Nobuoki ^a  

^a HIROSHIMA UNIVERSITY   (Japan)

^b West Corporation Hiroshima Health Administration Center   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIDIABETIC AGENT; ANTIHYPERTENSIVE AGENT; ANTILIPEMIC AGENT; CREATININE; DEXAMETHASONE; HYDROCORTISONE;

ADRENAL CORTEX ADENOMA; ADULT; ARTICLE; CREATININE URINE LEVEL; CUSHING SYNDROME; DEXAMETHASONE SUPPRESSION TEST; FEMALE; HUMAN; HYDROCORTISONE BLOOD LEVEL; HYDROCORTISONE URINE LEVEL; LATE NIGHT URINARY FREE CORTISOL TO CREATININE RATIO; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SENSITIVITY AND SPECIFICITY;

AGED; CREATININE; CUSHING SYNDROME; FEMALE; HUMANS; HYDROCORTISONE; MALE; MIDDLE AGED; TIME FACTORS;

EID: 84885197560     PISSN: 03000664     EISSN: 13652265     Source Type: Journal    
DOI: 10.1111/cen.12197     Document Type: Article

References (27)

1. Chiodini, I., (2011) Clinical review: diagnosis and treatment of subclinical hypercortisolism. Journal of Clinical Endocrinology and Metabolism, 96, 1223-1236.
2. Emral, R., Uysal, A.R., Asik, M., et al,. (2003) Prevalence of subclinical Cushing's syndrome in 70 patients with adrenal incidentaloma: clinical, biochemical and surgical outcomes. Endocrine Journal, 50, 399-408.
3. Rossi, R., Tauchmanova, L., Luciano, A., et al,. (2000) Subclinical Cushing's syndrome in patients with adrenal incidentaloma: clinical and biochemical features. Journal of Clinical Endocrinology and Metabolism, 85, 1440-1448.
4. Di Dalmazi, G., Vicennati, V., Rinaldi, E., et al,. (2012) Progressively increased patterns of subclinical cortisol hypersecretion in adrenal incidentalomas differently predict major metabolic and cardiovascular outcomes: a large cross-sectional study. European Journal of Endocrinology, 166, 669-677.
5. Giordano, R., Guaraldi, F., Berardelli, R., et al,. (2012) Glucose metabolism in patients with subclinical Cushing's syndrome. Endocrine, 41, 415-423.
6. Valli, N., Catargi, B., Ronci, N., et al,. (2001) Biochemical screening for subclinical cortisol-secreting adenomas amongst adrenal incidentalomas. European Journal of Endocrinology, 144, 401-408.
7. Suda, T., (1997) Preclinical Cushing's syndrome and adrenocorticotropic hormone-independent bilateral adrenocortical macronodular hyperplasia. Internal Medicine, 36, 601-602.
8. Nieman, L.K., Biller, B.M., Findling, J.W., et al,. (2008) The diagnosis of Cushing's syndrome: an Endocrine Society Clinical Practice Guideline. Journal of Clinical Endocrinology and Metabolism, 93, 1526-1540.
9. - (2002) NIH state-of-the-science statement on management of the clinically inapparent adrenal mass ("incidentaloma"). NIH consensus and state-of-the-science statements, 19, 1-25.
10. De Leo, M., Cozzolino, A., Colao, A., et al,. (2012) Subclinical Cushing's syndrome. Best Practice and Research. Clinical Endocrinology Metabolism, 26, 497-505.
11. Mantero, F., Terzolo, M., Arnaldi, G., et al,. (2000) A survey on adrenal incidentaloma in Italy. Study Group on Adrenal Tumors of the Italian Society of Endocrinology. Journal of Clinical Endocrinology and Metabolism, 85, 637-644.
12. Oki, K., Yamane, K., Nakanishi, S., et al,. (2012) Influence of adrenal subclinical hypercortisolism on hypertension in patients with adrenal incidentaloma. Experimental and Clinical Endocrinology & Diabetes, 120, 244-247.
13. Newell-Price, J., Trainer, P., Perry, L., et al,. (1995) A single sleeping midnight cortisol has 100% sensitivity for the diagnosis of Cushing's syndrome. Clinical Endocrinology, 43, 545-550.
14. Papanicolaou, D.A., Yanovski, J.A., Cutler, G.B. Jr, et al,. (1998) A single midnight serum cortisol measurement distinguishes Cushing's syndrome from pseudo-Cushing states. Journal of Clinical Endocrinology and Metabolism, 83, 1163-1167.
15. Köbberling, J., &, von zur Mühlen, A., (1974) The circadian rhythm of free cortisol determined by urine sampling at two-hour intervals in normal subjects and in patients with severe obesity or Cushing's syndrome. Journal of Clinical Endocrinology and Metabolism, 38, 313-319.
16. Burch, W., (2011) Using bedtime (PM) and early morning (AM) urine cortisol/creatinine ratios to evaluate pituitary-adrenal function in an office practice. Endocrine Practice, 17, 591-597.
17. Kong, W.M., Alaghband-Zadeh, J., Jones, J., et al,. (1999) The midnight to morning urinary cortisol increment is an accurate, noninvasive method for assessment of the hypothalamic-pituitary-adrenal axis. Journal of Clinical Endocrinology and Metabolism, 84, 3093-3098.
18. Zeiger, M.A., Siegelman, S.S., &, Hamrahian, A.H., (2011) Medical and surgical evaluation and treatment of adrenal incidentalomas. Journal of Clinical Endocrinology and Metabolism, 96, 2004-2015.
19. Outwater, E.K., Siegelman, E.S., Huang, A.B., et al,. (1996) Adrenal masses: correlation between CT attenuation value and chemical shift ratio at MR imaging with in-phase and opposed-phase sequences. Radiology, 200, 749-752.
20. International Expert Committee. (2009) International expert committee report on the role of the A1C assay in the diagnosis of diabetes. Diabetes Care, 32, 1327-1334.
21. Sakihara, S., Kageyama, K., Oki, Y., et al,. (2010) Evaluation of plasma, salivary, and urinary cortisol levels for diagnosis of Cushing's syndrome. Endocrine Journal, 57, 331-337.
22. Barrou, Z., Guiban, D., Maroufi, A., et al,. (1996) Overnight dexamethasone suppression test: comparison of plasma and salivary cortisol measurement for the screening of Cushing's syndrome. European Journal of Endocrinology, 134, 93-96.
23. Nunes, M.L., Vattaut, S., Corcuff, J.B., et al,. (2009) Late-night salivary cortisol for diagnosis of overt and subclinical Cushing's syndrome in hospitalized and ambulatory patients. Journal of Clinical Endocrinology and Metabolism, 94, 456-462.
24. Sereg, M., Toke, J., Patõcs, A., et al,. (2011) Diagnostic performance of salivary cortisol and serum osteocalcin measurements in patients with overt and subclinical Cushing's syndrome. Steroids, 76, 38-42.
25. Yaneva, M., Mosnier-Pudar, H., Dugué, M.A., et al,. (2004) Midnight salivary cortisol for the initial diagnosis of Cushing's syndrome of various causes. Journal of Clinical Endocrinology and Metabolism, 89, 3345-3351.
26. Morelli, V., Masserini, B., Salcuni, A.S., et al,. (2010) Subclinical hypercortisolism: correlation between biochemical diagnostic criteria and clinical aspects. Clinical Endocrinology, 73, 161-166.
27. Chan, K.C., Lit, L.C., Law, E.L., et al,. (2004) Diminished urinary free cortisol excretion in patients with moderate and severe renal impairment. Clinical Chemistry, 50, 757-759.