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Volumn 21, Issue 21, 2013, Pages 6634-6641

Development of a novel fluorine-18 labeled deuterated fluororasagiline ([18F]fluororasagiline-D2) radioligand for PET studies of monoamino oxidase B (MAO-B)

(8) Nag, S a Lehmann, L b Kettschau, G b Toth, M a Heinrich, T b Thiele, A b Varrone, A a Halldin, C a

a KAROLINSKA INSTITUTE (Sweden)

b BAYER PHARMA AG (Germany)

Author keywords

Deuterium; Fluorine 18; Kinetics; Monkey; Monoamine oxidase (MAO); PET; Radiometabolites

Indexed keywords

AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME A; AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME B; FLUORORASAGILINE D2 F 18; TRACER; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BRAIN CORTEX; CEREBELLUM; CONTROLLED STUDY; CORPUS STRIATUM; DRUG ACCUMULATION; DRUG DISTRIBUTION; DRUG METABOLISM; DRUG PROTEIN BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG UPTAKE; ENZYME INHIBITION; HYDROLYSIS; IC 50; IN VITRO STUDY; IN VIVO STUDY; ISOTOPE LABELING; MACACA FASCICULARIS; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; RADIOACTIVITY; RADIOCHEMISTRY; THALAMUS;

MACACA FASCICULARIS;

AD; ALZHEIMER'S DISEASE; DEUTERIUM; DIMETHYLFORMAMIDE; DIMETHYLSULFOXIDE; DMF; DMSO; FAD; FLAVIN ADENINE DINUCLEOTIDE; FLUORINE-18; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HPLC; IC; INHIBITORY CONCENTRATION; KINETICS; LC; LC-MS; LIQUID CHROMATOGRAPHY; LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY; MAO; MONKEY; MONOAMINE OXIDASE (MAO); MONOAMINO OXIDASE; NMR; NUCLEAR MAGNETIC RESONANCE; PARKINSON'S DISEASE; PBS; PD; PET; PHOSPHATE BUFFERED SALINE; POSITRON EMISSION TOMOGRAPHY; RADIOMETABOLITES; REGION OF INTEREST; ROI; SA; SPECIFIC RADIOACTIVITY; STANDARDIZED UPTAKE VALUE; SUV;

ANIMALS; BRAIN; CEREBRAL CORTEX; DEUTERIUM; FLUORINE RADIOISOTOPES; HUMANS; INDANS; MACACA FASCICULARIS; MONOAMINE OXIDASE; MONOAMINE OXIDASE INHIBITORS; POSITRON-EMISSION TOMOGRAPHY; PROTEIN BINDING; RADIOPHARMACEUTICALS; THALAMUS;

EID: 84885189703 PISSN: 09680896 EISSN: 14643391 Source Type: Journal
DOI: 10.1016/j.bmc.2013.08.019 Document Type: Article

Times cited : (44)

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