Synthesis of three novel fluorine-18 labeled analogues of l -deprenyl for Positron Emission Tomography (PET) studies of Monoamine Oxidase B (MAO-B)

Journal of Medicinal Chemistry

Volumn 54, Issue 20, 2011, Pages 7023-7029

  Nag, Sangram ^a   Lehmann, Lutz ^b   Heinrich, Tobias ^b   Thiele, Andrea ^b   Kettschau, Georg ^b   Nakao, Ryuji ^a   Gulyás, Balázs ^a   Halldin, Christer ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b BAYER PHARMA AG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME B; FLUORINE; FLUORINE 18; N (1 FLUORO 1 PHENYLPROPAN 2 YL) N METHYLPROP 2 YN 1 AMINE; N (1 FLUORO 3 PHENYLPROPAN 2 YL) N METHYLPROP 2 YN 1 AMINE; N (1 FLUOROETHYL) N (1 PHENYLPROPAN 2 YL)PROP 2 YL 1 AMINE; SELEGILINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; AUTORADIOGRAPHY; BRAIN REGION; CONTROLLED STUDY; DRUG BINDING; DRUG DISTRIBUTION; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG UPTAKE; FLUORINATION; HUMAN; HUMAN TISSUE; IC 50; INSECT; MOUSE; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; SUBSTITUTION REACTION;

ANIMALS; AUTORADIOGRAPHY; BLOOD PROTEINS; BLOOD-BRAIN BARRIER; BRAIN; FEMALE; FLUORINE RADIOISOTOPES; HUMANS; ISOENZYMES; MALE; MICE; MONOAMINE OXIDASE; POSITRON-EMISSION TOMOGRAPHY; PROTEIN BINDING; RADIOPHARMACEUTICALS; SELEGILINE; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TISSUE DISTRIBUTION;

EID: 80054932789     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm200710b     Document Type: Article

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