Association between blastocyst morphology and outcome of single-blastocyst transfer

Reproductive BioMedicine Online

Volumn 27, Issue 4, 2013, Pages 353-361

  Van Den Abbeel, Etienne ^a   Balaban, Basak ^b   Ziebe, Søren ^c   Lundin, Kersti ^d   Cuesta, Maria José Gómez ^e   Klein, Bjarke Mirner ^f   Helmgaard, Lisbeth ^f   Arce, Joan Carles ^f  

^a GHENT UNIVERSITY HOSPITAL   (Belgium)

^b AMERICAN HOSPITAL   (Turkey)

^c Rigshospitalet   (Denmark)

^d SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

^e INSTITUT UNIVERSITARI DEXEUS   (Spain)

^f Ferring Pharmaceuticals AS   (Denmark)

Author keywords

Blastocyst morphology; Early pregnancy loss; Live birth; Prediction; Single embryo transfer

Indexed keywords

GANIRELIX; GONADORELIN; GONADOTROPIN; RECOMBINANT CHORIONIC GONADOTROPIN;

ADULT; ARTICLE; BIRTH RATE; BLASTOCYST; CELL EXPANSION; CELL STRUCTURE; CELL TRANSFER; FEMALE; HUMAN; INNER CELL MASS; INTRACYTOPLASMIC SPERM INJECTION; LIVE BIRTH; MAJOR CLINICAL STUDY; OVARY CYCLE; PREDICTIVE VALUE; PREGNANCY RATE; SINGLE CELL ANALYSIS; TREATMENT OUTCOME;

BLASTOCYST MORPHOLOGY; EARLY PREGNANCY LOSS; LIVE BIRTH; PREDICTION; SINGLE-EMBRYO TRANSFER;

ADULT; BLASTOCYST; BLASTOCYST INNER CELL MASS; FEMALE; HUMANS; LOGISTIC MODELS; MULTICENTER STUDIES AS TOPIC; PREGNANCY; PREGNANCY OUTCOME; PREGNANCY RATE; RANDOMIZED CONTROLLED TRIALS AS TOPIC; SINGLE EMBRYO TRANSFER;

EID: 84885180563     PISSN: 14726483     EISSN: 14726491     Source Type: Journal    
DOI: 10.1016/j.rbmo.2013.07.006     Document Type: Article

References (40)

1. Ahlström, A., Westin, C., Reismer, E., Wikland, M., Hardarson, T., 2011. Trophectoderm morphology: an important parameter for predicting live birth after single blastocyst transfer. Hum. Reprod. 26, 3289-3296.
2. Alpha Scientists in Reproductive Medicine and ESHRE Special Interest Group of Embryology, 2011. The Istanbul consensus workshop on embryo assessment: proceedings of an expert meeting. Hum. Reprod. 26, 1270-1283.
3. Balaban, B., Yakin, K., Urman, B., 2006. Randomized comparison of two different blastocyst grading systems. Fertil. Steril. 85, 559-563. (Pubitemid 43261543)
4. Balaban, B., Urman, B., Sertac, A., Alatas, C., Aksoy, S., Mercan, R., 2000. Blastocyst quality affects the success of blastocyst-stage embryo transfer. Fertil. Steril. 74, 282-287. (Pubitemid 30604191)
5. Bergh, C., 2005. Single embryo transfer: a mini-review. Hum. Reprod. 20, 323-327. (Pubitemid 40277598)
6. Blake, D.A., Farquhar, C.M., Johnson, N., Proctor, M., 2007. Cleavage stage versus blastocyst stage embryo transfer in assisted conception. Cochrane Database Syst. Rev., CD002118.
7. Cummins, J.M., Breen, T.M., Harrison, K.L., Shaw, J.M., Wilson, L.M., Hennessey, J.F., 1986. A formula for scoring human embryo growth rates in in vitro fertilization: its value in predicting pregnancy and in comparison with visual estimates of embryo quality. J. In Vitro Fert. Embryo Transf. 3, 284-295. (Pubitemid 17208120)
8. della Ragione, T., Verheyen, G., Papanikolaou, E.G., Van Landuyt, L., Devroey, P., Van Steirteghem, A., 2007. Developmental stage on day-5 and fragmentation rate on day-3 can influence the implantation potential of top-quality blastocysts in IVF cycles with single embryo transfer. Reprod. Biol. Endocrinol. 5, 2.
9. Devroey, P., Pellicer, A., Nyboe Andersen, A., Arce, J.-C. on behalf of the Menopur in GnRH Antagonist Cycles with Single Embryo Transfer (MEGASET) Trial Group, 2012. A randomized assessor-blind trial comparing highly purified hMG and recombinant FSH in a GnRH antagonist cycle with compulsory single-blastocyst transfer. Fertil. Steril. 97, 561-571.
10. Fisch, J.D., Rodriguez, H., Ross, R., Overby, G., Sher, G., 2001. The graduated embryo score (GES) predicts blastocyst formation and pregnancy rate from cleavage-stage embryos. Hum. Reprod. 16, 1970-1975. (Pubitemid 32916231)
11. Gardner, D., Lane, M., 1999. Embryo culture systems. In: Trounson, A.O., Gardner, D.K. (Eds.), Handbook of In Vitro Fertilization, second ed. CRC Press, Boca Raton, FL, USA, pp. 205-264.
12. Gardner, D.K., Schoolcraft, W.B., 1999. In-vitro culture of human blastocysts. In: Jansen, R., Mortimer, D. (Eds.), Towards Reproductive Certainty: Fertility and Genetics Beyond 1999. The Parthenon Publishing Group, New York, pp. 378-388.
13. Gardner, D.K., Lane, M., Stevens, J., Schlenker, T., Schoolcraft, W.B., 2000. Blastocyst score affects implantation and pregnancy outcome: towards a single blastocyst transfer. Fertil. Steril. 73, 1155-1158. (Pubitemid 30336760)
14. Gelbaya, T.A., Tsoumpou, I., Nardo, L.G., 2010. The likelihood of live birth and multiple birth after single versus double embryo transfer at the cleavage stage: a systematic review and meta-analysis. Fertil. Steril. 94, 936-945.
15. Giorgetti, C., Terriou, P., Auquier, P., Hans, E., Spach, J.L., Salzman, J., Roulier, R., 1995. Embryo score to predict implantation after in vitro fertilization: based on 957 single embryo transfers. Hum. Reprod. 10, 2427-2431.
16. Goto, S., Kadowaki, T., Tanaka, S., Hashimoto, H., Kokeguchi, S., Shiotani, M., 2011. Prediction of pregnancy rate by blastocyst morphological score and age, based on 1,488 single frozen-thawed blastocyst transfer cycles. Fertil. Steril. 95, 948-952.
17. Hill, M.J., Richter, K.S., Heitmann, R.J., Graham, J.R., Tucker, M.J., Decherney, A.H., Browne, P.E., Levens, E.D., 2013. Trophectoderm grade predicts outcomes of single-blastocyst transfers. Fertil. Steril. 99, 1283-1289.
18. Holte, J., Berglund, L., Milton, K., Garello, C., Gennarelli, G., Revelli, A., Bergh, T., 2007. Construction of an evidence-based integrated morphology cleavage embryo score for implantation potential of embryos scored and transferred on day 2 after oocyte retrieval. Hum. Reprod. 22, 548-557. (Pubitemid 46152580)
19. Honnma, H., Baba, T., Sasaki, M., Hashiba, Y., Ohno, H., Fukunaga, T., Endo, T., Saito, T., Asada, Y., 2012. Trophectoderm morphology significantly affects the rates of ongoing pregnancy and miscarriage in frozen-thawed single-blastocyst transfer cycle in vitro fertilization. Fertil. Steril. 98, 361-367.
20. Kovacic, B., Vlaisavljevic, V., Reljic, M., Cizek-Sajko, M., 2004. Developmental capacity of different morphological types of day 5 human morulae and blastocysts. Reprod. Biomed. Online 8, 687-694. (Pubitemid 38744950)
21. Kresowik, J.D., Sparks, A.E., Van Voorhis, B.J., 2012. Clinical factors associated with live birth after single embryo transfer. Fertil. Steril. 98, 1152-1156.
22. Land, J.A., Evers, J.L., 2003. Risks and complications in assisted reproduction techniques: Report of an ESHRE consensus meeting. Hum. Reprod. 18, 455-457. (Pubitemid 36236287)
23. Martikainen, H., Tiitinen, A., Tomás, C., Tapanainen, J., Orava, M., Tuomivaara, L., Vilska, S., Hydén-Granskog, C., Hovatta, O.the Finnish ET Study Group, 2001. One versus two embryo transfer after IVF and ICSI: a randomized study. Hum. Reprod. 16, 1900-1903. (Pubitemid 32916219)
24. McLernon, D.J., Harrild, K., Bergh, C., Davies, M.J., de Neubourg, D., Dumoulin, J.C., Gerris, J., Kremer, J.A., Martikainen, H., Mol, B.W., Norman, R.J., Thurin-Kjellberg, A., Tiitinen, A., van Montfoort, A.P., van Peperstraten, A.M., Van Royen, E., Bhattacharya, S., 2010. Clinical effectiveness of elective single versus double embryo transfer: meta-analysis of individual patient data from randomised trials. BMJ 341, c6945.
25. Pandian, Z., Bhattacharya, S., Ozturk, O., Serour, G., Templeton, A., 2009. Number of embryos for transfer following in-vitro fertilisation or intra-cytoplasmic sperm injection. Cochrane Database Syst. Rev., CD003416.
26. Papanikolaou, E.G., Kolibianakis, E.M., Tournaye, H., Venetis, C.A., Fatemi, H., Tarlatzis, B., Devroey, P., 2008. Live birth rates after transfer of equal number of blastocysts or cleavage-stage embryos in IVF. A systematic review and meta-analysis. Hum. Reprod. 23, 91-99. (Pubitemid 351767314)
27. Papanikolaou, E.G., Camus, M., Kolibianakis, E.M., Van Landuyt, L., Van Steirteghem, A., Devroey, P., 2006. In vitro fertilization with single blastocyst-stage versus single cleavage-stage embryos. N. Engl. J. Med. 354, 1139-1146.
28. Prados, F.J., Debrock, S., Lemmen, J.G., Agerholm, I., 2012. The cleavage stage embryo. Hum. Reprod. 27, i50-i71.
29. Puissant, F., Van Rysselberge, M., Barlow, P., Deweze, J., Leroy, F., 1987. Embryo scoring as a prognostic tool in IVF treatment. Hum. Reprod. 2, 705-708.
30. Racowsky, C., Combelles, C., Nurredin, A., Pan, Y., Finn, A., Miles, L., Gale, S., O'Leary, T., Jackson, K.V., 2003. Day 3 and Day 5 morphological predictors of embryo viability. Reprod. Biomed. 6, 323-331. (Pubitemid 36849778)
31. Rehman, K.S., Bukulmez, O., Langley, M., Carr, B.R., Nackley, A.C., Doody, K.M., Doody, K.J., 2007. Late stages of embryo progression are a much better predictor of clinical pregnancy than early cleavage in intracytoplasmic sperm injection and in vitro fertilization cycles with blastocyst-stage transfer. Fertil. Steril. 87, 1041-1052. (Pubitemid 46659948)
32. Richter, K.S., Harris, D.C., Daneshmand, S.T., Shapiro, B.S., 2001. Quantitative grading of a human blastocyst: optimal inner cell mass size and shape. Fertil. Steril. 76, 1157-1167. (Pubitemid 33116380)
33. Shapiro, B.S., Daneshmand, S.T., Garner, F.C., Aguirre, M., Thomas, S., 2008. Large blastocyst diameter, early blastulation, and low preovulatory serum progesterone are dominant predictors of clinical pregnancy in fresh autologous cycles. Fertil. Steril. 90, 302-309. (Pubitemid 352040708)
34. Terriou, P., Sapin, C., Giorgetti, C., Hans, E., Spach, J.L., Roulier, R., 2001. Embryo score is a better predictor of pregnancy than the number of transferred embryos or female age. Fertil. Steril. 75, 525-531. (Pubitemid 32175667)
35. Thurin, A., Hardarson, T., Hausken, J., Jablonowska, B., Lundin, K., Pinborg, A., Bergh, C., 2005. Predictors of ongoing implantation in IVF in a good prognosis group of patients. Hum. Reprod. 20, 1876-1880. (Pubitemid 40932371)
36. Thurin, A., Hausken, J., Hillensjö, T., Jablonowska, B., Pinborg, A., Strandell, A., Bergh, C., 2004. Elective single embryo transfer versus double-embryo transfer in in vitro fertilization. N. Engl. J. Med. 351, 2392-2402. (Pubitemid 40485991)
37. Van Royen, E., Mangelschots, K., De Neubourg, D., Valkenburg, M., Van de Meerssche, M., Ryckaert, G., Eestermans, W., Gerris, J., 1999. Characterization of a top quality embryo, a step towards single-embryo transfer. Hum. Reprod. 14, 2345-2349. (Pubitemid 29425427)
38. Wilson, M., Hartke, K., Kiehl, M., Rodgers, J., Brabec, C., Lyles, R., 2004. Transfer of blastocysts and morulae on day 5. Fertil. Steril. 82, 327-333. (Pubitemid 39092030)
39. Yoon, H.J., Yoon, S.H., Son, W.Y., Im, K.S., Lim, J.H., 2001. High implantation and pregnancy rates with transfer of human hatching day 6 blastocysts. Fertil. Steril. 75, 832-833.
40. Ziebe, S., Petersen, K., Lindenberg, S., Andersen, A.G., Gabrielsen, A., Nyboe Andersen, A., 1997. Embryo morphology or cleavage stage: how to select the best embryos for transfer after in-vitro fertilization. Hum. Reprod. 12, 1545-1549. (Pubitemid 27373213)