A randomized assessor-blind trial comparing highly purified hMG and recombinant FSH in a GnRH antagonist cycle with compulsory single-blastocyst transfer

Fertility and Sterility

Volumn 97, Issue 3, 2012, Pages 561-571

  Devroey, Paul ^a   Pellicer, Antonio ^b   Nyboe Andersen, Anders ^c   Arce, Joan Carles ^d  

^a CENTRE FOR REPRODUCTIVE MEDICINE   (Belgium)

^b IVI Valencia   (Spain)

^c University of Copenhagen   (Denmark)

^d Ferring Pharmaceuticals AS   (Denmark)

Author keywords

GnRH antagonist; Highly purified menotropin; recombinant FSH; single blastocyst transfer

Indexed keywords

CHORIONIC GONADOTROPIN ALPHA SUBUNIT; GANIRELIX; GONADORELIN ANTAGONIST; HUMAN MENOPAUSAL GONADOTROPIN; LUTEINIZING HORMONE; RECOMBINANT CHORIONIC GONADOTROPIN; RECOMBINANT FOLLITROPIN;

ADULT; ARTICLE; BLASTOCYST; CONTROLLED STUDY; EMBRYO TRANSFER; FEMALE; FEMALE INFERTILITY; HUMAN; INTENTION TO TREAT ANALYSIS; LIVE BIRTH; MAJOR CLINICAL STUDY; MULTICENTER STUDY; NIDATION; OVARY STIMULATION; PATIENT SAFETY; PREGNANCY; PREGNANCY RATE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; STIMULATION; THERAPY EFFECT;

ADULT; BIOLOGICAL MARKERS; BIRTH RATE; DRUG THERAPY, COMBINATION; EUROPE; FEMALE; FERTILITY AGENTS, FEMALE; FOLLICLE STIMULATING HORMONE, BETA SUBUNIT; GONADOTROPIN-RELEASING HORMONE; HORMONE ANTAGONISTS; HUMANS; INFERTILITY; MENOTROPINS; OOCYTE RETRIEVAL; OVULATION INDUCTION; PREGNANCY; PREGNANCY RATE; PROGESTERONE; RECOMBINANT PROTEINS; SINGLE EMBRYO TRANSFER; TIME FACTORS; TREATMENT OUTCOME; TURKEY;

EID: 84857783171     PISSN: 00150282     EISSN: 15565653     Source Type: Journal    
DOI: 10.1016/j.fertnstert.2011.12.016     Document Type: Article

References (33)

1. A. Nyboe Andersen, P. Devroey, J.-C. Arce MERIT Group Clinical outcome following stimulation with highly purified hMG or recombinant FSH in patients undergoing IVF: a randomized assessor-blind controlled trial Hum Reprod 21 2006 3217 3227
2. J. Smitz, A. Nyboe Andersen, P. Devroey, J.-C. Arce MERIT Group Endocrine profile in serum and follicular fluid differs after ovarian stimulation with hphMG or recombinant FSH in IVF patients Hum Reprod 22 2007 676 687
3. S. Ziebe, K. Lundin, R. Janssens, L. Helmgaard, J.-C. Arce MERIT Group Influence of ovarian stimulation with hphMG or recombinant FSH on embryo quality parameters in patients undergoing IVF Hum Reprod 22 2007 2404 2413
4. H.G. Al-Inany, A.M. Abou-Setta, M.A. Aboulghar, R.T. Mansour, and G.I. Serour Efficacy and safety of human menopausal gonadotrophins versus recombinant FSH: a meta-analysis Reprod Biomed Online 16 2008 81 88
5. A. Coomarasamy, M. Afnan, D. Cheema, F. van der Veen, P.M. Bossuyt, and M. van Wely Urinary hMG versus recombinant FSH for controlled ovarian hyperstimulation following an agonist long down-regulation protocol in IVF or ICSI treatment: a systematic review and meta-analysis Hum Reprod 23 2008 310 315
6. E. Bosch, C. Vidal, E. Labarta, C. Simon, J. Remohi, and A. Pellicer Highly purified hMG versus recombinant FSH in ovarian hyperstimulation with GnRH antagonists - a randomized study Hum Reprod 23 2008 2346 2351
7. E.G. Papanikolaou, M. Camus, E.M. Kolibianakis, L. van Landuyt, A. Van Steirteghem, and P. Devroey In vitro fertilization with single blastocyst-stage versus single cleavage-stage embryos N Engl J Med 354 2006 1139 1146
8. E.G. Papanikolaou, E.M. Kolibianakis, H. Tournaye, C.A. Venetis, H. Fatemi, and B. Tarlatzis Live birth rates after transfer of equal number of blastocysts or cleavage-stage embryos in IVF. A systematic review and meta-analysis Hum Reprod 23 2008 91 99
9. C. Bergh Single embryo transfer: a mini review Hum Reprod 20 2005 323 327
10. D.J. McLernon, K. Harrild, C. Bergh, M.J. Davies, D. de Neubourg, and J.C. Dumoulin Clinical effectiveness of elective single versus double embryo transfer: meta-analysis of individual patient data from randomized trials BMJ 341 2010 c6945
11. L. Herrero, M. Martinez, and J.A. Garcia-Velasco Current status of human oocyte and embryo cryopreservation Curr Opin Obstet Gynecol 23 2011 245 250
12. K.E. Loutradi, E.M. Kolibianakis, C.A. Venetis, E.G. Papanikolaou, G. Pados, and I. Bontis Cryopreservation of human embryos by vitrification or slow freezing: a systematic review and meta-analysis Fertil Steril 90 2008 186 193
13. E. Stehlik, J. Stehlik, K.P. Katayama, M. Kuwayama, V. Jambor, and R. Brohammer Vitrification demonstrates significant improvement versus slow freezing of human blastocysts Reprod Biomed Online 11 2005 53 57
14. G. Griesinger Editorial commentary: is it time to abandon progesterone supplementation of early pregnancy after IVF? Hum Reprod 26 2011 1017 1019
15. A. Nyboe Andersen, B. Popovic-Todorovic, K.T. Schmidt, A. Loft, A. Lindhard, and A. Højgaard Progesterone supplementation during early gestations after IVF or ICSI has no effect on the delivery rates: a randomized controlled trial Hum Reprod 17 2002 357 361
16. D. Kyrou, H.M. Fatemi, L. Zepiridis, A. Riva, E.G. Papanikolaou, and B.C. Tarlatzis Does cessation of progesterone supplementation during early pregnancy in patients treated with recFSH/GnRH antagonist affect ongoing pregnancy rates? A randomized controlled trial Hum Reprod 26 2011 1020 1024
17. Gardner DK, Schoolcraft WB. The plenary proceedings of the 11th world congress on in vitro fertilization and human reproductive genetics. In: Jansen R, Mortimer D, eds. Toward reproductive certainty. 1999. New York: Parthenon, 1999:378-88.
18. A. Golan, R. Ron-el, A. Herman, Y. Soffer, Z. Weinraub, and E. Caspi Ovarian hyperstimulation syndrome: an update review Obstet Gynecol Surv 44 1989 430 440
19. P. Devroey, R. Boostanfar, N.P. Koper, B.M. Mannaerts, P.C. Ijzerman-Boon, B.C. Fauser ENGAGE Investigators A double-blind, noninferiority RCT comparing corifollitropin alfa and recombinant FSH during the first seven days of ovarian stimulation using a GnRH antagonist protocol Hum Reprod 24 2009 3063 3072
20. R.J. Stillman, K.S. Richter, N.K. Banks, and J.R. Graham Elective single embryo transfer: a 6-year progressive implantation of 784 single blastocyst transfers and the influence of payment method on patient choice Fertil Steril 92 2009 1895 1906
21. E. Bosch, E. Labarta, J. Crespo, C. Simón, J. Remohí, and J. Jenkins Circulating progesterone levels and ongoing pregnancy rates in controlled ovarian stimulation cycles for in vitro fertilization: analysis of over 4000 cycles Hum Reprod 25 2010 2092 2100
22. C. Bourgain, and P. Devroey The endometrium in stimulated cycles for IVF Hum Reprod Update 9 2003 515 522
23. R. Fleming, and J. Jenkins The source and implications of progesterone rise during the follicular phase of assisted reproduction cycles Reprod Biomed Online 21 2010 446 449
24. E.A. Elgindy Progesterone level and progesterone/estradiol ratio on the day of hCG administration: detrimental cutoff levels and new treatment strategy Fertil Steril 95 2011 1639 1644
25. E.G. Papanikolaou, E.M. Kolibianakis, C. Pozzobon, P. Tank, H. Tournaye, and C. Bourgain Progesterone rise on the day of human chorionic gonadotropin administration impairs pregnancy outcome in day 3 single-embryo transfer, while has no effect on day 5 single blastocyst transfer Fertil Steril 91 2009 949 952
26. M. Filicori, G.E. Cognigni, P. Pocognoli, C. Tabarelli, D. Spettoli, and S. Taraborrelli Modulation of folliculogenesis and steroidogenesis in women by graded menotrophin administration Hum Reprod 17 2002 2009 2015
27. E. Bosch, I. Valencia, E. Escudero, J. Crespo, C. Simón, J. Remohí, and A. Pellicer Premature luteinization during gonadotropin-releasing hormone antagonist cycles and its relationship with in vitro fertilization outcome Fertil Steril 80 2003 1444 1449
28. M.H. van der Gaast, M.J. Eijkemans, J.B. van der Net, E.J. de Boer, C.W. Burger, and F.E. van Leeuwen Optimum number of oocytes for a successful first IVF treatment cycle Reprod Biomed Online 13 2006 476 480
29. F. Lisi, L. Rinaldi, S. Fishel, D. Caserta, R. Lisi, and A. Campbell Evaluation of two doses of recombinant luteinizing hormone supplementation in an unselected group of women undergoing follicular stimulation for in vitro fertilization Fertil Steril 83 2005 309 315
30. H.J. Chang, J.R. Lee, B.C. Jee, C.S. Suh, and S.H. Kim Impact of blastocyst transfer on offspring sex ratio and the monozygotic twinning rate: a systematic review and meta-analysis Fertil Steril 91 2009 2381 2390
31. E.G. Papanikolaou, H. Fatemi, C. Venetis, P. Donoso, E. Kolibianakis, and H. Tournaye Monozygotic twinning is not increased after single blastocyst transfer compared with single cleavage-stage embryo transfer Fertil Steril 93 2010 592 597
32. F.I. Sharara, and G. Abdo Incidence of monozygotic twins in blastocyst and cleavage stage assisted reproductive technology cycles Fertil Steril 93 2010 642 645
33. S. Vitthala, T.A. Gelbaya, D.R. Brison, C.T. Fitzgerald, and L.G. Nardo The risk of monozygotic twins after assisted reproductive technology: a systematic review and meta-analysis Hum Reprod Update 15 2009 45 55