Nardilysin prevents amyloid plaque formation by enhancing α-secretase activity in an Alzheimer's disease mouse model

Neurobiology of Aging

Volumn 35, Issue 1, 2014, Pages 213-222

  Ohno, Mikiko ^a   Hiraoka, Yoshinori ^a   Lichtenthaler, Stefan F ^b,c,d   Nishi, Kiyoto ^a   Saijo, Sayaka ^a   Matsuoka, Tatsuhiko ^a   Tomimoto, Hidekazu ^e   Araki, Wataru ^f   Takahashi, Ryosuke ^a   Kita, Toru ^g   Kimura, Takeshi ^a   Nishi, Eiichiro ^a  

^a KYOTO UNIVERSITY   (Japan)

^b GERMAN CENTER FOR NEURODEGENERATIVE DISEASES DZNE   (Germany)

^c TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^d Germany 3 Munich Cluster for Systems Neurology   (Germany)

^e MIE UNIVERSITY   (Japan)

^f NATIONAL INSTITUTE OF NEUROSCIENCE   (Japan)

^g KOBE CITY MEDICAL CENTER GENERAL HOSPITAL   (Japan)

Author keywords

secretase; Alzheimer's disease; Amyloid precursor protein; Metalloendopeptidase; Nardilysin

Indexed keywords

ALPHA SECRETASE; AMYLOID BETA PROTEIN; BETA SECRETASE; METALLOPROTEINASE; NARDILYSIN; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; AMYLOID PLAQUE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME REGULATION; GENE DELETION; GENE OVEREXPRESSION; GLIOSIS; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN SYNTHESIS INHIBITION;

ALZHEIMER'S DISEASE; AMYLOID PRECURSOR PROTEIN; METALLOENDOPEPTIDASE; NARDILYSIN; Α-SECRETASE;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; BRAIN; DISEASE MODELS, ANIMAL; ENZYME ACTIVATION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; METALLOENDOPEPTIDASES; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; PLAQUE, AMYLOID; PROTEOLYSIS;

EID: 84885174201     PISSN: 01974580     EISSN: 15581497     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2013.07.014     Document Type: Article

References (29)

1. Chakrabarty P., Jansen-West K., Beccard A., Ceballos-Diaz C., Levites Y., Verbeeck C., Zubair A.C., Dickson D., Golde T.E., Das P. Massive gliosis induced by interleukin-6 suppresses Abeta deposition invivo: evidence against inflammation as a driving force for amyloid deposition. FASEB J. 2009, 24:548-559.
2. Chesneau V., Pierotti A.R., Prat A., Gaudoux F., Foulon T., Cohen P. N-arginine dibasic convertase (NRD convertase): a newcomer to the family of processing endopeptidases. An overview. Biochimie 1994, 76:234-240.
3. Colombo A., Wang H., Kuhn P.H., Page R., Kremmer E., Dempsey P.J., Crawford H.C., Lichtenthaler S.F. Constitutive alpha- and beta-secretase cleavages of the amyloid precursor protein are partially coupled in neurons, but not in frequently used cell lines. Neurobiol. Dis. 2012, 49C:137-147.
4. Fahrenholz F. Alpha-secretase as a therapeutic target. Curr. Alzheimer Res. 2007, 4:412-417.
5. Furukawa K., Sopher B.L., Rydel R.E., Begley J.G., Pham D.G., Martin G.M., Fox M., Mattson M.P. Increased activity-regulating and neuroprotective efficacy of alpha-secretase-derived secreted amyloid precursor protein conferred by a C-terminal heparin-binding domain. J.Neurochem. 1996, 67:1882-1896.
6. Haass C. Take five-BACE and the gamma-secretase quartet conduct Alzheimer's amyloid beta-peptide generation. EMBO J. 2004, 23:483-488.
7. Hiraoka Y., Ohno M., Yoshida K., Okawa K., Tomimoto H., Kita T., Nishi E. Enhancement of alpha-secretase cleavage of amyloid precursor protein by a metalloendopeptidase nardilysin. J.Neurochem. 2007, 102:1595-1605.
8. Hiraoka Y., Yoshida K., Ohno M., Matsuoka T., Kita T., Nishi E. Ectodomain shedding of TNF-alpha is enhanced by nardilysin via activation of ADAM proteases. Biochem. Biophys. Res. Commun. 2008, 370:154-158.
9. Jorissen E., Prox J., Bernreuther C., Weber S., Schwanbeck R., Serneels L., Snellinx A., Craessaerts K., Thathiah A., Tesseur I., Bartsch U., Weskamp G., Blobel C.P., Glatzel M., De Strooper B., Saftig P. The disintegrin/metalloproteinase ADAM10 is essential for the establishment of the brain cortex. J.Neurosci. 2010, 30:4833-4844.
10. Kanda K., Komekado H., Sawabu T., Ishizu S., Nakanishi Y., Nakatsuji M., Akitake-Kawano R., Ohno M., Hiraoka Y., Kawada M., Kawada K., Sakai Y., Matsumoto K., Kunichika M., Kimura T., Seno H., Nishi E., Chiba T. Nardilysin and ADAM proteases promote gastric cancer cell growth by activating intrinsic cytokine signalling via enhanced ectodomain shedding of TNF-alpha. EMBO Mol. Med. 2012, 4:396-411.
11. Kim M.L., Zhang B., Mills I.P., Milla M.E., Brunden K.R., Lee V.M. Effects of TNFalpha-converting enzyme inhibition on amyloid beta production and APP processing invitro and invivo. J.Neurosci. 2008, 28:12052-12061.
12. Kuhn P.H., Koroniak K., Hogl S., Colombo A., Zeitschel U., Willem M., Volbracht C., Schepers U., Imhof A., Hoffmeister A., Haass C., Rossner S., Brase S., Lichtenthaler S.F. Secretome protein enrichment identifies physiological BACE1 protease substrates in neurons. EMBO J. 2012, 31:3157-3168.
13. Kuhn P.H., Wang H., Dislich B., Colombo A., Zeitschel U., Ellwart J.W., Kremmer E., Rossner S., Lichtenthaler S.F. ADAM10 is the physiologically relevant, constitutive alpha-secretase of the amyloid precursor protein in primary neurons. EMBO J. 2010, 29:3020-3032.
14. Lichtenthaler S.F. Alpha-secretase in Alzheimer's disease: molecular identity, regulation and therapeutic potential. J.Neurochem. 2011, 116:10-21.
15. Luo X., Prior M., He W., Hu X., Tang X., Shen W., Yadav S., Kiryu-Seo S., Miller R., Trapp B.D., Yan R. Cleavage of neuregulin-1 by BACE1 or ADAM10 protein produces differential effects on myelination. J.Biol. Chem. 2011, 286:23967-23974.
16. Maes O.C., Xu S., Yu B., Chertkow H.M., Wang E., Schipper H.M. Transcriptional profiling of Alzheimer blood mononuclear cells by microarray. Neurobiol. Aging 2007, 28:1795-1809.
17. Morgan D., Gordon M.N., Tan J., Wilcock D., Rojiani A.M. Dynamic complexity of the microglial activation response in transgenic models of amyloid deposition: implications for Alzheimer therapeutics. J.Neuropathol. Exp. Neurol. 2005, 64:743-753.
18. Murayama K.S., Kametani F., Saito S., Kume H., Akiyama H., Araki W. Reticulons RTN3 and RTN4-B/C interact with BACE1 and inhibit its ability to produce amyloid beta-protein. Eur. J. Neurosci. 2006, 24:1237-1244.
19. Nishi E., Hiraoka Y., Yoshida K., Okawa K., Kita T. Nardilysin enhances ectodomain shedding of heparin-binding epidermal growth factor-like growth factor through activation of tumor necrosis factor-alpha-converting enzyme. J.Biol. Chem. 2006, 281:31164-31172.
20. Nishi E., Prat A., Hospital V., Elenius K., Klagsbrun M. N-arginine dibasic convertase is a specific receptor for heparin-binding EGF-like growth factor that mediates cell migration. EMBO J. 2001, 20:3342-3350.
21. Ohno M., Hiraoka Y., Matsuoka T., Tomimoto H., Takao K., Miyakawa T., Oshima N., Kiyonari H., Kimura T., Kita T., Nishi E. Nardilysin regulates axonal maturation and myelination in the central and peripheral nervous system. Nat. Neurosci. 2009, 12:1506-1513.
22. Pierotti A.R., Prat A., Chesneau V., Gaudoux F., Leseney A.M., Foulon T., Cohen P. N-arginine dibasic convertase, a metalloendopeptidase as a prototype of a class of processing enzymes. Proc. Natl. Acad. Sci. U.S.A 1994, 91:6078-6082.
23. Postina R., Schroeder A., Dewachter I., Bohl J., Schmitt U., Kojro E., Prinzen C., Endres K., Hiemke C., Blessing M., Flamez P., Dequenne A., Godaux E., van Leuven F., Fahrenholz F. Adisintegrin-metalloproteinase prevents amyloid plaque formation and hippocampal defects in an Alzheimer disease mouse model. J.Clin. Invest. 2004, 113:1456-1464.
24. Querfurth H.W., LaFerla F.M. Alzheimer's disease. N.Engl. J. Med. 2010, 362:329-344.
25. Selkoe D.J., Schenk D. Alzheimer's disease: molecular understanding predicts amyloid-based therapeutics. Annu. Rev. Pharmacol. Toxicol. 2003, 43:545-584.
26. Stein T.D., Anders N.J., DeCarli C., Chan S.L., Mattson M.P., Johnson J.A. Neutralization of transthyretin reverses the neuroprotective effects of secreted amyloid precursor protein (APP) in APPSW mice resulting in tau phosphorylation and loss of hippocampal neurons: support for the amyloid hypothesis. J.Neurosci. 2004, 24:7707-7717.
27. Thinakaran G., Koo E.H. Amyloid precursor protein trafficking, processing, and function. J.Biol. Chem. 2008, 283:29615-29619.
28. Willem M., Garratt A.N., Novak B., Citron M., Kaufmann S., Rittger A., DeStrooper B., Saftig P., Birchmeier C., Haass C. Control of peripheral nerve myelination by the beta-secretase BACE1. Science 2006, 314:664-666.
29. Wyss-Coray T. Inflammation in Alzheimer disease: driving force, bystander or beneficial response?. Nat. Med. 2006, 12:1005-1015.