Glycogen synthase kinase-3β-mediated CCAAT/enhancer-binding protein delta phosphorylation in astrocytes promot es migration and activation of microglia/macrophages

Neurobiology of Aging

Volumn 35, Issue 1, 2014, Pages 24-34

  Ko, Chiung Yuan ^a,b   Wang, Wen Ling ^c   Wang, Shao Ming ^d   Chu, Yu Yi ^e   Chang, Wen Chang ^a,e   Wang, Ju Ming ^a,d,e  

^a TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^b KYOTO UNIVERSITY   (Japan)

^c CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^d NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^e NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

Author keywords

Alzheimer's disease; Astrocytes; CEBPD; GSK3 ; Microglia

Indexed keywords

AMYLOID PRECURSOR PROTEIN; CCAAT ENHANCER BINDING PROTEIN DELTA; GLYCOGEN SYNTHASE KINASE 3BETA; INTERLEUKIN 1BETA; INTERSTITIAL COLLAGENASE; LITHIUM CHLORIDE; MITOGEN ACTIVATED PROTEIN KINASE P38; MONOCYTE CHEMOTACTIC PROTEIN 1; STROMELYSIN;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; CEBPD GENE; CELL ACTIVATION; CELL MIGRATION; GENE; HUMAN; HUMAN CELL; HUMAN TISSUE; MACROPHAGE; MCP 1 GENE; MICROGLIA; MMP 1 GENE; MMP 3 GENE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE; UPREGULATION;

ALZHEIMER'S DISEASE; ASTROCYTES; CEBPD; GSK3Β; MICROGLIA;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANIMALS; ASTROCYTES; CCAAT-ENHANCER-BINDING PROTEIN-DELTA; CELL MOVEMENT; CELLS, CULTURED; GLYCOGEN SYNTHASE KINASE 3; HUMANS; INTERLEUKIN-1BETA; MACROPHAGE ACTIVATION; MACROPHAGES; MICE; MICE, TRANSGENIC; MICROGLIA; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; TUMOR NECROSIS FACTOR-ALPHA; UP-REGULATION;

EID: 84885173010     PISSN: 01974580     EISSN: 15581497     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2013.07.021     Document Type: Article

References (55)

1. Akira S., Hirano T., Taga T., Kishimoto T. Biology of multifunctional cytokines: IL 6 and related molecules (IL 1 and TNF). FASEB J. 1990, 4:2860-2867.
2. Beurel E., Jope R.S. Lipopolysaccharide-induced interleukin-6 production is controlled by glycogen synthase kinase-3 and STAT3 in the brain. J.Neuroinflamm. 2009, 6:9-19.
3. Bhat R.V., Budd S.L. GSK3beta signalling: casting a wide net in Alzheimer's disease. Neurosignals 2002, 11:251-261.
4. Blasi E., Barluzzi R., Bocchini V., Mazzolla R., Bistoni F. Immortalization of murine microglial cells by a v-raf/v-myc carrying retrovirus. J.Neuroimmunol. 1990, 27:229-237.
5. Cardinaux J.R., Allaman I., Magistretti P.J. Pro-inflammatory cytokines induce the transcription factors C/EBPbeta and C/EBPdelta in astrocytes. Glia 2000, 29:91-97.
6. Cho J.H., Johnson G.V. Glycogen synthase kinase 3beta phosphorylates tau at both primed and unprimed sites. Differential impact on microtubule binding. J.Biol. Chem. 2003, 278:187-193.
7. Cohen P., Frame S. The renaissance of GSK3. Nat. Rev. Mol. Cell Biol. 2001, 2:769-776.
8. Correa-Cerro L.S., Mandell J.W. Molecular mechanisms of astrogliosis: new approaches with mouse genetics. J.Neuropathol. Exp. Neurol. 2007, 66:169-176.
9. Doble B.W., Woodgett J.R. GSK-3: tricks of the trade for a multi-tasking kinase. J.Cell Sci. 2003, 116:1175-1186.
10. Gottschall P.E., Deb S. Regulation of matrix metalloproteinase expressions in astrocytes, microglia and neurons. Neuroimmunomodulation 1996, 3:69-75.
11. Guillemin G.J., Brew B.J. Microglia, macrophages, perivascular macrophages, and pericytes: a review of function and identification. J.Leukoc. Biol. 2004, 75:388-397.
12. Hazell A.S. Astrocytes and manganese neurotoxicity. Neurochem. Int. 2002, 41:271-277.
13. Hur E.M., Zhou F.Q. GSK3 signalling in neural development. Nat. Rev. Neurosci. 2010, 11:539-551.
14. Hurwitz A.A., Lyman W.D., Berman J.W. Tumor necrosis factor alpha and transforming growth factor beta upregulate astrocyte expression of monocyte chemoattractant protein-1. J.Neuroimmunol. 1995, 57:193-198.
15. Ishii Y., Kasukabe T., Honma Y. Induction of CCAAT/enhancer binding protein-delta by cytokinins, but not by retinoic acid, during granulocytic differentiation of human myeloid leukaemia cells. Br. J. Haematol. 2005, 128:540-547.
16. Ishizuka K., Kimura T., Igata-yi R., Katsuragi S., Takamatsu J., Miyakawa T. Identification of monocyte chemoattractant protein-1 in senile plaques and reactive microglia of Alzheimer's disease. Psychiatry Clin. Neurosci 1997, 51:135-138.
17. Ji L., Mochon E., Arcinas M., Boxer L.M. CREB proteins function as positive regulators of the translocated bcl-2 allele in t(14;18) lymphomas. J.Biol. Chem. 1996, 271:22687-22691.
18. Jope R.S., Johnson G.V. The glamour and gloom of glycogen synthase kinase-3. Trends Biochem. Sci. 2004, 29:95-102.
19. Kaul M., Garden G.A., Lipton S.A. Pathways to neuronal injury and apoptosis in HIV-associated dementia. Nature 2001, 410:988-994.
20. Kim D.W., Lee J.H., Park S.K., Yang W.M., Jeon G.S., Lee Y.H., Chung C.K., Cho S.S. Astrocytic expressions of phosphorylated Akt, GSK3beta and CREB following an excitotoxic lesion in the mouse hippocampus. Neurochem. Res. 2007, 32:1460-1468.
21. Kinoshita S., Akira S., Kishimoto T. Amember of the C/EBP family, NF-IL6 beta, forms a heterodimer and transcriptionally synergizes with NF-IL6. Proc. Natl. Acad. Sci. U.S.A 1992, 89:1473-1476.
22. Kiyota T., Yamamoto M., Schroder B., Jacobsen M.T., Swan R.J., Lambert M.P., Klein W.L., Gendelman H.E., Ransohoff R.M., Ikezu T. AAV1/2-mediated CNS gene delivery of dominant-negative CCL2 mutant suppresses gliosis, beta-amyloidosis, and learning impairment of APP/PS1 mice. Mol. Ther. 2009, 17:803-809.
23. Ko C.Y., Chang L.H., Lee Y.C., Sterneck E., Cheng C.P., Chen S.H., Huang A.M., Tseng J.T., Wang J.M. CCAAT/enhancer binding protein delta (CEBPD) elevating PTX3 expression inhibits macrophage-mediated phagocytosis of dying neuron cells. Neurobiol. Aging 2012, 33:e11.422-e11.425.
24. Lai P.H., Wang W.L., Ko C.Y., Lee Y.C., Yang W.M., Shen T.W., Chang W.C., Wang J.M. HDAC1/HDAC3 modulates PPARG2 transcription through the sumoylated CEBPD in hepatic lipogenesis. Biochim. Biophys. Acta. 2008, 1783:1803-1814.
25. Leake A., Morris C.M., Whateley J. Brain matrix metalloproteinase 1 levels are elevated in Alzheimer's disease. Neurosci. Lett. 2000, 291:201-203.
26. Li R., Strohmeyer R., Liang Z., Lue L.F., Rogers J. CCAAT/enhancer binding protein delta (C/EBPdelta) expression and elevation in Alzheimer's disease. Neurobiol. Aging 2004, 25:991-999.
27. Liu Y.W., Tseng H.P., Chen L.C., Chen B.K., Chang W.C. Functional cooperation of simian virus 40 promoter factor 1 and CCAAT/enhancer-binding protein beta and delta in lipopolysaccharide-induced gene activation of IL-10 in mouse macrophages. J.Immunol. 2003, 171:821-828.
28. Lorenzl S., Albers D.S., Relkin N., Ngyuen T., Hilgenberg S.L., Chirichigno J., Cudkowicz M.E., Beal M.F. Increased plasma levels of matrix metalloproteinase-9 in patients with Alzheimer's disease. Neurochem. Int. 2003, 43:191-196.
29. Madrigal J.L., Leza J.C., Polak P., Kalinin S., Feinstein D.L. Astrocyte-derived MCP-1 mediates neuroprotective effects of noradrenaline. J.Neurosci. 2009, 29:263-267.
30. Maragakis N.J., Rothstein J.D. Mechanisms of disease: astrocytes in neurodegenerative disease. Nat. Clin. Pract. Neurol. 2006, 2:679-689.
31. Maranto J., Rappaport J., Datta P.K. Role of C/EBP-β, p38 MAPK, and MKK6 in IL-1β-mediated C3 gene regulation in astrocytes. J.Cell. Biochem. 2011, 112:1168-1175.
32. McManus C.M., Liu J.S., Hahn M.T., Hua L.L., Brosnan C.F., Berman J.W., Lee S.C. Differential induction of chemokines in human microglia by type I and II interferons. Glia 2000, 29:273-280.
33. Minagar A., Shapshak P., Fujimura R., Ownby R., Heyes M., Eisdorfer C. The role of macrophage/microglia and astrocytes in the pathogenesis of three neurologic disorders: HIV-associated dementia, Alzheimer disease, and multiple sclerosis. J.Neurol. Sci. 2002, 202:13-23.
34. Nagao M., Hayashi H. Glycogen synthase kinase-3beta is associated with Parkinson's disease. Neurosci. Lett. 2009, 449:103-107.
35. Nedergaard M. Direct signaling from astrocytes to neurons in cultures of mammalian brain cells. Science 1994, 263:1768-1771.
36. Pekny M., Nilsson M. Astrocyte activation and reactive gliosis. Glia 2005, 50:427-434.
37. Persidsky Y., Gendelman H.E. Mononuclear phagocyte immunity and the neuropathogenesis of HIV-1 infection. J.Leukoc. Biol. 2003, 74:691-701.
38. Pfrieger F.W., Barres B.A. Synaptic efficacy enhanced by glial cells invitro. Science 1997, 277:1684-1687.
39. Poli V. The role of C/EBP isoforms in the control of inflammatory and native immunity functions. J.Biol. Chem. 1998, 273:29279-29282.
40. Potts R., Leech R.W. Thalamic dementia: an example of primary astroglial dystrophy of Seitelberger. Clin. Neuropathol 2005, 24:271-275.
41. Prat E., Baron P., Meda L., Scarpini E., Galimberti D., Ardolino G., Catania A., Scarlato G. The human astrocytoma cell line U373MG produces monocyte chemotactic protein (MCP)-1 upon stimulation with beta-amyloid protein. Neurosci. Lett. 2000, 283:177-180.
42. Ramji D.P., Foka P. CCAAT/enhancer-binding proteins: structure, function and regulation. Biochem. J. 2002, 365:561-575.
43. Riccio A., Ahn S., Davenport C.M., Blendy J.A., Ginty D.D. Mediation by a CREB family transcription factor of NGF-dependent survival of sympathetic neurons. Science 1999, 286:2358-2361.
44. Rodriguez J.J., Olabarria M., Chvatal A., Verkhratsky A. Astroglia in dementia and Alzheimer's disease. Cell Death. Differ 2009, 16:378-385.
45. Rojo L.E., Fernandez J.A., Maccioni A.A., Jimenez J.M., Maccioni R.B. Neuroinflammation: implications for the pathogenesis and molecular diagnosis of Alzheimer's disease. Arch. Med. Res. 2008, 39:1-16.
46. Sanford D.C., DeWille J.W. C/EBPdelta is a downstream mediator of IL-6 induced growth inhibition of prostate cancer cells. Prostate 2005, 63:143-154.
47. Sofroniew M.V. Molecular dissection of reactive astrogliosis and glial scar formation. Trends Neurosci. 2009, 32:638-647.
48. Song H., Stevens C.F., Gage F.H. Astroglia induce neurogenesis from adult neural stem cells. Nature 2002, 417:39-44.
49. Sterneck E., Paylor R., Jackson-Lewis V., Libbey M., Przedborski S., Tessarollo L., Crawley J.N., Johnson P.F. Selectively enhanced contextual fear conditioning in mice lacking the transcriptional regulator CCAAT/enhancer binding protein delta. Proc. Natl. Acad. Sci. U.S.A 1998, 95:10908-10913.
50. Svotelis A., Doyon G., Bernatchez G., Desilets A., Rivard N., Asselin C. IL-1 beta-dependent regulation of C/EBP delta transcriptional activity. Biochem. Biophys. Res. Commun. 2005, 328:461-470.
51. Takeji M., Kawada N., Moriyama T., Nagatoya K., Oseto S., Akira S., Hori M., Imai E., Miwa T. CCAAT/Enhancer-binding protein delta contributes to myofibroblast transdifferentiation and renal disease progression. J.Am. Soc. Nephrol. 2004, 15:2383-2390.
52. Tengku-Muhammad T.S., Hughes T.R., Ranki H., Cryer A., Ramji D.P. Differential regulation of macrophage CCAAT-enhancer binding protein isoforms by lipopolysaccharide and cytokines. Cytokine 2000, 12:1430-1436.
53. Wang J.M., Ko C.Y., Chen L.C., Wang W.L., Chang W.C. Functional role of NF-IL6beta and its sumoylation and acetylation modifications in promoter activation of cyclooxygenase 2 gene. Nucleic Acids Res. 2006, 34:217-231.
54. Wang J.M., Tseng J.T., Chang W.C. Induction of human NF-IL6beta by epidermalgrowth factor is mediated through the p38 signaling pathway and cAMP response element-binding protein activation in A431 cells. Mol. Biol. Cell. 2005, 16:3365-3376.
55. Wang W.L., Lee Y.C., Yang W.M., Chang W.C., Wang J.M. Sumoylation of LAP1 is involved in the HDAC4-mediated repression of COX-2 transcription. Nucleic Acids Res. 2008, 36:6066-6079.