-
1
-
-
0034626988
-
Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents
-
Esteller, M. et al. Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents. N Engl J Med 343, 1350-4 (2000).
-
(2000)
N Engl J Med
, vol.343
, pp. 1350-1354
-
-
Esteller, M.1
-
2
-
-
20044372154
-
MGMT gene silencing and benefit from temozolomide in glioblastoma
-
DOI 10.1056/NEJMoa043331
-
Hegi, M. E. et al. MGMT gene silencing and benefit from temozolomide in glioblastoma. N Engl J Med 352, 997-1003 (2005). (Pubitemid 40349502)
-
(2005)
New England Journal of Medicine
, vol.352
, Issue.10
, pp. 997-1003
-
-
Hegi, M.E.1
Diserens, A.-C.2
Gorlia, T.3
Hamou, M.-F.4
De Tribolet, N.5
Weller, M.6
Kros, J.M.7
Hainfellner, J.A.8
Mason, W.9
Mariani, L.10
Bromberg, J.E.C.11
Hau, P.12
Mirimanoff, R.O.13
Cairncross, J.G.14
Janzer, R.C.15
Stupp, R.16
-
3
-
-
0037005988
-
Hypermethylation of the DNA repair gene O(6)-methylguanine DNA methyltransferase and survival of patients with diffuse large B-cell lymphoma
-
Esteller, M. et al. Hypermethylation of the DNA repair gene O(6)-methylguanine DNA methyltransferase and survival of patients with diffuse large B-cell lymphoma. J Natl Cancer Inst 94, 26-32 (2002).
-
(2002)
J Natl Cancer Inst
, vol.94
, pp. 26-32
-
-
Esteller, M.1
-
4
-
-
33744479180
-
6-methylguanine-DNA methyltransferase protein expression is a favorable prognostic marker in diffuse large B-cell lymphoma
-
DOI 10.1532/IJH97.05182
-
Ohno, T. et al. Loss of O6-methylguanine-DNA methyltransferase protein expression is a favorable prognostic marker in diffuse large B-cell lymphoma. Int J Hematol 83, 341-7 (2006). (Pubitemid 43807580)
-
(2006)
International Journal of Hematology
, vol.83
, Issue.4
, pp. 341-347
-
-
Ohno, T.1
Hiraga, J.2
Ohashi, H.3
Sugisaki, C.4
Li, E.5
Asano, H.6
Ito, T.7
Nagai, H.8
Yamashita, Y.9
Mori, N.10
Kinoshita, T.11
Naoe, T.12
-
5
-
-
72949102862
-
Is inactivation of O6-methylguanine DNA methyltransferase still a favorable prognostic factor of patients with diffuse large B-cell lymphoma in the era of R-CHOP chemotherapy?
-
Lee, G. W. et al. Is inactivation of O6-methylguanine DNA methyltransferase still a favorable prognostic factor of patients with diffuse large B-cell lymphoma in the era of R-CHOP chemotherapy? Leuk Lymphoma 50, 1992-8 (2009).
-
(2009)
Leuk Lymphoma
, vol.50
, pp. 1992-1998
-
-
Lee, G.W.1
-
6
-
-
43749123044
-
DNA methylation profiles in diffuse large B-cell lymphoma and their relationship to gene expression status
-
DOI 10.1038/leu.2008.18, PII LEU200818
-
Pike, B. L. et al. DNA methylation profiles in diffuse large B-cell lymphoma and their relationship to gene expression status. Leukemia 22, 1035-43 (2008). (Pubitemid 351689886)
-
(2008)
Leukemia
, vol.22
, Issue.5
, pp. 1035-1043
-
-
Pike, B.L.1
Greiner, T.C.2
Wang, X.3
Weisenburger, D.D.4
Hsu, Y.-H.5
Renaud, G.6
Wolfsberg, T.G.7
Kim, M.8
Weisenberger, D.J.9
Siegmund, K.D.10
Ye, W.11
Groshen, S.12
Mehrian-Shai, R.13
Delabie, J.14
Chan, W.C.15
Laird, P.W.16
Hacia, J.G.17
-
7
-
-
71149121511
-
MGMTmethylation is associated primarily with the germline C . T SNP (rs16906252) in colorectal cancer and normal colonic mucosa
-
Hawkins, N. J. et al.MGMTmethylation is associated primarily with the germline C . T SNP (rs16906252) in colorectal cancer and normal colonic mucosa. Mod Pathol (2009).
-
(2009)
Mod Pathol
-
-
Hawkins, N.J.1
-
8
-
-
78650953062
-
Methylation ofMGMT in malignant pleural mesothelioma occurs in a subset of patients and is associated with the T allele of the rs16906252MGMTpromoter SNP
-
Kristensen, L. S., Nielsen, H. M.,Hager, H. Hansen, L. L. Methylation ofMGMT in malignant pleural mesothelioma occurs in a subset of patients and is associated with the T allele of the rs16906252MGMTpromoter SNP. Lung Cancer 71, 130-6 (2011).
-
(2011)
Lung Cancer
, vol.71
, pp. 130-136
-
-
Kristensen, L.S.1
Nielsen, H.M.2
Hager, H.3
Hansen, L.L.4
-
9
-
-
34948886186
-
MGMT germline polymorphism is associated with somatic MGMT promoter methylation and gene silencing in colorectal cancer
-
DOI 10.1093/carcin/bgm160
-
Ogino, S. et al.MGMTgermline polymorphismis associated with somaticMGMT promoter methylation and gene silencing in colorectal cancer. Carcinogenesis 28, 1985-90 (2007). (Pubitemid 47514483)
-
(2007)
Carcinogenesis
, vol.28
, Issue.9
, pp. 1985-1990
-
-
Ogino, S.1
Hazra, A.2
Tranah, G.J.3
Kirkner, G.J.4
Kawasaki, T.5
Nosho, K.6
Ohnishi, M.7
Suemoto, Y.8
Meyerhardt, J.A.9
Hunter, D.J.10
Fuchs, C.S.11
-
10
-
-
79953323280
-
The A/G allele of rs16906252 predicts forMGMTmethylation and is selectively silenced in premalignant lesions from smokers and in lung adenocarcinomas
-
Leng, S. et al. The A/G allele of rs16906252 predicts forMGMTmethylation and is selectively silenced in premalignant lesions from smokers and in lung adenocarcinomas. Clin Cancer Res 17, 2014-23 (2011).
-
(2011)
Clin Cancer Res
, vol.17
, pp. 2014-2023
-
-
Leng, S.1
-
11
-
-
84872099058
-
The T genotype of the MGMT C . T (rs16906252) enhancer single-nucleotide polymorphism (SNP) is associated with promoter methylation and longer survival in glioblastoma patients
-
McDonald, K. L. et al. The T genotype of the MGMT C . T (rs16906252) enhancer single-nucleotide polymorphism (SNP) is associated with promoter methylation and longer survival in glioblastoma patients. Eur J Cancer 49, 360-8 (2013).
-
(2013)
Eur J Cancer
, vol.49
, pp. 360-368
-
-
McDonald, K.L.1
-
12
-
-
0035132145
-
Aberrant promoter methylation of multiple genes in non-small cell lung cancers
-
Zochbauer-Muller, S. et al. Aberrant promoter methylation of multiple genes in non-small cell lung cancers. Cancer Res 61, 249-55 (2001). (Pubitemid 32095725)
-
(2001)
Cancer Research
, vol.61
, Issue.1
, pp. 249-255
-
-
Zochbauer-Muller, S.1
Fong, K.M.2
Virmani, A.K.3
Geradts, J.4
Gazdar, A.F.5
Minna, J.D.6
-
13
-
-
33745812020
-
DAPK promotor methylation is an early event in colorectal carcinogenesis
-
DOI 10.1016/j.canlet.2005.08.034, PII S0304383505008074
-
Mittag, F. et al. DAPK promotor methylation is an early event in colorectal carcinogenesis. Cancer Lett 240, 69-75 (2006). (Pubitemid 44037174)
-
(2006)
Cancer Letters
, vol.240
, Issue.1
, pp. 69-75
-
-
Mittag, F.1
Kuester, D.2
Vieth, M.3
Peters, B.4
Stolte, B.5
Roessner, A.6
Schneider-Stock, R.7
-
14
-
-
53049090443
-
Prognostic significance of aberrant promoter hypermethylation of CpG islands in patients with diffuse large B-cell lymphomas
-
Amara, K. et al. Prognostic significance of aberrant promoter hypermethylation of CpG islands in patients with diffuse large B-cell lymphomas. Ann Oncol 19, 1774-86 (2008).
-
(2008)
Ann Oncol
, vol.19
, pp. 1774-1786
-
-
Amara, K.1
-
15
-
-
84867184362
-
Methylation profiling of normal individuals reveals mosaic promoter methylation of cancerassociated genes
-
Kristensen, L. S., Raynor, M. P., Candiloro, I. & Dobrovic, A. Methylation profiling of normal individuals reveals mosaic promoter methylation of cancerassociated genes. Oncotarget 3, 450-61 (2012).
-
(2012)
Oncotarget
, vol.3
, pp. 450-461
-
-
Kristensen, L.S.1
Raynor, M.P.2
Candiloro, I.3
Dobrovic, A.4
-
16
-
-
0036314222
-
Conversion-specific detection of DNA methylation using real-time polymerase chain reaction (ConLight-MSP) to avoid false positives
-
DOI 10.1016/S1046-2023(02)00062-2, PII S1046202302000622
-
Rand, K., Qu,W., Ho, T., Clark, S. J. Molloy, P. Conversion-specific detection of DNA methylation using real-time polymerase chain reaction (ConLight-MSP) to avoid false positives. Methods 27, 114-20 (2002). (Pubitemid 34757121)
-
(2002)
Methods
, vol.27
, Issue.2
, pp. 114-120
-
-
Rand, K.1
Qu, W.2
Ho, T.3
Clark, S.J.4
Molloy, P.5
-
17
-
-
33745666856
-
Methylation enrichment pyrosequencing: Combining the specificity of MSP with validation by pyrosequencing
-
Shaw, R. J., Akufo-Tetteh, E. K., Risk, J.M., Field, J. K. & Liloglou, T.Methylation enrichment pyrosequencing: combining the specificity of MSP with validation by pyrosequencing. Nucleic Acids Res 34, e78 (2006).
-
(2006)
Nucleic Acids Res
, vol.34
-
-
Shaw, R.J.1
Akufo-Tetteh, E.K.2
Risk, J.M.3
Field, J.K.4
Liloglou, T.5
-
18
-
-
34548147443
-
Optimization of quantitative MGMT promoter methylation analysis using pyrosequencing and combined bisulfite restriction analysis
-
DOI 10.2353/jmoldx.2007.060167
-
Mikeska, T. et al. Optimization of quantitative MGMT promoter methylation analysis using pyrosequencing and combined bisulfite restriction analysis. J Mol Diagn 9, 368-81 (2007). (Pubitemid 47305073)
-
(2007)
Journal of Molecular Diagnostics
, vol.9
, Issue.3
, pp. 368-381
-
-
Mikeska, T.1
Bock, C.2
Hubner, A.3
Ehrentraut, D.4
Schramm, J.5
Felsberg, J.6
Kahl, P.7
Buttner, R.8
Pietsch, T.9
Waha, A.10
-
19
-
-
70449366014
-
Detection of MGMT promoter methylation in normal individuals is strongly associated with the T allele of the rs16906252 MGMT promoter single nucleotide polymorphism
-
Candiloro, I. L. & Dobrovic, A. Detection of MGMT promoter methylation in normal individuals is strongly associated with the T allele of the rs16906252 MGMT promoter single nucleotide polymorphism. Cancer Prev Res (Phila Pa) 2, 862-7 (2009).
-
(2009)
Cancer Prev Res (Phila Pa)
, vol.2
, pp. 862-867
-
-
Candiloro, I.L.1
Dobrovic, A.2
-
20
-
-
0029843950
-
Methylation-specific PCR: A novel PCR assay for methylation status of CpG islands
-
DOI 10.1073/pnas.93.18.9821
-
Herman, J.G., Graff, J. R.,Myohanen, S., Nelkin, B. D. Baylin, S. B. Methylationspecific PCR: a novel PCR assay for methylation status of CpG islands. Proc Natl Acad Sci USA 93, 9821-6 (1996). (Pubitemid 26296693)
-
(1996)
Proceedings of the National Academy of Sciences of the United States of America
, vol.93
, Issue.18
, pp. 9821-9826
-
-
Herman, J.G.1
Graff, J.R.2
Myohanen, S.3
Nelkin, B.D.4
Baylin, S.B.5
-
21
-
-
33847019906
-
Rapid and quantitative method of allele-specific DNA methylation analysis
-
Wong, H. L. et al. Rapid and quantitative method of allele-specific DNA methylation analysis. Biotechniques 41, 734-9 (2006).
-
(2006)
Biotechniques
, vol.41
, pp. 734-739
-
-
Wong, H.L.1
-
22
-
-
68149163117
-
PCR-based methods for detecting single-locus DNA methylation biomarkers in cancer diagnostics, prognostics, and response to treatment
-
Kristensen, L. S. & Hansen, L. L. PCR-based methods for detecting single-locus DNA methylation biomarkers in cancer diagnostics, prognostics, and response to treatment. Clin Chem 55, 1471-83 (2009).
-
(2009)
Clin Chem
, vol.55
, pp. 1471-1483
-
-
Kristensen, L.S.1
Hansen, L.L.2
-
23
-
-
84883222332
-
Analysis of epigenetic modifications of DNA in human cells
-
Kristensen, L. S., Treppendahl, M. B. & Gronbaek, K. Analysis of epigenetic modifications of DNA in human cells. Curr Protoc Hum Genet 77, 20.2.1-20.2.22 (2013).
-
(2013)
Curr Protoc Hum Genet
, vol.77
, pp. 2021-20222
-
-
Kristensen, L.S.1
Treppendahl, M.B.2
Gronbaek, K.3
-
24
-
-
0030825309
-
COBRA: A sensitive and quantitative DNA methylation assay
-
DOI 10.1093/nar/25.12.2532
-
Xiong, Z. & Laird, P. W. COBRA: a sensitive and quantitative DNA methylation assay. Nucleic Acids Res 25, 2532-4 (1997). (Pubitemid 27303718)
-
(1997)
Nucleic Acids Research
, vol.25
, Issue.12
, pp. 2532-2534
-
-
Xiong, Z.1
Laird, P.W.2
-
25
-
-
0036315386
-
Profiling DNA methylation by melting analysis
-
DOI 10.1016/S1046-2023(02)00063-4, PII S1046202302000634
-
Guldberg, P., Worm, J. & Gronbaek, K. Profiling DNA methylation by melting analysis. Methods 27, 121-7 (2002). (Pubitemid 34757122)
-
(2002)
Methods
, vol.27
, Issue.2
, pp. 121-127
-
-
Guldberg, P.1
Worm, J.2
Gronbaek, K.3
-
26
-
-
84875416383
-
Evaluation of BRAF mutation testing methodologies in formalin-fixed, paraffin-embedded cutaneousmelanomas
-
Lade-Keller, J. et al. Evaluation of BRAF mutation testing methodologies in formalin-fixed, paraffin-embedded cutaneousmelanomas. JMol Diagn 15, 70-80 (2013).
-
(2013)
JMol Diagn
, vol.15
, pp. 70-80
-
-
Lade-Keller, J.1
-
27
-
-
77954238686
-
Allele-specific methylation is prevalent and is contributed by CpG-SNPs in the human genome
-
Shoemaker, R., Deng, J., Wang, W. & Zhang, K. Allele-specific methylation is prevalent and is contributed by CpG-SNPs in the human genome. Genome Res 20, 883-9 (2010).
-
(2010)
Genome Res
, vol.20
, pp. 883-889
-
-
Shoemaker, R.1
Deng, J.2
Wang, W.3
Zhang, K.4
-
28
-
-
46249117780
-
Genomic surveys by methylation-sensitive SNP analysis identify sequence-dependent allele-specific DNA methylation
-
Kerkel, K. et al. Genomic surveys by methylation-sensitive SNP analysis identify sequence-dependent allele-specific DNA methylation. Nat Genet 40, 904-8 (2008).
-
(2008)
Nat Genet
, vol.40
, pp. 904-908
-
-
Kerkel, K.1
-
29
-
-
60349085564
-
Prognostic significance of O6-methylguanine DNA methyltransferase and p57 methylation in patients with diffuse large B-cell lymphomas
-
Lee, S. M. et al. Prognostic significance of O6-methylguanine DNA methyltransferase and p57 methylation in patients with diffuse large B-cell lymphomas. APMIS 117, 87-94 (2009).
-
(2009)
APMIS
, vol.117
, pp. 87-94
-
-
Lee, S.M.1
-
30
-
-
33750379353
-
6- methylguanine-DNA methyltransferase and p53 mutation in diffuse large B-cell lymphoma
-
DOI 10.1532/IJH97.06087
-
Hiraga, J. et al. Promoter hypermethylation of the DNA-repair gene O6-methylguanine-DNA methyltransferase and p53 mutation in diffuse large B-cell lymphoma. Int J Hematol 84, 248-55 (2006). (Pubitemid 44619247)
-
(2006)
International Journal of Hematology
, vol.84
, Issue.3
, pp. 248-255
-
-
Hiraga, J.1
Kinoshita, T.2
Ohno, T.3
Mori, N.4
Ohashi, H.5
Fukami, S.6
Noda, A.7
Ichikawa, A.8
Naoe, T.9
-
31
-
-
39749186532
-
Presence of simian virus 40 in diffuse large B-cell lymphomas in Tunisia correlates with germinal center B-cell immunophenotype, t(14;18) translocation, and P53 accumulation
-
DOI 10.1038/modpathol.3800993, PII 3800993
-
Amara, K. et al. Presence of simian virus 40 in diffuse large B-cell lymphomas in Tunisia correlates with germinal center B-cell immunophenotype, t(14;18) translocation, and P53 accumulation. Mod Pathol 21, 282-96 (2008). (Pubitemid 351304282)
-
(2008)
Modern Pathology
, vol.21
, Issue.3
, pp. 282-296
-
-
Amara, K.1
Trimeche, M.2
Ziadi, S.3
Laatiri, A.4
Mestiri, S.5
Sriha, B.6
Mokni, M.7
Korbi, S.8
-
32
-
-
34347397813
-
Correlation between promoter hypermethylation of GSTP1 and response to chemotherapy in diffuse large B cell lymphoma
-
DOI 10.1007/s00277-007-0299-1
-
Nakamichi, I. et al. Correlation between promoter hypermethylation of GSTP1 and response to chemotherapy in diffuse large B cell lymphoma. Ann Hematol 86, 557-64 (2007). (Pubitemid 47018473)
-
(2007)
Annals of Hematology
, vol.86
, Issue.8
, pp. 557-564
-
-
Nakamichi, I.1
Tomita, Y.2
Zhang, B.3
Sugiyama, H.4
Kanakura, Y.5
Fukuhara, S.6
Hino, M.7
Kanamaru, A.8
Ogawa, H.9
Aozasa, K.10
-
33
-
-
0033564351
-
Hypermethylation of the DAP-kinase CpG island is a common alteration in B-cell malignancies
-
Katzenellenbogen, R. A., Baylin, S. B. & Herman, J. G. Hypermethylation of the DAP-kinase CpG island is a common alteration in B-cell malignancies. Blood 93, 4347-53 (1999). (Pubitemid 29279278)
-
(1999)
Blood
, vol.93
, Issue.12
, pp. 4347-4353
-
-
Katzenellenbogen, R.A.1
Baylin, S.B.2
Herman, J.G.3
-
34
-
-
0344844471
-
Death-associated protein kinase promoter hypermethylation in normal human lymphocytes
-
Reddy, A. N. et al.Death-associated protein kinase promoter hypermethylation in normal human lymphocytes. Cancer Res 63, 7694-8 (2003). (Pubitemid 37466698)
-
(2003)
Cancer Research
, vol.63
, Issue.22
, pp. 7694-7698
-
-
Reddy, A.N.1
Jiang, W.W.2
Kim, M.3
Benoit, N.4
Taylor, R.5
Clinger, J.6
Sidransky, D.7
Califano, J.A.8
-
35
-
-
0034654669
-
MethyLight: A high-throughput assay to measure DNA methylation
-
Eads, C. A. et al. MethyLight: a high-throughput assay to measure DNA methylation. Nucleic Acids Res 28, E32 (2000).
-
(2000)
Nucleic Acids Res
, vol.28
-
-
Eads, C.A.1
-
36
-
-
42449142344
-
Sensitive Melting Analysis after Real Time-Methylation Specific PCR (SMART-MSP): Highthroughput and probe-free quantitative DNA methylation detection
-
Kristensen, L. S., Mikeska, T., Krypuy, M. & Dobrovic, A. Sensitive Melting Analysis after Real Time-Methylation Specific PCR (SMART-MSP): highthroughput and probe-free quantitative DNA methylation detection. Nucleic Acids Res 36, e42 (2008).
-
(2008)
Nucleic Acids Res
, vol.36
-
-
Kristensen, L.S.1
Mikeska, T.2
Krypuy, M.3
Dobrovic, A.4
-
37
-
-
0031961112
-
Molecular genetic analysis of easily accessible breast tumour DNA, purified from tissue left over from hormone receptor measurement
-
Hansen, L. L., Andersen, J., Overgaard, J. Kruse, T. A. Molecular genetic analysis of easily accessible breast tumour DNA, purified from tissue left over from hormone receptor measurement. APMIS 106, 371-7 (1998). (Pubitemid 28157213)
-
(1998)
APMIS
, vol.106
, Issue.3
, pp. 371-377
-
-
Hansen, L.L.1
Andersen, J.2
Overgaard, J.3
Kruse, T.A.4
-
38
-
-
80054737698
-
Analysing DNA methylation using bisulphite pyrosequencing
-
Mikeska, T., Felsberg, J., Hewitt, C. A. & Dobrovic, A. Analysing DNA methylation using bisulphite pyrosequencing. Methods Mol Biol 791, 33-53 (2011).
-
(2011)
Methods Mol Biol
, vol.791
, pp. 33-53
-
-
Mikeska, T.1
Felsberg, J.2
Hewitt, C.A.3
Dobrovic, A.4
-
39
-
-
84862911969
-
Allelic methylation levels of the noncoding VTRNA2-1 located on chromosome 5q31.1 predict outcome in AML
-
Treppendahl, M. B. et al. Allelic methylation levels of the noncoding VTRNA2-1 located on chromosome 5q31.1 predict outcome in AML. Blood 119, 206-16 (2012).
-
(2012)
Blood
, vol.119
, pp. 206-216
-
-
Treppendahl, M.B.1
|