Identification of Novel Vaccine Candidates against Multidrug-Resistant Acinetobacter baumannii

PLoS ONE

Volumn 8, Issue 10, 2013, Pages

  Moriel, Danilo G ^a   Beatson, Scott A ^a   Wurpel, Daniël J ^a   Lipman, Jeffrey ^a   Nimmo, Graeme R ^a,b   Paterson, David L ^a,c   Schembri, Mark A ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b Central Queensland Pathology Laboratory   (Australia)

^c UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ACINETOBACTER BAUMANNII ANTIGEN; BACTERIAL ANTIGEN; UNCLASSIFIED DRUG;

ACINETOBACTER BAUMANNII; ACINETOBACTER INFECTION; ANTIBIOTIC RESISTANCE; ANTIGEN DETECTION; ARTICLE; COMPUTER MODEL; CONTROLLED STUDY; GENOME ANALYSIS; IN VITRO STUDY; MOLECULAR BIOLOGY; NONHUMAN; PROTEIN TARGETING; PROTEOMICS; REVERSE VACCINOLOGY; VACCINE PRODUCTION;

ACINETOBACTER BAUMANNII; ACINETOBACTER INFECTIONS; ANTIGENS, BACTERIAL; BACTERIAL OUTER MEMBRANE PROTEINS; BACTERIAL VACCINES; COMPUTER SIMULATION; DRUG RESISTANCE, MULTIPLE, BACTERIAL; GENOME, BACTERIAL; HUMANS; PROTEOMICS;

EID: 84885158859     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0077631     Document Type: Article

References (48)

1. Dijkshoorn L, Nemec A, Seifert H, (2007) An increasing threat in hospitals: multidrug-resistant Acinetobacter baumannii. Nat Rev Microbiol 5: 939-951. doi:10.1038/nrmicro1789. PubMed: 18007677.
2. Peleg AY, Seifert H, Paterson DL, (2008) Acinetobacter baumannii: emergence of a successful pathogen. Clin Microbiol Rev 21: 538-582. doi:10.1128/CMR.00058-07. PubMed: 18625687.
3. Mugnier PD, Poirel L, Naas T, Nordmann P, (2010) Worldwide dissemination of the blaOXA-23 carbapenemase gene of Acinetobacter baumannii. Emerg Infect Dis 16: 35-40. PubMed: 20031040.
4. Bartual SG, Seifert H, Hippler C, Luzon MA, Wisplinghoff H, et al. (2005) Development of a multilocus sequence typing scheme for characterization of clinical isolates of Acinetobacter baumannii. J Clin Microbiol 43: 4382-4390. doi:10.1128/JCM.43.9.4382-4390.2005. PubMed: 16145081.
5. Diancourt L, Passet V, Nemec A, Dijkshoorn L, Brisse S, (2010) The population structure of Acinetobacter baumannii: expanding multiresistant clones from an ancestral susceptible genetic pool. PLOS ONE 5: e10034. doi:10.1371/journal.pone.0010034. PubMed: 20383326.
6. Luo G, Lin L, Ibrahim AS, Baquir B, Pantapalangkoor P, et al. (2012) Active and passive immunization protects against lethal, extreme drug resistant-Acinetobacter baumannii infection. PLOS ONE 7: e29446. doi:10.1371/journal.pone.0029446. PubMed: 22253723.
7. Bentancor LV, Routray A, Bozkurt-Guzel C, Camacho-Peiro A, Pier GB, et al. (2012) Evaluation of the Trimeric Autotransporter Ata, as a Vaccine Candidate Against Acinetobacter baumannii Infections. Infect Immun 80: 3381-3388. doi:10.1128/IAI.06096-11. PubMed: 22825448.
8. Fattahian Y, Rasooli I, Mousavi Gargari SL, Rahbar MR, Alipour Astaneh Darvish S, et al. (2011) Protection against Acinetobacter baumannii infection via its functional deprivation of biofilm associated protein (Bap). Microb Pathog 51: 402-406.
9. Moriel DG, Bertoldi I, Spagnuolo A, Marchi S, Rosini R, et al. (2010) Identification of protective and broadly conserved vaccine antigens from the genome of extraintestinal pathogenic Escherichia coli. Proc Natl Acad Sci U S A 107: 9072-9077. doi:10.1073/pnas.0915077107. PubMed: 20439758.
10. Scorza FB, Doro F, Rodríguez-Ortega MJ, Stella M, Liberatori S, et al. (2008) Proteomics characterization of outer membrane vesicles from the extraintestinal pathogenic Escherichia coli DeltatolR IHE3034 mutant. Mol Cell Proteomics 7: 473-485. PubMed: 17982123.
11. Pizza M, Scarlato V, Masignani V, Giuliani MM, Aricò B, et al. (2000) Identification of vaccine candidates against serogroup B meningococcus by whole-genome sequencing. Science 287: 1816-1820. doi:10.1126/science.287.5459.1816. PubMed: 10710308.
12. Ferrari G, Garaguso I, Adu-Bobie J, Doro F, Taddei AR, et al. (2006) Outer membrane vesicles from group B Neisseria meningitidis delta gna33 mutant: proteomic and immunological comparison with detergent-derived outer membrane vesicles. Proteomics 6: 1856-1866. doi:10.1002/pmic.200500164. PubMed: 16456881.
13. Vallenet D, Nordmann P, Barbe V, Poirel L, Mangenot S, et al. (2008) Comparative analysis of Acinetobacters: three genomes for three lifestyles. PLOS ONE 3: e1805. doi:10.1371/journal.pone.0001805. PubMed: 18350144.
14. Kuehn MJ, Kesty NC, (2005) Bacterial outer membrane vesicles and the host-pathogen interaction. Genes Dev 19: 2645-2655. doi:10.1101/gad.1299905. PubMed: 16291643.
15. Kwon SO, Gho YS, Lee JC, Kim SI, (2009) Proteome analysis of outer membrane vesicles from a clinical Acinetobacter baumannii isolate. FEMS Microbiol Lett 297: 150-156. doi:10.1111/j.1574-6968.2009.01669.x. PubMed: 19548894.
16. Fournier PE, Vallenet D, Barbe V, Audic S, Ogata H, et al. (2006) Comparative genomics of multidrug resistance in Acinetobacter baumannii. PLOS Genet 2: e7. doi:10.1371/journal.pgen.0020007. PubMed: 16415984.
17. McConnell MJ, Pachón J, (2010) Active and passive immunization against Acinetobacter baumannii using an inactivated whole cell vaccine. Vaccine 29: 1-5. doi:10.1016/j.vaccine.2010.10.052. PubMed: 21044668.
18. McConnell MJ, Rumbo C, Bou G, Pachón J, (2011) Outer membrane vesicles as an acellular vaccine against Acinetobacter baumannii. Vaccine 29: 5705-5710. doi:10.1016/j.vaccine.2011.06.001. PubMed: 21679737.
19. McConnell MJ, Domínguez-Herrera J, Smani Y, López-Rojas R, Docobo-Pérez F, et al. (2011) Vaccination with outer membrane complexes elicits rapid protective immunity to multidrug-resistant Acinetobacter baumannii. Infect Immun 79: 518-526. doi:10.1128/IAI.00741-10. PubMed: 20974823.
20. Mihara K, Tanabe T, Yamakawa Y, Funahashi T, Nakao H, et al. (2004) Identification and transcriptional organization of a gene cluster involved in biosynthesis and transport of acinetobactin, a siderophore produced by Acinetobacter baumannii ATCC 19606T. Microbiology 150: 2587-2597. doi:10.1099/mic.0.27141-0. PubMed: 15289555.
21. Gaddy JA, Arivett BA, McConnell MJ, López-Rojas R, Pachón J, et al. (2012) Role of acinetobactin-mediated iron acquisition functions in the interaction of Acinetobacter baumannii strain ATCC 19606T with human lung epithelial cells, Galleria mellonella caterpillars, and mice. Infect Immun 80: 1015-1024. doi:10.1128/IAI.06279-11. PubMed: 22232188.
22. Gaddy JA, Tomaras AP, Actis LA, (2009) The Acinetobacter baumannii 19606 OmpA protein plays a role in biofilm formation on abiotic surfaces and in the interaction of this pathogen with eukaryotic cells. Infect Immun 77: 3150-3160. doi:10.1128/IAI.00096-09. PubMed: 19470746.
23. Choi CH, Lee EY, Lee YC, Park TI, Kim HJ, et al. (2005) Outer membrane protein 38 of Acinetobacter baumannii localizes to the mitochondria and induces apoptosis of epithelial cells. Cell Microbiol 7: 1127-1138. doi:10.1111/j.1462-5822.2005.00538.x. PubMed: 16008580.
24. McConnell MJ, Pachón J, (2011) Expression, purification, and refolding of biologically active Acinetobacter baumannii OmpA from Escherichia coli inclusion bodies. Protein Expr Purif 77: 98-103. doi:10.1016/j.pep.2010.11.019. PubMed: 21130880.
25. Giuliani MM, Santini L, Brunelli B, Biolchi A, Aricò B, et al. (2005) The region comprising amino acids 100 to 255 of Neisseria meningitidis lipoprotein GNA 1870 elicits bactericidal antibodies. Infect Immun 73: 1151-1160. doi:10.1128/IAI.73.2.1151-1160.2005. PubMed: 15664958.
26. Donati C, Rappuoli R, (2013) Reverse vaccinology in the 21st century: improvements over the original design. Ann N Y Acad Sci 1285: 115-132. doi:10.1111/nyas.12046. PubMed: 23527566.
27. Di Tommaso A, Bartalini M, Peppoloni S, Podda A, Rappuoli R, et al. (1997) Acellular pertussis vaccines containing genetically detoxified pertussis toxin induce long-lasting humoral and cellular responses in adults. Vaccine 15: 1218-1224. doi:10.1016/S0264-410X(97)00023-6. PubMed: 9286047.
28. Langermann S, Palaszynski S, Barnhart M, Auguste G, Pinkner JS, et al. (1997) Prevention of mucosal Escherichia coli infection by FimH-adhesin-based systemic vaccination. Science 276: 607-611. doi:10.1126/science.276.5312.607. PubMed: 9110982.
29. Roberts JA, Kaack MB, Baskin G, Chapman MR, Hunstad DA, et al. (2004) Antibody responses and protection from pyelonephritis following vaccination with purified Escherichia coli PapDG protein. J Urol 171: 1682-1685. doi:10.1097/01.ju.0000116123.05160.43. PubMed: 15017266.
30. Marti S, Nait Chabane Y, Alexandre S, Coquet L, Vila J, et al. (2011) Growth of Acinetobacter baumannii in pellicle enhanced the expression of potential virulence factors. PLOS ONE 6: e26030. doi:10.1371/journal.pone.0026030. PubMed: 22046254.
31. Tomaras AP, Dorsey CW, Edelmann RE, Actis LA, (2003) Attachment to and biofilm formation on abiotic surfaces by Acinetobacter baumannii: involvement of a novel chaperone-usher pili assembly system. Microbiology 149: 3473-3484. doi:10.1099/mic.0.26541-0. PubMed: 14663080.
32. Antunes LC, Imperi F, Carattoli A, Visca P, (2011) Deciphering the multifactorial nature of Acinetobacter baumannii pathogenicity. PLOS ONE 6: e22674. doi:10.1371/journal.pone.0022674. PubMed: 21829642.
33. Bentancor LV, Camacho-Peiro A, Bozkurt-Guzel C, Pier GB, Maira-Litrán T, (2012) Identification of Ata, a Multifunctional Trimeric Autotransporter of Acinetobacter baumannii. J Bacteriol 194: 3950-3960. doi:10.1128/JB.06769-11. PubMed: 22609912.
34. Ishikawa M, Nakatani H, Hori K, (2012) AtaA, a New Member of the Trimeric Autotransporter Adhesins from Acinetobacter sp. Tol 5 Mediating High Adhesiveness to Various Abiotic Surfaces. PLOS ONE 7: e48830. doi:10.1371/journal.pone.0048830. PubMed: 23155410.
35. King LB, Pangburn MK, McDaniel LS, (2013) Serine Protease PKF of Acinetobacter baumannii Results in Serum Resistance and Suppression of Biofilm Formation. J Infect Dis 207: 1128-1134. doi:10.1093/infdis/jis939. PubMed: 23303803.
36. Vincent JL, Rello J, Marshall J, Silva E, Anzueto A, et al. (2009) International study of the prevalence and outcomes of infection in intensive care units. JAMA 302: 2323-2329. doi:10.1001/jama.2009.1754. PubMed: 19952319.
37. O'Shea MK, (2012) Acinetobacter in modern warfare. Int J Antimicrob Agents 39: 363-375. doi:10.1016/j.ijantimicag.2012.01.018. PubMed: 22459899.
38. Poirel L, Menuteau O, Agoli N, Cattoen C, Nordmann P, (2003) Outbreak of extended-spectrum beta-lactamase VEB-1-producing isolates of Acinetobacter baumannii in a French hospital. J Clin Microbiol 41: 3542-3547. doi:10.1128/JCM.41.8.3542-3547.2003. PubMed: 12904353.
39. Runnegar N, Sidjabat H, Goh HM, Nimmo GR, Schembri MA, et al. (2010) Molecular epidemiology of multidrug-resistant Acinetobacter baumannii in a single institution over a 10-year period. J Clin Microbiol 48: 4051-4056. doi:10.1128/JCM.01208-10. PubMed: 20739495.
40. Murphy TF, Loeb MR, (1989) Isolation of the outer membrane of Branhamella catarrhalis. Microb Pathog 6: 159-174. doi:10.1016/0882-4010(89)90066-1. PubMed: 2500575.
41. Pearson WR, Wood T, Zhang Z, Miller W, (1997) Comparison of DNA sequences with protein sequences. Genomics 46: 24-36. doi:10.1006/geno.1997.4995. PubMed: 9403055.
42. Altschul SF, Madden TL, Schäffer AA, Zhang J, Zhang Z, et al. (1997) Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res 25: 3389-3402. doi:10.1093/nar/25.17.3389. PubMed: 9254694.
43. Yu NY, Wagner JR, Laird MR, Melli G, Rey S, et al. (2010) PSORTb 3.0: improved protein subcellular localization prediction with refined localization subcategories and predictive capabilities for all prokaryotes. Bioinformatics 26: 1608-1615. doi:10.1093/bioinformatics/btq249. PubMed: 20472543.
44. Petersen TN, Brunak S, von Heijne G, Nielsen H, (2011) SignalP 4.0: discriminating signal peptides from transmembrane regions. Nat Methods 8: 785-786. doi:10.1038/nmeth.1701. PubMed: 21959131.
45. Juncker AS, Willenbrock H, Von Heijne G, Brunak S, Nielsen H, et al. (2003) Prediction of lipoprotein signal peptides in Gram-negative bacteria. Protein Sci 12: 1652-1662. doi:10.1110/ps.0303703. PubMed: 12876315.
46. Punta M, Coggill PC, Eberhardt RY, Mistry J, Tate J, et al. (2012) The Pfam protein families database. Nucleic Acids Res 40: D290-D301. doi:10.1093/nar/gkr717. PubMed: 22127870.
47. Kelley LA, Sternberg MJ, (2009) Protein structure prediction on the Web: a case study using the Phyre server. Nat Protoc 4: 363-371. doi:10.1038/nprot.2009.2. PubMed: 19247286.
48. Tamura K, Peterson D, Peterson N, Stecher G, Nei M, et al. (2011) MEGA5: molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods. Mol Biol Evol 28: 2731-2739. doi:10.1093/molbev/msr121. PubMed: 21546353.