Role of Acinetobactin-mediated iron acquisition functions in the interaction of Acinetobacter baumannii strain ATCC 19606T with human lung epithelial cells, Galleria mellonella caterpillars, and mice

Infection and Immunity

Volumn 80, Issue 3, 2012, Pages 1015-1024

  Gaddy, Jennifer A ^a   Actis, Luis A ^a   Arivett, Brock A ^a   Mcconnell, Michael J ^b   Rafael, López Rojas ^b   Pachón, Jerónimo ^b  

^a MIAMI UNIVERSITY   (United States)

^b HOSPITAL UNIVERSITARIO VIRGEN DEL ROCÍO   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ACINETOBACTIN; BACTERIAL PROTEIN; BASD PROTEIN; BAUA PROTEIN; IRON; MUTANT PROTEIN; UNCLASSIFIED DRUG;

ACINETOBACTER BAUMANNII; ACINETOBACTER INFECTION; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BACTERIAL STRAIN; BACTERIAL VIRULENCE; CATERPILLAR; CELL INTERACTION; CONTROLLED STUDY; EX VIVO STUDY; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; IRON METABOLISM; LUNG ALVEOLUS EPITHELIUM; MORTALITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SYNTHESIS; PROTEIN TRANSPORT; SEPSIS;

ACINETOBACTER BAUMANNII; ACINETOBACTER INFECTIONS; ANIMALS; CELL LINE; DISEASE MODELS, ANIMAL; EPITHELIAL CELLS; FEMALE; HUMANS; IMIDAZOLES; IRON; LARVA; LEPIDOPTERA; MICE; MICE, INBRED C57BL; OXAZOLES; SEPSIS; SURVIVAL ANALYSIS; VIRULENCE FACTORS;

EID: 84857661091     PISSN: 00199567     EISSN: 10985522     Source Type: Journal    
DOI: 10.1128/IAI.06279-11     Document Type: Article

References (49)

1. Abbott A. 2005. Medics braced for fresh superbug. Nature 436:758.
2. Antunes LC, Imperi F, Towner KJ, Visca P. 2011. Genome-assisted identification of putative iron-utilization genes in Acinetobacter baumannii and their distribution among a genotypically diverse collection of clinical isolates. Res. Microbiol. 162:279-284.
3. Bellaire BH, Elzer PH, Baldwin CL, Roop RM, II. 2003. Production of the siderophore 2,3-dihydroxybenzoic acid is required for wild-type growth of Brucella abortus in the presence of erythritol under low-iron conditions in vitro. Infect. Immun. 71:2927-2932.
4. Brachelente C, Wiener D, Malik Y, Huessy D. 2007. A case of necrotizing fasciitis with septic shock in a cat caused by Acinetobacter baumannii. Vet. Dermatol. 18:432-438.
5. Britigan BE, Rasmussen GT, Cox CD. 1997. Augmentation of oxidant injury to human pulmonary epithelial cells by the Pseudomonas aeruginosa siderophore pyochelin. Infect. Immun. 65:1071-1076.
6. Bullen JJ, Rogers HJ, Spalding PB, Ward CG. 2005. Iron and infection: the heart of the matter. FEMS Immunol. Med. Microbiol. 43:325-330.
7. Calhoun JH, Murray CK, Manring MM. 2008. Multidrug-resistant organisms in military wounds from Iraq and Afghanistan. Clin. Orthop. Relat. Res. 466:1356-1362.
8. Cendrowski S, MacArthur W, Hanna P. 2004. Bacillus anthracis requires siderophore biosynthesis for growth in macrophages and mouse virulence. Mol. Microbiol. 51:407-417.
9. Charnot-Katsikas A, et al. 2009. Two cases of necrotizing fasciitis due to Acinetobacter baumannii. J. Clin. Microbiol. 47:258-263.
10. Choi CH, et al. 2008. Acinetobacter baumannii outer membrane protein A targets the nucleus and induces cytotoxicity. Cell. Microbiol. 10:309-319.
11. Choi CH, et al. 2005. Outer membrane protein 38 of Acinetobacter baumannii localizes to the mitochondria and induces apoptosis of epithelial cells. Cell. Microbiol. 7:1127-1138.
12. Ciche TA, Blackburn M, Carney JR, Ensign JC. 2003. Photobactin: a catechol siderophore produced by Photorhabdus luminescens, an entomopathogen mutually associated with Heterorhabditis bacteriophora NC1 nematodes. Appl. Environ. Microbiol. 69:4706-4713.
13. Coffman TJ, Cox CD, Edeker B, Britigan BE. 1990. Possible role of bacterial siderophores in inflammation. Iron bound to the Pseudomonas siderophore pyochelin can function as a hydroxyl radical catalyst. J. Clin. Invest. 86:1030-1037.
14. Corradino B, Toia F, di Lorenzo S, Cordova A, Moschella F. 2010. A difficult case of necrotizing fasciitis caused by Acinetobacter baumannii. Int. J. Low Extrem. Wounds 9:152-154.
15. Crichton R. 2009. Iron metabolism: from molecular mechanisms to clinical consequences, 3rd ed. John Wiley & Sons Ltd, West Sussex, United Kingdom.
16. Crosa JH, Mey AR, Payne SM. 2004. Iron transport in bacteria. ASM Press, Washington, DC.
17. De Voss JJ, et al. 2000. The salicylate-derived mycobactin siderophores of Mycobacterium tuberculosis are essential for growth in macrophages. Proc. Natl. Acad. Sci. U. S. A. 97:1252-1257.
18. Dijkshoorn L, Nemec A, Seifert H. 2007. An increasing threat in hospitals: multidrug-resistant Acinetobacter baumannii. Nat. Rev. Microbiol. 5:939-951.
19. Dorsey CW, Tomaras AP, Actis LA. 2002. Genetic and phenotypic analysis of Acinetobacter baumannii insertion derivatives generated with a transposome system. Appl. Environ. Microbiol. 68:6353-6360.
20. Dorsey CW, et al. 2004. The siderophore-mediated iron acquisition systems of Acinetobacter baumannii ATCC 19606 and Vibrio anguillarum 775 are structurally and functionally related. Microbiology 150:3657-3667.
21. Eijkelkamp BA, Hassan KA, Paulsen IT, Brown MH. 2011. Investigation of the human pathogen Acinetobacter baumannii under iron limiting conditions. BMC Genomics 12:126.
22. Falagas ME, Bliziotis IA. 2007. Pandrug-resistant Gram-negative bacte-ria: the dawn of the post-antibiotic era? Int. J. Antimicrob. Agents 29:630-636.
23. Falagas ME, Rafailidis PI. 2007. Attributable mortality of Acinetobacter baumannii: no longer a controversial issue. Crit. Care 11:134.
24. Feldmann F, Sorsa LJ, Hildinger K, Schubert S. 2007. The salmochelin siderophore receptor IroN contributes to invasion of urothelial cells by extraintestinal pathogenic Escherichia coli in vitro. Infect. Immun. 75:3183-3187.
25. Fetherston JD, Kirillina O, Bobrov AG, Paulley JT, Perry RD. 2010. The yersiniabactin transport system is critical for the pathogenesis of bubonic and pneumonic plague. Infect. Immun. 78:2045-2052.
26. Gaddy JA, Tomaras AP, Actis LA. 2009. The Acinetobacter baumannii 19606 OmpA protein plays a role in biofilm formation on abiotic surfaces and the interaction of this pathogen with eukaryotic cells. Infect. Immun. 77:3150-3160.
27. Hunger M, Schmucker R, Kishan V, Hillen W. 1990. Analysis and nucleotide sequence of an origin of DNA replication in Acinetobacter calcoaceticus and its use for Escherichia coli shuttle plasmids. Gene 87:45-51.
28. Kaplan EL, Meier P. 1958. Nonparametric estimation from incomplete data. J. Am. Statist. Assn. 53:457-481.
29. Lima RM, et al. 2008. Cytotoxic effects of catechol to neuroblastoma N2a cells. Gen. Physiol. Biophys. 27:306-314.
30. McConnell MJ, et al. 2011. Vaccination with outer membrane complexes elicits rapid protective immunity to multidrug-resistant Acinetobacter baumannii. Infect. Immun. 79:518-526.
31. Mihara K, et al. 2004. Identification and transcriptional organization of a gene cluster involved in biosynthesis and transport of acinetobactin, a siderophore produced by Acinetobacter baumannii ATCC 19606T. Microbiology 150:2587-2597.
32. Miyata S, Casey M, Frank DW, Ausubel FM, Drenkard E. 2003. Use of the Galleria mellonella caterpillar as a model host to study the role of the type III secretion system in Pseudomonas aeruginosa pathogenesis. Infect. Immun. 71:2404-2413.
33. Nwugo CC, Gaddy JA, Zimbler DL, Actis LA. 2011. Deciphering the iron response in Acinetobacter baumannii: a proteomics approach. J. Proteomics 74:44-58.
34. Parent MA, Bellaire BH, Murphy EA, Roop RM, II, Elzer PH, Baldwin CL. 2002. Brucella abortus siderophore 2,3-dihydroxybenzoic acid (DHBA) facilitates intracellular survival of the bacteria. Microb. Pathog. 32:239-248.
35. Peleg AY, et al. 2009. Galleria mellonella as a model system to study Acinetobacter baumannii pathogenesis and therapeutics. Antimicrob. Agents Chemother. 53:2605-2609.
36. Peleg AY, Seifert H, Paterson DL. 2008. Acinetobacter baumannii: emergence of a successful pathogen. Clin. Microbiol. Rev. 21:538-582.
37. Ratledge C. 2007. Iron metabolism and infection. Food Nutr. Bull. 28: S515-S523.
38. Russo TA, et al. 2008. Rat pneumonia and soft-tissue infection models for the study of Acinetobacter baumannii biology. Infect. Immun. 76:3577-3586.
39. Russo TA, Carlino UB, Johnson JR. 2001. Identification of a new ironregulated virulence gene, ireA, in an extraintestinal pathogenic isolate of Escherichia coli. Infect. Immun. 69:6209-6216.
40. Sambrook J, Russell DW. 2001. Molecular cloning: a laboratory manual, 3rd ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
41. Schell MA, Lipscomb L, DeShazer D. 2008. Comparative genomics and an insect model rapidly identify novel virulence genes of Burkholderia mallei. J. Bacteriol. 190:2306-2313.
42. Seed KD, Dennis JJ. 2008. Development of Galleria mellonella as an alternative infection model for the Burkholderia cepacia complex. Infect. Immun. 76:1267-1275.
43. Smoot LM, Bell EC, Crosa JH, Actis LA. 1999. Fur and iron transport proteins in the Brazilian purpuric fever clone of Haemophilus influenzae biogroup aegyptius. J. Med. Microbiol. 48:629-636.
44. Villegas MV, Hartstein AI. 2003. Acinetobacter outbreaks, 1977-2000. Infect. Control Hosp. Epidemiol. 24:284-295.
45. Wandersman C, Delepelaire P. 2004. Bacterial iron sources: from siderophores to hemophores. Annu. Rev. Microbiol. 58:611-647.
46. Watson RJ, Joyce SA, Spencer GV, Clarke DJ. 2005. The exbD gene of Photorhabdus temperata is required for full virulence in insects and symbiosis with the nematode Heterorhabditis. Mol. Microbiol. 56:763-773.
47. Weinberg ED. 2009. Iron availability and infection. Biochim. Biophys. Acta 1790:600-605.
48. Yamamoto S, Okujo N, Kataoka H, Narimatsu S. 1999. Siderophoremediated utilization of transferrin-and lactoferrin-bound iron by Acinetobacter baumannii. J. Health Sci. 45:297-302.
49. Zimbler DL, et al. 2009. Iron acquisition functions expressed by the human pathogen Acinetobacter baumannii. Biometals 22:23-32.