Mapping the Interactions between the Alzheimer's Aβ-Peptide and human serum albumin beyond domain resolution

Biophysical Journal

Volumn 105, Issue 7, 2013, Pages 1700-1709

  Algamal, Moustafa ^a   Milojevic, Julijana ^a   Jafari, Naeimeh ^a   Zhang, William ^a   Melacini, Giuseppe ^a  

^a MCMASTER UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN (1 42); AMYLOID BETA-PROTEIN (1-42); FATTY ACID; HUMAN SERUM ALBUMIN; MYRISTIC ACID; PEPTIDE FRAGMENT; SERUM ALBUMIN;

AD; ALZHEIMER DISEASE; AMINO ACID SEQUENCE; ARTICLE; BINDING SITE; BLOOD BRAIN BARRIER; CENTRAL NERVOUS SYSTEM; CEREBROSPINAL FLUID; CHEMISTRY; FA; HSA; HUMAN; ICP; INDUCTIVELY COUPLED PLASMA; MA; METABOLISM; MOLECULAR GENETICS; PROTEIN BINDING; PROTEIN TERTIARY STRUCTURE; RANDOM COIL; RC; SATURATION TRANSFER DIFFERENCE; SATURATION TRANSFER REFERENCE; SEXUALLY TRANSMITTED DISEASE; SL; SPIN-LOCK; STR; WATERGATE WATER-SUPPRESSION NMR TECHNIQUE; WG;

AD; ALZHEIMER'S DISEASE; BBB; BLOOD BRAIN BARRIER; CENTRAL NERVOUS SYSTEM; CEREBROSPINAL FLUID; CNS; CSF; FA; FATTY ACID; HSA; HUMAN SERUM ALBUMIN; ICP; INDUCTIVELY COUPLED PLASMA; MA; MYRISTIC ACID; RANDOM COIL; RC; SATURATION TRANSFER DIFFERENCE; SATURATION TRANSFER REFERENCE; SL; SPIN-LOCK; STD; STR; WATERGATE WATER-SUPPRESSION NMR TECHNIQUE; WG;

AMINO ACID SEQUENCE; AMYLOID BETA-PEPTIDES; BINDING SITES; FATTY ACIDS; HUMANS; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; SERUM ALBUMIN;

EID: 84885156655     PISSN: 00063495     EISSN: 15420086     Source Type: Journal    
DOI: 10.1016/j.bpj.2013.08.025     Document Type: Article

References (39)

1. K.G. Mawuenyega, and W. Sigurdson R.J. Bateman Decreased clearance of CNS β-amyloid in Alzheimer's disease Science 330 2010 1774
2. Y. Miller, B. Ma, and R. Nussinov Polymorphism in Alzheimer Aβ amyloid organization reflects conformational selection in a rugged energy landscape Chem. Rev. 110 2010 4820 4838
3. J. Zheng, and B. Ma R. Nussinov Molecular dynamics simulations of Alzheimer Aβ40 elongation and lateral association Frontiers Biosci. 13 2008 3919 3930
4. W.D. Brubaker, and J.A. Freites R.W. Martin Separating instability from aggregation propensity in γS-crystallin variants Biophys. J. 100 2011 498 506
5. A.S. DeToma, and S. Salamekh M.H. Lim Misfolded proteins in Alzheimer's disease and type II diabetes Chem. Soc. Rev. 41 2012 608 621
6. J.-S. Choi, and J.J. Braymer M.H. Lim Design of small molecules that target metal-Aβ species and regulate metal-induced Aβ aggregation and neurotoxicity Proc. Natl. Acad. Sci. USA 107 2010 21990 21995
7. S.S. Hindo, and A.M. Mancino M.H. Lim Small molecule modulators of copper-induced Aβ aggregation J. Am. Chem. Soc. 131 2009 16663 16665
8. B.V. Zlokovic Clearing amyloid through the blood-brain barrier J. Neurochem. 89 2004 807 811
9. R.B. DeMattos, and K.R. Bales D.M. Holtzman Peripheral anti-A β antibody alters CNS and plasma A β clearance and decreases brain A β burden in a mouse model of Alzheimer's disease Proc. Natl. Acad. Sci. USA 98 2001 8850 8855
10. A.L. Biere, and B. Ostaszewski D.J. Selkoe Amyloid β-peptide is transported on lipoproteins and albumin in human plasma J. Biol. Chem. 271 1996 32916 32922
11. D.J. Llewellyn, and K.M. Langa I.A. Lang Serum albumin concentration and cognitive impairment Curr. Alzheimer Res. 7 2010 91 96
12. M. Boada, and P. Ortiz A. Páez Amyloid-targeted therapeutics in Alzheimer's disease: use of human albumin in plasma exchange as a novel approach for Aβ mobilization Drug News Perspect. 22 2009 325 339
13. J. Milojevic, and G. Melacini Stoichiometry and affinity of the human serum albumin-Alzheimer's Aβ peptide interactions Biophys. J. 100 2011 183 192
14. H. Mao, A.H. Gunasekera, and S.W. Fesik Expression, refolding, and isotopic labeling of human serum albumin domains for NMR spectroscopy Protein Expr. Purif. 20 2000 492 499
15. I. Petitpas, and T. Grüne S. Curry Crystal structures of human serum albumin complexed with monounsaturated and polyunsaturated fatty acids J. Mol. Biol. 314 2001 955 960
16. S. Curry, and H. Mandelkow N. Franks Crystal structure of human serum albumin complexed with fatty acid reveals an asymmetric distribution of binding sites Nat. Struct. Biol. 5 1998 827 835
17. J.R. Simard, and P.A. Zunszain J.A. Hamilton Locating high-affinity fatty acid-binding sites on albumin by x-ray crystallography and NMR spectroscopy Proc. Natl. Acad. Sci. USA 102 2005 17958 17963
18. A.A. Bhattacharya, T. Grüne, and S. Curry Crystallographic analysis reveals common modes of binding of medium and long-chain fatty acids to human serum albumin J. Mol. Biol. 303 2000 721 732
19. S. Sugio, and A. Kashima K. Kobayashi Crystal structure of human serum albumin at 2.5 Å resolution Protein Eng. 12 1999 439 446
20. J. Jarvet, and P. Damberg A. Gräslund Reversible random coil to β-sheet transition and the early stage of aggregation of the Aβ(12-28) fragment from the Alzheimer peptide J. Am. Chem. Soc. 122 2000 4261 4268
21. J. Milojevic, and V. Esposito G. Melacini Understanding the molecular basis for the inhibition of the Alzheimer's Aβ-peptide oligomerization by human serum albumin using saturation transfer difference and off-resonance relaxation NMR spectroscopy J. Am. Chem. Soc. 129 2007 4282 4290
22. J. Milojevic, A. Raditsis, and G. Melacini Human serum albumin inhibits Aβ fibrilization through a "monomer-competitor" mechanism Biophys. J. 97 2009 2585 2594
23. V.V. Andrushchenko, H.J. Vogel, and E.J. Prenner Optimization of the hydrochloric acid concentration used for trifluoroacetate removal from synthetic peptides J. Pept. Sci. 13 2007 37 43
24. F. Delaglio, and S. Grzesiek A. Bax NMRPIPE: a multidimensional spectral processing system based on UNIX pipes J. Biomol. NMR 6 1995 277 293
25. D.G. Kneller, and I.D. Kuntz UCSF SPARKY: an NMR display, annotation and assignment tool J. Cell. Biochem. 53 1993 254
26. N. Benseny-Cases, M. Cócera, and J. Cladera Conversion of non-fibrillar β-sheet oligomers into amyloid fibrils in Alzheimer's disease amyloid peptide aggregation Biochem. Biophys. Res. Commun. 361 2007 916 921
27. R. Koradi, M. Billeter, and K. Wüthrich MOLMOL: a program for display and analysis of macromolecular structures J. Mol. Graphics. 14 1996 29 32 51-55
28. S. Maurer-Stroh, and M. Debulpaep F. Rousseau Exploring the sequence determinants of amyloid structure using position-specific scoring matrices Nat. Methods 7 2010 237 242
29. H.F. Stanyon, and J.H. Viles Human serum albumin can regulate amyloid-β peptide fiber growth in the brain interstitium: implications for Alzheimer disease J. Biol. Chem. 287 2012 28163 28168
30. A. Sagare, and R. Deane B.V. Zlokovic Clearance of amyloid-β by circulating lipoprotein receptors Nat. Med. 13 2007 1029 1031
31. E. Matsubara, B. Frangione, and J. Ghiso Characterization of apolipoprotein J-Alzheimer's Aβ interaction J. Biol. Chem. 270 1995 7563 7567
32. M. Calero, and A. Rostagno J. Ghiso Apolipoprotein J (clusterin) and Alzheimer's disease Microsc. Res. Tech. 50 2000 305 315
33. J. Petrlova, and H.-S. Hong J.C. Voss A differential association of Apolipoprotein E isoforms with the amyloid-β oligomer in solution Proteins 79 2011 402 416
34. J.W. Lustbader, and M. Cirilli H. Wu ABAD directly links Aβ to mitochondrial toxicity in Alzheimer's disease Science 304 2004 448 452
35. W. Hoyer, and T. Härd Interaction of Alzheimer's A β peptide with an engineered binding protein - thermodynamics and kinetics of coupled folding-binding J. Mol. Biol. 378 2008 398 411
36. W. Hoyer, and C. Grönwall T. Härd Stabilization of a β-hairpin in monomeric Alzheimer's amyloid-β peptide inhibits amyloid formation Proc. Natl. Acad. Sci. USA 105 2008 5099 5104
37. A.V. Raditsis, J. Milojevic, and G. Melacini Aβ association inhibition by transferrin Biophys. J. 105 2013 473 480
38. A. Ramamoorthy, and M.H. Lim Structural characterization and inhibition of toxic amyloid-β oligomeric intermediates Biophys. J. 105 2013 287 288
39. J.L. Moreland, and A. Gramada P.E. Bourne The Molecular Biology Toolkit (MBT): a modular platform for developing molecular visualization applications BMC Bioinformatics 6 2005 21