Reversible random coil to β-sheet transition and the early stage of aggregation of the Aβ(12-28) fragment from the Alzheimer peptide

Journal of the American Chemical Society

Volumn 122, Issue 18, 2000, Pages 4261-4268

  Jarvet, Jüri ^a   Damberg, Peter ^a   Bodell, Karl ^a,b   Goran Eriksson L E ^a   Gräslund, Astrid ^a  

^a STOCKHOLM UNIVERSITY   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN;

ALZHEIMER DISEASE; ARTICLE; CIRCULAR DICHROISM; CONTROLLED STUDY; DIFFUSION; IONIC STRENGTH; ISOELECTRIC POINT; LOW TEMPERATURE; MOLECULAR WEIGHT; PH; PROTEIN AGGREGATION; PROTEIN SECONDARY STRUCTURE; PROTON NUCLEAR MAGNETIC RESONANCE; TEMPERATURE DEPENDENCE;

EID: 0034630847     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja991167z     Document Type: Article

References (52)

1. Maggio, J. E.; Mantyh, P. W. Brain Pathol. 1996, 6, 147-162.
2. Harper, J. D.; Lansbury, P. T., Jr. Annu. Rev. Biochem. 1997, 66, 385-407.
3. Roher, A. E.; Chaney, M. O.; Kuo, Y. M.; Webster, S. D.; Stine, W. B.; Haverkamp, L. J.; Woods, A. S.; Cotter, R. J.; Tuohy, J. M.; Krafft, G. A.; Bonnell, B. S.; Emmerling, M. R. J. Biol. Chem. 1996, 271, 20631-20635.
4. Cherny, R. A.; Legg, J. T.; McLean, C. A.; Fairlie, D. P.; Huang, X.; Atwood, C. S.; Beyreuther, K.; Tanzi, R. E.; Masters, C. L.; Bush, A. I. J. Biol. Chem. 1999, 274, 23223-23228.
5. Garzon-Rodriguez, W.; Sepulveda-Becerra M.; Milton, S.; Glabe, C. G. J. Biol. Chem. 1997, 272, 21037-21044.
6. Walsh, D. M.; Lomakin, A.; Benedek, G. B.; Condron, M. M.; Teplow, D. B. J. Biol. Chem. 1997, 272, 22364-22372.
7. Kuo, Y.-M.; Emmerling, M. R.; De Lima, N.; Roher, A. E. Biochim. Biophys. Act. 1998, 1406, 291-298.
8. Tseng, B. P.; Esler, W. P.; Clish, C. B.; Stimson, E. R.; Ghilardi, J. R.; Vinters, H. V.; Mantyh, P. W.; Lee, J. P.; Maggio, J. E. Biachemistry 1999, 38, 10424-10431.
9. Harper, J. D.; Wong, S. S.; Lieber, C. M.; Lansburj, P. T., Jr. Biochemistry 1999, 38, 8972-8980.
10. Walsh, D. M.; Hartley, D. M.; Kusumoto, Y.; Fezoui, Y.; Condron, M. M.; Lomakin, A.; Benedek, G. B.; Selkoe, D. J.; Teplow, D. B. J. Biol. Chem. 1999, 274, 25945-25952.
11. Jao, S.-C.; Ma, K.; Talafous, J.; Orlando, R.; Zagorski, M. G. J. Exp. Clin. Invest. 1997, 4, 240-252.
12. Fraser, P. E.; Nguyen, J. T.; Surewicz, W. K.; Kirschner, D. A. Biophys. J. 1991, 60, 1190-1201.
13. Lee, J. P.; Stimson, E. R.; Ghilardi, J. R.; Mantyh, P. W.; Lu, Y.-A.; Felix, A. M.; Llanos, W.; Behbin, A.; Cummings, M.; Criekinge, M. V.; Timms, W.; Maggio, J. E. Biochemists 1995, 34, 5191-5200.
14. Esler, W. P.; Stimson, E. R.; Ghilardi, J. R.; Vinters, H. V.; Lee, J. P.; Mantyh, P. W.; Maggio, J. E. Biochemistry 1996, 35, 749-757.
15. Mansfield, S. L.; Jayawickrama, D. A.; Timmons, J. S.; Larive, C. K. Biochim. Biophys. Acta 1998, 1382, 257-265.
16. Mansfield, S. L.; Gotch, A. J.; Harms, G. S.; Johnson, C. K.; Larive, C. K. J. Phys. Chem. B 1999, 103, 2262-2269.
17. Sticht, H.; Bayer, P.; Willbold, D.; Dames, S.; Hilbich, C.; Beyreuther, K.; Frank, R. W.; Rösch, P. Eur. J. Biochem. 1995, 233, 293-298.
18. Jayawickrama, D.; Zink, S.; Vander Velde, D.; Effiong, R. I.; Larive, C. K. J. Biomol. Struct. Dyn. 1995, 13, 229-244.
19. Talafous, J.; Marcinowski, K. J.; Klopman, G.; Zagorski, M. G. Biochemistry 1994, 33, 7788-7796.
20. Salomon, A. R.; Marcinowski, K. J.; Friedland, R. P.; Zagorski, M. G. Biochemistry 1996, 35, 13568-13578.
21. Fletcher, T. G.; Keire, D. A. Protein. Sci. 1997, 6, 666-675.
22. Marcinowski, K. J.; Shao, H.; Clancy, E. L.; Zagorski, M. G. J. Am. Chem. Soc. 1998, 720, 11082-11091.
23. Coles, M.; Bicknell, W.; Watson, A. A.; Fairlie, D. P.; Craik, D. J. Biochemistry 1998, 37, 11064-11077.
24. Shao, H.; Jao, S. C.; Ma, K.; Zagorski, M. G. J. Mol. Biol. 1999, 285, 755-773.
25. Burkoth, T. S.; Benzinger, T. L. S.; Jones, D. N. M.; Hallenga, K.; Meredith, S. C.; Lynn, D. G. J. Am. Chem. Soc. 1998, 120, 7655-7656.
26. Burkoth, T. S.; Benzinger, T. L. S.; Urban, V.; Lynn, D. G.; Meredith, S. C.; Thiyagarajan, P. J. Am. Chem. Soc. 1999, 121, 7429-7430.
27. Zhang, S.; Casey, N.; Lee, J. P. Folding Des. 1998, 3, 413-422.
28. Barrow, C. J.; Yasuda, A.; Kenny, P. T. M.; Zagorski, M. G. J. Mol Biol. 1992, 225, 1075-1093.
29. Huang, T. H. J.; Fraser, P. E.; Chakrabartty, A. J. Mol. Biol. 1998, 269, 214-224.
30. It should be pointed out that when the terms random coil and β-sheet like secondary structure are used here, we refer to the dihedral angle structure of the individual peptide strand as revealed by spectroscopy. The state of oligomerization and aggregation is dealt with separately.
31. Wüthrich, K. NMR of Proteins and Nucleic Acids; Wiley: New York, 1986.
32. Wishart, D. S.; Sykes, B. O.; Richards, F. M. J. Mol. Biol. 1991, 222, 311-333.
33. Mills, R J. Phys. Chem. 1973, 77, 685-688. Kirshenbaum, I. Physical Properties and Analysis of Heavy Water, Urey H. C., Murphy G. M., Eds.; McGraw-Hill: New York, 1951.
34. Mills, R J. Phys. Chem. 1973, 77, 685-688. Kirshenbaum, I. Physical Properties and Analysis of Heavy Water, Urey H. C., Murphy G. M., Eds.; McGraw-Hill: New York, 1951.
35. Aggeli, A.; Bell, M.; Boden, N.; Keen, J. N.; Knowles, P. F.; McLeish, T. C. B.; Pitkeathly, M.; Radford, S. E. Nature 1997, 386, 259-262.
36. α resonances between random coil and β-sheet secondary structure (ca 0.4 ppm, i.e., 320 Hz in an 800 MHz spectrometer) the characteristic time for intermediate exchange is 1/(2π320) = 0.5 ms.
37. Terzi, E.; Hölzemann, G.; Seelig, J. Biochemistry 1994, 33, 1345-1350.
38. -1.
39. h is in reasonable agreement with a monomeric peptide with a normal hydration layer.
40. Tjernberg, L. O.; Lilliehöök, C.; Callaway, D. J.; Näslund, J.; Hahne, S.; Thyberg, J.; Terenius, L.; Nordstedt, C. J. Biol. Chem. 1997, 272, 12601-12605.
41. Tjernberg, L. O.; Pramanik, A.; Björling, S.; Thyberg, P.; Thyberg, J.; Nordstedt C.; Berndt, K. D.; Terenius, L.; Rigler, R. Chem. Biol. 1999, 6, 53-62.
42. Hilbich, C.; Kisters-Woike, B.; Reed, J.; Masters, C. L.; Beyreuther, K. J Mol. Biol. 1991, 218, 149-63.
43. Snyder, S. W.; Ladror, U. S.; Wade, W. S.; Wang, G. T.; Barrett, L. W.; Matayoshi, E. D.; Huffaker, H. J.; Krafft, G. A.; Holzman, T. F. Biophys. J. 1994, 67, 1216-28.
44. Ma, K.; Clancy, E. L.; Zhang, Y.; Ray, D. G.; Wollenberg, K.; Zagorski, M. G. J. Am. Chem. Soc. 1999, 121, 8698-8706.
45. Neve, R. L.; Robakis, N. K. Trends Neurosci. 1998, 21, 15-19.
46. Lambert, M. P.; Barlow, A. K.; Chromy, B. A.; Edwards, C.; Freed, R.; Liosatos, M.; Morgan, T. E.; Rozovsky, I.; Trommer, B.; Viola, K. A.; Wals, P.; Zhang, C.; Finch, C. E.; Krafft, G. A.; Klein, W. L. Proc. Natl. Acad. Sci. 1998, 95, 6448-6453.
47. After the submission of the present manuscript, a CD study was reported on the temperature dependence of solutions of Aβ(1-40) in water at pH 4.6 (Gursky O.; Aleshkov S. Biochim. Biophys. Acta 2000, 1476, 93-102). Their results and interpretation on the longer peptide are in accordance with the present conclusions based on NMR and CD on the I order of magnitude more concentrated solutions of Aβ(12-28).
48. Glasoe, P. K.; Long, F. A. J. Phys. Chem. 1960, 64, 188-190.
49. Greenfield, N.; Fasman, G. Biochemistry 1969, 8, 4108-4116.
50. Stejskal, E. O.; Tanner, J. E. J. Phys. Chem. 1965, 42, 288-292.
51. Cantor, C. R.; Schimmel, P. R. Biophysical Chemistry, Part II; W. H. Freeman and Company: San Francisco, 1980; Chapter 10.
52. Uedaira, H.; Uedaira, H. J. Phys. Chem. 1970, 74, 2211-2214.