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Volumn 9, Issue 10, 2013, Pages 2216-2221

DNA vaccines: A simple DNA sensing matter?

Author keywords

Adjuvant; DNA vaccine; STING; TBK1; Type I interferon

Indexed keywords

ABSENCE IN MELANOMA 2; CELL DNA; CHEMOKINE; CYCLIC GMP; DEAD BOX PROTEIN; DNA BINDING PROTEIN; DNA DIRECTED RNA POLYMERASE III; DNA VACCINE; DOUBLE STRANDED DNA; GAMMA INTERFERON INDUCIBLE PROTEIN 16; HIGH MOBILITY GROUP B1 PROTEIN; HISTONE H2B; INFLAMMASOME; PLASMID DNA; PLASMID VECTOR; PROTEIN DDX41; PROTEIN STING; PROTEIN TRIM56; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; VADIMEZAN; Z DNA BINDING PROTEIN;

EID: 84885142956     PISSN: 21645515     EISSN: 2164554X     Source Type: Journal    
DOI: 10.4161/hv.25893     Document Type: Review
Times cited : (48)

References (55)
  • 1
    • 78650573649 scopus 로고    scopus 로고
    • DNA vaccines: An historical perspective and view to the future
    • PMID:21198665
    • Liu MA. DNA vaccines: an historical perspective and view to the future. Immunol Rev 2011;239:62-84; PMID:21198665; http://dx.doi. Org/10.1111/j.1600- 065X.2010.00980.x
    • (2011) Immunol Rev , vol.239 , pp. 62-84
    • Liu, M.A.1
  • 3
    • 84868484767 scopus 로고    scopus 로고
    • The future of human DNA vaccines
    • PMID:22981627
    • Li L, Saade F, Petrovsky N. The future of human DNA vaccines. J Biotechnol 2012;162:171-82; PMID:22981627; http://dx.doi.org/10.10l6/j.jbiotec. 2012.08.012
    • (2012) J Biotechnol , vol.162 , pp. 171-182
    • Li, L.1    Saade, F.2    Petrovsky, N.3
  • 4
    • 0035051928 scopus 로고    scopus 로고
    • West Nile virus recombinant DNA vaccine protects mouse and horse from virus challenge and expresses in vitro a noninfectious recombinant antigen that can be used in enzymelinked immunosorbent assays
    • PMID:11287553
    • Davis BS, Chang GJ, Cropp B, Roehrig JT, Martin DA, Mitchell CJ, et al. West Nile virus recombinant DNA vaccine protects mouse and horse from virus challenge and expresses in vitro a noninfectious recombinant antigen that can be used in enzymelinked immunosorbent assays. J Virol 2001;75:4040-7; PMID:11287553; http://dx.doi.org/10.1128/JVI.75.9.4040-4047.2001
    • (2001) J Virol , vol.75 , pp. 4040-4047
    • Davis, B.S.1    Chang, G.J.2    Cropp, B.3    Roehrig, J.T.4    Martin, D.A.5    Mitchell, C.J.6
  • 5
    • 0037389779 scopus 로고    scopus 로고
    • Long-term survival of dogs with advanced malignant melanoma after DNA vaccination with xenogeneic human tyrosinase: A phase I trial
    • PMID:12684396
    • Bergman PJ, McKnight J, Novosad A, Charney S, Farrelly J, Craft D, et al. Long-term survival of dogs with advanced malignant melanoma after DNA vaccination with xenogeneic human tyrosinase: a phase I trial. Clin Cancer Res 2003;9:1284-90; PMID:12684396
    • (2003) Clin Cancer Res , vol.9 , pp. 1284-1290
    • Bergman, P.J.1    McKnight, J.2    Novosad, A.3    Charney, S.4    Farrelly, J.5    Craft, D.6
  • 6
    • 0033596241 scopus 로고    scopus 로고
    • Evaluation of the protective immunogenicity of the N, P, M, NV and G proteins of infectious hematopoietic necrosis virus in rainbow trout oncorhynchus my kiss using DNA vaccines
    • PMID:11407402
    • Corbeil S, Lapatra SE, Anderson ED, Jones J, Vincent B, Hsu YL, et al. Evaluation of the protective immunogenicity of the N, P, M, NV and G proteins of infectious hematopoietic necrosis virus in rainbow trout oncorhynchus my kiss using DNA vaccines. Dis Aquat Organ 1999;39:29-36; PMID:11407402; http://dx.doi.org/10.3 35 4/dao03 9 02 9
    • (1999) Dis Aquat Organ , vol.39 , pp. 29-36
    • Corbeil, S.1    Lapatra, S.E.2    Anderson, E.D.3    Jones, J.4    Vincent, B.5    Hsu, Y.L.6
  • 7
    • 29244471275 scopus 로고    scopus 로고
    • A Toll-like receptor-independent antiviral response induced by double-stranded B-form DNA
    • PMID: 16286919
    • Ishii KJ, Coban C, Kato H, Takahashi K, Torii Y, Takeshita F, et al. A Toll-like receptor-independent antiviral response induced by double-stranded B-form DNA. Nat Immunol 2006;7:40-8; PMID: 16286919; http://dx.doi.org/10.1038/ nil282
    • (2006) Nat Immunol , vol.7 , pp. 40-48
    • Ishii, K.J.1    Coban, C.2    Kato, H.3    Takahashi, K.4    Torii, Y.5    Takeshita, F.6
  • 8
    • 84862855875 scopus 로고    scopus 로고
    • Nucleic acid sensing at the interface between innate and adaptive immunity in vaccination
    • PMID=22728526
    • Desmet CJ, Ishii KJ. Nucleic acid sensing at the interface between innate and adaptive immunity in vaccination. Nat Rev Immunol 2012;12:479-91; PMID=22728526; http://dx.doi.org/10.1038/nri3247
    • (2012) Nat Rev Immunol , vol.12 , pp. 479-491
    • Desmet, C.J.1    Ishii, K.J.2
  • 9
    • 38949093002 scopus 로고    scopus 로고
    • TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines
    • PMID: 18256672
    • Ishii KJ, Kawagoe T, Koyama S, Matsui K, Kumar H, Kawai T, et al. TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines. Nature 2008;451:725-9; PMID: 18256672; http://dx. doi.org/10.10 38/nature065 37
    • (2008) Nature , vol.451 , pp. 725-729
    • Ishii, K.J.1    Kawagoe, T.2    Koyama, S.3    Matsui, K.4    Kumar, H.5    Kawai, T.6
  • 10
    • 79957781340 scopus 로고    scopus 로고
    • Electroporation delivery of DNA vaccines: Prospects for success
    • PMID:21530212
    • Sardesai NY, Weiner DB. Electroporation delivery of DNA vaccines: prospects for success. Curr Opin Immunol 2011;23:421-9; PMID:21530212; http://dx.doi.org/10.1016/j.coi.2011.03.008
    • (2011) Curr Opin Immunol , vol.23 , pp. 421-429
    • Sardesai, N.Y.1    Weiner, D.B.2
  • 11
    • 84869761013 scopus 로고    scopus 로고
    • What you always needed to know about electroporation based DNA vaccines
    • PMID:23111168
    • Gothelf A, Gehl J. What you always needed to know about electroporation based DNA vaccines. Hum Vaccin Immunother 2012;8:1694-702; PMID:23111168; http://dx.doi.org/10.4l61/hv. 22062
    • (2012) Hum Vaccin Immunother , vol.8 , pp. 1694-1702
    • Gothelf, A.1    Gehl, J.2
  • 12
    • 70349943834 scopus 로고    scopus 로고
    • STING regulates intracellular DNA-mediated, type I interferondependent innate immunity
    • PMID: 19776740
    • Ishikawa H, Ma Z, Barber GN. STING regulates intracellular DNA-mediated, type I interferondependent innate immunity. Nature 2009;461:788-92; PMID: 19776740; http://dx.doi.org/10.1038/nature08476
    • (2009) Nature , vol.461 , pp. 788-792
    • Ishikawa, H.1    Ma, Z.2    Barber, G.N.3
  • 13
    • 50449205290 scopus 로고    scopus 로고
    • Potential link between the immune system and metabolism of nucleic acids
    • PMID: 18662775
    • Ishii KJ, Akira S. Potential link between the immune system and metabolism of nucleic acids. Curr Opin Immunol 2008;20:524-9; PMID: 18662775; http://dx.doi.org/10.1016/j.coi.2008.07.002
    • (2008) Curr Opin Immunol , vol.20 , pp. 524-529
    • Ishii, K.J.1    Akira, S.2
  • 14
    • 34547143110 scopus 로고    scopus 로고
    • DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response
    • PMID: 17618271
    • Takaoka A, Wang Z, Choi MK, Yanai H, Negishi H, Ban T, et al. DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response. Nature 2007;448:501-5; PMID: 17618271; http://dx.doi.org/10.1038/ nature06013
    • (2007) Nature , vol.448 , pp. 501-505
    • Takaoka, A.1    Wang, Z.2    Choi, M.K.3    Yanai, H.4    Negishi, H.5    Ban, T.6
  • 15
    • 55749088259 scopus 로고    scopus 로고
    • IFNbeta responses induced by intracellular bacteria or cytosolic DNA in different human cells do not require ZBP1 (DLM-1/DAI)
    • PMID: 18771559
    • Lippmann J, Rothenburg S, Deigendesch N, Eitel J, Meixenberger K, Van Laak V, et al. IFNbeta responses induced by intracellular bacteria or cytosolic DNA in different human cells do not require ZBP1 (DLM-1/DAI). Cell Microbiol 2008;10:2579-88; PMID: 18771559; http://dx.doi.org/l 0.1111/j. 1462-5822.2008.01232.x
    • (2008) Cell Microbiol , vol.10 , pp. 2579-2588
    • Lippmann, J.1    Rothenburg, S.2    Deigendesch, N.3    Eitel, J.4    Meixenberger, K.5    Van Laak, V.6
  • 16
    • 60749136484 scopus 로고    scopus 로고
    • An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome
    • PMID:19158679
    • Burckstummer T, Baumann C, Bliiml S, Dixit E, Diirnberger G, Jahn H, et al. An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome. Nat Immunol 2009;10:266-72; PMID:19158679; http://dx.doi.org/10.1038/ni. 1702
    • (2009) Nat Immunol , vol.10 , pp. 266-272
    • Burckstummer, T.1    Baumann, C.2    Bliiml, S.3    Dixit, E.4    Diirnberger, G.5    Jahn, H.6
  • 17
    • 63649145255 scopus 로고    scopus 로고
    • AIM 2 activates the inflammasome and cell death in response to cytoplasmic DNA
    • PMID: 19158676
    • Fernandes-Alnemri T, Yu JW, Datta P, Wu J, Alnemri ES. AIM 2 activates the inflammasome and cell death in response to cytoplasmic DNA. Nature 2009;458:509-13; PMID: 19158676; http://dx.doi.org/10.1038/nature07710
    • (2009) Nature , vol.458 , pp. 509-513
    • Fernandes-Alnemri, T.1    Yu, J.W.2    Datta, P.3    Wu, J.4    Alnemri, E.S.5
  • 18
    • 63649133278 scopus 로고    scopus 로고
    • AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC
    • PMID:19158675
    • Hornung V, Ablasser A, Charrel-Dennis M, Bauernfeind F, Horvath G, Caffrey DR, et al. AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC. Nature 2009;458:514-8; PMID:19158675; http://dx.doi.org/10.103 8/nature07725
    • (2009) Nature , vol.458 , pp. 514-518
    • Hornung, V.1    Ablasser, A.2    Charrel-Dennis, M.3    Bauernfeind, F.4    Horvath, G.5    Caffrey, D.R.6
  • 19
    • 60749104535 scopus 로고    scopus 로고
    • HIN-200 proteins regulate caspase activation in response to foreign cytoplasmic DNA
    • PMID:19131592
    • Roberts TL, Idris A, Dunn JA, Kelly GM, Burnton CM, Hodgson S, et al. HIN-200 proteins regulate caspase activation in response to foreign cytoplasmic DNA. Science 2009;323:1057-60; PMID:19131592; http://dx. doi.org/10.1126/ science. 1169841
    • (2009) Science , vol.323 , pp. 1057-1060
    • Roberts, T.L.1    Idris, A.2    Dunn, J.A.3    Kelly, G.M.4    Burnton, C.M.5    Hodgson, S.6
  • 20
    • 77958140656 scopus 로고    scopus 로고
    • IFI16 is an innate immune sensor for intracellular DNA
    • PMID:20890285
    • Unterholzner L, Keating SE, Baran M, Horan KA, Jensen SB, Sharma S, et al. IFI16 is an innate immune sensor for intracellular DNA. Nat Immunol 2010;11:997-1004; PMID:20890285; http://dx.doi.org/10.1038/ni. 1932
    • (2010) Nat Immunol , vol.11 , pp. 997-1004
    • Unterholzner, L.1    Keating, S.E.2    Baran, M.3    Horan, K.A.4    Jensen, S.B.5    Sharma, S.6
  • 21
    • 68049092912 scopus 로고    scopus 로고
    • RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathway
    • PMID: 19631370
    • Chiu YH, Macmillan JB, Chen ZJ. RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathway. Cell 2009;138:576-91; PMID: 19631370; http://dx.doi.org/10.1016/j.cell.2009.06.015
    • (2009) Cell , vol.138 , pp. 576-591
    • Chiu, Y.H.1    Macmillan, J.B.2    Chen, Z.J.3
  • 22
    • 0037062934 scopus 로고    scopus 로고
    • Release of chromatin protein HMGB1 by necrotic cells triggers inflammation
    • PMID:12110890
    • Scaffidi P, Misteli T, Bianchi ME. Release of chromatin protein HMGB1 by necrotic cells triggers inflammation. Nature 2002;418:191-5; PMID:12110890; http://dx.doi.org/10.1038/nature00858
    • (2002) Nature , vol.418 , pp. 191-195
    • Scaffidi, P.1    Misteli, T.2    Bianchi, M.E.3
  • 23
    • 70449092388 scopus 로고    scopus 로고
    • HMGB proteins function as universal sentinels for nucleic-acid-mediated innate immune responses
    • PMID: 19890330
    • Yanai H, Ban T, Wang Z, Choi MK, Kawamura T, Negishi H, et al. HMGB proteins function as universal sentinels for nucleic-acid-mediated innate immune responses. Nature 2009;462:99-103; PMID: 19890330; http://dx.doi.org/10.1038/ natureO 8512
    • (2009) Nature , vol.462 , pp. 99-103
    • Yanai, H.1    Ban, T.2    Wang, Z.3    Choi, M.K.4    Kawamura, T.5    Negishi, H.6
  • 24
    • 73849118671 scopus 로고    scopus 로고
    • Extrachromosomal histone H2B mediates innate antiviral immune responses induced by intracellular double-stranded DNA
    • PMID:19906922
    • Kobiyama K, Takeshita F, Jounai N, Sakaue-Sawano A, Miyawaki A, Ishii KJ, et al. Extrachromosomal histone H2B mediates innate antiviral immune responses induced by intracellular double-stranded DNA. J Virol 2010;84:822-32; PMID:19906922; http://dx.doi.org/10.1128/JVI.01339-09
    • (2010) J Virol , vol.84 , pp. 822-832
    • Kobiyama, K.1    Takeshita, F.2    Jounai, N.3    Sakaue-Sawano, A.4    Miyawaki, A.5    Ishii, K.J.6
  • 25
    • 80052164116 scopus 로고    scopus 로고
    • Cytoplasmic DNA innate immune pathways
    • PMID:21884170
    • Barber GN. Cytoplasmic DNA innate immune pathways. Immunol Rev 2011;243:99-108; PMID:21884170; http://dx.doi.org/10.1 111/j. 1600-065X.2011.01051.x
    • (2011) Immunol Rev , vol.243 , pp. 99-108
    • Barber, G.N.1
  • 26
    • 80054966913 scopus 로고    scopus 로고
    • STING is a direct innate immune sensor of cyclic di-GMP
    • PMID:21947006
    • Burdette DL, Monroe KM, Sotelo-Troha K, Iwig JS, Eckert B, Hyodo M, et al. STING is a direct innate immune sensor of cyclic di-GMP. Nature 2011;478:515-8; PMID:21947006; http://dx.doi.org/10.103 8/nature10429
    • (2011) Nature , vol.478 , pp. 515-518
    • Burdette, D.L.1    Monroe, K.M.2    Sotelo-Troha, K.3    Iwig, J.S.4    Eckert, B.5    Hyodo, M.6
  • 27
    • 78650214109 scopus 로고    scopus 로고
    • The ubiquitin ligase TRIM56 regulates innate immune responses to intracellular double-stranded DNA
    • PMID:21074459
    • Tsuchida T, Zou J, Saitoh T, Kumar H, Abe T, Matsuura Y, et al. The ubiquitin ligase TRIM56 regulates innate immune responses to intracellular double-stranded DNA. Immunity 2010;33:765-76; PMID:21074459; http://dx.doi. Org/10.1016/j.immuni.2010.10.013
    • (2010) Immunity , vol.33 , pp. 765-776
    • Tsuchida, T.1    Zou, J.2    Saitoh, T.3    Kumar, H.4    Abe, T.5    Matsuura, Y.6
  • 28
    • 84869403247 scopus 로고    scopus 로고
    • The helicase DDX41 recognizes the bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a type I interferon immune response
    • PMID:23142775
    • Parvatiyar K, Zhang Z, Teles RM, Ouyang S, Jiang Y, Iyer SS, et al. The helicase DDX41 recognizes the bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a type I interferon immune response. Nat Immunol 2012;13:1155-61; PMID:23142775; http://dx.doi.org/10.1038/ni.2460
    • (2012) Nat Immunol , vol.13 , pp. 1155-1161
    • Parvatiyar, K.1    Zhang, Z.2    Teles, R.M.3    Ouyang, S.4    Jiang, Y.5    Iyer, S.S.6
  • 29
    • 84863009492 scopus 로고    scopus 로고
    • Structural analysis of the STING adaptor protein reveals a hydrophobic dimer interface and mode of cyclic di-GMP binding
    • PMID:22579474
    • Ouyang S, Song X, Wang Y, Ru H, Shaw N, Jiang Y, et al. Structural analysis of the STING adaptor protein reveals a hydrophobic dimer interface and mode of cyclic di-GMP binding. Immunity 2012;36:1073-86; PMID:22579474; http://dx.doi.org/10.1016/j.immuni.2012.03.019
    • (2012) Immunity , vol.36 , pp. 1073-1086
    • Ouyang, S.1    Song, X.2    Wang, Y.3    Ru, H.4    Shaw, N.5    Jiang, Y.6
  • 30
    • 84869479505 scopus 로고    scopus 로고
    • Innate sensing of bacterial cyclic dinucleotides: More than just STING
    • PMID:23160208
    • Bowie AG. Innate sensing of bacterial cyclic dinucleotides: more than just STING. Nat Immunol 2012;13:1137-9; PMID:23160208; http://dx.doi.org/10. 1038/ni.2469
    • (2012) Nat Immunol , vol.13 , pp. 1137-1139
    • Bowie, A.G.1
  • 31
    • 84873711885 scopus 로고    scopus 로고
    • Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway
    • PMID:23258413
    • Sun L, Wu J, Du F, Chen X, Chen ZJ. Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway. Science 2013;339:786-91; PMID:23258413; http://dx.doi.org/10.1126/science. 1232458
    • (2013) Science , vol.339 , pp. 786-791
    • Sun, L.1    Wu, J.2    Du, F.3    Chen, X.4    Chen, Z.J.5
  • 33
    • 77953627757 scopus 로고    scopus 로고
    • Essential role for TLR9 in prime but not prime-boost plasmid DNA vaccination to activate dendritic cells and protect from lethal viral infection
    • PMID:20483769
    • Rottembourg D, Filippi CM, Bresson D, Ehrhardt K, Estes EA, Oldham JE, et al. Essential role for TLR9 in prime but not prime-boost plasmid DNA vaccination to activate dendritic cells and protect from lethal viral infection. J Immunol 2010;184:7100-7; PMID:20483769; http://dx.doi.org/l 0.4049/jimmunol.0803935
    • (2010) J Immunol , vol.184 , pp. 7100-7107
    • Rottembourg, D.1    Filippi, C.M.2    Bresson, D.3    Ehrhardt, K.4    Estes, E.A.5    Oldham, J.E.6
  • 34
    • 82055176771 scopus 로고    scopus 로고
    • Novel strategies to improve DNA vaccine immunogenicity
    • PMID:22023477
    • Coban C, Kobiyama K, Aoshi T, Takeshita F, Horii T, Akira S, et al. Novel strategies to improve DNA vaccine immunogenicity. Curr Gene Ther 2011;11:479-84; PMID:22023477; http://dx.doi.org/10.2174/156652311798192815
    • (2011) Curr Gene Ther , vol.11 , pp. 479-484
    • Coban, C.1    Kobiyama, K.2    Aoshi, T.3    Takeshita, F.4    Horii, T.5    Akira, S.6
  • 35
    • 82055188524 scopus 로고    scopus 로고
    • Cytokine and costimulatory factor-encoding plasmids as adjuvants for DNA vaccination
    • PMID:21374321
    • Okuda K, Kawamoto S, Fukushima J. Cytokine and costimulatory factor-encoding plasmids as adjuvants for DNA vaccination. Methods Mol Med 2000;29:197-204; PMID:21374321
    • (2000) Methods Mol Med , vol.29 , pp. 197-204
    • Okuda, K.1    Kawamoto, S.2    Fukushima, J.3
  • 36
    • 0035006080 scopus 로고    scopus 로고
    • Apoptosis-mediated enhancement of DNA-raised immune responses by mutant caspases
    • PMID:11385458
    • Sasaki S, Amara RR, Oran AE, Smith JM, Robinson HL. Apoptosis-mediated enhancement of DNA-raised immune responses by mutant caspases. Nat Biotechnol 2001;19:543-7; PMID:11385458; http://dx.doi.org/10.1038/89289
    • (2001) Nat Biotechnol , vol.19 , pp. 543-547
    • Sasaki, S.1    Amara, R.R.2    Oran, A.E.3    Smith, J.M.4    Robinson, H.L.5
  • 37
    • 61549091187 scopus 로고    scopus 로고
    • Contribution of IRF-3 mediated IFNbeta production to DNA vaccine dependent cellular immune responses
    • PMID: 19356618
    • Shirota H, Petrenko L, Hattori T, Klinman DM. Contribution of IRF-3 mediated IFNbeta production to DNA vaccine dependent cellular immune responses. Vaccine 2009;27:2144-9; PMID: 19356618; http://dx.doi.org/10.1016/j.vaccine. 2009.01.134
    • (2009) Vaccine , vol.27 , pp. 2144-2149
    • Shirota, H.1    Petrenko, L.2    Hattori, T.3    Klinman, D.M.4
  • 38
    • 33745226259 scopus 로고    scopus 로고
    • Toll-like receptor adaptor molecules enhance DNA-raised adaptive immune responses against influenza and tumors through activation of innate immunity
    • PMID:16775309
    • Takeshita F, Tanaka T, Matsuda T, Tozuka M, Kobiyama K, Saha S, et al. Toll-like receptor adaptor molecules enhance DNA-raised adaptive immune responses against influenza and tumors through activation of innate immunity. J Virol 2006;80:6218-24; PMID:16775309; http://dx.doi.org/10.1128/JVI.00121-06
    • (2006) J Virol , vol.80 , pp. 6218-6224
    • Takeshita, F.1    Tanaka, T.2    Matsuda, T.3    Tozuka, M.4    Kobiyama, K.5    Saha, S.6
  • 39
    • 78651410969 scopus 로고    scopus 로고
    • Coexpressed RIG-I agonist enhances humoral immune response to influenza virus DNA vaccine
    • PMID:21106745
    • Luke JM, Simon GG, Soderholm J, Errett JS, August JT, Gale M Jr., et al. Coexpressed RIG-I agonist enhances humoral immune response to influenza virus DNA vaccine. J Virol 2011;85:1370-83; PMID:21106745; http://dx.doi.org/10.1128/ JVI.01250-10
    • (2011) J Virol , vol.85 , pp. 1370-1383
    • Luke, J.M.1    Simon, G.G.2    Soderholm, J.3    Errett, J.S.4    August, J.T.5    Gale Jr., M.6
  • 40
    • 84870838643 scopus 로고    scopus 로고
    • MDA5 can be exploited as efficacious genetic adjuvant for DNA vaccination against lethal H5N1 influenza virus infection in chickens
    • PMID:23227156
    • Liniger M, Summerfield A, Ruggli N. MDA5 can be exploited as efficacious genetic adjuvant for DNA vaccination against lethal H5N1 influenza virus infection in chickens. PLoS One 2012;7:e49952; PMID:23227156; http://dx.doi.org/10.1371/journal. pone.0049952
    • (2012) PLoS One , vol.7
    • Liniger, M.1    Summerfield, A.2    Ruggli, N.3
  • 41
    • 68249160771 scopus 로고    scopus 로고
    • Co-immunization with an optimized plasmid-encoded immune stimulatory interleukin, high-mobility group box 1 protein, results in enhanced interferon-gamma secretion by antigen-specific CD8 T cells
    • PMID: 19740322
    • Muthumani G, Laddy DJ, Sundaram SG, Fagone P, Shedlock DJ, Kannan S, et al. Co-immunization with an optimized plasmid-encoded immune stimulatory interleukin, high-mobility group box 1 protein, results in enhanced interferon-gamma secretion by antigen-specific CD8 T cells. Immunology 2009;128(Suppl):e612-20; PMID: 19740322; http://dx.doi.org/10.1111/j.1365-2567. 2009.03044. X
    • (2009) Immunology , vol.128 , Issue.SUPPL.
    • Muthumani, G.1    Laddy, D.J.2    Sundaram, S.G.3    Fagone, P.4    Shedlock, D.J.5    Kannan, S.6
  • 42
    • 80855144171 scopus 로고    scopus 로고
    • Molecular adjuvant HMGB1 enhances anti-influenza immunity during DNA vaccination
    • PMID:21544096
    • Fagone P, Shedlock DJ, Bao H, Kawalekar OU, Yan J, Gupta D, et al. Molecular adjuvant HMGB1 enhances anti-influenza immunity during DNA vaccination. Gene Ther 2011;18:1070-7; PMID:21544096; http://dx. doi.org/10.103 8/gt.2 011.59
    • (2011) Gene Ther , vol.18 , pp. 1070-1077
    • Fagone, P.1    Shedlock, D.J.2    Bao, H.3    Kawalekar, O.U.4    Yan, J.5    Gupta, D.6
  • 43
    • 79952184381 scopus 로고    scopus 로고
    • DAI (DLM-1/ZBP1) as a genetic adjuvant for DNA vaccines that promotes effective antitumor CTL immunity
    • PMID:21157438
    • Lladser A, Mougiakakos D, Tufvesson H, Ligtenberg MA, Quest AF, Kiessling R, et al. DAI (DLM-1/ZBP1) as a genetic adjuvant for DNA vaccines that promotes effective antitumor CTL immunity. Mol Ther 2011;19:594-601; PMID:21157438; http://dx.doi.org/10.1038/mt.2010.268
    • (2011) Mol Ther , vol.19 , pp. 594-601
    • Lladser, A.1    Mougiakakos, D.2    Tufvesson, H.3    Ligtenberg, M.A.4    Quest, A.F.5    Kiessling, R.6
  • 44
    • 77954576021 scopus 로고    scopus 로고
    • Interferon regulatory factor-1 acts as a powerful adjuvant in tat DNA based vaccination
    • PMID:20432465
    • Castaldello A, Sgarbanti M, Marsili G, Brocca-Cofano E, Remoli AL, Caputo A, et al. Interferon regulatory factor-1 acts as a powerful adjuvant in tat DNA based vaccination. J Cell Physiol 2010;224:702-9; PMID:20432465; http://dx.doi.org/10.1002/jcp. 22169
    • (2010) J Cell Physiol , vol.224 , pp. 702-709
    • Castaldello, A.1    Sgarbanti, M.2    Marsili, G.3    Brocca-Cofano, E.4    Remoli, A.L.5    Caputo, A.6
  • 45
    • 0035451081 scopus 로고    scopus 로고
    • Genomic DNA released by dying cells induces the maturation of APCs
    • PMID:11509601
    • Ishii KJ, Suzuki K, Coban C, Takeshita F, Itoh Y, Matoba H, et al. Genomic DNA released by dying cells induces the maturation of APCs. J Immunol 2001;167:2602-7; PMID:11509601
    • (2001) J Immunol , vol.167 , pp. 2602-2607
    • Ishii, K.J.1    Suzuki, K.2    Coban, C.3    Takeshita, F.4    Itoh, Y.5    Matoba, H.6
  • 46
    • 79961167250 scopus 로고    scopus 로고
    • DNA released from dying host cells mediates aluminum adjuvant activity
    • PMID:21765404
    • Marichal T, Ohata K, Bedoret D, Mesnil C, Sabatel C, Kobiyama K, et al. DNA released from dying host cells mediates aluminum adjuvant activity. Nat Med 2011;17:996-1002; PMID:21765404; http://dx.doi.org/10.103 8/nm.2403
    • (2011) Nat Med , vol.17 , pp. 996-1002
    • Marichal, T.1    Ohata, K.2    Bedoret, D.3    Mesnil, C.4    Sabatel, C.5    Kobiyama, K.6
  • 47
    • 67651125824 scopus 로고    scopus 로고
    • A host type I interferon response is induced by cytosolic sensing of the bacterial second messenger cyclic-di-GMP
    • PMID: 19652017
    • McWhirter SM, Barbalat R, Monroe KM, Fontana MF, Hyodo M, Joncker NT, et al. A host type I interferon response is induced by cytosolic sensing of the bacterial second messenger cyclic-di-GMP. J Exp Med 2009;206:1899-911; PMID: 19652017; http://dx.doi.org/10.1084/jem.20082874
    • (2009) J Exp Med , vol.206 , pp. 1899-1911
    • McWhirter, S.M.1    Barbalat, R.2    Monroe, K.M.3    Fontana, M.F.4    Hyodo, M.5    Joncker, N.T.6
  • 48
    • 0035369109 scopus 로고    scopus 로고
    • The regulation of DNA vaccines
    • PMID: 11404109
    • Smith HA, Klinman DM. The regulation of DNA vaccines. Curr Opin Biotechnol 2001;12:299-303; PMID: 11404109; http://dx.doi.org/10.1016/S0958-1669 (00) 00215-9
    • (2001) Curr Opin Biotechnol , vol.12 , pp. 299-303
    • Smith, H.A.1    Klinman, D.M.2
  • 49
    • 77949655991 scopus 로고    scopus 로고
    • The potential of 3', 5'-cyclic diguanylic acid (c-di-GMP) as an effective vaccine adjuvant
    • PMID:20197136
    • Chen W, Kuolee R, Yan H. The potential of 3', 5'-cyclic diguanylic acid (c-di-GMP) as an effective vaccine adjuvant. Vaccine 2010;28:3080-5; PMID:20197136; http://dx.doi. Org/10.1016/j.vaccine.2010.02.081
    • (2010) Vaccine , vol.28 , pp. 3080-3085
    • Chen, W.1    Kuolee, R.2    Yan, H.3
  • 50
    • 84858256662 scopus 로고    scopus 로고
    • Evaluation of the sublingual route for administration of influenza H5N1 virosomes in combination with the bacterial second messenger c-di-GMP
    • PMID:22069479
    • Pedersen GK, Ebensen T, Gjeraker IH, Svindland S, Bredholt G, Guzman CA, et al. Evaluation of the sublingual route for administration of influenza H5N1 virosomes in combination with the bacterial second messenger c-di-GMP. PLoS One 2011;6:e26973; PMID:22069479; http://dx.doi.org/10.1371/journal. pone.0026973
    • (2011) PLoS One , vol.6
    • Pedersen, G.K.1    Ebensen, T.2    Gjeraker, I.H.3    Svindland, S.4    Bredholt, G.5    Guzman, C.A.6
  • 51
    • 0141998606 scopus 로고    scopus 로고
    • Molecular identification of a danger signal that alerts the immune system to dying cells
    • PMID: 14520412
    • Shi Y, Evans JE, Rock KL. Molecular identification of a danger signal that alerts the immune system to dying cells. Nature 2003;425:516-21; PMID: 14520412; http://dx.doi.org/10.1038/nature01991
    • (2003) Nature , vol.425 , pp. 516-521
    • Shi, Y.1    Evans, J.E.2    Rock, K.L.3
  • 52
    • 34447330454 scopus 로고    scopus 로고
    • The chemotherapeutic agent DMXAA potently and specifically activates the TBK1-IRF-3 signaling axis
    • PMID: 17562815
    • Roberts ZJ, Goutagny N, Perera PY, Kato H, Kumar H, Kawai T, et al. The chemotherapeutic agent DMXAA potently and specifically activates the TBK1-IRF-3 signaling axis. J Exp Med 2007;204:1559-69; PMID: 17562815; http://dx.doi.org/ 10.1084/jem.20061845
    • (2007) J Exp Med , vol.204 , pp. 1559-1569
    • Roberts, Z.J.1    Goutagny, N.2    Perera, P.Y.3    Kato, H.4    Kumar, H.5    Kawai, T.6
  • 53
    • 84875311005 scopus 로고    scopus 로고
    • The chemotherapeutic agent DMXAA as a unique IRF3-dependent type-2 vaccine adjuvant
    • PMID:23555875
    • Tang CK, Aoshi T, Jounai N, Ito J, Ohata K, Kobiyama K, et al. The chemotherapeutic agent DMXAA as a unique IRF3-dependent type-2 vaccine adjuvant. PLoS One 2013;8:e60038; PMID:23555875; http://dx.doi.org/10.1371/journal, pone. 0060 038
    • (2013) PLoS One , vol.8
    • Tang, C.K.1    Aoshi, T.2    Jounai, N.3    Ito, J.4    Ohata, K.5    Kobiyama, K.6
  • 54
    • 84878638162 scopus 로고    scopus 로고
    • Species-specific detection of the antiviral small-molecule compound CM A by STING
    • PMID:23604073
    • Caviar T, Deimling T, Ablasser A, Hopfner KP, Hornung V. Species-specific detection of the antiviral small-molecule compound CM A by STING. EMBO J 2013;32:1440-50; PMID:23604073; http://dx.doi.org/10.1038/emboj.2013.86
    • (2013) EMBO J , vol.32 , pp. 1440-1450
    • Caviar, T.1    Deimling, T.2    Ablasser, A.3    Hopfner, K.P.4    Hornung, V.5
  • 55
    • 84877795529 scopus 로고    scopus 로고
    • Mouse, but not human STING, binds and signals in response to the vascular disrupting agent 5, 6-dimethylxanthenone-4-acetic acid
    • PMID:23585680
    • Conlon J, Burdette DL, Sharma S, Bhat N, Thompson M, Jiang Z, et al. Mouse, but not human STING, binds and signals in response to the vascular disrupting agent 5, 6-dimethylxanthenone-4-acetic acid. J Immunol 2013;190:5216-25; PMID:23585680; http://dx. doi.org/10.4049/j immuno1.1300097
    • (2013) J Immunol , vol.190 , pp. 5216-5225
    • Conlon, J.1    Burdette, D.L.2    Sharma, S.3    Bhat, N.4    Thompson, M.5    Jiang, Z.6


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