Plasma pharmacochemistry combined with microdialysis to screen potential bioactive components and their metabolites in Anemarrhena asphodeloides saponin extract using ultrahigh-performance liquid chromatography/quadrupole-time-of- flight mass spectrometry

Journal of Separation Science

Volumn 36, Issue 9-10, 2013, Pages 1659-1666

  Liu, Zhirui ^a,b   Liu, Min ^a,b,c   Qi, Yunpeng ^a,b   Zhu, Zhenyu ^a,b   Chai, Yifeng ^a,b   Yuan, Chao ^d   Lin, Yang ^d  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b SHANGHAI KEY LABORATORY FOR PHARMACEUTICAL METABOLITE RESEARCH   (China)

^c Nanjing Military Medical Institute   (China)

^d Shenyang Military Area Command ^*  (China)

Author keywords

Anemarrhena asphodeloides; Bioactive components; Micro dialysis; Plasma pharmacochemistry; Quadrupole TOF MS

Indexed keywords

ACCURATE MASS MEASUREMENTS; ANEMARRHENA ASPHODELOIDES; BIOACTIVE COMPONENTS; METABOLIC CHARACTERISTICS; MICRO-DIALYSIS; QUADRUPOLE-TOF MS; TRADITIONAL CHINESE MEDICINE; ULTRA-HIGH PERFORMANCE LIQUID CHROMATOGRAPHIES;

BIOMOLECULES; CARDIOVASCULAR SYSTEM; CHEMICAL COMPOUNDS; DIALYSIS; MAMMALS; MASS SPECTROMETRY; MEDICINE; METABOLISM; PLANT EXTRACTS; PLASMAS;

METABOLITES;

DEGLYCOSYLATED TIMOSAPONIN D; DEGLYCOSYLATED TIMOSAPONIN E1; DEHYDROGENATED SARSASAPOGENIN; DEHYDROGENATED SARSASAPOGENIN GLUCURONIDE; DRUG METABOLITE; GLYCOSYLATED ISOPREGNANOLONE; SAPONIN; SARSASAPOGENIN; SEPRANOLONE; TIMOSAPONIN A1; TIMOSAPONIN A3; TIMOSAPONIN B2; TIMOSAPONIN B3; TIMOSAPONIN D; TIMOSAPONIN E1; UNCLASSIFIED DRUG;

ANEMARRHENA ASPHODELOIDES; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CIRCULATION; CLINICAL CHEMISTRY; CONTROLLED STUDY; DIFFUSION COEFFICIENT; DRUG ABSORPTION; DRUG ACTIVITY; DRUG BLOOD LEVEL; DRUG ELIMINATION; DRUG IDENTIFICATION; DRUG METABOLISM; DRUG SCREENING; DRUG STRUCTURE; FLOW RATE; HERBAL MEDICINE; IN VITRO STUDY; IN VIVO STUDY; JUGULAR VEIN; MALE; MICRODIALYSIS; MOLECULAR WEIGHT; NONHUMAN; PRIORITY JOURNAL; QUADRUPLE TIME OF FLIGHT MASS SPECTROMETRY; RAT; REPRODUCIBILITY; TIME OF FLIGHT MASS SPECTROMETRY; TIME TO MAXIMUM PLASMA CONCENTRATION; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY;

ADMINISTRATION, ORAL; ANEMARRHENA; ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DIALYSIS; DRUGS, CHINESE HERBAL; MALE; MASS SPECTROMETRY; MOLECULAR STRUCTURE; RATS; RATS, SPRAGUE-DAWLEY; SAPONINS;

EID: 84877689815     PISSN: 16159306     EISSN: 16159314     Source Type: Journal    
DOI: 10.1002/jssc.201201116     Document Type: Article

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