An immunodominant La/SSB autoantibody proteome derives from public clonotypes

Clinical and Experimental Immunology

Volumn 174, Issue 2, 2013, Pages 237-244

  Thurgood, L A ^a   Arentz, G ^a   Lindop, R ^a   Jackson, M W ^a   Whyte, A F ^a   Colella, A D ^a   Chataway, T K ^a   Gordon, T P ^a  

^a FLINDERS UNIVERSITY   (Australia)

Author keywords

La SSB; Mass spectrometry; Primary Sj grens syndrome; Public clonotypes

Indexed keywords

EPITOPE; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN LIGHT CHAIN; LA ANTIBODY; LA ANTIGEN; POLYCLONAL ANTIBODY; PROTEOME;

ADULT; AFFINITY CHROMATOGRAPHY; AGED; AMINO ACID SUBSTITUTION; ANTIBODY RESPONSE; ANTIBODY SPECIFICITY; ANTIGEN MEDIATED CLONAL SELECTION; ARTICLE; AUTOIMMUNITY; B LYMPHOCYTE; CLINICAL ARTICLE; CLONAL VARIATION; COMPLEMENTARITY DETERMINING REGION; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; HUMORAL IMMUNITY; IMMUNOLOGICAL TOLERANCE; MALE; MASS SPECTROMETRY; PRIORITY JOURNAL; SJOEGREN SYNDROME;

LA/SSB; MASS SPECTROMETRY; PRIMARY SJÖGRENS SYNDROME; PUBLIC CLONOTYPES;

ADOLESCENT; ADULT; AUTOANTIBODIES; AUTOANTIGENS; B-LYMPHOCYTES; CHILD; CHILD, PRESCHOOL; CHROMATOGRAPHY, AFFINITY; CLONAL SELECTION, ANTIGEN-MEDIATED; CLONE CELLS; FEMALE; HUMANS; IMMUNE TOLERANCE; IMMUNITY, HUMORAL; IMMUNODOMINANT EPITOPES; MALE; MASS SPECTROMETRY; PROTEOMICS; RIBONUCLEOPROTEINS; SJOGREN'S SYNDROME; YOUNG ADULT;

EID: 84885114650     PISSN: 00099104     EISSN: 13652249     Source Type: Journal    
DOI: 10.1111/cei.12171     Document Type: Article

References (34)

1. Alexander EL, Hirsch TJ, Arnett FC, Provost TT, Stevens MB. Ro(SSA) and La(SSB) antibodies in the clinical spectrum of Sjögrens syndrome. J Rheumatol 1982; 9:239-246.
2. Harley JB, Alexander EL, Bias WB etal. Anti-Ro (SS-A) and anti-La (SS-B) in patients with Sjogren's syndrome. Arthritis Rheum 1986; 29:196-206.
3. Whittingham S, Naselli G, McNeilage LJ, Coppel RL, Sturgess AD. Serological diagnosis of primary Sjogren's syndrome by means of human recombinant La (SS-B) as nuclear antigen. Lancet 1987; 2:1-3.
4. Hendrick JP, Wolin SL, Rinke J, Lerner MR, Steitz JA. Ro small cytoplasmic ribonucleoproteins are a subclass of La ribonucleoproteins: further characterization of the Ro and La small ribonucleoproteins from uninfected mammalian cells. Mol Cell Biol 1981; 1:1138-1149.
5. McCluskey J, Farris AD, Keech CL etal. Determinant spreading: lessons from animal models and human disease. Immunol Rev 1998; 164:209-229.
6. Schulte J, Fritzler M, Mahler M. Latest update on the Ro/SSA autoantibody system. Autoimmun Rev 2009; 8:632-637.
7. Stefano JE. Purified lupus antigen La recognizes an oligouridylate strech common to the 3′ termini of RNA polymerase III transcripts. Cell 1984; 36:145-154.
8. Roy R, Kozlov AG, Lohman TM, Ha T. SSB protein diffusion on single-stranded DNA stimulates RecA filament formation. Nature 2009; 461:1092-1097.
9. McNeilage LJ, Macmillan EM, Whittingham SF. Mapping epitopes on the La (SS-B) autoantigen of primary Sjogrens syndrome: identification of a cross-reactive epitope. J Immunol 1990; 145:3829-3835.
10. Kenan DJ, Keene JD. La gets its wings. Nat Struct Mol Biol 2004; 11:303-305.
11. Gordon TP, Mavrangelos C, McCluskey J. Restricted epitope recognition by precipitin-negative anti-La/SS-B-positive sera. Arthritis Rheum 1992; 35:663-666.
12. Gordon TP, Greer M, Reynolds P, Guidolin A, McNeilage LJ. Estimation of amounts of anti-La (SS-B) antibody directed against immunodominant epitopes of the La(SS-B) autoantigen. Clin Exp Immunol 1991; 85:402-406.
13. Reed JH, Neufing PJ, Jackson MW etal. Different temporal expression of immunodominant Ro60/60kDa-SSA and La/SSB apotopes. Clin Exp Immunol 2007; 148:153-160.
14. Neufing PJ, Clancy RM, Jackson MW, Tran HB, Buyon JP, Gordon TP. Exposure and binding of selected immunodominant La/SSB epitopes on human apoptotic cells. Arthritis Rheum 2005; 52:3934-3942.
15. McNeilage LJ, Umapathysivam K, Macmillion E, Guidolin A, Whittingham S, Gordon T. Definition of a discontinuous immunodominant epitope at the NH2 terminus of the La/SS-B ribonucleoprotein autoantigen. J Clin Invest 1992; 89:1652-1656.
16. Bini P, Chu J-L, Okolo C, Elkon K. Analysis of autoantibodies to recombinant La (SS-B) peptides in systemic lupus erythematosus and primary Sjogren's syndrome. J Clin Invest 1990; 85:325-333.
17. Lindop R, Arentz G, Chataway TK etal. Molecular signature of a public clonotypic autoantibody in primary Sjogrens syndrome: a 'forbidden' clone in systemic autoimmunity. Arthritis Rheum 2011; 63:3477-3486.
18. Arentz G, Thurgood LA, Lindop R, Chataway TK, Gordon TP. Secreted human Ro52 autoantibody proteomes express a restricted set of public clonotypes. J Autoimmun 2012; 39:466-470.
19. Lindop R, Arentz G, Thurgood LA, Reed JH, Jackson MW, Gordon TP. Pathogenicity and proteomic signatures of autoantibodies to Ro and La. Immunol Cell Biol 2012; 90:304-309.
20. Vitali C, Bombardieri S, Jonsson R etal. European Study Group on Classification Criteria for Sjögrens Syndrome. Classification criteria for Sjögrens syndrome: a revised version of the European criteria proposed by the American-European Consensus Group. Ann Rheum Dis 2002; 61:554-558.
21. Reed JH, Dudek NL, Osborne SE etal. Reactivity with dichotomous determinants of Ro 60 stratifies autoantibody responses in lupus and primary Sjogrens syndrome. Arthritis Rheum 2010; 62:1448-1456.
22. Layer A, Tissot JD, Schneider P, Duchosal MA. Micropurification and two-dimensional polyacrylamide gel electrophoresis of immunoglobulins for studying the clonal diversity of antigen-specific antibodies. J Immunol Methods 1999; 227:137-148.
23. Liu H, Gaza-Bulseco G, Faldu D, Chumsae C, Sun J. Heterogeneity of monoclonal antibodies. J Pharm Sci 2008; 97:2426-2447.
24. Meffre E, Wardemann H. B-cell tolerance checkpoints in health and autoimmunity. Curr Opin Immunol 2008; 20:632-638.
25. Vinuesa CG, Sanz I, Cook MC. Dysregulation of germinal centres in autoimmune disease. Nat Rev Immunol 2009; 9:845-857.
26. Ho M, Kreitman RJ, Onda M, Pastan I. In vitro antibody evolution targeting germline hot spots to increase activity of an anti-CD22 immunotoxin. J Biol Chem 2004; 280:607-617.
27. Tengner P, Halse A-K, Haga H-J, Jonsson R, Wahren-Herlenius M. Detection of anti-Ro/SSA and anti-La/SSB autoantibody-producing cells in salivary glands from patients with Sjogren's syndrome. Arthritis Rheum 1998; 41:2238-2248.
28. Xiang X, Smith DS, Guth A, Wysocki LJ. A receptor presentation hypothesis for T cell help that recruits autoreactive B cells. J Immunol 2001; 166:1562-1571.
29. Kalsi JK, Hahn BH. The role of VH determinants in systemic lupus erythematosus. Lupus 2002; 11:878-884.
30. Munthe LA, Corthay A, Os A, Zangani M, Bogen B. Systemic autoimmune disease caused by autoreactive B cells that receive chronic help from Ig V region-specific T cells. J Immunol 2005; 175:2391-2400.
31. Demaison C, Chastagner P, Theze J etal. Somatic diversification in the heavy chain variable region genes expressed by human autoantibodies bearing a lupus-associated nephritogenic anti-DNA idiotype. Proc Natl Acad Sci USA 1994; 91:514-518.
32. Cheung WC, Beausoleil SA, Zhang X etal. A proteomics approach for the identification and cloning of monoclonal antibodies from serum. Nat Biotechnol 2012; 30:447-452.
33. Sato S, Beausoleil SA, Popova L etal. Proteomics-directed cloning of circulating antiviral human monoclonal antibodies. Nat Biotechnol 2012; 30:1039-1043.
34. Wine Y, Boutz DR, Lavinder JL etal. Molecular deconvolution of the monoclonal antibodies that comprise the polyclonal serum response. Proc Natl Acad Sci USA 2013; 110:2993-2998.