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In vitro characterization of a novel dUTPase inhibitor, TAS-114, as a fluoropyrimidine enhancer
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TAS-114 enhances S-1 activity in vivo when used in combination
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TAS-114 in combination, with capecitabine-based chemotherapy may represent a novel therapeutic strategy
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An optimal dosing schedule for a novel combination antimetabolite, TAS-102, based on its intracellular metabolism and its incorporation into DNA
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Trifluorothymidine incorporation into DNA is the primary mechanism of action of TAS-102, and leads to markedly prolonged survival in a mouse model
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The prominent safety profile of TAS-115, a novel c-Met+VEGFR dual kinase inhibitor can lead to potentiate the efficacy via durable inhibitor of angiogenesis
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MET/VEGFR dual inhibition and prominent safety profiles of TAS-115 are favorable for the combination with chemotherapeutic drugs
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Highly potent and selective Aurora A inhibitor, TAS-2104 enhanced antitumor activity of taxanes in vitro
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TAS-2104, a highly potent and effective Aurora A inhibitor, enhanced antitumor activity of taxanes in vivo
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Characterization of TAS-117, a novel, highly potent and selective inhibitor of AKT
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A novel highly potent AKT inhibitor TAS-117 demonstrated synergistic antitumor activity in combination with paclitaxel through enhancement of apoptosis induction
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Identification & biological characterization of a highly potent, irreversible inhibitor of FGFR, TAS-2985
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Significant in vivo antitumor activity by a highly potent, irreversible FGFR Inhibitor, TAS-2985
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TAS-2913 is a mutant selective EGFR inhibitor for NSCLC: characterization against EGFR T790M in cell and xenograft models
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Miyadera K, Kato M, Takahashi I, et al. TAS-2913 is a mutant selective EGFR inhibitor for NSCLC: characterization against EGFR T790M in cell and xenograft models. In: 24th EORTC-NCI-AACR symposium 2012 (Abstract 142).
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Miyadera, K.1
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84885097578
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TAS-116, a novel, orally bioavailable HSP90a/β selective inhibitor demonstrates highly potent antitumor activity in preclinical models with a favorable PK profile
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Evolution of highly selective HSP90a/β inhibitors with unique binding mode
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84885142951
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TAS-116, a novel, orally bioavailable highly potent HSP90a/β selective inhibitor demonstrates favorable tissue distribution properties which lead to minimized ocular toxicity
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(Abstract 290)
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Kodama Y, Hitotsumachi H, Shibata Y, et al. TAS-116, a novel, orally bioavailable highly potent HSP90a/β selective inhibitor demonstrates favorable tissue distribution properties which lead to minimized ocular toxicity. In: 24th EORTC-NCI-AACR symposium 2012 (Abstract 290).
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Kodama, Y.1
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Shibata, Y.3
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