SLC26A6 and NaDC-1 transporters interact to regulate oxalate and citrate homeostasis

Journal of the American Society of Nephrology

Volumn 24, Issue 10, 2013, Pages 1617-1626

  Ohana, Ehud ^a   Shcheynikov, Nikolay ^a   Moe, Orson W ^b   Muallem, Shmuel ^a  

^a NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CITRIC ACID; COTRANSPORTER; OXALIC ACID; PROTEIN; SLC26A6 PROTEIN; SODIUM DICARBOXYLATE TRANSPORTER; SUCCINIC ACID; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CHEMICAL ANALYSIS; CONTROLLED STUDY; FEMALE; HOMEOSTASIS AND REGULATION; HYPEROXALURIA; HYPOCITRATURIA; KIDNEY TUBULE ABSORPTION; MOUSE; NONHUMAN; OOCYTE; PHYSIOLOGICAL PROCESS; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; PROTEIN TRANSPORT; PROTEIN URINE LEVEL; SODIUM URINE LEVEL; URINE PH; WILD TYPE; XENOPUS LAEVIS;

EID: 84885063137     PISSN: 10466673     EISSN: 15333450     Source Type: Journal    
DOI: 10.1681/ASN.2013010080     Document Type: Article

References (37)

1. Moe OW: Kidney stones: Pathophysiology and medical management. Lancet 367: 333-344, 2006
2. Harrison JD: Causes, natural history, and incidence of salivary stones and obstructions. Otolaryngol Clin North Am 42: 927-947, 2009
3. Moe OW, Preisig PA: Dual role of citrate inmammalian urine. Curr Opin Nephrol Hypertens 15: 419-424, 2006
4. Aronson PS: Role of SLC26A6-mediated Cl.-oxalate exchange in renal physiology and pathophysiology. J Nephrol 23 [Suppl 16]: S158-S164, 2010
5. Lee MG, Ohana E, Park HW, Yang D, Muallem S: Molecular mechanism of pancreatic and salivary gland fluid and HCO3 secretion. Physiol Rev 92: 39-74, 2012
6. Shcheynikov N, Wang Y, Park M, Ko SB, Dorwart M, Naruse S, Thomas PJ, Muallem S: Coupling modes and stoichiometry of Cl-/HCO3-exchange by slc26a3 and slc26a6. J Gen Physiol 127: 511-524, 2006
7. Ohana E, Shcheynikov N, Yang D, So I, Muallem S: Determinants of coupled transport and uncoupled current by the electrogenic SLC26 transporters. J Gen Physiol 137: 239-251, 2011
8. Jiang Z, Asplin JR, Evan AP, Rajendran VM, Velazquez H, Nottoli TP, Binder HJ, Aronson PS: Calcium oxalate urolithiasis in mice lacking anion transporter Slc26a6. Nat Genet 38: 474-478, 2006
9. Knauf F, Ko N, Jiang Z, Robertson WG, Van Itallie CM, Anderson JM, Aronson PS: Net intestinal transport of oxalate reflects passive absorption and SLC26A6-mediated secretion. J Am Soc Nephrol 22: 2247-2255, 2011
10. Aronson PS: Essential roles of CFEX-mediated Cl (-)-oxalate exchange in proximal tubuleNaCl transport and prevention of urolithiasis. Kidney Int 70: 1207-1213, 2006
11. Zacchia M, Preisig P: Low urinary citrate: an overview. J Nephrol 23 [Suppl 16]: S49-S56, 2010
12. El-Shall H, Jeon J-h, Abdel-Aal EA, Khan S, Gower L, Rabinovich Y: A study of primary nucleation of calcium oxalate monohydrate: II. Effect of urinary species. Cryst Res Technol 39: 222-229, 2004
13. Sheng X, Jung T, Wesson JA, Ward MD: Adhesion at calcium oxalate crystal surfaces and the effect of urinary constituents. Proc Natl Acad Sci U S A 102: 267-272, 2005
14. Hess B, Zipperle L, Jaeger P: Citrate and calcium effects on Tamm-Horsfall glycoprotein as a modifier of calcium oxalate crystal aggregation. Am J Physiol 265: F784-F791, 1993
15. Qiu SR, Wierzbicki A, Orme CA, Cody AM, Hoyer JR, Nancollas GH, Zepeda S, De Yoreo JJ: Molecular modulation of calcium oxalate crystallization by osteopontin and citrate. Proc Natl Acad Sci U S A 101: 1811-1815, 2004
16. Sekine T, Cha SH, Hosoyamada M, Kanai Y, Watanabe N, Furuta Y, Fukuda K, Igarashi T, Endou H: Cloning, functional characterization, and localization of a rat renal Na+-dicarboxylate transporter. Am J Physiol 275: F298-F305, 1998
17. Alpern RJ: Cell mechanisms of proximal tubule acidification. Physiol Rev 70: 79-114, 1990
18. Pajor AM: Molecular properties of the SLC13 family of dicarboxylate and sulfate transporters. Pflugers Arch 451: 597-605, 2006
19. Garcia-Perez I, Villaseñor A, Wijeyesekera A, Posma JM, Jiang Z, Stamler J, Aronson P, Unwin R, Barbas C, Elliott P, Nicholson J, Holmes E: Urinary metabolic phenotyping the slc26a6 (chloride-oxalate exchanger) null mouse model. J Proteome Res 11: 4425-4435, 2012
20. Pajor AM: Sequence and functional characterization of a renal sodium/dicarboxylate cotransporter. J Biol Chem 270: 5779-5785, 1995
21. Pajor AM: Citrate transport by the kidney and intestine. Semin Nephrol 19: 195-200, 1999
22. Wolffram S, Badertscher M, Scharrer E: Carrier-mediated transport is involved in mucosal succinate uptake by rat large intestine. Exp Physiol 79: 215-226, 1994
23. Ohana E, Shcheynikov N, Park M, Muallem S: Solute carrier family 26 member a2 (Slc26a2) protein functions as an electroneutral SOFormula/OH-/Cl- exchanger regulated by extracellular Cl-. JBiol Chem 287: 5122-5132, 2012
24. Ko SB, Zeng W, Dorwart MR, Luo X, Kim KH, Millen L, Goto H, Naruse S, Soyombo A, Thomas PJ, Muallem S: Gating of CFTR by the STAS domain of SLC26 transporters. Nat Cell Biol 6: 343-350, 2004
25. Pajor AM: Sodium-coupled transporters for Krebs cycle intermediates. Annu Rev Physiol 61: 663-682, 1999
26. Wang Y, Soyombo AA, Shcheynikov N, Zeng W, Dorwart M, Marino CR, Thomas PJ, Muallem S: Slc26a6 regulates CFTR activity in vivo to determine pancreatic duct HCO3-secretion: relevance to cystic fibrosis. EMBO J 25: 5049-5057, 2006
27. Avella M, Loriol C, Boulukos K, Borgese F, Ehrenfeld J: SLC26A9 stimulates CFTR expression and function in human bronchial cell lines. J Cell Physiol 226: 212-223, 2011
28. Bertrand CA, Zhang R, Pilewski JM, Frizzell RA: SLC26A9 is a constitutively active, CFTR-regulated anion conductance in human bronchial epithelia. J Gen Physiol 133: 421-438, 2009
29. Alvarez BV, Vilas GL, Casey JR: Metabolon disruption: A mechanism that regulates bicarbonate transport. EMBO J 24: 2499-2511, 2005
30. Dorwart MR, Shcheynikov N, Yang D, Muallem S: The solute carrier 26 family of proteins in epithelial ion transport. Physiology (Bethesda) 23: 104-114, 2008
31. van Geest M, Lolkema JS: Membrane topology of the Na (+) /citrate transporter CitS of Klebsiella pneumoniae by insertion mutagenesis. Biochim Biophys Acta 1466: 328-338, 2000
32. Mancusso R, Gregorio GG, Liu Q, Wang DN: Structure and mechanism of a bacterial sodium-dependent dicarboxylate transporter. Nature 491: 622-626, 2012
33. Brennan S, Hering-Smith K, Hamm LL: Effect of pH on citrate reabsorption in the proximal convoluted tubule. Am J Physiol 255: F301-F306, 1988
34. Wright SH, Kippen I, Wright EM: Effect of pH on the transport of Krebs cycle intermediates in renal brush border membranes. Biochim Biophys Acta 684: 287-290, 1982
35. Davidovich E, Davidovits M, Peretz B, Shapira J, Aframian DJ: The correlation between dental calculus and disturbed mineral metabolism in paediatric patients with chronic kidney disease. Nephrol Dial Transplant 24: 2439-2445, 2009
36. Strohmaier WL, Seilnacht J, Schubert G: Urinary stone formers with hypocitraturia and 'normal' urinary pH are at high risk for recurrence. Urol Int 88: 294-297, 2012
37. Shcheynikov N, Kim KH, Kim KM, Dorwart MR, Ko SB, Goto H, Naruse S, Thomas PJ, Muallem S: Dynamic control of cystic fibrosis transmembrane conductance regulator Cl (-) /HCO3 (-) selectivity by external Cl (-). J Biol Chem 279: 21857-21865, 2004