Sodium-coupled transporters for krebs cycle intermediates

Annual Review of Physiology

Volumn 61, Issue , 1999, Pages 663-682

  Pajor, Ana M ^a  

^a UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

Author keywords

ketoglutarate; Citrate; Citric acid cycle intermediates; Sodium; Succinate

Indexed keywords

2 OXOGLUTARIC ACID; CARRIER PROTEIN; CITRIC ACID; COMPLEMENTARY DNA; DICARBOXYLIC ACID; SODIUM ION; SUCCINIC ACID;

ACTIVE TRANSPORT; CELL MEMBRANE TRANSPORT; CITRIC ACID CYCLE; HUMAN; INTESTINE EPITHELIUM; KIDNEY EPITHELIUM; MEMBRANE VESICLE; MULTIGENE FAMILY; NONHUMAN; PRIORITY JOURNAL; RABBIT; REVIEW; SODIUM TRANSPORT; XENOPUS;

ANIMALS; CARRIER PROTEINS; CITRIC ACID CYCLE; CLONING, MOLECULAR; DICARBOXYLIC ACID TRANSPORTERS; HUMANS; MEMBRANE PROTEINS; ORGANIC ANION TRANSPORTERS, SODIUM-DEPENDENT; SODIUM; STRUCTURE-ACTIVITY RELATIONSHIP; SYMPORTERS;

EID: 0033037180     PISSN: 00664278     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.physiol.61.1.663     Document Type: Review

References (80)

1. 1. Aruga S, Preisig PA, Moe OW, Pajor AM, Alpern RJ. 1997. Chronic metabolic acidosis (CMA) increases renal cortical NaDC-1 mRNA and protein abundance in rats. J. Am. Soc. Nephrol. 8:A0006
2. +-dependent dicarboxylate transporter. Am. J. Physiol. 273:G267-74
3. 3. Barac-Nieto M. 1984. Effects of pH, calcium, and succinate on sodium citrate cotransport in renal microvilli. Am. J. Physiol. 247:F282-90
4. +/succinate cotransporter in rabbit renal brush borders. J. Biol. 81:159-70
5. 5. Bond PA, Jenner FA. 1974. The effect of lithium and related metal ions on the urinary excretion of 2-oxoglutarate and citrate in the rat. Br. J. Pharmacol. 50:283-39
6. 6. Bond PA, Jenner FA, Lee CR, Lenton E, Pollitt RJ, Sampson GA. 1972. The effect of lithium salts on the urinary excretion of 2-oxoglutarate in man. Br. J. Pharmacol. 46:116-23
7. 7. Brennan S, Hering-Smith K, Hamm LL. 1988. Effect of pH on citrate reabsorption in the proximal convoluted tubule. Am. J. Physiol. 255:F301-6
8. 8. Browne JL, Sanford PA, Smyth DH. 1978. Transfer and metabolism of citrate, succinate, α-ketoglutarate and pyruvate by hamster small intestine. Proc. R, Soc. London Ser. B 200:117-35
9. 9. Buck KJ, Amara SG. 1994. Chimeric dopamine-norepinephrine transporters delineate structural domains influencing selectivity for catecholamines and 1-methyl-4-phenylpyridinium. Proc. Natl. Acad. Sci. USA 91:12584-88
10. 10. Burckhardt G. 1984. Sodium-dependent dicarboxylate transport in rat renal basolateral membrane vesicles. Pflügers Arch. 401:254-61
11. 4 transport protein NaSi-1. J. Biol. Chem. 269:12407-9
12. 12. Canary JJ, Meloni CR, Clive D, Grossman E. 1964. The renal clearance of citrate in man. Metabolism 13:21-30
13. +-dicarboxylate cotransporter. J. Biol. Chem. 273:20972-81
14. 13. Dantzler WH, Evans KK. 1996. Effect of αKG in lumen on PAH transport by isolated-perfused rabbit renal proximal tubules. Am. J. Physiol. 271:F521-26
15. 14. Edwards RM, Stack E, Trizna W. 1997. α-ketoglutarate transport in rat renal brush-border and basolateral membrane-vesicles. J. Pharmacol. Exp. Ther. 281: 1059-64
16. 15. Deleted in proof
17. 16. Ferraris RP. 1994. Regulation of intestinal nutrient transport. In Physiology of the Gastrointestinal Tract, ed. LR Johnson, pp. 1821-44. New York: Raven
18. 17. Fukuhara Y, Turner RJ. 1983. Sodium-dependent succinate transport in renal outer cortical brush border membrane vesicles. Am. J. Physiol. 245:F374-81
19. 18. Ganapathy V, Ganapathy ME, Tiruppathi C, Miyamoto Y, Mahesh VB, Leibach FH. 1988. Sodium-gradient-driven, high-affinity, uphill transport of succinate in human placental brush-border membrane vesicles. Biochem. J. 249:179-84
20. + on sodium/citrate cotransport in renal brush-border vesicles. Biochim. Biophys. Acta 736:178-88
21. 20. Griffith DA, Pajor AM. 1998. Acidic residues of the sodium-dicarboxylate cotransporter NaDC-1 involved in cation binding and selectivity. FASEB J. 12: A1018 (Abstr.)
22. 21. Hamm LL. 1990. Renal handling of citrate. Kidney Int. 38:728-35
23. +-succinate cotransporter in rabbit renal brush-border membranes. Biochim. Biophys. Acta 775:17-21
24. 23. Hirayama B, Wright EM. 1986. Coupling between sodium and succinate transport across renal brush border membrane vesicles. Pflügers Arch. 407:S174-79 (Suppl.)
25. 24. Jenkins AD, Dousa TP, Smith LH. 1985. Transport of citrate across renal brush border membrane: effects of dietary acid and alkali loading. Am. J. Physiol. 249:F590-95
26. 25. Jorgensen KE, Kragh-Hansen U, Roigaard-Petersen H, Iqbal Sheik M. 1983. Citrate uptake by basolateral and luminal membrane vesicles from rabbit kidney cortex. Am. J. Physiol. 244: F686-95
27. 26. Kahn ES, Pajor AM. 1998. Identification of citrate binding domains of sodium-dicarboxylate transporters using human/rabbit chimeric transporters. FASEB J. 12:A424 (Abstr.)
28. +/dicarboxylate cotransporter reveals partial sequence homology with a rat intestinal mucin. Biochim. Biophys. Acta 1309:58-62
29. 28. Kimmich GA, Randles J, Bennett E. 1991. Sodium-dependent succinate transport by isolated chick intestinal cells. Am. J. Physiol. 260:C1151-57
30. 29. Kippen I, Hirayama B, Klinenberg JR, Wright EM. 1979. Transport of tricarboxylic acid cycle intermediates by membrane vesicles from renal brush border. Proc. Natl. Acad. Sci. USA 76:3397-400
31. 30. Law D, Hering-Smith KS, Hamm LL. 1992. Citrate transport in proximal cell line. Am. J. Physiol. 263:C220-25
32. 31. Levi M, McDonald LA, Preisig PA, Alpern RJ. 1991. Chronic K depletion stimulates rat renal brush-border membrane Na-citrate cotranspotter. Am. J. Physiol. 261:F767-73
33. 32. Lohse J, Verine HJ, Charbit JJ, Sarles H. 1981. Studies on pancreatic stones. II. Citrate secretion in the canine pancreatic juice. Digestion 21:198-204
34. 33. Lolkema JS, Enequist H, van der Rest ME. 1994. Transport of citrate catalyzed by the sodium-dependent citrate carrier of Klebsiella pneumoniae is obligatorily coupled to the transport of two sodium ions. Eur. J. Biochem. 220:469-75
35. 4 cotransport. Proc. Natl. Acad. Sci. USA 90:8073-77
36. 35. Melnick JZ, Srere PA, Elshourbagy NA, Moe OW, Preisig PA, Alpern RJ. 1996. Adenosine triphosphate citrate lyase mediates hypocitraturia in rats. J. Clin. Invest. 98:2381-87
37. + on intestinal succinate transport and metabolism in vitro. Am. J. Physiol. 255:C95-101
38. +-dicarboxylate cotransport: identification, characterization, and acinar location. Am. J. Physiol. 263:G871-79
39. 38. Murer H, Manganel M, Roch-Ramel F. 1992. Tubular transport of monocarboxylates, Krebs cycle intermediates, and inorganic sulfate. In Handbook of Physiology-Renal Physiology, ed. EE Windhager, pp. 2165-88 New York: Am. Physiol. Soc.
40. 4 cotransporter. Pflügers Arch. 428:217-23
41. 40. Ogin C, Grassl SM. 1989. Dicarboxylate transport in human placental brush-border membrane vesicles. Biochim. Biophys. Acta 980:248-54
42. 41. Pajor AM. 1995. Sequence and functional characterization of a renal sodium/dicarboxylate cotransporter. J. Biol. Chem. 270:5779-85
43. 42. Pajor AM. 1996. Molecular cloning and functional expression of a sodium-dicarboxylate cotransporter from human kidney. Am. J. Physiol. 270:F642-48
44. +/dicarboxylate cotransporter. J. Biol. Chem. 273:18923-29
45. +/dicarboxylate cotransporter using anti-fusion protein antibodies. Am. J. Physiol. 271:C1808-16
46. +-dicarboxylate cotransporters, NaDC-1 and hNaDC-1. Am. J. Physiol. 271:F 1093-99
47. +/sulfate cotransporters is located in the carboxy-terminal portion of the protein. Biochim. Biophys. Acta 1370:98-106
48. +/dicarboxylate cotransporter, NaDC-1. Biochem. J. 331:257-64
49. +/dicarboxylate Cotransporter, NaDC-1, in COS-7 cells. Pflügers Arch. 431:645-51
50. 49. PakCYC. 1991. Etiology and treatment of urolithiasis. Am. J. Kidney Dis. 18:624-37
51. +/glucose cotransporter: I. Voltage-clamp studies. J. Biol. 125:49-6
52. +/glucose cotransporter: II. A transport model under nonrapid equilibrium conditions. J. Membr. Biol. 125:63-79
53. 52. Piper DW, Fenton BH, Goodman LR. 1967. Lactic, pyruvic, citric and uric acid and urea content of human gastric juice. Gastroenterology 53:42-48
54. 53. Pritchard JB, Miller DS. 1993. Mechanisms mediating renal secretion of organic anions and cations. Physiol. Rev. 73:765-96
55. 53a. Sakhaee K, Alpern RJ, Pointdexter J, Pak CYC. 1998. Citraturic response to oral citric acid load. J. Urol. 147:975-76
56. 54. Schell RE, Wright EM. 1985. Electro-physiology of succinate transport across rabbit renal brush border membranes. J. Physiol. 360:95-104
57. +-dicarboxylate transporter. Am. J. Physiol. 275:F298-305
58. 55. Sekine T, Watanabe N, Hosoyamada M, Kanai Y, Endou H. 1997. Expression cloning and characterization of a novel multispecific organic anion transporter. J. Biol. Chem. 272:18526-29
59. 56. Shank RP, Bennett DJ. 1993. 2-Oxoglutarate transport: a potential mechanism for regulating glutamate and tricarboxylic-acid cycle intermediates in neurons. Neurochem. Res. 18:401-10
60. +-dependent, high affinity uptake of alpha-ketoglutarate by nerve terminal enriched material from mouse cerebellum. Life Sci. 28:843-50
61. 58. Sheridan E, Rumrich G, Ullrich KJ. 1983. Reabsorption of dicarboxylic acids from the proximal convolution of rat kidney. Pflügers Arch. 399:18-28
62. 59. Simpson DP. 1983. Citrate excretion: a window on renal metabolism. Am. J. Physiol. 244:F223-34
63. 60. Steffgen J, Kienle S, Scheyerl F, Franz HE. 1994. Expression of a rat renal sodium-dependent dicarboxylate transporter in Xenopus oocytes. Biochem. J. 297:35-39
64. 61. Stevens BR, Wright SH, Hirayama B, Gunther RD, Ross HJ, et al. 1982. Organic and inorganic solute transport in renal and intestinal membrane vesicles preserved in liquid nitrogen. Membr. Biochem. 4:271-82
65. 62. Stoll B, McNelly S, Buscher HP, Haussinger D. 1991. Functional hepatocyte heterogeneity in glutamate, aspartate and α-ketoglutarate uptake: a histoautoradiographical study. Hepatology 13:247-53
66. 63. Ullrich KJ. 1997. Renal transporters for organic anions and organic cations. Structural requirements for substrates. J. Membr. Biol. 158:95-107
67. 64. Ullrich KJ, Fasold H, Rumrich G, Kloss S. 1984. Secretion and contraluminal uptake of dicarboxylic acids in the proximal convolution of rat kidney. Pflügers Arch. 400:241-49
68. 65. van der Rest ME, Siewe RM, Abee T, Schwarz E, Oesterhelt D, Konings WN. 1992. Nucleotide sequence and functional properties of a sodium-dependent citrate transport system from Klebsiella pneumoniae. J. Biol. Chem. 267:8971-76
69. 66. Windus DW, Conn DE, Heifets M. 1986. Effects of fasting on citrate transport by the brush-border membrane of the rat kidney. Am. J. Physiol. 251:F678-82
70. 67. Wolffram S, Badertscher M, Scharrer E. 1994. Carrier-mediated transport is involved in mucosal succinate uptake by rat large intestine. Exp. Physiol 79:215-26
71. 68. Wolffram S, Bisang B, Grenadier B, Scharrer E. 1990. Transport of tri-and dicarboxylic acids across the intestinal brush-border membrane of calves. J. Nutr. 120:767-74
72. 69. Wolffram S, Hagemann C, Grenacher B, Scharrer E. 1992. Characterization of the transport of tri-and dicarboxylates by pig intestinal brush-border membrane vesicles. Comp. Biochem. Physiol. A 101:759-67
73. 70. Wolffram S, Unternahrer R, Grenacher B, Scharrer E. 1994. Transport of citrate across the brush border and basolateral membrane of rat small intestine. Comp. Biochem. Physiol. A 109:39-52
74. 71. Wright EM. 1985. Transport of carboxylic acids by renal membrane vesicles. Annu. Rev. Physiol. 47:127-41
75. 72. Wright EM, Wright SH, Hirayama BA, Kippen I. 1982. Interactions between lithium and renal transport of Krebs cycle intermediates. Proc. Natl. Acad. Sci. USA 79:7514-17
76. 73. Wright SH, Hirayama B, Kaunitz JD, Kippen I, Wright EM. 1983. Kinetics of sodium succinate cotransport across renal brush-border membranes. J. Biol. Chem. 258:5456-62
77. 74. Wright SH, Kippen I, Klinenberg JR, Wright EM. 1980. Specificity of the transport system for tricarboxylic acid cycle intermediates in renal brush borders. J. Membr. Biol. 57:73-82
78. 75. Wright SH, Kippen I, Wright EM. 1982. Effect of pH on the transport of Krebs cycle intermediates in renal brush border membranes. Biochim. Biophys. Acta 684:287-90
79. 76. Wright SH, Wunz TM. 1987. Succinate and citrate transport in renal basolateral and brush-border membranes. Am. J. Physiol. 253:F432-39
80. 77. Zimmerli B, O'Neill B, Meier PJ. 1992. Identification of sodium-dependent and sodium-independent dicarboxylate transport systems in rat liver basolateral membrane vesicles. Pflügers Arch. 421:329-35