Dissolving polymer microneedle patches for rapid and efficient transdermal delivery of insulin to diabetic rats

Acta Biomaterialia

Volumn 9, Issue 11, 2013, Pages 8952-8961

  Ling, Ming Hung ^a   Chen, Mei Chin ^a  

^a NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

Author keywords

Bioavailability; Bolus release; Hypoglycemic effect; Polysaccharide; Protein delivery

Indexed keywords

CONTROLLED DRUG DELIVERY; DISSOLUTION; INSULIN; NEEDLES; PROTEINS; RATS; STARCH; TARGETED DRUG DELIVERY;

BOLUS RELEASE; DIABETIC RATS; HISTOLOGICAL EXAMINATION; HYPOGLYCEMIC EFFECT; MECHANICAL; MICRONEEDLE PATCHES; MICRONEEDLES; POLYMER MICRO NEEDLES; PROTEIN DELIVERY; TRANSDERMAL DELIVERY;

BIOCHEMISTRY;

DISSOLVING MICRONEEDLE PATCH; GELATIN; INSULIN; POLYMER; STARCH; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIDIABETIC ACTIVITY; ARTICLE; BIOAVAILABILITY; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; ENCAPSULATION; HISTOPATHOLOGY; IN VITRO STUDY; MICRONEEDLE; NOCICEPTION; NONHUMAN; PRIORITY JOURNAL; RAT; SKIN IRRITATION; TRANSDERMAL PATCH;

RATTUS; SUS;

BIOAVAILABILITY; BOLUS RELEASE; HYPOGLYCEMIC EFFECT; POLYSACCHARIDE; PROTEIN DELIVERY;

ADMINISTRATION, CUTANEOUS; ANIMALS; BLOOD GLUCOSE; DEXTRANS; DIABETES MELLITUS, EXPERIMENTAL; DRUG DELIVERY SYSTEMS; FLUORESCEIN-5-ISOTHIOCYANATE; INSULIN; MALE; NEEDLES; POLYMERS; RATS; RATS, SPRAGUE-DAWLEY; SKIN;

EID: 84885060699     PISSN: 17427061     EISSN: 18787568     Source Type: Journal    
DOI: 10.1016/j.actbio.2013.06.029     Document Type: Article

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