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Volumn 30, Issue 5, 2013, Pages 2063-2070

Ghrelin inhibits ovarian epithelial carcinoma cell proliferation in vitro

Author keywords

Apoptosis; Autophagy; Ghrelin; Mammalian target of rapamycin; Ovarian epithelial carcinoma; Proliferation

Indexed keywords

GHRELIN; GHRELIN NEUTRALIZING ANTIBODY; GHRELIN RECEPTOR; HISTIDYL DEXTRO TRYPTOPHYLALANYLTRYPTOPHYL DEXTRO PHENYLALANYLLYSINAMIDE; MAMMALIAN TARGET OF RAPAMYCIN; NEUTRALIZING ANTIBODY; PROTEIN INHIBITOR; UNCLASSIFIED DRUG;

EID: 84885033980     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2013.2692     Document Type: Article
Times cited : (20)

References (36)
  • 1
    • 0037153374 scopus 로고    scopus 로고
    • Rapid tumor development and potent vascularization are independent events in carcinoma producing FGF-1 or FGF-2
    • Billottet C, Janji B, Thiery JP and Jouanneau J: Rapid tumor development and potent vascularization are independent events in carcinoma producing FGF-1 or FGF-2. Oncogene 21: 8128-8139, 2002.
    • (2002) Oncogene , vol.21 , pp. 8128-8139
    • Billottet, C.1    Janji, B.2    Thiery, J.P.3    Jouanneau, J.4
  • 2
    • 0027142057 scopus 로고
    • Basic fibroblast growth factor and its receptor messenger ribonucleic acids are expressed in human ovarian epithelial neoplasms
    • Di Blasio AM, Cremonesi L, Viganó P, et al: Basic fibroblast growth factor and its receptor messenger ribonucleic acids are expressed in human ovarian epithelial neoplasms. Am J Obstet Gynecol 169: 1517-1523, 1993.
    • (1993) Am J Obstet Gynecol , vol.169 , pp. 1517-1523
    • Di Blasio, A.M.1    Cremonesi, L.2    Viganó, P.3
  • 4
    • 0033540056 scopus 로고    scopus 로고
    • Ghrelin is a growth-hormone-releasing acylated peptide from stomach
    • Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H and Kangawa K: Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 402: 656-660, 1999.
    • (1999) Nature , vol.402 , pp. 656-660
    • Kojima, M.1    Hosoda, H.2    Date, Y.3    Nakazato, M.4    Matsuo, H.5    Kangawa, K.6
  • 5
    • 15544385058 scopus 로고    scopus 로고
    • Ghrelin: Structure and function
    • Kojima M and Kangawa K: Ghrelin: structure and function. Physiol Rev 85: 495-522, 2005.
    • (2005) Physiol Rev , vol.85 , pp. 495-522
    • Kojima, M.1    Kangawa, K.2
  • 6
    • 0035083549 scopus 로고    scopus 로고
    • Growth hormone secretagogue receptor family members and ligands
    • Smith RG, Leonard R, Bailey AR, et al: Growth hormone secretagogue receptor family members and ligands. Endocrine 14: 9-14, 2001.
    • (2001) Endocrine , vol.14 , pp. 9-14
    • Smith, R.G.1    Leonard, R.2    Bailey, A.R.3
  • 8
    • 4644244251 scopus 로고    scopus 로고
    • Ghrelin stimulates neurogenesis in the dorsal motor nucleus of the vagus
    • Zhang W, Lin TR, Hu Y, et al: Ghrelin stimulates neurogenesis in the dorsal motor nucleus of the vagus. J Physiol 559: 729-737, 2004.
    • (2004) J Physiol , vol.559 , pp. 729-737
    • Zhang, W.1    Lin, T.R.2    Hu, Y.3
  • 9
    • 23844447768 scopus 로고    scopus 로고
    • Ghrelin stimulates proliferation and differentiation and inhibits apoptosis in osteoblastic MC3T3-E1 cells
    • Kim SW, Her SJ, Park SJ, et al: Ghrelin stimulates proliferation and differentiation and inhibits apoptosis in osteoblastic MC3T3-E1 cells. Bone 37: 359-369, 2005.
    • (2005) Bone , vol.37 , pp. 359-369
    • Kim, S.W.1    Her, S.J.2    Park, S.J.3
  • 10
    • 33947433307 scopus 로고    scopus 로고
    • Autocrine proliferative effect of ghrelin on leukemic HL-60 and THP-1 cells
    • De Vriese C and Delporte C: Autocrine proliferative effect of ghrelin on leukemic HL-60 and THP-1 cells. J Endocrinol 192: 199-205, 2007.
    • (2007) J Endocrinol , vol.192 , pp. 199-205
    • De Vriese, C.1    Delporte, C.2
  • 11
    • 47649092734 scopus 로고    scopus 로고
    • Role of ghrelin axis in colorectal cancer: A novel association
    • Waseem T, Javaid-Ur-Rehman, Ahmad F, Azam M and Qureshi MA: Role of ghrelin axis in colorectal cancer: a novel association. Peptides 29: 1369-1376, 2008.
    • (2008) Peptides , vol.29 , pp. 1369-1376
    • Waseem, T.1    Javaid-Ur-Rehman Ahmad, F.2    Azam, M.3    Qureshi, M.A.4
  • 12
    • 0036155811 scopus 로고    scopus 로고
    • The antiproliferative effect of synthetic peptidyl GH secretagogues in human CALU-1 lung carcinoma cells
    • Ghè C, Cassoni P, Catapano F, et al: The antiproliferative effect of synthetic peptidyl GH secretagogues in human CALU-1 lung carcinoma cells. Endocrinology 143: 484-491, 2002.
    • (2002) Endocrinology , vol.143 , pp. 484-491
    • Ghè, C.1    Cassoni, P.2    Catapano, F.3
  • 13
    • 3042735648 scopus 로고    scopus 로고
    • The tissue distribution of the mRNA of ghrelin and subtypes of its receptor, GHS-R, in humans
    • Gnanapavan S, Kola B, Bustin SA, et al: The tissue distribution of the mRNA of ghrelin and subtypes of its receptor, GHS-R, in humans. J Clin Endocrinol Metab 87: 2988, 2002.
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 2988
    • Gnanapavan, S.1    Kola, B.2    Bustin, S.A.3
  • 14
    • 84859999866 scopus 로고    scopus 로고
    • MTOR signaling pathway and mTOR inhibitors in cancer therapy
    • Gomez-Pinillos A and Ferrari AC: mTOR signaling pathway and mTOR inhibitors in cancer therapy. Hematol Oncol Clin North Am 26: 483-505, 2012.
    • (2012) Hematol Oncol Clin North Am , vol.26 , pp. 483-505
    • Gomez-Pinillos, A.1    Ferrari, A.C.2
  • 15
    • 0035094978 scopus 로고    scopus 로고
    • Role of leucine in the regulation of mTOR by amino acids: Revelations from structure-activity studies
    • Lynch CJ: Role of leucine in the regulation of mTOR by amino acids: revelations from structure-activity studies. J Nutr 131: 861S-865S, 2001.
    • (2001) J Nutr , vol.131
    • Lynch, C.J.1
  • 16
    • 79957883170 scopus 로고    scopus 로고
    • The multiple roles of autophagy in cancer
    • Rosenfeldt MT and Ryan KM: The multiple roles of autophagy in cancer. Carcinogenesis 32: 955-963, 2011.
    • (2011) Carcinogenesis , vol.32 , pp. 955-963
    • Rosenfeldt, M.T.1    Ryan, K.M.2
  • 18
    • 15944364270 scopus 로고    scopus 로고
    • Expression of growth hormone secretagogue receptor type 1a, the functional ghrelin receptor, in human ovarian surface epithelium, mullerian duct derivatives, and ovarian tumors
    • Gaytan F, Morales C, Barreiro ML, et al: Expression of growth hormone secretagogue receptor type 1a, the functional ghrelin receptor, in human ovarian surface epithelium, mullerian duct derivatives, and ovarian tumors. J Clin Endocrinol Metab 90: 1798-1804, 2005.
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 1798-1804
    • Gaytan, F.1    Morales, C.2    Barreiro, M.L.3
  • 19
    • 70350061742 scopus 로고    scopus 로고
    • Elevated blood plasma concentrations of active ghrelin and obestatin in benign ovarian neoplasms and ovarian cancers
    • Markowska A, Ziółkowska A, Jaszczyńska-Nowinka K, Madry R and Malendowicz LK: Elevated blood plasma concentrations of active ghrelin and obestatin in benign ovarian neoplasms and ovarian cancers. Eur J Gynaecol Oncol 30: 518-522, 2009.
    • (2009) Eur J Gynaecol Oncol , vol.30 , pp. 518-522
    • Markowska, A.1    Ziółkowska, A.2    Jaszczyńska-Nowinka, K.3    Madry, R.4    Malendowicz, L.K.5
  • 20
    • 44049094269 scopus 로고    scopus 로고
    • Ghrelin octanoylation mediated by an orphan lipid transferase
    • Gutierrez JA, Solenberg PJ, Perkins DR, et al: Ghrelin octanoylation mediated by an orphan lipid transferase. Proc Natl Acad Sci USA 105: 6320-6325, 2008.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 6320-6325
    • Gutierrez, J.A.1    Solenberg, P.J.2    Perkins, D.R.3
  • 21
    • 38849090670 scopus 로고    scopus 로고
    • Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone
    • Yang J, Brown MS, Liang G, Grishin NV and Goldstein JL: Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone. Cell 132: 387-396, 2008.
    • (2008) Cell , vol.132 , pp. 387-396
    • Yang, J.1    Brown, M.S.2    Liang, G.3    Grishin, N.V.4    Goldstein, J.L.5
  • 22
    • 80052583940 scopus 로고    scopus 로고
    • The expression of ghrelin O-acyltransferase (GOAT) in human tissues
    • Lim CT, Kola B, Grossman A and Korbonits M: The expression of ghrelin O-acyltransferase (GOAT) in human tissues. Endocr J 58: 707-710, 2011.
    • (2011) Endocr J , vol.58 , pp. 707-710
    • Lim, C.T.1    Kola, B.2    Grossman, A.3    Korbonits, M.4
  • 23
    • 50449085374 scopus 로고    scopus 로고
    • Effect of des-acyl ghrelin on adiposity and glucose metabolism
    • Zhang W, Chai B, Li JY, Wang H and Mulholland MW: Effect of des-acyl ghrelin on adiposity and glucose metabolism. Endocrinology 149: 4710-4716, 2008.
    • (2008) Endocrinology , vol.149 , pp. 4710-4716
    • Zhang, W.1    Chai, B.2    Li, J.Y.3    Wang, H.4    Mulholland, M.W.5
  • 24
    • 0034731310 scopus 로고    scopus 로고
    • Ghrelin and des-acyl ghrelin: Two major forms of rat ghrelin peptide in gastrointestinal tissue
    • Hosoda H, Kojima M, Matsuo H and Kangawa K: Ghrelin and des-acyl ghrelin: two major forms of rat ghrelin peptide in gastrointestinal tissue. Biochem Biophys Res Commun 279: 909-913, 2000.
    • (2000) Biochem Biophys Res Commun , vol.279 , pp. 909-913
    • Hosoda, H.1    Kojima, M.2    Matsuo, H.3    Kangawa, K.4
  • 25
    • 11244297916 scopus 로고    scopus 로고
    • Dysregulation of the TSC-mTOR pathway in human disease
    • Inoki K, Corradetti MN and Guan KL: Dysregulation of the TSC-mTOR pathway in human disease. Nat Genet 37: 19-24, 2005.
    • (2005) Nat Genet , vol.37 , pp. 19-24
    • Inoki, K.1    Corradetti, M.N.2    Guan, K.L.3
  • 26
    • 34547907805 scopus 로고    scopus 로고
    • Expanding mTOR signaling
    • Yang Q and Guan KL: Expanding mTOR signaling. Cell Res 17: 666-681, 2007.
    • (2007) Cell Res , vol.17 , pp. 666-681
    • Yang, Q.1    Guan, K.L.2
  • 27
    • 84859778293 scopus 로고    scopus 로고
    • MTOR signaling in growth control and disease
    • Laplante M and Sabatini DM: mTOR signaling in growth control and disease. Cell 149: 274-293, 2012.
    • (2012) Cell , vol.149 , pp. 274-293
    • Laplante, M.1    Sabatini, D.M.2
  • 28
    • 84868237217 scopus 로고    scopus 로고
    • Mammalian target of rapamycin as a rational therapeutic target for breast cancer treatment
    • LoRusso PM: Mammalian target of rapamycin as a rational therapeutic target for breast cancer treatment. Oncology 84: 43-56, 2013.
    • (2013) Oncology , vol.84 , pp. 43-56
    • Lorusso, P.M.1
  • 29
    • 81055125652 scopus 로고    scopus 로고
    • Programmed cell death in animal development and disease
    • Fuchs Y and Steller H: Programmed cell death in animal development and disease. Cell 147: 742-758, 2011.
    • (2011) Cell , vol.147 , pp. 742-758
    • Fuchs, Y.1    Steller, H.2
  • 30
    • 78049502859 scopus 로고    scopus 로고
    • Apoptosis, stem cells, and tissue regeneration
    • Bergmann A and Steller H: Apoptosis, stem cells, and tissue regeneration. Sci Signal 3: re8, 2010.
    • (2010) Sci Signal , vol.3
    • Bergmann, A.1    Steller, H.2
  • 31
    • 0037981384 scopus 로고    scopus 로고
    • Amino acids as regulators and components of nonproteinogenic pathways
    • Meijer AJ: Amino acids as regulators and components of nonproteinogenic pathways. J Nutr 133: 2057S-2062S, 2003.
    • (2003) J Nutr , vol.133
    • Meijer, A.J.1
  • 32
    • 1842583789 scopus 로고    scopus 로고
    • Development by self-digestion: Molecular mechanisms and biological functions of autophagy
    • Levine B and Klionsky DJ: Development by self-digestion: molecular mechanisms and biological functions of autophagy. Dev Cell 6: 463-477, 2004.
    • (2004) Dev Cell , vol.6 , pp. 463-477
    • Levine, B.1    Klionsky, D.J.2
  • 33
    • 33745885329 scopus 로고    scopus 로고
    • DRAM, a p53-induced modulator of autophagy, is critical for apoptosis
    • Crighton D, Wilkinson S, O'Prey J, et al: DRAM, a p53-induced modulator of autophagy, is critical for apoptosis. Cell 126: 121-134, 2006.
    • (2006) Cell , vol.126 , pp. 121-134
    • Crighton, D.1    Wilkinson, S.2    O'Prey, J.3
  • 34
    • 43649104579 scopus 로고    scopus 로고
    • Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia
    • Zhang H, Bosch-Marce M, Shimoda LA, et al: Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia. J Biol Chem 283: 10892-10903, 2008.
    • (2008) J Biol Chem , vol.283 , pp. 10892-10903
    • Zhang, H.1    Bosch-Marce, M.2    Shimoda, L.A.3
  • 36
    • 59749098315 scopus 로고    scopus 로고
    • Nutrient-dependent regulation of autophagy through the target of rapamycin pathway
    • Chang YY, Juhász G, Goraksha-Hicks P, et al: Nutrient-dependent regulation of autophagy through the target of rapamycin pathway. Biochem Soc Trans 37: 232-236, 2009.
    • (2009) Biochem Soc Trans , vol.37 , pp. 232-236
    • Chang, Y.Y.1    Juhász, G.2    Goraksha-Hicks, P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.