An MRI-Visible Non-Viral Vector Bearing GD2 Single Chain Antibody for Targeted Gene Delivery to Human Bone Marrow Mesenchymal Stem Cells

PLoS ONE

Volumn 8, Issue 10, 2013, Pages

  Pang, Pengfei ^a,b   Wu, Chun ^a   Shen, Min ^a   Gong, Faming ^b   Zhu, Kangshun ^a,b   Jiang, Zaibo ^a,b   Guan, Shouhai ^a,b   Shan, Hong ^a,b   Shuai, Xintao ^b  

^a THE THIRD AFFILIATED HOSPITAL OF SUN YAT SEN UNIVERSITY   (China)

^b SUN YAT SEN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

GANGLIOSIDE GD2; LIPOFECTAMINE; MACROGOL; PLASMID DNA; POLYETHYLENEIMINE; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY; SUPERPARAMAGNETIC IRON OXIDE NANOPARTICLE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOCOMPATIBILITY; CELL DIFFERENTIATION; CELL ISOLATION; CELL MIGRATION; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; CYTOTOXICITY; GENETIC TRANSFECTION; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; IMMUNOGENICITY; IN VITRO STUDY; IN VIVO STUDY; LIVER FIBROSIS; MALE; MESENCHYMAL STEM CELL; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; NUCLEAR MAGNETIC RESONANCE IMAGING; PARTICLE SIZE; RAT; REPORTER GENE; ZETA POTENTIAL;

ADULT; ANIMALS; CELL SURVIVAL; CELLS, CULTURED; FEMALE; GANGLIOSIDES; GENETIC VECTORS; GREEN FLUORESCENT PROTEINS; HUMANS; LIVER CIRRHOSIS; MAGNETIC RESONANCE IMAGING; MAGNETITE NANOPARTICLES; MALE; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STROMAL CELLS; MICROSCOPY, CONFOCAL; PARTICLE SIZE; POLYETHYLENE GLYCOLS; POLYETHYLENEIMINE; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCIBILITY OF RESULTS; SINGLE-CHAIN ANTIBODIES; TRANSFECTION; TRANSPLANTATION, HETEROLOGOUS; YOUNG ADULT;

EID: 84885033461     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0076612     Document Type: Article

References (27)

1. Merceron C, Portron S, Vignes-Colombeix C, Rederstorff E, Masson M, et al. (2012) Pharmacological modulation of human mesenchymal stem cell chondrogenesis by a chemically oversulfated polysaccharide of marine origin: potential application to cartilage regenerative medicine. Stem Cells. 30: 471-480. doi:10.1002/stem.1686. PubMed: 22131189.
2. Elabd C, Chiellini C, Carmona M, Galitzky J, Cochet O, et al. (2009) Human multipotent adipose-derived stem cells differentiate into functional brown adipocytes. Stem Cells. 27: 2753-2760. doi:10.1002/stem.200. PubMed: 19697348.
3. Thibault RA, Scott Baggett L, Mikos AG, Kasper FK, (2010) Osteogenic differentiation of mesenchymal stem cells on pregenerated extracellular matrix scaffolds in the absence of osteogenic cell culture supplements. Tissue Eng Part A 16: 431-440. doi:10.1089/ten.tea.2009.0583. PubMed: 19863274.
4. Barzilay R, Ben-Zur T, Bulvik S, Melamed E, Offen D, (2009) Lentiviral delivery of LMX1a enhances dopaminergic phenotype in differentiated human bone marrow mesenchymal stem cells. Stem Cells Dev 18: 591-601. doi:10.1089/scd.2008.0138. PubMed: 19298173.
5. Loebinger MR, Eddaoudi A, Davies D, Janes SM, (2009) Mesenchymal stem cell delivery of TRAIL can eliminate metastatic cancer. Cancer Res 69: 4134-4142. doi:10.1158/0008-5472.SABCS-4134. PubMed: 19435900.
6. Williams AR, Hare JM, (2011) Mesenchymal stem cells: biology, pathophysiology, translational findings, and therapeutic implications for cardiac disease. Circ Res 109: 923-940. doi:10.1161/CIRCRESAHA.111.243147. PubMed: 21960725.
7. Sordi V, Melzi R, Mercalli A, Formicola R, Doglioni C, et al. (2010) Mesenchymal cells appearing in pancreatic tissue culture are bone marrow-derived stem cells with the capacity to improve transplanted islet function. Stem Cells. 28: 140-151. PubMed: 19924826.
8. Dai LJ, Li HY, Guan LX, Ritchie G, Zhou JX, (2009) The therapeutic potential of bone marrow-derived mesenchymal stem cells on hepatic cirrhosis. Stem. Cell Res 2: 16-25.
9. Martinez C, Hofmann TJ, Marino R, Dominici M, Horwitz EM, (2007) Human bone marrow mesenchymal stromal cells express the neural ganglioside GD2: a novel surface marker for the identification of MSCs. Blood. 109: 4245-4248. doi:10.1182/blood-2006-08-039347. PubMed: 17264296.
10. Xu J, Liao WB, Gu D, Liang L, Liu M, et al. (2009) Neural Ganglioside GD2 Identifies a Subpopulation of Mesenchymal Stem Cells in Umbilical Cord. Cell Physiol Biochem 23: 415-424. doi:10.1159/000218188. PubMed: 19471109.
11. Kim SM, Lim JY, Park SI, Jeong CH, Oh JH, et al. (2008) Gene therapy using TRAIL-secreting human umbilical cord blood-derived mesenchymal stem cells against intracranial glioma. Cancer Res 68: 9614-9623. doi:10.1158/0008-5472.CAN-08-0451. PubMed: 19047138.
12. Bosch P, Fouletier-Dilling C, Olmsted-Davis EA, Davis AR, Stice SL, (2006) Efficient adenoviral-mediated gene delivery into porcine mesenchymal stem cells. Mol Reprod Dev 73: 1393-1403. doi:10.1002/mrd.20593. PubMed: 16897738.
13. Ricks DM, Kutner R, Zhang XY, Welsh DA, Reiser J, (2008) Optimized lentiviral transduction of mouse bone marrow-derived mesenchymal stem cells. Stem Cells Dev 17: 441-450. doi:10.1089/scd.2007.0194. PubMed: 18513160.
14. Meyerrose TE, Roberts M, Ohlemiller KK, Vogler CA, Wirthlin L, et al. (2008) Lentiviral-transduced human mesenchymal stem cells persistently express therapeutic levels of enzyme in a xenotransplantation model of human disease. Stem Cells. 26: 1713-1722. doi:10.1634/stemcells.2008-0008. PubMed: 18436861.
15. Shan Y, Luo T, Peng C, Sheng R, Cao A, et al. (2012) Gene delivery using dendrimer-entrapped gold nanoparticles as nonviral vectors. Biomaterials. 33: 3025-3035. doi:10.1016/j.biomaterials.2011.12.045. PubMed: 22248990.
16. Dutta T, Jain NK, McMillan NA, Parekh HS, (2010) Dendrimer nanocarriers as versatile vectors in gene delivery. Nanomedicine. 6: 25-34. doi:10.1016/j.nano.2009.05.005. PubMed: 19450708.
17. Pandita D, Santos JL, Rodrigues J, Pêgo AP, Granja PL, et al. (2011) Gene delivery into mesenchymal stem cells: a biomimetic approach using RGD nanoclusters based on poly (amidoamine) dendrimers. Biomacromolecules. 12: 472-481. doi:10.1021/bm1012647. PubMed: 21210673.
18. Akinc A, Thomas M, Klibanov AM, Langer R, (2005) Exploring polyethyl- enimine-mediated DNA transfection and the proton sponge hypothesis. J Gene Med 7: 657-663. doi:10.1097/00125817-200511000-00012. PubMed: 15543529.
19. Brunot C, Ponsonnet L, Lagneau C, Farge P, Picart C, et al. (2007) Cytotoxicity of polyethyleneimine (PEI), precursor base layer of polyelectrolyte multilayer films. Biomaterials. 28: 632-640. doi:10.1016/j.biomaterials.2006.09.026. PubMed: 17049374.
20. Ahn HH, Lee JH, Kim KS, Lee JY, Kim MS, et al. (2008) Polyethyleneimine-mediated gene delivery into human adipose derived stem cells. Biomaterials. 29: 2415-2422. doi:10.1016/j.biomaterials.2008.02.006. PubMed: 18295879.
21. Chen G, Chen W, Wu Z, Yuan R, Li H, et al. (2009) MRI-visible polymeric vector bearing CD3 single chain antibody for gene delivery to T cells for immunosuppression. Biomaterials. 30: 1962-1970. doi:10.1016/j.biomaterials.2008.12.043. PubMed: 19162315.
22. Shen M, Gong F, Pang P, Zhu K, Meng X, et al. (2012) An MRI-visible non-viral vector for targeted Bcl-2 siRNA delivery to neuroblastoma. Int J Nanomed. 7: 3319-3332.
23. Nemeth K, Wilson T, Rada B, Parmelee A, Mayer B, et al. (2012) Characterization and function of histamine receptors in human bone marrow stromal cells. Stem Cells. 30: 222-231. doi:10.1002/stem.771. PubMed: 22045589.
24. Zhou B, Shan H, Li D, Jiang ZB, Qian JS, et al. (2010) MR tracking of magnetically labeled mesenchymal stem cells in rats with liver fibrosis. Magn Reson Imaging. 28: 394-399. doi:10.1016/j.mri.2009.12.005. PubMed: 20096523.
25. Kim SW, Ogawa T, Tabata Y, Nishimura I, (2004) Efficacy and cytotoxicity of cationic-agent-mediated nonviral gene transfer into osteoblasts. J Biomed Mater Res A. 71: 308-315. PubMed: 15372469.
26. Fischer D, von Harpe A, Kunath K, Petersen H, Li Y, et al. (2002) Copolymers of ethylene imine and N-(2-hydroxyethyl)-ethylene imine as tools to study effects of polymer structure on physicochemical and biological properties of DNA complexes. Bioconjug Chem 13: 1124-1133. doi:10.1021/bc025550w. PubMed: 12236795.
27. Farrell LL, Pepin J, Kucharski C, Lin X, Xu Z, et al. (2007) A comparison of the effectiveness of cationic polymers poly-L-lysine (PLL) and polyethylenimine (PEI) for non-viral delivery of plasmid DNA to bone marrow stromal cells (BMSC). Eur J Pharm Biopharm 65: 388-397. doi:10.1016/j.ejpb.2006.11.026. PubMed: 17240127.